KR880009933A - 아실-CoA: 콜레스테롤 아실전이효소 억제제로서의 포화 지방산 아미드류 - Google Patents
아실-CoA: 콜레스테롤 아실전이효소 억제제로서의 포화 지방산 아미드류 Download PDFInfo
- Publication number
- KR880009933A KR880009933A KR1019880001910A KR880001910A KR880009933A KR 880009933 A KR880009933 A KR 880009933A KR 1019880001910 A KR1019880001910 A KR 1019880001910A KR 880001910 A KR880001910 A KR 880001910A KR 880009933 A KR880009933 A KR 880009933A
- Authority
- KR
- South Korea
- Prior art keywords
- trimethoxyphenyl
- ethyl
- compound
- dimethyl
- pyridinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 102000001494 Sterol O-Acyltransferase Human genes 0.000 title 1
- 108010054082 Sterol O-acyltransferase Proteins 0.000 title 1
- 239000002404 acyltransferase inhibitor Substances 0.000 title 1
- 150000004671 saturated fatty acids Chemical class 0.000 title 1
- -1 2, 6-diethylphenyl Chemical group 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 12
- ILRSCQWREDREME-UHFFFAOYSA-N dodecanamide Chemical compound CCCCCCCCCCCC(N)=O ILRSCQWREDREME-UHFFFAOYSA-N 0.000 claims 8
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 7
- 125000003545 alkoxy group Chemical group 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000005808 2,4,6-trimethoxyphenyl group Chemical group [H][#6]-1=[#6](-[#8]C([H])([H])[H])-[#6](-*)=[#6](-[#8]C([H])([H])[H])-[#6]([H])=[#6]-1-[#8]C([H])([H])[H] 0.000 claims 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 2
- 150000001721 carbon Chemical group 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 239000000460 chlorine Substances 0.000 claims 2
- 235000012000 cholesterol Nutrition 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 239000011737 fluorine Substances 0.000 claims 2
- HSEMFIZWXHQJAE-UHFFFAOYSA-N hexadecanamide Chemical compound CCCCCCCCCCCCCCCC(N)=O HSEMFIZWXHQJAE-UHFFFAOYSA-N 0.000 claims 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 230000031891 intestinal absorption Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- XRUJKPYWZVRKJT-YPKPFQOOSA-N (z)-n-(2-methoxy-6-methylphenyl)-2,2-dimethylicos-11-enamide Chemical compound CCCCCCCC\C=C/CCCCCCCCC(C)(C)C(=O)NC1=C(C)C=CC=C1OC XRUJKPYWZVRKJT-YPKPFQOOSA-N 0.000 claims 1
- WAFNZAURAWBNDZ-UHFFFAOYSA-N 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide Chemical compound CCCCCCCCCCC(C)(C)C(=O)NC1=C(OC)C=C(OC)C=C1OC WAFNZAURAWBNDZ-UHFFFAOYSA-N 0.000 claims 1
- ZAZVXQPEOBBYRY-UHFFFAOYSA-N 2,2-dimethyl-n-(2,4,6-trimethoxyphenyl)hexadecanamide Chemical compound CCCCCCCCCCCCCCC(C)(C)C(=O)NC1=C(OC)C=C(OC)C=C1OC ZAZVXQPEOBBYRY-UHFFFAOYSA-N 0.000 claims 1
- SNRXHHCLJULQQR-UHFFFAOYSA-N 2,2-dimethyl-n-(2,4,6-trimethoxyphenyl)octadecanamide Chemical compound CCCCCCCCCCCCCCCCC(C)(C)C(=O)NC1=C(OC)C=C(OC)C=C1OC SNRXHHCLJULQQR-UHFFFAOYSA-N 0.000 claims 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 claims 1
- CQGWDLIWBJTOAO-UHFFFAOYSA-N 2-ethyl-n-(2,4,6-trimethoxyphenyl)tetradecanamide Chemical compound CCCCCCCCCCCCC(CC)C(=O)NC1=C(OC)C=C(OC)C=C1OC CQGWDLIWBJTOAO-UHFFFAOYSA-N 0.000 claims 1
- LPQCXGFQNAHQFU-UHFFFAOYSA-N 2-methyl-n-(2,4,6-trimethoxyphenyl)hexadecanamide Chemical compound CCCCCCCCCCCCCCC(C)C(=O)NC1=C(OC)C=C(OC)C=C1OC LPQCXGFQNAHQFU-UHFFFAOYSA-N 0.000 claims 1
- VYIBCOSBNVFEIW-UHFFFAOYSA-N 3-phenylpropanamide Chemical compound NC(=O)CCC1=CC=CC=C1 VYIBCOSBNVFEIW-UHFFFAOYSA-N 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 238000007796 conventional method Methods 0.000 claims 1
- XRLDSWLMHUQECH-UHFFFAOYSA-N cyclopentanecarboxamide Chemical compound NC(=O)C1CCCC1 XRLDSWLMHUQECH-UHFFFAOYSA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 229940081141 hexadecanamide Drugs 0.000 claims 1
- LBHQTVBKPMHICN-UHFFFAOYSA-N icos-11-enamide Chemical compound CCCCCCCCC=CCCCCCCCCCC(N)=O LBHQTVBKPMHICN-UHFFFAOYSA-N 0.000 claims 1
- 239000012442 inert solvent Substances 0.000 claims 1
- FBRAMUFBRPEQDV-UHFFFAOYSA-N n-(2,6-diethylphenyl)-2,2-dimethyldodecanamide Chemical compound CCCCCCCCCCC(C)(C)C(=O)NC1=C(CC)C=CC=C1CC FBRAMUFBRPEQDV-UHFFFAOYSA-N 0.000 claims 1
- HVJRZYYYBUJSGK-UHFFFAOYSA-N n-(2,6-dimethylphenyl)-2,2-dimethyldodecanamide Chemical compound CCCCCCCCCCC(C)(C)C(=O)NC1=C(C)C=CC=C1C HVJRZYYYBUJSGK-UHFFFAOYSA-N 0.000 claims 1
- LMAFBFKEXNZZHQ-UHFFFAOYSA-N n-(2-ethoxy-6-methylphenyl)-2,2-dimethyldodecanamide Chemical compound CCCCCCCCCCC(C)(C)C(=O)NC1=C(C)C=CC=C1OCC LMAFBFKEXNZZHQ-UHFFFAOYSA-N 0.000 claims 1
- FTAVACWCNRCIOR-UHFFFAOYSA-N n-(4,6-diethoxypyrimidin-5-yl)-2-methyltetradecanamide Chemical compound CCCCCCCCCCCCC(C)C(=O)NC1=C(OCC)N=CN=C1OCC FTAVACWCNRCIOR-UHFFFAOYSA-N 0.000 claims 1
- UPKSTIJQZHNGLT-UHFFFAOYSA-N n-(4,6-dimethoxy-2-phenylpyrimidin-5-yl)-2,2-dimethyldodecanamide Chemical compound N1=C(OC)C(NC(=O)C(C)(C)CCCCCCCCCC)=C(OC)N=C1C1=CC=CC=C1 UPKSTIJQZHNGLT-UHFFFAOYSA-N 0.000 claims 1
- OQPCGRGYLNPAIF-UHFFFAOYSA-N n-(4,6-dimethoxypyrimidin-5-yl)-2,2-dimethyldodecanamide Chemical compound CCCCCCCCCCC(C)(C)C(=O)NC1=C(OC)N=CN=C1OC OQPCGRGYLNPAIF-UHFFFAOYSA-N 0.000 claims 1
- RXKHRZVIVMVFKE-UHFFFAOYSA-N n-(4,6-dimethoxypyrimidin-5-yl)-2-ethyltetradecanamide Chemical compound CCCCCCCCCCCCC(CC)C(=O)NC1=C(OC)N=CN=C1OC RXKHRZVIVMVFKE-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 150000003512 tertiary amines Chemical class 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C233/07—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/09—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/017,960 US4716175A (en) | 1987-02-24 | 1987-02-24 | Saturated fatty acid amides as inhibitors of acyl-CoA:cholesterol acyltransferase |
| US017,960 | 1987-02-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR880009933A true KR880009933A (ko) | 1988-10-05 |
Family
ID=21785503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019880001910A Abandoned KR880009933A (ko) | 1987-02-24 | 1988-02-24 | 아실-CoA: 콜레스테롤 아실전이효소 억제제로서의 포화 지방산 아미드류 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4716175A (cg-RX-API-DMAC10.html) |
| EP (1) | EP0283742B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JPH07121895B2 (cg-RX-API-DMAC10.html) |
| KR (1) | KR880009933A (cg-RX-API-DMAC10.html) |
| AT (1) | ATE89814T1 (cg-RX-API-DMAC10.html) |
| CA (1) | CA1336913C (cg-RX-API-DMAC10.html) |
| DE (1) | DE3881249T2 (cg-RX-API-DMAC10.html) |
| DK (1) | DK165406C (cg-RX-API-DMAC10.html) |
| ES (1) | ES2056843T3 (cg-RX-API-DMAC10.html) |
| FI (1) | FI89593C (cg-RX-API-DMAC10.html) |
| HK (1) | HK148195A (cg-RX-API-DMAC10.html) |
| IE (1) | IE59998B1 (cg-RX-API-DMAC10.html) |
| MX (1) | MX9203139A (cg-RX-API-DMAC10.html) |
| NO (1) | NO174043C (cg-RX-API-DMAC10.html) |
| NZ (1) | NZ223410A (cg-RX-API-DMAC10.html) |
| PT (1) | PT86811B (cg-RX-API-DMAC10.html) |
| ZA (1) | ZA88604B (cg-RX-API-DMAC10.html) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5290814A (en) * | 1988-11-21 | 1994-03-01 | Burroughs Wellcome Co. | Anti-atherosclerotic diaryl compounds |
| GB8827152D0 (en) * | 1988-11-21 | 1988-12-29 | Wellcome Found | Anti-atherosclerotic diaryl compounds |
| US5153226A (en) * | 1989-08-31 | 1992-10-06 | Warner-Lambert Company | Acat inhibitors for treating hypocholesterolemia |
| MX22406A (es) * | 1989-09-15 | 1994-01-31 | Pfizer | Nuevos derivados de n-aril y n-heteroarilamidas y urea como inhibidores de acil coenzima a: acil transferasa del colesterol (acat). |
| AU6659090A (en) * | 1989-11-16 | 1991-06-13 | Warner-Lambert Company | Acat inhibitors |
| AU7745991A (en) * | 1990-04-11 | 1991-10-30 | Warner-Lambert Company | Amide ester acat inhibitors |
| US5149709A (en) * | 1990-07-03 | 1992-09-22 | Schering Corporation | Inhibitors of acyl-coenzyme A: cholesterol acyl transferase |
| CA2087423A1 (en) * | 1990-07-25 | 1992-01-26 | Tatsuki Shiota | Benzopyran derivative, process for producing the same and pharmaceutical composition containing the same |
| US5668136A (en) * | 1990-09-25 | 1997-09-16 | Eisai Co., Ltd. | Trisubstituted benzene derivatives, composition and methods of treatment |
| CA2096970C (en) * | 1990-11-26 | 1998-07-14 | Masakazu Sato | Anilide derivative |
| FR2673625B1 (fr) * | 1991-03-08 | 1993-05-07 | Adir | Nouveaux derives d'acylaminophenol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US5420164A (en) * | 1991-04-04 | 1995-05-30 | Yoshitomi Pharmaceutical Industries, Ltd. | Cycloalkylurea compounds |
| JP3087307B2 (ja) * | 1991-12-25 | 2000-09-11 | 大正製薬株式会社 | アニリド誘導体 |
| BR9306421A (pt) * | 1992-05-28 | 1998-09-15 | Pfizer | Novos derivados n-aril e n-heteroariluréia como inbidores da acilcoenzima a:colesterol aciltransferase (acat) |
| CA2115915A1 (en) * | 1992-07-20 | 1994-02-03 | Kenji Hayashi | Benzene derivatives |
| US5321031A (en) * | 1992-09-23 | 1994-06-14 | Schering Corporation | 1,2-disubstituted ethyl amides as inhibitors of ACAT |
| CA2107196A1 (en) * | 1992-09-29 | 1994-03-30 | Mitsubishi Chemical Corporation | Carboxamide derivatives |
| US5565472A (en) * | 1992-12-21 | 1996-10-15 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents |
| IL110151A (en) * | 1993-06-30 | 1998-10-30 | Sankyo Co | Amide derivatives and pharmaceutical compositions containing them |
| NZ264063A (en) * | 1993-08-13 | 1995-11-27 | Nihon Nohyaku Co Ltd | N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions |
| US5596001A (en) * | 1993-10-25 | 1997-01-21 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)quinoline derivatves |
| IT1265209B1 (it) * | 1993-11-22 | 1996-10-31 | Pierrel Spa | Difenilimidazoli utili nel trattamento di dislipidemia, arteriosclerosi e malattie coronariche procedimento per la loro |
| US6133326A (en) | 1994-08-31 | 2000-10-17 | Pfizer Inc | Compositions and methods for decreasing sebum production |
| DE69600396T2 (de) * | 1995-02-08 | 1998-10-29 | Nippon Shoji Kaisha Ltd | Anilinderivate, die einen mehrfach ungesättigten Fettsäurerest tragen und ihre Anwendung |
| EA004255B1 (ru) * | 2000-02-02 | 2004-02-26 | Уорнер-Ламберт Компани | Применение 2,6-диизопропилфенилового эфира [(2,4,6-триизопропилфенил)ацетил]сульфаминовой кислоты в качестве ингибитора секреции сальных желез, в частности, для лечения акне и композиции и способы на основе данного соединения |
| KR20020011986A (ko) * | 2000-03-16 | 2002-02-09 | 해피 페너 ; 해리 에이치. 페너 2세 | 5-치환된 아릴피리미딘 |
| US20040072903A1 (en) * | 2001-05-08 | 2004-04-15 | Auerbach Bruce Jeffrey | Carboxyalkylether-acat inhibitors combinations |
| EP1281399A3 (en) * | 2001-08-01 | 2004-02-11 | Warner-Lambert Company | Dual inhibitors of wax ester and cholesteryl ester synthesis for inhibiting sebum production |
| NZ549721A (en) | 2004-03-05 | 2010-08-27 | Univ Pennsylvania | Methods for treating disorders or diseases associated with hyperlipidemia and hypercholesterolemia while minimizing side-effects |
| US20100210633A1 (en) * | 2006-10-12 | 2010-08-19 | Epix Delaware, Inc. | Carboxamide compounds and their use |
| EP2280766A1 (en) | 2007-12-11 | 2011-02-09 | CytoPathfinder, Inc. | Carboxamide compounds and their use as chemokine receptor agonists |
| WO2010039801A2 (en) | 2008-10-02 | 2010-04-08 | The J. David Gladstone Institutes | Methods of treating hepatitis c virus infection |
| US20230285376A1 (en) | 2020-07-29 | 2023-09-14 | Amryt Pharmaceuticals Inc. | Lomitapide for use in methods of treating hyperlipidemia and hypercholesterolemia in pediatric patients |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL120013C (cg-RX-API-DMAC10.html) * | 1958-04-14 | |||
| BE620639A (cg-RX-API-DMAC10.html) * | 1961-07-25 | |||
| SE353319B (cg-RX-API-DMAC10.html) * | 1964-08-15 | 1973-01-29 | Sumitomo Chemical Co | |
| DE1618959C3 (de) * | 1967-10-04 | 1978-12-14 | Sumitomo Chemical Co., Ltd., Osaka (Japan) | Fettsäureamide und Verfahren zu ihrer Herstellung |
| DE2830351A1 (de) * | 1978-07-11 | 1980-01-24 | Consortium Elektrochem Ind | Acylanilide |
| GR69292B (cg-RX-API-DMAC10.html) * | 1979-06-25 | 1982-05-13 | May & Baker Ltd | |
| CH649078A5 (de) * | 1980-01-25 | 1985-04-30 | Reanal Finomvegyszergyar | Verfahren zur herstellung von n-mono- oder disubstituierten n-aryl-harnstoff-derivaten. |
| NZ216253A (en) * | 1985-05-27 | 1989-07-27 | Mitsui Toatsu Chemicals | N-(3-chloro-4-isopropylphenyl)-carboxamide derivatives and herbicidal compositions |
| MA20552A1 (fr) * | 1985-10-11 | 1986-07-01 | Pan Medica Sa | Alkylacarboxamides de pyridylalkylamines,leurs preparations et leurs utilisations |
-
1987
- 1987-02-24 US US07/017,960 patent/US4716175A/en not_active Expired - Lifetime
-
1988
- 1988-01-26 IE IE20488A patent/IE59998B1/en not_active IP Right Cessation
- 1988-01-27 CA CA000557467A patent/CA1336913C/en not_active Expired - Fee Related
- 1988-01-28 ZA ZA88604A patent/ZA88604B/xx unknown
- 1988-02-04 NZ NZ223410A patent/NZ223410A/xx unknown
- 1988-02-19 FI FI880796A patent/FI89593C/fi not_active IP Right Cessation
- 1988-02-23 DE DE8888102644T patent/DE3881249T2/de not_active Expired - Fee Related
- 1988-02-23 EP EP88102644A patent/EP0283742B1/en not_active Expired - Lifetime
- 1988-02-23 NO NO880774A patent/NO174043C/no unknown
- 1988-02-23 AT AT88102644T patent/ATE89814T1/de not_active IP Right Cessation
- 1988-02-23 PT PT86811A patent/PT86811B/pt not_active IP Right Cessation
- 1988-02-23 DK DK094188A patent/DK165406C/da not_active IP Right Cessation
- 1988-02-23 ES ES88102644T patent/ES2056843T3/es not_active Expired - Lifetime
- 1988-02-23 JP JP63038777A patent/JPH07121895B2/ja not_active Expired - Lifetime
- 1988-02-24 KR KR1019880001910A patent/KR880009933A/ko not_active Abandoned
-
1992
- 1992-06-23 MX MX9203139A patent/MX9203139A/es unknown
-
1995
- 1995-09-14 HK HK148195A patent/HK148195A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| MX9203139A (es) | 1992-07-01 |
| US4716175B1 (cg-RX-API-DMAC10.html) | 1993-06-22 |
| NZ223410A (en) | 1989-11-28 |
| AU1135488A (en) | 1988-08-25 |
| DK165406B (da) | 1992-11-23 |
| FI880796A0 (fi) | 1988-02-19 |
| EP0283742A2 (en) | 1988-09-28 |
| CA1336913C (en) | 1995-09-05 |
| PT86811A (pt) | 1988-03-01 |
| DK165406C (da) | 1993-04-13 |
| DK94188D0 (da) | 1988-02-23 |
| AU610558B2 (en) | 1991-05-23 |
| US4716175A (en) | 1987-12-29 |
| NO880774D0 (no) | 1988-02-23 |
| ZA88604B (en) | 1989-09-27 |
| FI880796A7 (fi) | 1988-08-25 |
| NO174043C (no) | 1994-03-09 |
| IE59998B1 (en) | 1994-05-18 |
| DE3881249T2 (de) | 1993-09-16 |
| EP0283742A3 (en) | 1989-07-26 |
| HK148195A (en) | 1995-09-22 |
| DK94188A (da) | 1988-08-25 |
| DE3881249D1 (en) | 1993-07-01 |
| NO174043B (no) | 1993-11-29 |
| IE880204L (en) | 1988-08-24 |
| FI89593C (fi) | 1993-10-25 |
| NO880774L (no) | 1988-08-25 |
| ES2056843T3 (es) | 1994-10-16 |
| JPH07121895B2 (ja) | 1995-12-25 |
| PT86811B (pt) | 1992-05-29 |
| EP0283742B1 (en) | 1993-05-26 |
| ATE89814T1 (de) | 1993-06-15 |
| JPS63253060A (ja) | 1988-10-20 |
| FI89593B (fi) | 1993-07-15 |
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