FI89593C - Foerfarande foer framstaellning av saosom laekemedel anvaendbara 2,4,6-trimetoxifenyl-substituerade fettsyraamider - Google Patents
Foerfarande foer framstaellning av saosom laekemedel anvaendbara 2,4,6-trimetoxifenyl-substituerade fettsyraamider Download PDFInfo
- Publication number
- FI89593C FI89593C FI880796A FI880796A FI89593C FI 89593 C FI89593 C FI 89593C FI 880796 A FI880796 A FI 880796A FI 880796 A FI880796 A FI 880796A FI 89593 C FI89593 C FI 89593C
- Authority
- FI
- Finland
- Prior art keywords
- trimethoxyphenyl
- prepared
- process according
- cholesterol
- dimethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C233/07—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/09—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/017,960 US4716175A (en) | 1987-02-24 | 1987-02-24 | Saturated fatty acid amides as inhibitors of acyl-CoA:cholesterol acyltransferase |
| US1796087 | 1987-02-24 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI880796A0 FI880796A0 (fi) | 1988-02-19 |
| FI880796A7 FI880796A7 (fi) | 1988-08-25 |
| FI89593B FI89593B (fi) | 1993-07-15 |
| FI89593C true FI89593C (fi) | 1993-10-25 |
Family
ID=21785503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI880796A FI89593C (fi) | 1987-02-24 | 1988-02-19 | Foerfarande foer framstaellning av saosom laekemedel anvaendbara 2,4,6-trimetoxifenyl-substituerade fettsyraamider |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4716175A (cg-RX-API-DMAC10.html) |
| EP (1) | EP0283742B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JPH07121895B2 (cg-RX-API-DMAC10.html) |
| KR (1) | KR880009933A (cg-RX-API-DMAC10.html) |
| AT (1) | ATE89814T1 (cg-RX-API-DMAC10.html) |
| CA (1) | CA1336913C (cg-RX-API-DMAC10.html) |
| DE (1) | DE3881249T2 (cg-RX-API-DMAC10.html) |
| DK (1) | DK165406C (cg-RX-API-DMAC10.html) |
| ES (1) | ES2056843T3 (cg-RX-API-DMAC10.html) |
| FI (1) | FI89593C (cg-RX-API-DMAC10.html) |
| HK (1) | HK148195A (cg-RX-API-DMAC10.html) |
| IE (1) | IE59998B1 (cg-RX-API-DMAC10.html) |
| MX (1) | MX9203139A (cg-RX-API-DMAC10.html) |
| NO (1) | NO174043C (cg-RX-API-DMAC10.html) |
| NZ (1) | NZ223410A (cg-RX-API-DMAC10.html) |
| PT (1) | PT86811B (cg-RX-API-DMAC10.html) |
| ZA (1) | ZA88604B (cg-RX-API-DMAC10.html) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8827152D0 (en) * | 1988-11-21 | 1988-12-29 | Wellcome Found | Anti-atherosclerotic diaryl compounds |
| US5290814A (en) * | 1988-11-21 | 1994-03-01 | Burroughs Wellcome Co. | Anti-atherosclerotic diaryl compounds |
| US5153226A (en) * | 1989-08-31 | 1992-10-06 | Warner-Lambert Company | Acat inhibitors for treating hypocholesterolemia |
| MX22406A (es) * | 1989-09-15 | 1994-01-31 | Pfizer | Nuevos derivados de n-aril y n-heteroarilamidas y urea como inhibidores de acil coenzima a: acil transferasa del colesterol (acat). |
| AU6659090A (en) * | 1989-11-16 | 1991-06-13 | Warner-Lambert Company | Acat inhibitors |
| WO1991015464A1 (en) * | 1990-04-11 | 1991-10-17 | Warner-Lambert Company | Amide ester acat inhibitors |
| US5149709A (en) * | 1990-07-03 | 1992-09-22 | Schering Corporation | Inhibitors of acyl-coenzyme A: cholesterol acyl transferase |
| DE69128630T2 (de) * | 1990-07-25 | 1998-04-23 | Teijin Ltd | Benzopyran derivat, seine darstellung und pharmazeutische zusammensetzung, welche dieses enthält |
| US5668136A (en) * | 1990-09-25 | 1997-09-16 | Eisai Co., Ltd. | Trisubstituted benzene derivatives, composition and methods of treatment |
| KR0169501B1 (ko) * | 1990-11-26 | 1999-03-20 | 우에하라 아키라 | 아닐리드 유도체 |
| FR2673625B1 (fr) * | 1991-03-08 | 1993-05-07 | Adir | Nouveaux derives d'acylaminophenol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US5420164A (en) * | 1991-04-04 | 1995-05-30 | Yoshitomi Pharmaceutical Industries, Ltd. | Cycloalkylurea compounds |
| EP0619312A4 (en) * | 1991-12-25 | 1995-07-19 | Taisho Pharmaceutical Co Ltd | ANILIDE DERIVATIVES. |
| EP0642498A1 (en) * | 1992-05-28 | 1995-03-15 | Pfizer Inc. | NEW $i(N)-ARYL AND $i(N)-HETEROARYLUREA DERIVATIVES AS INHIBITORS OF ACYL COENZYME A:CHOLESTEROL ACYL TRANSFERASE (ACAT) |
| JP3612328B2 (ja) * | 1992-07-20 | 2005-01-19 | エーザイ株式会社 | ベンゼン誘導体 |
| US5321031A (en) * | 1992-09-23 | 1994-06-14 | Schering Corporation | 1,2-disubstituted ethyl amides as inhibitors of ACAT |
| CA2107196A1 (en) * | 1992-09-29 | 1994-03-30 | Mitsubishi Chemical Corporation | Carboxamide derivatives |
| US5565472A (en) * | 1992-12-21 | 1996-10-15 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents |
| US5534529A (en) * | 1993-06-30 | 1996-07-09 | Sankyo Company, Limited | Substituted aromatic amides and ureas derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses |
| NZ264063A (en) * | 1993-08-13 | 1995-11-27 | Nihon Nohyaku Co Ltd | N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions |
| US5596001A (en) * | 1993-10-25 | 1997-01-21 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)quinoline derivatves |
| IT1265209B1 (it) * | 1993-11-22 | 1996-10-31 | Pierrel Spa | Difenilimidazoli utili nel trattamento di dislipidemia, arteriosclerosi e malattie coronariche procedimento per la loro |
| US6133326A (en) | 1994-08-31 | 2000-10-17 | Pfizer Inc | Compositions and methods for decreasing sebum production |
| EP0726247B1 (en) * | 1995-02-08 | 1998-07-08 | Nippon Shoji Kaisha, Limited | Aniline derivatives having a polyunsaturated fatty acid residue and use thereof |
| UA75345C2 (en) * | 2000-02-02 | 2006-04-17 | Warner Lambert Co | Pharmaceutical composition for topical use intended for treating sebaceous gland disorders and methods of treating acnes using this composition |
| CN1636000A (zh) * | 2000-03-16 | 2005-07-06 | 神经能质公司 | 5－取代芳基嘧啶类 |
| US20040072903A1 (en) * | 2001-05-08 | 2004-04-15 | Auerbach Bruce Jeffrey | Carboxyalkylether-acat inhibitors combinations |
| EP1281399A3 (en) * | 2001-08-01 | 2004-02-11 | Warner-Lambert Company | Dual inhibitors of wax ester and cholesteryl ester synthesis for inhibiting sebum production |
| JP5697296B2 (ja) | 2004-03-05 | 2015-04-08 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 高脂血症および高コレステロール血症に関連する障害または疾患を、副作用を最小限にしつつ処置するための方法 |
| TW200831497A (en) * | 2006-10-12 | 2008-08-01 | Epix Delaware Inc | Carboxamide compounds and their use |
| BRPI0820701A2 (pt) | 2007-12-11 | 2015-06-16 | Cytopathfinder Inc | Composto de carboxamida e seu uso como agonistas do receptor de quimiocina |
| WO2010039801A2 (en) | 2008-10-02 | 2010-04-08 | The J. David Gladstone Institutes | Methods of treating hepatitis c virus infection |
| CN116322682A (zh) | 2020-07-29 | 2023-06-23 | 艾米琳制药有限责任公司 | 在治疗儿科患者的高脂血症和高胆固醇血症的方法中使用的洛美他派 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL238088A (cg-RX-API-DMAC10.html) * | 1958-04-14 | |||
| BE620639A (cg-RX-API-DMAC10.html) * | 1961-07-25 | |||
| SE353319B (cg-RX-API-DMAC10.html) * | 1964-08-15 | 1973-01-29 | Sumitomo Chemical Co | |
| DE1618959C3 (de) * | 1967-10-04 | 1978-12-14 | Sumitomo Chemical Co., Ltd., Osaka (Japan) | Fettsäureamide und Verfahren zu ihrer Herstellung |
| DE2830351A1 (de) * | 1978-07-11 | 1980-01-24 | Consortium Elektrochem Ind | Acylanilide |
| GR69292B (cg-RX-API-DMAC10.html) * | 1979-06-25 | 1982-05-13 | May & Baker Ltd | |
| BR8106184A (pt) * | 1980-01-25 | 1981-11-24 | Reanal Finomvegyszergyar | Processo para preparacao de derivados de n-aril-n'-(mono-ou dissubstituido)-ureia |
| NZ216253A (en) * | 1985-05-27 | 1989-07-27 | Mitsui Toatsu Chemicals | N-(3-chloro-4-isopropylphenyl)-carboxamide derivatives and herbicidal compositions |
| MA20552A1 (fr) * | 1985-10-11 | 1986-07-01 | Pan Medica Sa | Alkylacarboxamides de pyridylalkylamines,leurs preparations et leurs utilisations |
-
1987
- 1987-02-24 US US07/017,960 patent/US4716175A/en not_active Expired - Lifetime
-
1988
- 1988-01-26 IE IE20488A patent/IE59998B1/en not_active IP Right Cessation
- 1988-01-27 CA CA000557467A patent/CA1336913C/en not_active Expired - Fee Related
- 1988-01-28 ZA ZA88604A patent/ZA88604B/xx unknown
- 1988-02-04 NZ NZ223410A patent/NZ223410A/xx unknown
- 1988-02-19 FI FI880796A patent/FI89593C/fi not_active IP Right Cessation
- 1988-02-23 DE DE8888102644T patent/DE3881249T2/de not_active Expired - Fee Related
- 1988-02-23 ES ES88102644T patent/ES2056843T3/es not_active Expired - Lifetime
- 1988-02-23 EP EP88102644A patent/EP0283742B1/en not_active Expired - Lifetime
- 1988-02-23 AT AT88102644T patent/ATE89814T1/de not_active IP Right Cessation
- 1988-02-23 DK DK094188A patent/DK165406C/da not_active IP Right Cessation
- 1988-02-23 PT PT86811A patent/PT86811B/pt not_active IP Right Cessation
- 1988-02-23 JP JP63038777A patent/JPH07121895B2/ja not_active Expired - Lifetime
- 1988-02-23 NO NO880774A patent/NO174043C/no unknown
- 1988-02-24 KR KR1019880001910A patent/KR880009933A/ko not_active Abandoned
-
1992
- 1992-06-23 MX MX9203139A patent/MX9203139A/es unknown
-
1995
- 1995-09-14 HK HK148195A patent/HK148195A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK165406B (da) | 1992-11-23 |
| NZ223410A (en) | 1989-11-28 |
| EP0283742A2 (en) | 1988-09-28 |
| DE3881249T2 (de) | 1993-09-16 |
| NO174043C (no) | 1994-03-09 |
| FI89593B (fi) | 1993-07-15 |
| PT86811B (pt) | 1992-05-29 |
| CA1336913C (en) | 1995-09-05 |
| NO174043B (no) | 1993-11-29 |
| DK94188D0 (da) | 1988-02-23 |
| KR880009933A (ko) | 1988-10-05 |
| EP0283742B1 (en) | 1993-05-26 |
| JPS63253060A (ja) | 1988-10-20 |
| DK94188A (da) | 1988-08-25 |
| JPH07121895B2 (ja) | 1995-12-25 |
| PT86811A (pt) | 1988-03-01 |
| NO880774L (no) | 1988-08-25 |
| ZA88604B (en) | 1989-09-27 |
| MX9203139A (es) | 1992-07-01 |
| FI880796A0 (fi) | 1988-02-19 |
| IE880204L (en) | 1988-08-24 |
| AU1135488A (en) | 1988-08-25 |
| NO880774D0 (no) | 1988-02-23 |
| ES2056843T3 (es) | 1994-10-16 |
| US4716175B1 (cg-RX-API-DMAC10.html) | 1993-06-22 |
| FI880796A7 (fi) | 1988-08-25 |
| AU610558B2 (en) | 1991-05-23 |
| DE3881249D1 (en) | 1993-07-01 |
| EP0283742A3 (en) | 1989-07-26 |
| DK165406C (da) | 1993-04-13 |
| HK148195A (en) | 1995-09-22 |
| ATE89814T1 (de) | 1993-06-15 |
| IE59998B1 (en) | 1994-05-18 |
| US4716175A (en) | 1987-12-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| MM | Patent lapsed |
Owner name: WARNER-LAMBERT COMPANY |