KR890014544A - 비스(히드록시메틸)시클로부틸 푸린 및 피리미딘 - Google Patents

비스(히드록시메틸)시클로부틸 푸린 및 피리미딘 Download PDF

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KR890014544A
KR890014544A KR1019890003979A KR890003979A KR890014544A KR 890014544 A KR890014544 A KR 890014544A KR 1019890003979 A KR1019890003979 A KR 1019890003979A KR 890003979 A KR890003979 A KR 890003979A KR 890014544 A KR890014544 A KR 890014544A
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compound
phosphorus compounds
hydroxymethyl
bis
cyclobutyl
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KR1019890003979A
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KR970009223B1 (ko
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에이. 슬루사르킥 윌리암
자흘러 로버트
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니콜라스 피. 말라테스티닉
이이, 아르, 스퀴브 앤드 산즈, 인크
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic
    • C07C35/04—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic containing a three or four-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

내용 없음.

Description

비스(히드록시메틸)시클로부틸 푸린 및 피리미딘
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (31)

  1. 하기 일반식 1을 갖는 화합물 및 제약상 허용되는 그의 염.
    식중, R1은
    이고, R2는 수소, 메틸, 플루오로, 클로로, 브로모, 요오드, 히드록시 또는 아미노기이고, R3는 플루오로, 클로로, 브로도, 요오도, 수소, 메틸 트리플루오로메틸, 에틸, n-프로필, 2-플루오로에틸, 2-클로로에틸 또는
    (식중, R4는 클로로, 브로모, 요오도, 수소, 메틸 또는 트리플루오로메틸기임)이고, R5는 알킬기이고, R6는 수소, 알킬 치환알킬 또는 아릴기이고, R7및 R8은 각각 독립적으로 수소, -PO3H2또는이다.
  2. 제1항에 있어서, R1이
    인 화합물.
  3. 제2항에 있어서, R1이
    인 화합물.
  4. 제2항에 있어서, R1이
    인 화합물.
  5. 제2항에 있어서, R1이
    인 화합물.
  6. 제2항에 있어서, R1이
    인 화합물.
  7. 제2항에 있어서, R1이
    인 화합물.
  8. 제2항에 있어서, R1이
    인 화합물.
  9. 제1항에 있어서, R7및 R8이 독립적으로 수소 또는인 화합물.
  10. 제1항에 있어서, R7및 R8이 독립적으로 수소 또는 -PO3H2인 화합물.
  11. 제1항에 있어서, R7및 R8이 수소인 화합물.
  12. 제1항에 있어서, R1이
    인 화합물.
  13. 제1항에 있어서, R1이
    인 화합물.
  14. 제1항에 있어서, R1이
    인 화합물.
  15. 제1항에 있어서, R1이
    인 화합물.
  16. 제1항에 있어서, R1이
    인 화합물.
  17. 제1항에 있어서, R1이
    인 화합물.
  18. 제1항에 있어서, R1이
    인 화합물.
  19. 제1항에 있어서, R1이
    인 화합물.
  20. 제1항에 있어서, 화합물이 (1α, 2β, 3α)-9-[2,3-비스(히드록시메틸)시클로부틸]구아닌인 화합물.
  21. 제1항에 있어서, 화합물이 (1α, 2β, 3β)-3-(6-아미노-9H-푸린-9-일)-1,2-시클로부탄-디메탄올인 화합물.
  22. 제1항에 있어서, 화합물이 (1α, 2β, 3α)-1-[2,3-비스(히드록시메틸)시클로부틸]-5-메틸-2,4-(1H,3H)-피리미딘디온인 화합물.
  23. 제1항에 있어서, 화합물이 (1α, 2β, 3α)-4-아미노-1-[2,3-비스(히드록시메틸)시클로부틸]-2-(1H)-피리미디논인 화합물.
  24. 제1항에 있어서, 화합물이 (1α(E), 2β, 3α)-1-[2,3-비스(히드록시메틸)시클로부틸]-5-(2-브로모에테닐)-2,4-(1H,3H)-피리미딘디온인 화합물.
  25. 제1항에 있어서, 화합물이 (1α, 2β, 3α)-2-아미노-9-[2,3-비스(히드록시메틸)시클로부틸]-8-브로모-1,9-디히드로-6H-푸린-6-온인 화합물.
  26. 제1항에 있어서, 화합물이 (1α, 2β, 3α)-1-[2,3-비스(히드록시메틸)시클로부틸]-5-요오도-2,4-(1H,3H)-피리미딘디온인 화합물.
  27. 제1항에 있어서, 화합물이 (1α, 2β, 3α)-5-아미노-3-[2,3-비스(히드록시메틸)시클로부틸]-3,6-디히드로-7H-1,2,3-트리아졸로[4,5-d]-피리미딘-7-온인 화합물.
  28. 하기 구조식의 화합물
    식중, P는 히드록시 보호기임.
  29. 하기 구조식의 화합물
    식중, P는 히드록시 보호기임.
  30. 하기 구조식의 화합물
    식중, X는 이탈기이고, P는 히드록시 보호기임.
  31. 제30항에 있어서, X가 클로로, 브로모, 요오도, 아릴술포네이트 또는 알킬술포네이트기인 화합물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890003979A 1988-03-30 1989-03-29 비스(히드록시메틸)시클로부틸 푸린 및 피리미딘 KR970009223B1 (ko)

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US175,376 1980-08-06
US17537688A 1988-03-30 1988-03-30

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KR970009223B1 KR970009223B1 (ko) 1997-06-09

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PL278545A1 (en) 1989-10-02
EP0335355A2 (en) 1989-10-04
EG18734A (en) 1994-06-30
CZ193489A3 (en) 1993-08-11
DE68928353D1 (de) 1997-11-06
EP0335355A3 (en) 1991-11-13
ATE158797T1 (de) 1997-10-15
BR1100660A (pt) 2000-03-14
YU63789A (en) 1990-08-31
DD280325A5 (de) 1990-07-04
HUT49592A (en) 1989-10-30
IE81079B1 (en) 2000-02-23
SK193489A3 (en) 1996-02-07
NO891322L (no) 1989-10-02
DK170749B1 (da) 1996-01-08
PH26562A (en) 1992-08-19
ZA892185B (en) 1989-11-29
US5723609A (en) 1998-03-03
EP0335355B1 (en) 1997-10-01
PL158539B1 (pl) 1992-09-30
NO168423B (no) 1991-11-11
FI96420B (fi) 1996-03-15
MX15464A (es) 1993-12-01
ES2109218T3 (es) 1998-01-16
AU3227689A (en) 1989-10-05
AU616494B2 (en) 1991-10-31
SK278165B6 (en) 1996-02-07
IL89796A0 (en) 1989-09-28
AR247395A1 (es) 1994-12-29
CN1036575A (zh) 1989-10-25
DE68928353T2 (de) 1998-04-09
IL89796A (en) 1993-01-31
FI891492A (fi) 1989-10-01
PT90159A (pt) 1989-11-10
GR3025693T3 (en) 1998-03-31
IE890969L (en) 1989-09-30
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FI891492A0 (fi) 1989-03-29
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CZ278493B6 (en) 1994-02-16
AU630570B2 (en) 1992-10-29
KR970009223B1 (ko) 1997-06-09
JPH026478A (ja) 1990-01-10
NO891322D0 (no) 1989-03-29
DK151889D0 (da) 1989-03-29
DK151889A (da) 1989-10-01
HU203734B (en) 1991-09-30
JP2694999B2 (ja) 1997-12-24
FI96420C (fi) 1996-06-25
PT90159B (pt) 1994-11-30
AU8162591A (en) 1991-10-31
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