KR900701326A - 감염성 및 염증성 병변의 검색 및 치료법 - Google Patents

감염성 및 염증성 병변의 검색 및 치료법

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KR900701326A
KR900701326A KR1019900700663A KR900700663A KR900701326A KR 900701326 A KR900701326 A KR 900701326A KR 1019900700663 A KR1019900700663 A KR 1019900700663A KR 900700663 A KR900700663 A KR 900700663A KR 900701326 A KR900701326 A KR 900701326A
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leukocyte
antibody
conjugate
therapeutic
multispecific
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제이. 한센 한스
데이비드 골덴베르그 밀톤
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원본미기재
임뮤노메딕스, 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • A61K47/6845—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a cytokine, e.g. growth factors, VEGF, TNF, a lymphokine or an interferon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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Abstract

내용 없음

Description

감염성 및 염증성 병변의 검색 및 치료법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (14)

  1. 치료학적 항미생물제. 붕소-함유 부가제 또는 방사성핵종(radionuclide)과 결합된, 적어도 하나의 백혈구 세포 유형과 특이적으로 결합하는 실질적으로 단일특이적인 직어도 하나의 면역반응성 항체 또는 항체 단편을 함유하는. 백혈구 유착 부위를 표적화하기 위한 치료학적 항-백혈구 결합체.
  2. 영상화제와 결합되거나 치료학적 항미생물제, 붕소-함유 부가물 또는 방사상핵종과 결합된, 상이한 백혈구 세포 유형과 특이적으로 결합하는 실질적으로 단일특이적인 적어도 두개의 상이한 항체 또는 항체 단편의 면역반응성 다중특이적(polyspecific) 복합물을 함유하는, 백혈구 유착 부위를 표적화하기 위한 다중특이적 항-백혈구 결합체.
  3. 제2항에 있어서. 실질직으로 단일특이적인 면역반응성 항체 또는 항체 단편, 또는 다중특이적 복합물이 50내지 500KeV 범위의 감마 방사선을 방출하는 방사선 동위원소 또는 자기공명 영상 증진제인 영상화제와 결합된 항-백혈구 결합체.
  4. 제1항 또는 2항에 있어서. 실질적으로 단일특이적인 면역반응성 항체 또는 항체 단편, 또는 다중특이적 복합물이 항세균제, 항바이러스제. 항진균제 및 구충제로 이루어진 그룹 중에서 선택된 치료학적 항미생물제와 결합된 항-백혈구 결합체.
  5. 제1항 또는 2항에 있어서. 실질적으로 단일특이직인 면역반응성 항체 또는 항체 단편. 또는 다중특이적 복합물이 치료학적 방사성핵증과 결합된 항-백혈구 결합체
  6. 제1항 또는 2항에 있어서. 실질적으로 단일특이적인 면역반응성 항체 또는 항체 단편. 또는 다중특이적 복합물이 대다수의 붕소-10원자를 함유하는 부가물과 결합된 항-백혈구 결합체.
  7. 제1항 또는 2항에 있어서, 실질적으로 단일특이적인 면역반응성 항체 또는 항체 단편, 또는 다중특이적 복합물이 치료학적 항미생물제와 결합되고 치료학적 방사성핵증 또는 붕소-함유 부가물과 결합된 항-백혈구 결합체.
  8. 제1항 내지 7항 중 어느 한 항에 있어서, 각 백혈구 세포 유형이 과립구, 단핵구, B-림포구 및 T-림프구로 구성된 그룹 중에서 선택되는 항-백혈구 결합체.
  9. 제1항 내지 8항 중 어느 한 항에 있어서, 각 항체 또는 항체 단편이 모노클로날 또는 항체 단편인 항-백혈구 결합체.
  10. 두개의 별개의 제제로서, (a) 제1항 내지 9항 중 어느 한 항에 따른 항-백힐구 결합체를 표적화하는데 유효한 양의 제제 및 (b) 항-백혈구 결합체의 극부화 비를 약 20%이상 증가시키는데 충분한 양 또는, 치료학적 결항체의 경우에 있어서는, 이의 치료지수를 2내지 72시간내에 약 10%이상 증가시키기에 충분한 양의 항-백혈구 결합체와 특이적으로 결합하는 제2의, 표지되지 않은 항체 또는 항체 단편을 함유하는 제제.
  11. 항-백혈구 결합체를 표적화하는데 유효한 양으로 포유동물에게 비경구 주입시켜 영상화제를 염증 또는 감염성 병변에 표적화하는 방법에 사용하기 위한 제제를 제조하기 위한, 영상화제와 결합된, 상이한 백혈구 세포유형과 특이적으로 결합하는 실질적으로 단일특이적인 적어도 두개의 상이한 항체 또는 항체 단편의 면역 반응성 다중특이적 조성물을 함유하는 다중특이적 항-백혈구 항체 결합체의 용도.
  12. 제11항에 있어서, (a) 상기 영상화제가 방사선등위원소이고, 상기 방법이 항-백혈구 결합체를 병변의 부위에 극부시키는데 충분한 시간 후에 병변의 섬광그래피적 영상을 수득함을 추가로 포함하거나, (b) 상기 영상화제가 자기 공명 영상 증진제이고, 상기 방법이 항-백혈구 결합체를 병변의 부위에 국부시키는데, 충분한 시간 후에 병변의 자기 공명 영상을 수득함을 추가로 포함하는 용도.
  13. 염증 또는 감염성 병변으로 고통받고 있는 포유동물에게 항-백혈구 결합체를 치료하는데 유효한 양으로 비경구 주입시켜 상기 병변을 치료하는 방법에 사용하기 위한 제제를 제조하기 위한, 실질적으로 단일특이적인 면역반응성 항체 또는 항체 단편, 또는 다중특이직 복합물이 치료학적 항미생물제, 붕소-함유 부가물 또는 방사성핵증과 결합된 제1항, 2항, 및 4항 내지 9항 중 어느 한 항에 따른 치료학적 양의 항-백혈구 결합체의 용도.
  14. 제11항 내지 13항 중 어느 한 항에 있어서, 상기 제제가 별개의 제제로서, 항-백혈구 결합체의 국부화비를 약 20%이상 증가시키는데 충분한 양 또는, 치료학적 결할체의 경우에 있어서는, 이의 치료지수를 2내지 72시간 내에 약 10%이상 증가시키기에 충분한 양의, 항-백혈구 결합체와 특이적으로 결합되는 제2의, 표지되지 않은 항체 또는 항체 단편을 부가적으로 함유하고, 상기 방법의 병변의 부위에 있는 백혈구에 의해 그의 최대의 선택적 흡수가 이루어지기에 충분한 항-백혈구 결합체를 투여한 후, 제2의, 표지되지 않은 항체 또는 항체 단편의 상기 량을 피검자에게 비경구 투여하는 단계를 부가적으로 포함하는 용도.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900700663A 1988-07-29 1989-07-26 감염성 및 염증성 병변 표적용 항-백혈구 결합체 및 이를 함유하는 제제 및 키트 KR0135632B1 (ko)

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US226,180 1988-07-29
US07/226,180 US4925648A (en) 1988-07-29 1988-07-29 Detection and treatment of infectious and inflammatory lesions
PCT/US1989/003170 WO1990001339A1 (en) 1988-07-29 1989-07-26 Detection and treatment of infectious and inflammatory lesions

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KR0135632B1 KR0135632B1 (ko) 1998-04-23

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EP (1) EP0353960B1 (ko)
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AT (1) ATE89746T1 (ko)
AU (1) AU614659B2 (ko)
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US4925648A (en) * 1988-07-29 1990-05-15 Immunomedics, Inc. Detection and treatment of infectious and inflammatory lesions
US5439665A (en) * 1988-07-29 1995-08-08 Immunomedics Detection and treatment of infectious and inflammatory lesions
US5601819A (en) * 1988-08-11 1997-02-11 The General Hospital Corporation Bispecific antibodies for selective immune regulation and for selective immune cell binding
EP0434765B1 (en) * 1988-09-30 1995-11-08 Neorx Corporation Targeting substance-diagnostic/therapeutic agent conjugates having schiff base linkages
US5066789A (en) * 1988-09-30 1991-11-19 Neorx Corporation Targeting substance-diagnostic/therapeutic agent conjugates having Schiff base linkages
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US5332567A (en) * 1989-08-24 1994-07-26 Immunomedics Detection and treatment of infections with immunoconjugates
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