KR910009289B1 - 비스-아자-바이시클릭 불안해소제 - Google Patents

비스-아자-바이시클릭 불안해소제 Download PDF

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Publication number
KR910009289B1
KR910009289B1 KR1019900000701A KR900000701A KR910009289B1 KR 910009289 B1 KR910009289 B1 KR 910009289B1 KR 1019900000701 A KR1019900000701 A KR 1019900000701A KR 900000701 A KR900000701 A KR 900000701A KR 910009289 B1 KR910009289 B1 KR 910009289B1
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KR
South Korea
Prior art keywords
nmr
hrms
compound
tlc
calculated
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
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KR1019900000701A
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English (en)
Korean (ko)
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KR900011774A (ko
Inventor
암라트랄 데사이 키쇼르
마이클 브라이트 진
Original Assignee
화이자 인코포레이티드
윌리암 데이비스 헌
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Publication of KR900011774A publication Critical patent/KR900011774A/ko
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Publication of KR910009289B1 publication Critical patent/KR910009289B1/ko
Expired legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
KR1019900000701A 1989-01-23 1990-01-22 비스-아자-바이시클릭 불안해소제 Expired KR910009289B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
USPCT/US89/00275 1989-01-23
PCT/US1989/000275 WO1990008148A1 (en) 1989-01-23 1989-01-23 Bis-aza-bicyclic anxiolytic agents
PCT/US1989/003811 WO1990008144A1 (en) 1989-01-23 1989-09-01 Bis-aza-bicyclic anxiolytic agents
USPCT/US89/03811 1989-09-01

Publications (2)

Publication Number Publication Date
KR900011774A KR900011774A (ko) 1990-08-02
KR910009289B1 true KR910009289B1 (ko) 1991-11-09

Family

ID=22214801

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900000701A Expired KR910009289B1 (ko) 1989-01-23 1990-01-22 비스-아자-바이시클릭 불안해소제

Country Status (38)

Country Link
US (1) US5122525A (https=)
EP (1) EP0380217B1 (https=)
JP (1) JPH0643427B2 (https=)
KR (1) KR910009289B1 (https=)
CN (1) CN1022186C (https=)
AP (1) AP128A (https=)
AR (1) AR246969A1 (https=)
AT (1) ATE82574T1 (https=)
AU (1) AU614214B2 (https=)
BA (1) BA98302A (https=)
BG (1) BG51046A3 (https=)
CA (1) CA2008108C (https=)
CZ (1) CZ277698B6 (https=)
DD (1) DD291560A5 (https=)
DE (1) DE69000467T2 (https=)
DK (1) DK0380217T3 (https=)
EG (1) EG19306A (https=)
ES (1) ES2053094T3 (https=)
FI (1) FI95381C (https=)
GR (1) GR3006925T3 (https=)
HU (1) HU215154B (https=)
IE (1) IE62670B1 (https=)
IL (1) IL93073A (https=)
IS (1) IS1667B (https=)
MA (1) MA21735A1 (https=)
MX (1) MX19222A (https=)
MY (1) MY104861A (https=)
NO (1) NO175978C (https=)
NZ (1) NZ232168A (https=)
OA (1) OA10041A (https=)
PL (1) PL163836B1 (https=)
PT (1) PT92919B (https=)
RO (1) RO110142B1 (https=)
RU (1) RU2015977C1 (https=)
SK (1) SK279339B6 (https=)
WO (2) WO1990008148A1 (https=)
YU (1) YU47554B (https=)
ZA (1) ZA90430B (https=)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990008148A1 (en) * 1989-01-23 1990-07-26 Pfizer Inc. Bis-aza-bicyclic anxiolytic agents
WO1992000075A1 (en) * 1990-06-29 1992-01-09 Pfizer Inc. Pyridopyrazine derivatives for treating substance abuse and addiction
DE69108743T2 (de) * 1991-01-31 1995-08-17 Pfizer Recematspaltung von trans-2-(2-pyrimidinyl)-7-(hydroxymethyl)octahydro-2h-pyrido[1,2-a]-pyrazin.
US5185449A (en) * 1991-02-27 1993-02-09 Pfizer Inc. Process and intermediate for certain bis-aza-bicyclic anxiolytic agents
US5157034A (en) * 1991-02-27 1992-10-20 Pfizer Inc. Neuroleptic perhydro-1H-pyrido[1,2-a]pyrazines
DE69218414T2 (de) * 1991-02-27 1998-01-22 Pfizer Verfahren zur herstellung von trans-piperidin-2,5-dicarboxylaten
US5311195A (en) * 1991-08-30 1994-05-10 Etak, Inc. Combined relative and absolute positioning method and apparatus
FI941377A0 (fi) * 1991-09-25 1994-03-24 Pfizer Neuroleptisiä 2-substituoituja perhydro-1-H-pyrido/1,2-a/-pyratsiineja
DE69326767T2 (de) * 1992-06-16 2000-03-02 Pfizer Inc., New York Verfahren und zwischenprodukte zur herstellung von bis-aza-bicyclischen anxiolytica
WO1994006794A1 (en) * 1992-09-24 1994-03-31 National Institutes Of Health Aralkyl diazabicycloalkane derivatives for cns disorders
IL104506A (en) * 1993-01-25 1997-11-20 Israel State Fast changing heating- cooling device and method, particularly for cryogenic and/or surgical use
US5637713A (en) * 1993-08-20 1997-06-10 Pfizer Inc. Process for preparing trans-piperidine-2,5-dicarboxylates
US5455350A (en) * 1993-10-13 1995-10-03 Pfizer Inc. Process and intermediate for certain bis-aza-bicyclic anxiolytic agents
IL107460A (en) * 1993-11-01 1999-06-20 Israel State Controlled cryogenic contact system
US6231833B1 (en) 1999-08-05 2001-05-15 Pfizer Inc 2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors
DK0783503T3 (da) * 1994-09-30 2002-02-11 Pfizer 2,7-substituerede octahydro-1H-pyrido(1,2-a)pyrazinderivater
WO1996010570A1 (en) * 1994-09-30 1996-04-11 Pfizer Inc. NEUROLEPTIC 2,7-DISUBSTITUTED PERHYDRO-1H-PYRIDO[1,2-a]PYRAZINES
ES2161377T3 (es) * 1995-12-21 2001-12-01 Pfizer Derivados de octahidro-pirrolo(1,2-a)-pirazina 2,7-sustituidos.
KR20000022490A (ko) * 1996-07-01 2000-04-25 스피겔 알렌 제이 (7에스,트란스)-2-(2-피리미디닐)-7-(하이드록시메틸)옥타하이드로-2에이치-피리도[1,2-에이]피라진의 제조방법
PA8469101A1 (es) * 1998-04-09 2000-09-29 Pfizer Prod Inc Ligandos azabiciclicos de receptores 5ht1
US6251893B1 (en) * 1998-06-15 2001-06-26 Nps Allelix Corp. Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity
HN1999000146A (es) * 1998-09-21 2000-11-11 Pfizer Prod Inc Agentes farmaceuticos para el tratamiento de la enfermedad de parkinson, adhd y microadenomas.
US20020016334A1 (en) * 2000-07-31 2002-02-07 Coe Jotham Wadsworth Pharmaceutical composition for the treatment of attention deficit hyperactivity disorder (ADHD)
US6670476B2 (en) 2000-11-29 2003-12-30 Pfizer Inc. Resolution of trans-7-(hydroxy-methyl)octa-hydro-2H-pyrido[1,2-a]pyrazine
KR100767854B1 (ko) * 2003-03-12 2007-10-17 화이자 프로덕츠 인크. 피리딜옥시메틸 및 벤즈이속사졸 아자비시클릭 유도체
WO2004092173A2 (en) 2003-04-09 2004-10-28 Biogen Idec Ma Inc. A2a adenosine receptor antagonists
US7671072B2 (en) * 2003-11-26 2010-03-02 Pfizer Inc. Aminopyrazole derivatives as GSK-3 inhibitors
US20070219201A1 (en) * 2004-05-27 2007-09-20 Warner-Lambert Company Llc Combination of atomoxetine and a 5ht1a receptor agonist for treating adhd and other disorders
US7658206B2 (en) 2006-12-05 2010-02-09 Kohler Co. Plumbing valve with stick control handle

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3388128A (en) * 1965-09-03 1968-06-11 Allan R. Day Substituted 1, 4-diazabicyclo [4. 4. 9] decanes
US4182763A (en) * 1978-05-22 1980-01-08 Mead Johnson & Company Buspirone anti-anxiety method
US4339579A (en) * 1980-12-29 1982-07-13 American Home Products Corporation 2,6-Bis-(pyrrolopyrazinyl)pyrazines
US4400511A (en) * 1982-05-07 1983-08-23 American Home Products Corporation 2-Substituted octahydropyrrolo(1,2-A)-pyrazine-3-carboxylic acids
US4414389A (en) * 1982-05-25 1983-11-08 American Home Products Corporation 4-Substituted-piperidino carboxamides
US4517187A (en) * 1982-10-18 1985-05-14 Pennwalt Corporation 1,3,4,6,7-11b-Hexahydro-7-phenyl-2H-pyrazino[2,1-a]isoquinolines methods of preparation, and use as antidepressants
DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
DE3409440A1 (de) * 1984-03-15 1985-09-26 Bayer Ag, 5090 Leverkusen Imidazo(1,5-a)pyridyl-methan- und imidazo(1,5-b)pyridazinylmethan-derivate, ihre herstellung und sie enthaltende aufzeichnungsmaterialien
IT1204803B (it) * 1986-02-17 1989-03-10 Acraf Composto farmacologicamente attivo e composizioni farmaceutiche che lo contengono,procedimento per prepararlo e intermedio utile in detto procedimento
US4788290A (en) * 1987-12-11 1988-11-29 American Home Products Corporation Serotonergic pyrazine derivatives
JP2668259B2 (ja) * 1988-02-18 1997-10-27 塩野義製薬株式会社 複素環化合物および抗潰瘍剤
WO1990008148A1 (en) * 1989-01-23 1990-07-26 Pfizer Inc. Bis-aza-bicyclic anxiolytic agents

Also Published As

Publication number Publication date
BG51046A3 (bg) 1993-01-15
MX19222A (es) 1993-12-01
AU4867990A (en) 1990-07-26
CS29990A3 (en) 1992-11-18
CN1022186C (zh) 1993-09-22
BA98302A (bs) 2001-09-14
IS3529A7 (is) 1990-07-24
NO175978B (no) 1994-10-03
IL93073A (en) 1994-05-30
PT92919A (pt) 1990-07-31
CN1044464A (zh) 1990-08-08
AP9000158A0 (en) 1990-01-31
FI913510A0 (fi) 1991-07-22
GR3006925T3 (https=) 1993-06-30
PT92919B (pt) 1995-12-29
CA2008108A1 (en) 1990-07-23
IE62670B1 (en) 1995-03-08
EP0380217A1 (en) 1990-08-01
AP128A (en) 1991-03-20
ES2053094T3 (es) 1994-07-16
YU11190A (sh) 1993-05-28
PL163836B1 (pl) 1994-05-31
HUT63163A (en) 1993-07-28
US5122525A (en) 1992-06-16
JPH02233681A (ja) 1990-09-17
DD291560A5 (de) 1991-07-04
MA21735A1 (fr) 1990-10-01
NO175978C (no) 1995-01-11
HU215154B (hu) 2000-09-28
FI95381C (fi) 1996-01-25
RO110142B1 (ro) 1995-10-30
EG19306A (en) 1995-01-31
WO1990008148A1 (en) 1990-07-26
FI95381B (fi) 1995-10-13
DK0380217T3 (da) 1992-12-14
ATE82574T1 (de) 1992-12-15
ZA90430B (en) 1991-08-28
DE69000467T2 (de) 1993-04-01
JPH0643427B2 (ja) 1994-06-08
IE900225L (en) 1990-07-23
EP0380217B1 (en) 1992-11-19
NZ232168A (en) 1991-08-27
SK279339B6 (sk) 1998-10-07
NO912863L (no) 1991-07-22
WO1990008144A1 (en) 1990-07-26
IS1667B (is) 1997-11-14
DE69000467D1 (de) 1992-12-24
RU2015977C1 (ru) 1994-07-15
AU614214B2 (en) 1991-08-22
NO912863D0 (no) 1991-07-22
YU47554B (sh) 1995-10-03
CA2008108C (en) 1995-08-08
AR246969A1 (es) 1994-10-31
KR900011774A (ko) 1990-08-02
MY104861A (en) 1994-06-30
OA10041A (en) 1996-10-14
CZ277698B6 (en) 1993-03-17

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