KR910018045A - 흡입에 의해 약제를 투여하기 위한 운반 기구 - Google Patents

흡입에 의해 약제를 투여하기 위한 운반 기구 Download PDF

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KR910018045A
KR910018045A KR1019910007083A KR910007083A KR910018045A KR 910018045 A KR910018045 A KR 910018045A KR 1019910007083 A KR1019910007083 A KR 1019910007083A KR 910007083 A KR910007083 A KR 910007083A KR 910018045 A KR910018045 A KR 910018045A
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flexible sheet
depressions
sheet material
sheet
medicament
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조셉 벨라스 퀘즈 데이비드
데이비드 호전 피터
데이비드 칼호운 클라이드
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더블유. 죠지 매러디스
라이커 래보러토리스, 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0051—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a tape, e.g. strips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/02—Inhalators with activated or ionised fluids, e.g. electrohydrodynamic [EHD] or electrostatic devices; Ozone-inhalators with radioactive tagged particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/02—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure
    • B29C65/18—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure using heated tools
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/80—General aspects of machine operations or constructions and parts thereof
    • B29C66/81—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps
    • B29C66/814—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps
    • B29C66/8145—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the constructional aspects of the pressing elements, e.g. of the welding jaws or clamps
    • B29C66/81457—General aspects of the pressing elements, i.e. the elements applying pressure on the parts to be joined in the area to be joined, e.g. the welding jaws or clamps characterised by the design of the pressing elements, e.g. of the welding jaws or clamps characterised by the constructional aspects of the pressing elements, e.g. of the welding jaws or clamps comprising a block or layer of deformable material, e.g. sponge, foam, rubber
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/80—General aspects of machine operations or constructions and parts thereof
    • B29C66/83—General aspects of machine operations or constructions and parts thereof characterised by the movement of the joining or pressing tools
    • B29C66/834—General aspects of machine operations or constructions and parts thereof characterised by the movement of the joining or pressing tools moving with the parts to be joined
    • B29C66/8341—Roller, cylinder or drum types; Band or belt types; Ball types
    • B29C66/83411—Roller, cylinder or drum types
    • B29C66/83413—Roller, cylinder or drum types cooperating rollers, cylinders or drums
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2821/00—Use of unspecified rubbers as mould material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/712—Containers; Packaging elements or accessories, Packages
    • B29L2031/7162—Boxes, cartons, cases
    • B29L2031/7164—Blister packages
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Laminated Bodies (AREA)
  • Absorbent Articles And Supports Therefor (AREA)

Abstract

내용 없음

Description

흡입에 의해 약제를 투여하기 위한 운반 기구
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 함몰부에 분말이 함유되지 않은 공백 시이트(blank sheet)의 사진, 제3도는 함몰부에 분말이 함유된 시이트의 개략적 단면도 제9도는 시이트에 분말을 도포하기 위한 장치의 개략도

Claims (22)

  1. 최소한 하나의 표면상에서 복수의 불연속 함몰부들을 포함하는 유연한 시트상 재료로서, 상기의 각각의 함몰부들은 5 내지 500㎛ 이지만, 상기의 시이트상 재료의 두께에 비해 더 작은 깊이를 갖고 상기의 시이트상 재료의 표면에서 지름으로 약10 내지 500㎛의 오프닝을 갖고 있으며, 실제적 수의 상기의 함몰부들은 미립자화된 약제로서 최소한 부분적으로 채워지며, 그리고 상기의 함몰부들 사이의 상기의 표면부위는 상기의 미립자화 된 약제가 실제적으로 없는 유연한 시이트 재료.
  2. 제1항에 있어서, 상기의 함몰부들이 만들어지는 중합체층을 포함하는, 유연한 시이트상 재료.
  3. 제2항에 있어서, 상기의 중합체층은 폴리에틸렌, 폴리프로필, 폴리에스테르, 폴리테트라플루오로에틸렌 및 셀룰로오스로 이루어진 군에서 선택된 중합체로 구성되는, 유연한 시이트상 재료.
  4. 제2항에 있어서, 상기의 중합체층은 지지층상에 적층되거나 용융 접합 되거나또는 압출되는 유연한 시이트상 재료.
  5. 제4항에 있어서, 상기의 지지층은 부직재료, 직재료 및 금속화된 층으로 이루어진 군에서 선택되는, 유연한 시이트상 재료.
  6. 제5항에 있어서, 상기의 지지층은 크라프트지인 유연한 시이트상 재료
  7. 제1항에 있어서, 상기의 약제는 항알레르기, 기관지 확장기, 항히스타민, 스테로이드 및 이들중 두개 이상의 화합물로 이루어진 중에서 선택되는 유연한 시이트상 재료.
  8. 제7항에 있어서, 상기의 약제는 알부테롤, 알부테롤 설페이트, 피르부테롤 아세테이트, 피블부테롤히드로 클로라이드, 베클로메타손 디프로피온에이트, 디소듐 크로모글리케이드, 에피네페린 비타르트레이트 및 이들 중 두개 이상의 혼합물로 이루어진 군에서 선택되는 유연한 시이트상 재료
  9. 제1항에 있어서, 실제적인 수의 상기의 함몰부들은 상기의 약제외에도 생리학적으로 허용 가능한 불활성 부형제를 함유하는 유연한 시이트상 재료.
  10. 제1항에 있어서, 상기의 함몰부들은 약5 내지 150㎛ 의 깊이 및 상기의 시이트상 재료의 표면세어 지름으로 약50 내지 200㎛의 오프닝을 갖는, 유연한 시이트상 재료.
  11. 제1항에 있어서, 상기의 함몰부들의 수는 상기의 시이트상 재료의 ㎝2당 약500개 내지 약15,000개인, 유연한 시이트상 재료.
  12. 제1항에 있어서, 상기의 함몰부들은 실제적으로 규칙적인 배열을 갖는, 유연한 시이트상 재료
  13. 제1항에 있어서 단위 면적당 실제적으로 균일한 함몰부 체적을 갖는 유연한 시이트상 재료
  14. 제1항에 있어서, 상기의 함몰부들은 끝이 잘린 원뿔형, 끝이 잘린 피라미드형, 부분적 반구체형 및 4면체형으로 부터 선택된 모양을 갖는, 유연한 시이트상 재료.
  15. 제1항에 있어서, 실제적인 수의 상기의 함몰부들이 상기의 시이트상 재료의 단위 면적당 기지 체적의 약제로서 실제적으로 채워지는, 유연한 시이트상 재료.
  16. 제1항에 있어서, 실제적인 수의 상기의 함몰부들이 상기의 시이트상 재료의단위면적당 기지 체적의 약제로서 실제적으로 채워지는, 유연한 시이트상 재료.
  17. 제6항에 있어서, 약0.1 내지 25㎝2의 상기의 시이트상 재료의 면적이 흡입에 의해 투여되는 때의 상기의 약제의 단일도우즈에 대응하는 유연한 시이트상 재료.
  18. 제1항에 있어서, 테이프의 형태인 유연한 시이트상 재료.
  19. 스풀에 감겨지거나 또는 로울의 형태인 제16항에 따른 유연한 시이트상 재료를 포함하는 제품.
  20. 제1항에 있어서, 상기의 약제는 환자에 의한 흡입을 위한 실제적으로 탈응집된 상태에서 상기의 함몰부로부터 에어로졸화될 수 있는, 유연한 시이트상 재료.
  21. 균일한 테이프 어드벤스를 제공하도록 테이프 어드벤스 제어 매커니즘, 하우징 및 로울링된 테이프 형태의 제1항에 따른 시이트상 재료를 포함하는 카셋트.
  22. 제1항에 있어서, 상기의 함몰부들은 적절한 크기 및 형태의 돌출부들을 갖는 매스터 표면에 대하여 시이트상 재료를 압축하여 함몰부들을 형성하는 프린트 공정에 의해 형성되며, 상기의 공정은 상기의 함몰부들이 만들어지는 어떠한 중합체 재료의 융점이하의 온도까지 상기의 시이트상 재료를 가열하는 것을 포함하는, 유연한 시이트상 재료.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910007083A 1990-04-30 1991-05-02 흡입에 의한 약제를 투여하기 위한 운반 기구 KR0171212B1 (ko)

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US516,327 1990-04-30
US07/516,327 US5192548A (en) 1990-04-30 1990-04-30 Device

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KR910018045A true KR910018045A (ko) 1991-11-30
KR0171212B1 KR0171212B1 (ko) 1999-02-01

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US (1) US5192548A (ko)
EP (1) EP0455463B1 (ko)
JP (1) JP3055570B2 (ko)
KR (1) KR0171212B1 (ko)
AU (1) AU645788B2 (ko)
CA (1) CA2039655C (ko)
DE (1) DE69105609T2 (ko)
DK (1) DK0455463T3 (ko)
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HK (1) HK1000586A1 (ko)
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DK0455463T3 (da) 1995-05-08
JP3055570B2 (ja) 2000-06-26
KR0171212B1 (ko) 1999-02-01
EP0455463B1 (en) 1994-12-07
AU7391691A (en) 1991-11-07
JPH0724032A (ja) 1995-01-27
ES2064908T3 (es) 1995-02-01
AU645788B2 (en) 1994-01-27
US5192548A (en) 1993-03-09
EP0455463A1 (en) 1991-11-06
NZ237645A (en) 1993-12-23
MX173994B (es) 1994-04-13
CA2039655C (en) 2001-10-23
HK1000586A1 (en) 1998-04-09
CA2039655A1 (en) 1991-10-31
DE69105609D1 (de) 1995-01-19

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