KR880011115A - 1-(1-아릴-2- 하이드록시에틸)- 이미다졸 및 그의 염, 이의 제조방법, 이 화합물을 함유한 약제 및 이의 용도 - Google Patents
1-(1-아릴-2- 하이드록시에틸)- 이미다졸 및 그의 염, 이의 제조방법, 이 화합물을 함유한 약제 및 이의 용도 Download PDFInfo
- Publication number
- KR880011115A KR880011115A KR1019880002282A KR880002282A KR880011115A KR 880011115 A KR880011115 A KR 880011115A KR 1019880002282 A KR1019880002282 A KR 1019880002282A KR 880002282 A KR880002282 A KR 880002282A KR 880011115 A KR880011115 A KR 880011115A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- formula
- och
- alkyl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 title claims 17
- 239000003814 drug Substances 0.000 title claims 5
- 150000003839 salts Chemical class 0.000 title claims 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Substances C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title claims 2
- 238000002360 preparation method Methods 0.000 title claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 8
- 238000000034 method Methods 0.000 claims 6
- -1 and Y is H Chemical group 0.000 claims 5
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 4
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 3
- 230000001430 anti-depressive effect Effects 0.000 claims 3
- 239000000935 antidepressant agent Substances 0.000 claims 3
- 229940005513 antidepressants Drugs 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000006729 (C2-C5) alkenyl group Chemical group 0.000 claims 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- 230000000843 anti-fungal effect Effects 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000006730 (C2-C5) alkynyl group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- 125000006554 (C4-C8) cycloalkenyl group Chemical group 0.000 claims 1
- KKKDZZRICRFGSD-UHFFFAOYSA-N 1-benzylimidazole Chemical compound C1=CN=CN1CC1=CC=CC=C1 KKKDZZRICRFGSD-UHFFFAOYSA-N 0.000 claims 1
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 claims 1
- 125000004135 2-norbornyl group Chemical group [H]C1([H])C([H])([H])C2([H])C([H])([H])C1([H])C([H])([H])C2([H])* 0.000 claims 1
- 101150065749 Churc1 gene Proteins 0.000 claims 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 1
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Natural products C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 1
- 208000031888 Mycoses Diseases 0.000 claims 1
- 102100038239 Protein Churchill Human genes 0.000 claims 1
- 229910052783 alkali metal Chemical group 0.000 claims 1
- 150000001340 alkali metals Chemical group 0.000 claims 1
- 229910052784 alkaline earth metal Chemical group 0.000 claims 1
- 150000001342 alkaline earth metals Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 229940121375 antifungal agent Drugs 0.000 claims 1
- 239000003429 antifungal agent Substances 0.000 claims 1
- 239000002585 base Substances 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 150000007522 mineralic acids Chemical class 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 230000000269 nucleophilic effect Effects 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 238000007142 ring opening reaction Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Paper (AREA)
- Photoreceptors In Electrophotography (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Lubricants (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEP3707151.3 | 1987-03-06 | ||
| DE19873707151 DE3707151A1 (de) | 1987-03-06 | 1987-03-06 | 1-(1-aryl-2-hydroxy-ethyl)-imidazole und deren salze, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR880011115A true KR880011115A (ko) | 1988-10-26 |
Family
ID=6322380
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019880002282A Withdrawn KR880011115A (ko) | 1987-03-06 | 1988-03-05 | 1-(1-아릴-2- 하이드록시에틸)- 이미다졸 및 그의 염, 이의 제조방법, 이 화합물을 함유한 약제 및 이의 용도 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4999352A (enExample) |
| EP (1) | EP0281121B1 (enExample) |
| JP (1) | JPS63230673A (enExample) |
| KR (1) | KR880011115A (enExample) |
| AT (1) | ATE75466T1 (enExample) |
| AU (1) | AU621815B2 (enExample) |
| DE (2) | DE3707151A1 (enExample) |
| DK (1) | DK118988A (enExample) |
| FI (1) | FI880987A7 (enExample) |
| GR (1) | GR3005194T3 (enExample) |
| HU (1) | HU201745B (enExample) |
| IL (2) | IL85641A0 (enExample) |
| NO (1) | NO170151C (enExample) |
| NZ (1) | NZ223749A (enExample) |
| PH (3) | PH24990A (enExample) |
| PT (1) | PT86890B (enExample) |
| ZA (1) | ZA881557B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5229385A (en) * | 1986-01-30 | 1993-07-20 | Takeda Chemical Industries, Ltd. | Quinone derivatives, their production and use |
| DE3931554A1 (de) * | 1989-09-22 | 1991-04-04 | Hoechst Ag | (+)-(2-hydroxy-2-adamantyl)-1-imidazolyl-3- tolyl-methan und dessen salze, verfahren zu dessen herstellung, diese verbindung enthaltende arzneimittel und dessen verwendung |
| AT409084B (de) * | 2000-07-13 | 2002-05-27 | Ledochowski Maximilian Dr | Antimykotisch wirkendes arzneimittel |
| US7678749B2 (en) * | 2007-12-17 | 2010-03-16 | International Flavors & Fragrances Inc. | Organoleptic compounds |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3658813A (en) * | 1970-01-13 | 1972-04-25 | Janssen Pharmaceutica Nv | 1-(beta-aryl-beta-(r-oxy)-ethyl)-imidazoles |
| DE2009020C3 (de) * | 1970-02-26 | 1979-09-13 | Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von N-(l,l,l-trisubstituierten)-Methylazolen |
| DE2041771C3 (de) * | 1970-08-22 | 1979-07-26 | Bayer Ag, 5090 Leverkusen | derivate |
| DE2430039C2 (de) * | 1974-06-22 | 1983-11-10 | Bayer Ag, 5090 Leverkusen | Climbazol in kosmetischen Mitteln |
| DE2431407C2 (de) * | 1974-06-29 | 1982-12-02 | Bayer Ag, 5090 Leverkusen | 1,2,4-Triazol-1-yl-alkanone und -alkanole, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Fungizide |
| IE44186B1 (en) * | 1975-12-03 | 1981-09-09 | Ici Ltd | 1,2,4-triazolyl alkanols and their use as pesticides |
| IE45765B1 (en) * | 1976-08-19 | 1982-11-17 | Ici Ltd | Triazoles and imidazoles useful as plant fungicides and growth regulating agents |
| DE2720868A1 (de) * | 1977-05-10 | 1978-11-23 | Bayer Ag | Antimikrobielle mittel |
| DE2758784A1 (de) * | 1977-12-29 | 1979-07-12 | Basf Ag | Triazolyl-glykolaether |
| DE2938575A1 (de) * | 1979-09-24 | 1981-04-23 | Bayer Ag, 5090 Leverkusen | Acylierte imidazolyl-(gamma)-fluorpinakolyl-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide |
| DE2948206A1 (de) * | 1979-11-30 | 1981-06-25 | Basf Ag, 6700 Ludwigshafen | Fungizide (gamma) -azolyl-verbindungen, ihre herstellung und verwendung |
| EP0061835B1 (en) * | 1981-03-18 | 1989-02-01 | Imperial Chemical Industries Plc | Triazole compounds, a process for preparing them, their use as plant fungicides and fungicidal compositions containing them |
| DE3124580A1 (de) * | 1981-06-23 | 1983-01-05 | Bayer Ag, 5090 Leverkusen | Fungizide mittel |
| EP0099165A1 (en) * | 1982-03-23 | 1984-01-25 | Imperial Chemical Industries Plc | Triazole and imidazole compounds, process for their preparation and their use as fungicides and plant growth regulators, and intermediates for their synthesis |
| DE3222191A1 (de) * | 1982-06-12 | 1983-12-15 | Bayer Ag, 5090 Leverkusen | Hydroxyalkinyl-azolyl-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide |
| EP0097426B1 (en) * | 1982-06-14 | 1988-09-07 | Imperial Chemical Industries Plc | Triazole compounds |
| DE3322526A1 (de) * | 1983-06-23 | 1985-01-10 | Basf Ag, 6700 Ludwigshafen | Fungizide azolverbindungen, ihre herstellung und verwendung |
| DE3345813A1 (de) * | 1983-12-17 | 1985-06-27 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue 2-(1-imidazolyl)-ethanol-derivate |
| EP0149976A3 (de) * | 1983-12-30 | 1986-12-10 | Ciba-Geigy Ag | Substituierte Imidazole |
| DE3628545A1 (de) * | 1985-09-23 | 1987-04-23 | Hoechst Ag | Arylmethylazole und deren salze, verfahren zu ihrer herstellung, sie enthaltende mittel und ihre verwendung |
-
1987
- 1987-03-06 DE DE19873707151 patent/DE3707151A1/de not_active Withdrawn
-
1988
- 1988-03-03 EP EP88103225A patent/EP0281121B1/de not_active Expired - Lifetime
- 1988-03-03 AT AT88103225T patent/ATE75466T1/de not_active IP Right Cessation
- 1988-03-03 FI FI880987A patent/FI880987A7/fi not_active Application Discontinuation
- 1988-03-03 PT PT86890A patent/PT86890B/pt not_active IP Right Cessation
- 1988-03-03 DE DE8888103225T patent/DE3870486D1/de not_active Expired - Fee Related
- 1988-03-04 AU AU12641/88A patent/AU621815B2/en not_active Ceased
- 1988-03-04 HU HU881058A patent/HU201745B/hu not_active IP Right Cessation
- 1988-03-04 NZ NZ223749A patent/NZ223749A/en unknown
- 1988-03-04 NO NO880973A patent/NO170151C/no unknown
- 1988-03-04 JP JP63049939A patent/JPS63230673A/ja active Pending
- 1988-03-04 DK DK118988A patent/DK118988A/da not_active Application Discontinuation
- 1988-03-04 ZA ZA881557A patent/ZA881557B/xx unknown
- 1988-03-04 PH PH36596A patent/PH24990A/en unknown
- 1988-03-05 KR KR1019880002282A patent/KR880011115A/ko not_active Withdrawn
- 1988-03-06 IL IL85641A patent/IL85641A0/xx unknown
- 1988-03-06 IL IL85640A patent/IL85640A/xx unknown
- 1988-12-07 PH PH37893A patent/PH25682A/en unknown
- 1988-12-07 PH PH37895A patent/PH25797A/en unknown
-
1989
- 1989-11-28 US US07/441,200 patent/US4999352A/en not_active Expired - Fee Related
-
1992
- 1992-07-16 GR GR920401189T patent/GR3005194T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US4999352A (en) | 1991-03-12 |
| IL85640A (en) | 1992-11-15 |
| JPS63230673A (ja) | 1988-09-27 |
| EP0281121B1 (de) | 1992-04-29 |
| PT86890A (pt) | 1988-04-01 |
| IL85640A0 (en) | 1988-08-31 |
| NO170151B (no) | 1992-06-09 |
| GR3005194T3 (enExample) | 1993-05-24 |
| DK118988D0 (da) | 1988-03-04 |
| AU1264188A (en) | 1988-09-08 |
| FI880987A7 (fi) | 1988-09-07 |
| EP0281121A1 (de) | 1988-09-07 |
| ATE75466T1 (de) | 1992-05-15 |
| AU621815B2 (en) | 1992-03-26 |
| NZ223749A (en) | 1990-11-27 |
| PH24990A (en) | 1990-12-26 |
| ZA881557B (en) | 1988-08-25 |
| IL85641A0 (en) | 1988-08-31 |
| PH25682A (en) | 1991-09-04 |
| NO880973L (no) | 1988-09-07 |
| DK118988A (da) | 1988-09-07 |
| NO170151C (no) | 1992-09-16 |
| FI880987A0 (fi) | 1988-03-03 |
| DE3707151A1 (de) | 1988-09-15 |
| HU201745B (en) | 1990-12-28 |
| NO880973D0 (no) | 1988-03-04 |
| PT86890B (pt) | 1992-05-29 |
| PH25797A (en) | 1991-11-05 |
| DE3870486D1 (de) | 1992-06-04 |
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