KR880701711A - 화 합 물 - Google Patents

화 합 물

Info

Publication number
KR880701711A
KR880701711A KR1019880700495A KR880700495A KR880701711A KR 880701711 A KR880701711 A KR 880701711A KR 1019880700495 A KR1019880700495 A KR 1019880700495A KR 880700495 A KR880700495 A KR 880700495A KR 880701711 A KR880701711 A KR 880701711A
Authority
KR
South Korea
Prior art keywords
alkyl
phenyl
methoxyquinoline
compound according
compound
Prior art date
Application number
KR1019880700495A
Other languages
English (en)
Other versions
KR950013850B1 (ko
Inventor
토마스 헨리 브라운
로버트 죤 이훼
콜린 앤드류 리취
Original Assignee
데비드 마틴 위터스
스미스 클라인 앤드 프렌취 라보라토리스 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 데비드 마틴 위터스, 스미스 클라인 앤드 프렌취 라보라토리스 리미티드 filed Critical 데비드 마틴 위터스
Publication of KR880701711A publication Critical patent/KR880701711A/ko
Application granted granted Critical
Publication of KR950013850B1 publication Critical patent/KR950013850B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음

Description

화합물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. R1이 수소, C이 수고, C1-8알킬, C1-6알콕실, C1-6알킬, C3-6시클로알킬, C3-6시클로알킬 C1-6알킬, 페닐, 페닐 C1-6알킬, 임의로 치환된 페닐그룹이며 ; R2는 C1-6알킬, C3-6시클로알킬, C3-6시클로알킬 -C1-6알킬, 페닐, 페닐 C1-6알킬 또는 C1-6알킬, C1-6알콕시, 아미노 C1-6알킬티오, 할로겐, 시아노, 히드록시, 카바모일, 카르복시, C1-6알카노일, 트리플루오로메틸 및 니트로로부터 선택된 1-3기에 의해 치환되는 페닐이며 ; R3는 C1-6알킬, 페닐, C1-6알콕시, C1-6알킬티오, C1-6알카노일, 아미노, C1-6알킬아미노, 디-C1-6알킬아미노, 할로겐, 트리플루오로 또는 시아노이며 ; n은 0, 1 또는 2인 일반식(Ⅰ)화합물이나 제약학적으로 허용되는 염.
  2. R2가 치환된 페닐그룹인 제1항에 따른 화합물.
  3. R2가 단일 치환체에 의해 치환된 페닐그룹인 제2항에 따른 화합물.
  4. R2가 단일치환체에 의해 2-위치에 치환된 페닐그룹인 제3항에 따른 화합물.
  5. n이 1이며 R3가 C1-6알킬 또는 C1-6알콕시그룹인 제4항에 따른 화합물.
  6. R3그룹이 8-위치에 있는 제5항에 따른 화합물.
  7. 3-아세틸-4-(2-메틸페닐아미노)-8-메톡시퀴놀린, 3-부티릴-4-(2-메틸페닐아미노)-8-메톡시퀴놀린, 3-헥사노일-4-(2-메틸페닐아미노)-8-메톡시퀴놀린, 3-사이클로헥실카보닐-4-(2-메틸페닐아미노)-8-메톡시퀴놀린, 3-벤조일-4-(2-메톡시페닐아미노)-8-메톡시퀴놀린, 3-벤조일-4-(2-메틸페닐아미노)-8-메톡시퀴놀린, 3-메톡시아세틸-4-(2-메틸페닐아미노)-8-메톡시퀴놀린, 3-이소부티릴-4-(2-메틸페닐아미노)-8-메톡시퀴놀린, 3-부티릴-4-(2-메톡시페닐아미노)-8-메톡시퀴놀린, 3-부티릴-4-(4-메톡시-2-메틸페닐아미노)-8-메톡시퀴놀린, 3-부티릴-4-(2-메틸페닐아미노)-8-메틸귀놀린, 3-부티릴-4-(2-메톡시-2-메톡시페닐아미노)-8메틸퀴놀린, 3-부티릴-4-(2,4-디메톡시페닐아미노)-8-메틸퀴놀린인 제6항에 따른 화합물.
  8. 제1 내지 6항중의 어느 하나에 따른 화합물과 제약학적으로 허용되는 담체로 이루어지는 제약학적 조성물.
  9. 치료에 사용하기 위한 제1 내지 6항중의 어느 하나에 따른 화합물.
  10. 위산 분비의 억제에 사용하기 위한 제1 내지 6항중의 어느 하나에 따른 화합물.
  11. (a) R1, R2, R3와 n은 일반식(Ⅰ)에서 언급된 것과 같으며 X는 아민에 의해 치환될 수 있는 그룹인 다음 일반식(Ⅱ) 화합물과 일반식(Ⅲ) 화합물을 반응시키며;
    (b) R2가 C1-6알킬, C1-6알킬, C3-6시클로알킬, 시클로알킬 C1-6알킬 또는 페닐 C1-6알킬인 일반식(Ⅰ) 화합물을 제조하기 위해서, R1, R3및 n은 일반식 (Ⅰ)에서 언급한 것과 같으며 ; R2`는 C1-6알킬, C3-6시클로알킬, C3-6시클로알콕시 C1-6알킬 또는 페닐 C1-6알킬이고 X1은 유리그룹(leaving group)인 다음 일반식(Ⅳ) 화합물을 일반식(Ⅴ) 화합물로 반응시키며 ;
    (c) R1, R2, R3및 n은 일반식(Ⅰ)에서 언급한 것과 동일하며 ; R4는 수소이거나, 질소보그룹인 다음 일반식(Ⅵ) 화합물을 환원하며 ;
    (d) R1이 C2-6알킬, C3-6시클로알킬 C1-6알킬 또는 임의로 치환된 페닐 C1-6알킬인 일반식(Ⅰ) 화합물을 제조하기 위해서, R2, R3및 n은 일반식(Ⅰ)에서 언급한 것과 같으며 R4는 수소 또는 보호그룹인 다음 일반식(Ⅶ) 화합물을 알킬화 하며 ;
    (e) R1, R2, R3및 n은 일반식 (Ⅰ)에서 언급한 것과 같으며 R4는 수소 또는 질소보호그룹인 다음 일반식(Ⅷ) 화합물을 산화하며 ; 그 이후에 원한다면,
    임의의 보호그룹을 제거하고 ; -R1그룹을 다른 R1그룹으로 전환하고 ; -제약학적으로 허용되는 염을 형성하는 것으로 이루어지는 제1항에 따른 화합물을 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880700495A 1986-09-05 1987-09-04 4-아미노퀴놀린 유도체, 및 이의 제조방법 및 이를 함유한 약제학적 조성물 KR950013850B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB86-21425 1986-09-05
GB868621425A GB8621425D0 (en) 1986-09-05 1986-09-05 Compounds
GB8621425 1986-09-05
PCT/GB1987/000624 WO1988001621A1 (en) 1986-09-05 1987-09-04 4-aminoquinoline derivatives and their use as medicaments

Publications (2)

Publication Number Publication Date
KR880701711A true KR880701711A (ko) 1988-11-04
KR950013850B1 KR950013850B1 (ko) 1995-11-17

Family

ID=10603729

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880700495A KR950013850B1 (ko) 1986-09-05 1987-09-04 4-아미노퀴놀린 유도체, 및 이의 제조방법 및 이를 함유한 약제학적 조성물

Country Status (28)

Country Link
US (2) US4806549A (ko)
EP (1) EP0259174B1 (ko)
JP (1) JPH07602B2 (ko)
KR (1) KR950013850B1 (ko)
CN (1) CN1019802B (ko)
AT (1) ATE73776T1 (ko)
AU (1) AU598299B2 (ko)
CA (1) CA1308106C (ko)
CZ (1) CZ398291A3 (ko)
DE (1) DE3777505D1 (ko)
DK (1) DK159308C (ko)
EG (1) EG18408A (ko)
ES (1) ES2033316T3 (ko)
FI (1) FI88919C (ko)
GB (1) GB8621425D0 (ko)
GR (1) GR3004692T3 (ko)
HU (1) HU199804B (ko)
IE (1) IE61104B1 (ko)
IL (1) IL83691A (ko)
MX (1) MX9203550A (ko)
MY (1) MY102689A (ko)
NO (1) NO172388C (ko)
NZ (1) NZ221663A (ko)
PH (1) PH23695A (ko)
PT (1) PT85651B (ko)
WO (1) WO1988001621A1 (ko)
ZA (1) ZA876581B (ko)
ZW (1) ZW16787A1 (ko)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8610981D0 (en) * 1986-05-06 1986-06-11 Ici America Inc Quinoline amides
US4789678A (en) * 1986-08-25 1988-12-06 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing α-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl)alkanones and related compounds
GB8804446D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804445D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
US5049567A (en) * 1988-02-25 1991-09-17 Smithkline Beckman Intercredit B.V. Substituted 4-aminoquinazoline derivatives and method of use
GB8804448D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804443D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804444D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804447D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
DK273689A (da) * 1988-06-06 1989-12-07 Sanofi Sa 4-amino-3-carboxyquinoliner og -naphthyridiner, fremgangsmaade til deres fremstilling og anvendelse deraf i laegemidler
FR2632305B1 (fr) * 1988-06-06 1992-05-15 Sanofi Sa Amino-4 aroyl-3 quinoleines et naphtyridines, leur procede de preparation et leur application en therapeutique
CA2011086A1 (en) * 1989-03-17 1990-09-17 Karl-Heinz Geiss 2-alkyl-4-arylmethylaminoquinolines, the use thereof and drugs prepared therefrom
GB8918265D0 (en) * 1989-08-10 1989-09-20 Smithkline Beckman Intercredit Compounds
WO1991014677A1 (fr) * 1990-03-28 1991-10-03 Otsuka Pharmaceutical Co., Ltd. Derive de quinoline, medicament anti-ulcereux contenant ce derive et production de ce derive
GB9126438D0 (en) * 1991-12-12 1992-02-12 Smithkline Beecham Intercredit New quinoline derivatives
US5493027A (en) * 1993-01-22 1996-02-20 Board Of Regents, The University Of Texas System Anticonvulsive agents and uses thereof
US5362743A (en) * 1993-03-09 1994-11-08 Pfizer Inc. Aminoquinoline derivatives
SE9302005D0 (sv) 1993-06-11 1993-06-11 Ab Astra New active compounds
US5556863A (en) * 1993-06-11 1996-09-17 Astra Aktiebolag Compound for gastric acid secretion inhibition
IS4164A (is) * 1993-06-11 1994-12-12 Ab Astra Efnasambönd sem hindra flæði magasýru
US5650415A (en) * 1995-06-07 1997-07-22 Sugen, Inc. Quinoline compounds
IN188411B (ko) * 1997-03-27 2002-09-21 Yuhan Corp
US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
GB2355657B (en) * 1999-10-27 2004-07-28 Phytopharm Plc Inhibitors Of Gastric Acid Secretion
UA80393C2 (uk) 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці
AU2002342917A1 (en) * 2001-11-19 2003-06-10 Altana Pharma Ag Reversible proton pump inhibitors for the treatment of airway disorders
MY140561A (en) * 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
US20050222193A1 (en) * 2002-05-07 2005-10-06 Guido Hanauer Novel combination for the treatment of airway disorders
JP4634144B2 (ja) * 2002-08-01 2011-02-16 ニコックス エスエー ニトロソ化プロトンポンプ阻害剤、組成物および使用方法
ME00524B (me) 2003-03-10 2011-10-10 Astrazeneca Ab Novi postupak za dobijanje roflumilasta
CN1874772A (zh) 2003-11-03 2006-12-06 阿斯利康(瑞典)有限公司 治疗隐匿性胃食管反流的咪唑并[1,2－a]吡啶衍生物
SE0400284D0 (sv) * 2004-02-10 2004-02-10 Astrazeneca Ab Novel compounds
WO2006097456A1 (en) * 2005-03-16 2006-09-21 Nycomed Gmbh Taste masked dosage form containing roflumilast
US7803817B2 (en) 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
US7981908B2 (en) 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
EP2046334B1 (en) 2006-07-25 2014-05-21 Vecta Ltd. Compositions and meth0ds for inhibiting gastric acide secretion using derivatives of small dicarboxylic acids in combination with ppi
US20080103169A1 (en) 2006-10-27 2008-05-01 The Curators Of The University Of Missouri Compositions comprising acid labile proton pump inhibiting agents, at least one other pharmaceutically active agent and methods of using same
TW200829555A (en) * 2006-11-10 2008-07-16 Astrazeneca Ab Chemical compounds
CL2008000191A1 (es) * 2007-01-25 2008-08-22 Astrazeneca Ab Compuestos derivados de 4-amino-cinnotina-3-carboxamida; inhibidores de csf-1r quinasa; su proceso de preparacion; y su uso para tratar el cancer.
AU2009215514B9 (en) 2008-02-20 2014-01-30 The Curators Of The University Of Missouri Composition comprising a combination of omeprazole and lansoprazole, and a buffering agent, and methods of using same
TW200948803A (en) * 2008-05-07 2009-12-01 Astrazeneca Ab Chemical compounds
US8247280B2 (en) 2009-10-20 2012-08-21 Taiwan Semiconductor Manufacturing Company, Ltd. Integration of low and high voltage CMOS devices
US20210177827A1 (en) * 2017-10-25 2021-06-17 Children`S Medical Center Corporation Papd5 inhibitors and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4343804A (en) * 1979-03-26 1982-08-10 A. H. Robins Company, Inc. 4-Amino-3-quinolinecarboxylic acids and esters-antisecretory anti-ulcer compounds
JO1406B1 (en) * 1984-11-02 1986-11-30 سميث كلاين اند فرينش لابوراتوريز ليمتد Chemical compounds
PH22302A (en) * 1985-02-11 1988-07-22 Fujisawa Pharmaceutical Co Piperidine compounds
EP0193329A3 (en) * 1985-02-22 1987-08-19 Beecham Group Plc Pyrazolopyridines, their preparation and pharmaceutical compositions containing them
US4789678A (en) * 1986-08-25 1988-12-06 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing α-alkyl-4-amino-3-quinolinemethanols and 1-(4-aralkylamino-3-quinolinyl)alkanones and related compounds

Also Published As

Publication number Publication date
IE61104B1 (en) 1994-10-05
NO172388B (no) 1993-04-05
PT85651A (en) 1987-10-01
FI882089A0 (fi) 1988-05-04
HUT47913A (en) 1989-04-28
WO1988001621A1 (en) 1988-03-10
CN1019802B (zh) 1992-12-30
JPH01500664A (ja) 1989-03-09
EG18408A (en) 1993-02-28
FI88919C (fi) 1993-07-26
US4806549A (en) 1989-02-21
NZ221663A (en) 1989-08-29
US4806550A (en) 1989-02-21
IL83691A (en) 1993-08-18
KR950013850B1 (ko) 1995-11-17
JPH07602B2 (ja) 1995-01-11
IE872370L (en) 1988-03-05
NO172388C (no) 1993-07-14
ZA876581B (en) 1989-04-26
DK159308B (da) 1990-10-01
CA1308106C (en) 1992-09-29
HU199804B (en) 1990-03-28
CN87106163A (zh) 1988-03-16
EP0259174A1 (en) 1988-03-09
DK245888A (da) 1988-05-05
CZ398291A3 (en) 1994-02-16
FI88919B (fi) 1993-04-15
DK159308C (da) 1991-03-11
GB8621425D0 (en) 1986-10-15
AU598299B2 (en) 1990-06-21
DK245888D0 (da) 1988-05-05
ZW16787A1 (en) 1988-05-25
AU7874187A (en) 1988-03-24
GR3004692T3 (ko) 1993-04-28
ATE73776T1 (de) 1992-04-15
NO881940L (no) 1988-05-04
FI882089A (fi) 1988-05-04
MY102689A (en) 1992-09-30
NO881940D0 (no) 1988-05-04
EP0259174B1 (en) 1992-03-18
ES2033316T3 (es) 1993-03-16
MX9203550A (es) 1992-09-01
DE3777505D1 (de) 1992-04-23
PT85651B (pt) 1990-05-31
PH23695A (en) 1989-09-27

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