DE3565049D1 - Water soluble drug complex and method for production of same - Google Patents

Water soluble drug complex and method for production of same

Info

Publication number
DE3565049D1
DE3565049D1 DE8585103816T DE3565049T DE3565049D1 DE 3565049 D1 DE3565049 D1 DE 3565049D1 DE 8585103816 T DE8585103816 T DE 8585103816T DE 3565049 T DE3565049 T DE 3565049T DE 3565049 D1 DE3565049 D1 DE 3565049D1
Authority
DE
Germany
Prior art keywords
production
same
water soluble
soluble drug
drug complex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8585103816T
Other languages
English (en)
Inventor
Tsunekazu Fukushima
Hiroshi Emoto
Yoshio Kagitani
Kazumasa Yokoyama
Masayuki Nishida
Tadakazu Suyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Tanabe Pharma Corp
Original Assignee
Green Cross Corp Japan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=13245333&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3565049(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Green Cross Corp Japan filed Critical Green Cross Corp Japan
Application granted granted Critical
Publication of DE3565049D1 publication Critical patent/DE3565049D1/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A61K47/544—Phospholipids
DE8585103816T 1984-03-31 1985-03-29 Water soluble drug complex and method for production of same Expired DE3565049D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59063994A JPS60208910A (ja) 1984-03-31 1984-03-31 水難溶性薬物・リン脂質複合体の製造方法

Publications (1)

Publication Number Publication Date
DE3565049D1 true DE3565049D1 (en) 1988-10-27

Family

ID=13245333

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585103816T Expired DE3565049D1 (en) 1984-03-31 1985-03-29 Water soluble drug complex and method for production of same

Country Status (7)

Country Link
US (1) US4687762A (de)
EP (1) EP0161445B1 (de)
JP (1) JPS60208910A (de)
KR (1) KR890000115B1 (de)
CA (1) CA1238853A (de)
DE (1) DE3565049D1 (de)
ES (1) ES542478A0 (de)

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JPS6124524A (ja) * 1984-07-13 1986-02-03 Nikko Kemikaruzu Kk 膜組成物
US5171566A (en) * 1986-05-16 1992-12-15 The Green Cross Corporation Flurbiprofen derivative ophthalmic preparation
CA1338736C (fr) * 1986-12-05 1996-11-26 Roger Baurain Microcristaux comportant une substance active presentant une affinite pour les phospholipides, et au moins un phospholipide, procede de preparation
IT1201149B (it) * 1987-01-14 1989-01-27 Indena Spa Complessi di bioflavonoidi con fosfolipidi,loro preparazione,uso e composizioni farmaceutici e cosmetiche
IT1201151B (it) * 1987-01-14 1989-01-27 Indena Spa Complessi fosfolipidici con estratti da vitis vinifera,procedimento per la loro preparazione e composizioni che li cntengono
US6406713B1 (en) * 1987-03-05 2002-06-18 The Liposome Company, Inc. Methods of preparing low-toxicity drug-lipid complexes
US4828837A (en) * 1987-03-30 1989-05-09 Liposome Technology, Inc. Non-crystalline minoxidil composition, its production and application
US5030442A (en) * 1987-03-30 1991-07-09 Liposome Technology, Inc. Non-crystalline minoxidil composition
US4927571A (en) * 1987-05-18 1990-05-22 Liposome Technology, Inc. Preparation of injectable doxorubicin/liposome suspension
US4904768A (en) * 1987-08-04 1990-02-27 Bristol-Myers Company Epipodophyllotoxin glucoside 4'-phosphate derivatives
US5830498A (en) * 1987-10-16 1998-11-03 Board Of Regents, The University Of Texas System Liposomal-polyene preliposomal powder and method for its preparation
US4950432A (en) * 1987-10-16 1990-08-21 Board Of Regents, The University Of Texas System Polyene microlide pre-liposomal powders
US5178875A (en) * 1991-01-14 1993-01-12 The Board Of Regents, The University Of Texas System Liposomal-polyene preliposomal powder and method for its preparation
US4946683A (en) * 1987-11-18 1990-08-07 Vestar, Inc. Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
JP2926749B2 (ja) 1989-04-25 1999-07-28 吉富製薬株式会社 プロスタグランジン含有液状組成物
US5091188A (en) * 1990-04-26 1992-02-25 Haynes Duncan H Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs
US5246707A (en) * 1990-04-26 1993-09-21 Haynes Duncan H Sustained release delivery of water-soluble bio-molecules and drugs using phospholipid-coated microcrystals, microdroplets and high-concentration liposomes
GB9126209D0 (en) * 1991-12-10 1992-02-12 Orion Yhtymae Oy Drug formulations for parenteral use
DE4309579C3 (de) * 1993-03-24 2000-01-27 Sanol Arznei Schwarz Gmbh Pharmazeutische Zusammensetzung in Form einer Packung
CA2234957C (en) * 1995-10-17 2006-12-19 Inge B. Henriksen Insoluble drug delivery
US7255877B2 (en) * 1996-08-22 2007-08-14 Jagotec Ag Fenofibrate microparticles
US6465016B2 (en) 1996-08-22 2002-10-15 Research Triangle Pharmaceuticals Cyclosporiine particles
GB9625589D0 (en) 1996-12-10 1997-01-29 Boots Co Plc Therapeutic agents
CA2320807C (en) * 1998-02-11 2011-01-18 Research Triangle Pharmaceuticals Method and composition for treatment of inflammatory conditions
US6979456B1 (en) 1998-04-01 2005-12-27 Jagotec Ag Anticancer compositions
DE69914742T2 (de) 1998-05-29 2004-11-25 Skyepharma Canada Inc., Verdun Gegen hitzeeinwirkung geschützte mikropartikel und verfahren zur terminalen dampfsterilisation derselben
WO2000010531A1 (en) 1998-08-19 2000-03-02 Rtp Pharma Inc. Injectable aqueous dispersions of propofol
ID29270A (id) 1998-11-20 2001-08-16 Rtp Pharma Inc Partikel-partikel mikro yang distabilkan oleh fosfolipid yang dapat menyebar
CN1174741C (zh) * 1999-09-21 2004-11-10 Rtp药品公司 生物活性物质的表面改性微粒组合物
US6682761B2 (en) 2000-04-20 2004-01-27 Rtp Pharma, Inc. Water-insoluble drug particle process
US6761901B1 (en) 2000-05-02 2004-07-13 Enzrel Inc. Liposome drug delivery
CA2412376A1 (en) * 2000-07-26 2002-01-31 Onkar N. Singh Pharmaceutical suspension compositions lacking a polymeric suspending agent
AU8847101A (en) 2000-08-31 2002-03-13 Rtp Pharma Inc Milled particles
US8586094B2 (en) 2000-09-20 2013-11-19 Jagotec Ag Coated tablets
US20040092186A1 (en) * 2000-11-17 2004-05-13 Patricia Wilson-Nguyen Textile electronic connection system
CN102258457B (zh) * 2000-12-19 2015-07-01 得克萨斯系统大学董事会 非水性组合物
US20100173876A1 (en) * 2000-12-19 2010-07-08 The Board Of Regents Of The University Of Texas System Oil-based nsaid compositions and methods for making and using same
US20040077604A1 (en) 2001-12-19 2004-04-22 Lenard Lichtenberger Method and compositions employing formulations of lecithin oils and nsaids for protecting the gastrointestinal tract and providingenhanced therapeutic activity
CN1273112C (zh) * 2001-02-22 2006-09-06 斯凯伊药品加拿大公司 具有减少进食－禁食作用的贝特－它汀组合
EP1474108A2 (de) * 2002-01-09 2004-11-10 Enzrel, Inc. Liposom-arzneimittelabgabe von polyzyklischen, aromatischen, antioxidativen oder antiphlogistischen verbindungen
US7838034B2 (en) 2002-07-30 2010-11-23 Grunenthal Gmbh Intravenous pharmaceutical form of administration
DE10234784A1 (de) * 2002-07-30 2004-02-19 Günenthal GmbH Intravenös applizierbare, pharmazeutische Darreichungsform
DE10255285A1 (de) * 2002-11-26 2004-06-03 Mcs Micro Carrier Systems Gmbh Selbst formende Phospholipid-Gele
US20130085146A1 (en) * 2003-01-14 2013-04-04 Rodney J.Y. Ho Lipid-drug formulations and methods for targeted delivery of lipid-drug complexes to lymphoid tissues
EP1804766A2 (de) * 2004-10-12 2007-07-11 The Board Of Regents, The University Of Texas System Gereinigte zusammensetzungen im zusammenhang mit phospholipidhaltigen, nichtsteroiden, entzündungshemmenden arzneimitteln sowie verfharen zu ihrer herstellung und verwendung
JP5558712B2 (ja) * 2005-08-02 2014-07-23 ドロサファーム アクチェンゲゼルシャフト インドメタシン及び／又はアセメタシンを含む医薬組成物
BRPI0614197B8 (pt) * 2005-08-02 2021-05-25 Drossapharm Ag composição farmaceuticamente eficaz em uma forma farmacêutica para administração peroral contendo pelo menos um dos ingredientes ativos indometacina e acemetacina, formas de administração, e, uso da composição
JPWO2009125858A1 (ja) * 2008-04-07 2011-08-04 静岡県公立大学法人 ２−インドリノン誘導体を含有する脂質分散体製剤
KR102180667B1 (ko) 2011-09-29 2020-11-20 피엘엑스 옵코 인코포레이티드 위장관을 따라 약물을 표적화 방출하기 위한 pH 감응성 담체, 그로부터의 조성물, 및 이들의 제조 및 사용 방법
KR101751533B1 (ko) * 2012-09-14 2017-06-28 주식회사 아미팜 포스파티딜콜린 및 바이페닐-디메틸-디카르복실레이트를 포함하는 간 질환 예방 또는 치료용 조성물
WO2015071841A1 (en) 2013-11-12 2015-05-21 Druggability Technologies Holdings Limited Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them
CA3172595A1 (en) 2020-03-26 2021-09-30 Ronald Zimmerman Pharmaceutical carriers capable of ph dependent reconstitution and methods for making and using same

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2374910A1 (fr) * 1976-10-23 1978-07-21 Choay Sa Preparation a base d'heparine, comprenant des liposomes, procede pour l'obtenir et medicaments contenant de telles preparations
DE2656333C2 (de) * 1976-12-13 1985-08-08 Karl Prof. Dr.med. 7302 Ostfildern Theurer Verfahren zur Herstellung von Liposomen, welche Arzneistoffe enthalten
GB1575343A (en) * 1977-05-10 1980-09-17 Ici Ltd Method for preparing liposome compositions containing biologically active compounds
US4196202A (en) * 1977-12-20 1980-04-01 Taiji Okada Carcinostatic composition containing 3-N-o-toluyl-5-fluorouracil producing the same
US4377567A (en) * 1978-10-02 1983-03-22 The Procter & Gamble Company Lipid membrane drug delivery
GR73668B (de) * 1978-11-21 1984-03-28 Hoffmann La Roche
US4328222A (en) * 1978-11-21 1982-05-04 Hoffmann-La Roche Inc. Pharmaceutical compositions for parenteral or local administration
GB2046092B (en) * 1979-03-05 1983-11-02 Toyama Chemical Co Ltd Pharmaceutical composition containing a lysophospholid and a phospholipid
CA1173360A (en) * 1979-06-22 1984-08-28 Jurg Schrank Pharmaceutical preparations
JPS5793909A (en) * 1980-12-03 1982-06-11 Sankyo Co Ltd Carcinostatic pharmaceutical having directivity to specific internal organ and its preparation
EP0084898B1 (de) * 1982-01-22 1986-09-03 FISONS plc Liposomen und Natriumcromoglycat enthaltende Präparate und Verfahren zu ihrer Herstellung
US4880041A (en) * 1987-04-15 1989-11-14 Tokyo Seikan Kaisha, Ltd. Apparatus for flowing and filling liquified inert gas

Also Published As

Publication number Publication date
US4687762A (en) 1987-08-18
CA1238853A (en) 1988-07-05
JPS60208910A (ja) 1985-10-21
EP0161445B1 (de) 1988-09-21
ES8602404A1 (es) 1985-12-16
EP0161445A1 (de) 1985-11-21
ES542478A0 (es) 1985-12-16
JPH0534334B2 (de) 1993-05-21
KR890000115B1 (ko) 1989-03-08
KR850006129A (ko) 1985-10-02

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8339 Ceased/non-payment of the annual fee