KR890000115B1 - 수용성 약제 콤플렉스의 제조방법 - Google Patents

수용성 약제 콤플렉스의 제조방법 Download PDF

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Publication number
KR890000115B1
KR890000115B1 KR1019850002109A KR850002109A KR890000115B1 KR 890000115 B1 KR890000115 B1 KR 890000115B1 KR 1019850002109 A KR1019850002109 A KR 1019850002109A KR 850002109 A KR850002109 A KR 850002109A KR 890000115 B1 KR890000115 B1 KR 890000115B1
Authority
KR
South Korea
Prior art keywords
phospholipid
drug
water
complex
insoluble
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019850002109A
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English (en)
Korean (ko)
Other versions
KR850006129A (ko
Inventor
쯔네까즈 후꾸시마
히로시 에모또
요시오 가기따니
가즈마사 요꼬야마
마사유끼 니시다
다다까즈 스야마
Original Assignee
가부시끼 가이샤 미도리쥬우지
마쯔시따 렌죠오
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=13245333&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR890000115(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 가부시끼 가이샤 미도리쥬우지, 마쯔시따 렌죠오 filed Critical 가부시끼 가이샤 미도리쥬우지
Publication of KR850006129A publication Critical patent/KR850006129A/ko
Application granted granted Critical
Publication of KR890000115B1 publication Critical patent/KR890000115B1/ko
Expired legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A61K47/544—Phospholipids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1019850002109A 1984-03-31 1985-03-29 수용성 약제 콤플렉스의 제조방법 Expired KR890000115B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP59063994A JPS60208910A (ja) 1984-03-31 1984-03-31 水難溶性薬物・リン脂質複合体の製造方法
JP63994 1984-03-31

Publications (2)

Publication Number Publication Date
KR850006129A KR850006129A (ko) 1985-10-02
KR890000115B1 true KR890000115B1 (ko) 1989-03-08

Family

ID=13245333

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850002109A Expired KR890000115B1 (ko) 1984-03-31 1985-03-29 수용성 약제 콤플렉스의 제조방법

Country Status (7)

Country Link
US (1) US4687762A (enExample)
EP (1) EP0161445B1 (enExample)
JP (1) JPS60208910A (enExample)
KR (1) KR890000115B1 (enExample)
CA (1) CA1238853A (enExample)
DE (1) DE3565049D1 (enExample)
ES (1) ES8602404A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014042448A1 (ko) * 2012-09-14 2014-03-20 (주)아미팜 포스파티딜콜린 및 바이페닐—디메틸-디카르복실레이트를 포함하는 간 질환 예방 또는 치료용 조성물 및 이의 용도

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JPS6124524A (ja) * 1984-07-13 1986-02-03 Nikko Kemikaruzu Kk 膜組成物
US5171566A (en) * 1986-05-16 1992-12-15 The Green Cross Corporation Flurbiprofen derivative ophthalmic preparation
CA1338736C (fr) * 1986-12-05 1996-11-26 Roger Baurain Microcristaux comportant une substance active presentant une affinite pour les phospholipides, et au moins un phospholipide, procede de preparation
IT1201149B (it) * 1987-01-14 1989-01-27 Indena Spa Complessi di bioflavonoidi con fosfolipidi,loro preparazione,uso e composizioni farmaceutici e cosmetiche
IT1201151B (it) * 1987-01-14 1989-01-27 Indena Spa Complessi fosfolipidici con estratti da vitis vinifera,procedimento per la loro preparazione e composizioni che li cntengono
US6406713B1 (en) * 1987-03-05 2002-06-18 The Liposome Company, Inc. Methods of preparing low-toxicity drug-lipid complexes
US4828837A (en) * 1987-03-30 1989-05-09 Liposome Technology, Inc. Non-crystalline minoxidil composition, its production and application
US5030442A (en) * 1987-03-30 1991-07-09 Liposome Technology, Inc. Non-crystalline minoxidil composition
US4927571A (en) * 1987-05-18 1990-05-22 Liposome Technology, Inc. Preparation of injectable doxorubicin/liposome suspension
US4904768A (en) * 1987-08-04 1990-02-27 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-phosphate derivatives
US5830498A (en) * 1987-10-16 1998-11-03 Board Of Regents, The University Of Texas System Liposomal-polyene preliposomal powder and method for its preparation
US4950432A (en) * 1987-10-16 1990-08-21 Board Of Regents, The University Of Texas System Polyene microlide pre-liposomal powders
US5178875A (en) * 1991-01-14 1993-01-12 The Board Of Regents, The University Of Texas System Liposomal-polyene preliposomal powder and method for its preparation
US4946683A (en) * 1987-11-18 1990-08-07 Vestar, Inc. Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
JP2926749B2 (ja) 1989-04-25 1999-07-28 吉富製薬株式会社 プロスタグランジン含有液状組成物
US5091188A (en) * 1990-04-26 1992-02-25 Haynes Duncan H Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs
US5246707A (en) * 1990-04-26 1993-09-21 Haynes Duncan H Sustained release delivery of water-soluble bio-molecules and drugs using phospholipid-coated microcrystals, microdroplets and high-concentration liposomes
GB9126209D0 (en) * 1991-12-10 1992-02-12 Orion Yhtymae Oy Drug formulations for parenteral use
DE4309579C3 (de) * 1993-03-24 2000-01-27 Sanol Arznei Schwarz Gmbh Pharmazeutische Zusammensetzung in Form einer Packung
ES2306452T3 (es) 1995-10-17 2008-11-01 Jagotec Ag Aporte de farmacos insolubles.
US6465016B2 (en) 1996-08-22 2002-10-15 Research Triangle Pharmaceuticals Cyclosporiine particles
US7255877B2 (en) 1996-08-22 2007-08-14 Jagotec Ag Fenofibrate microparticles
GB9625589D0 (en) 1996-12-10 1997-01-29 Boots Co Plc Therapeutic agents
WO1999040906A2 (en) * 1998-02-11 1999-08-19 Research Triangle Pharmaceuticals Method and composition for treatment of inflammatory conditions
US6979456B1 (en) 1998-04-01 2005-12-27 Jagotec Ag Anticancer compositions
AU764001B2 (en) 1998-05-29 2003-08-07 Skyepharma Canada Inc. Thermoprotected microparticle compositions and process for terminal steam sterilization thereof
CN1221249C (zh) 1998-08-19 2005-10-05 斯凯伊药品加拿大公司 普鲁泊福的可注射水分散体
SK288117B6 (sk) 1998-11-20 2013-09-03 Skyepharma Canada Inc. Rapidly dispersing solid dry therapeutic dosage form
WO2001021154A2 (en) * 1999-09-21 2001-03-29 Rtp Pharma Inc. Surface modified particulate compositions of biologically active substances
AU2001257115B2 (en) 2000-04-20 2005-01-27 Rtp Pharma Inc. Improved water-insoluble drug particle process
US6761901B1 (en) * 2000-05-02 2004-07-13 Enzrel Inc. Liposome drug delivery
AU2001277891A1 (en) * 2000-07-26 2002-02-05 Alcon Universal Ltd. Pharmaceutical suspension compositions lacking a polymeric suspending agent
CA2420597C (en) 2000-08-31 2011-05-17 Rtp Pharma Inc. Milled particles
US8586094B2 (en) 2000-09-20 2013-11-19 Jagotec Ag Coated tablets
US20040092186A1 (en) * 2000-11-17 2004-05-13 Patricia Wilson-Nguyen Textile electronic connection system
ATE414542T1 (de) * 2000-12-19 2008-12-15 Univ Texas Nsaid zusammensetzungen enthaltend lecithinöl zum schutz des magen-darm-traktes und zur erhöhten therapeutischen wirkung
US20040077604A1 (en) 2001-12-19 2004-04-22 Lenard Lichtenberger Method and compositions employing formulations of lecithin oils and nsaids for protecting the gastrointestinal tract and providingenhanced therapeutic activity
US20100173876A1 (en) * 2000-12-19 2010-07-08 The Board Of Regents Of The University Of Texas System Oil-based nsaid compositions and methods for making and using same
NZ527408A (en) * 2001-02-22 2005-04-29 Skyepharma Canada Inc Hydroxymethylglutarylcoenzyme A (HMG CoA) reductase inhibitor (or a statin) and a fibrate in a single effective oral dosage form to treat dyslipidaemia and dyslipoproteinaemia
US6824790B2 (en) * 2002-01-09 2004-11-30 Enzrel Inc. Liposome drug delivery of polycyclic, aromatic, antioxidant or anti-inflammatory compounds
US7838034B2 (en) 2002-07-30 2010-11-23 Grunenthal Gmbh Intravenous pharmaceutical form of administration
DE10234784A1 (de) * 2002-07-30 2004-02-19 Günenthal GmbH Intravenös applizierbare, pharmazeutische Darreichungsform
DE10255285A1 (de) * 2002-11-26 2004-06-03 Mcs Micro Carrier Systems Gmbh Selbst formende Phospholipid-Gele
US20130085146A1 (en) * 2003-01-14 2013-04-04 Rodney J.Y. Ho Lipid-drug formulations and methods for targeted delivery of lipid-drug complexes to lymphoid tissues
KR20070063587A (ko) * 2004-10-12 2007-06-19 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 정제된 인지질-비스테로이드성 소염 약물 연합 조성물 및이의 제조방법 및 사용방법
JP5558712B2 (ja) * 2005-08-02 2014-07-23 ドロサファーム アクチェンゲゼルシャフト インドメタシン及び／又はアセメタシンを含む医薬組成物
EP1912621B1 (de) * 2005-08-02 2019-09-11 Drossapharm AG Pharmazeutische zusammensetzung enthaltend indometacin und/oder acemetacin
WO2009125858A1 (ja) * 2008-04-07 2009-10-15 大鵬薬品工業株式会社 ２－インドリノン誘導体を含有する脂質分散体製剤
WO2013049749A2 (en) 2011-09-29 2013-04-04 Plx Pharma Inc. pH DEPENDENT CARRIERS FOR TARGETED RELEASE OF PHARMACEUTICALS ALONG THE GASTROINTESTINAL TRACT, COMPOSITIONS THEREFROM, AND MAKING AND USING SAME
WO2015071841A1 (en) 2013-11-12 2015-05-21 Druggability Technologies Holdings Limited Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them
KR20220158031A (ko) 2020-03-26 2022-11-29 피엘엑스 옵코 인코포레이티드 pH 의존성 재구성이 가능한 제약 담체 및 그의 제조 및 사용 방법

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DE2656333C2 (de) * 1976-12-13 1985-08-08 Karl Prof. Dr.med. 7302 Ostfildern Theurer Verfahren zur Herstellung von Liposomen, welche Arzneistoffe enthalten
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014042448A1 (ko) * 2012-09-14 2014-03-20 (주)아미팜 포스파티딜콜린 및 바이페닐—디메틸-디카르복실레이트를 포함하는 간 질환 예방 또는 치료용 조성물 및 이의 용도

Also Published As

Publication number Publication date
CA1238853A (en) 1988-07-05
EP0161445A1 (en) 1985-11-21
ES542478A0 (es) 1985-12-16
DE3565049D1 (en) 1988-10-27
EP0161445B1 (en) 1988-09-21
US4687762A (en) 1987-08-18
ES8602404A1 (es) 1985-12-16
JPS60208910A (ja) 1985-10-21
KR850006129A (ko) 1985-10-02
JPH0534334B2 (enExample) 1993-05-21

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