DK94188D0 - Maettede fedtsyreamider som inhibitorer for kolesterol-acyltransferase - Google Patents
Maettede fedtsyreamider som inhibitorer for kolesterol-acyltransferaseInfo
- Publication number
- DK94188D0 DK94188D0 DK094188A DK94188A DK94188D0 DK 94188 D0 DK94188 D0 DK 94188D0 DK 094188 A DK094188 A DK 094188A DK 94188 A DK94188 A DK 94188A DK 94188 D0 DK94188 D0 DK 94188D0
- Authority
- DK
- Denmark
- Prior art keywords
- cholesterol
- saturated fatty
- inhibitors
- fatty acid
- acid amides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C233/07—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/09—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1796087 | 1987-02-24 | ||
| US07/017,960 US4716175A (en) | 1987-02-24 | 1987-02-24 | Saturated fatty acid amides as inhibitors of acyl-CoA:cholesterol acyltransferase |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| DK94188D0 true DK94188D0 (da) | 1988-02-23 |
| DK94188A DK94188A (da) | 1988-08-25 |
| DK165406B DK165406B (da) | 1992-11-23 |
| DK165406C DK165406C (da) | 1993-04-13 |
Family
ID=21785503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK094188A DK165406C (da) | 1987-02-24 | 1988-02-23 | Substituerede n-(2,4,6-trimethoxyphenyl)-fedtsyreamider, fremgangsmaade til fremstilling deraf, farmaceutisk praeparat indeholdende disse forbindelser samt anvendelse af disse forbindelser til fremstilling af et farmaceutisk praeparat til inhibering af intestinal absorption af kolesterol |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4716175A (da) |
| EP (1) | EP0283742B1 (da) |
| JP (1) | JPH07121895B2 (da) |
| KR (1) | KR880009933A (da) |
| AT (1) | ATE89814T1 (da) |
| CA (1) | CA1336913C (da) |
| DE (1) | DE3881249T2 (da) |
| DK (1) | DK165406C (da) |
| ES (1) | ES2056843T3 (da) |
| FI (1) | FI89593C (da) |
| HK (1) | HK148195A (da) |
| IE (1) | IE59998B1 (da) |
| MX (1) | MX9203139A (da) |
| NO (1) | NO174043C (da) |
| NZ (1) | NZ223410A (da) |
| PT (1) | PT86811B (da) |
| ZA (1) | ZA88604B (da) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8827152D0 (en) * | 1988-11-21 | 1988-12-29 | Wellcome Found | Anti-atherosclerotic diaryl compounds |
| US5290814A (en) * | 1988-11-21 | 1994-03-01 | Burroughs Wellcome Co. | Anti-atherosclerotic diaryl compounds |
| US5153226A (en) * | 1989-08-31 | 1992-10-06 | Warner-Lambert Company | Acat inhibitors for treating hypocholesterolemia |
| MX22406A (es) * | 1989-09-15 | 1994-01-31 | Pfizer | Nuevos derivados de n-aril y n-heteroarilamidas y urea como inhibidores de acil coenzima a: acil transferasa del colesterol (acat). |
| AU6659090A (en) * | 1989-11-16 | 1991-06-13 | Warner-Lambert Company | Acat inhibitors |
| WO1991015464A1 (en) * | 1990-04-11 | 1991-10-17 | Warner-Lambert Company | Amide ester acat inhibitors |
| US5149709A (en) * | 1990-07-03 | 1992-09-22 | Schering Corporation | Inhibitors of acyl-coenzyme A: cholesterol acyl transferase |
| ATE161837T1 (de) * | 1990-07-25 | 1998-01-15 | Teijin Ltd | Benzopyran derivat, seine darstellung und pharmazeutische zusammensetzung, welche dieses enthält |
| US5668136A (en) * | 1990-09-25 | 1997-09-16 | Eisai Co., Ltd. | Trisubstituted benzene derivatives, composition and methods of treatment |
| ATE137744T1 (de) * | 1990-11-26 | 1996-05-15 | Taisho Pharmaceutical Co Ltd | Anilidderivat |
| FR2673625B1 (fr) * | 1991-03-08 | 1993-05-07 | Adir | Nouveaux derives d'acylaminophenol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US5420164A (en) * | 1991-04-04 | 1995-05-30 | Yoshitomi Pharmaceutical Industries, Ltd. | Cycloalkylurea compounds |
| CA2126663A1 (en) * | 1991-12-25 | 1993-07-08 | Masakazu Sato | Anilide derivatives |
| CA2134359C (en) * | 1992-05-28 | 1997-07-01 | Ernest S. Hamanaka | New n-aryl and n-heteroarylurea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat) |
| EP0609457B1 (en) * | 1992-07-20 | 1997-10-29 | Eisai Co., Ltd. | Benzene derivative |
| US5321031A (en) * | 1992-09-23 | 1994-06-14 | Schering Corporation | 1,2-disubstituted ethyl amides as inhibitors of ACAT |
| CA2107196A1 (en) * | 1992-09-29 | 1994-03-30 | Mitsubishi Chemical Corporation | Carboxamide derivatives |
| US5565472A (en) * | 1992-12-21 | 1996-10-15 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents |
| AU672699B2 (en) * | 1993-06-30 | 1996-10-10 | Sankyo Company Limited | Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses |
| NZ264063A (en) * | 1993-08-13 | 1995-11-27 | Nihon Nohyaku Co Ltd | N-(2-phenylpyrid-3-yl)- and n-(4-phenylpyrimidin-5-yl)-n'-phenylurea derivatives and pharmaceutical compositions |
| US5596001A (en) * | 1993-10-25 | 1997-01-21 | Pfizer Inc. | 4-aryl-3-(heteroarylureido)quinoline derivatves |
| IT1265209B1 (it) * | 1993-11-22 | 1996-10-31 | Pierrel Spa | Difenilimidazoli utili nel trattamento di dislipidemia, arteriosclerosi e malattie coronariche procedimento per la loro |
| US6133326A (en) | 1994-08-31 | 2000-10-17 | Pfizer Inc | Compositions and methods for decreasing sebum production |
| KR960031425A (ko) * | 1995-02-08 | 1996-09-17 | 시미주 마사미 | 다중불포화된 지방산 잔기를 갖는 아닐린 유도체 및 그의 용도 |
| JP2003531113A (ja) | 2000-02-02 | 2003-10-21 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 皮脂腺障害のためのコレステロールエステルとワックスエステルの合成の二重阻害剤 |
| CA2373411A1 (en) * | 2000-03-16 | 2001-09-20 | Taeyoung Yoon | 5-substituted arylpyrimidines |
| US20040072903A1 (en) * | 2001-05-08 | 2004-04-15 | Auerbach Bruce Jeffrey | Carboxyalkylether-acat inhibitors combinations |
| EP1281399A3 (en) * | 2001-08-01 | 2004-02-11 | Warner-Lambert Company | Dual inhibitors of wax ester and cholesteryl ester synthesis for inhibiting sebum production |
| ES2399721T5 (es) | 2004-03-05 | 2016-05-25 | Univ Pennsylvania | Métodos para tratar trastornos o enfermedades asociados a la hiperlipidemia e hipercolesterolemia minimizando los efectos adversos |
| US20100210633A1 (en) * | 2006-10-12 | 2010-08-19 | Epix Delaware, Inc. | Carboxamide compounds and their use |
| JP2011506466A (ja) | 2007-12-11 | 2011-03-03 | 株式会社サイトパスファインダー | カルボキサミド化合物ならびにケモカイン受容体アゴニストとしてのそれらの使用 |
| EP3025727A1 (en) | 2008-10-02 | 2016-06-01 | The J. David Gladstone Institutes | Methods of treating liver disease |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL238088A (da) * | 1958-04-14 | |||
| BE620639A (da) * | 1961-07-25 | |||
| SE353319B (da) * | 1964-08-15 | 1973-01-29 | Sumitomo Chemical Co | |
| DE1618959C3 (de) * | 1967-10-04 | 1978-12-14 | Sumitomo Chemical Co., Ltd., Osaka (Japan) | Fettsäureamide und Verfahren zu ihrer Herstellung |
| DE2830351A1 (de) * | 1978-07-11 | 1980-01-24 | Consortium Elektrochem Ind | Acylanilide |
| GR69292B (da) * | 1979-06-25 | 1982-05-13 | May & Baker Ltd | |
| WO1981002156A1 (en) * | 1980-01-25 | 1981-08-06 | Reanal Finomvegyszergyar | Process for the preparation of n-aryl-n'-(mono-or disubstiuted)-urea derivatives |
| NZ216253A (en) * | 1985-05-27 | 1989-07-27 | Mitsui Toatsu Chemicals | N-(3-chloro-4-isopropylphenyl)-carboxamide derivatives and herbicidal compositions |
| MA20552A1 (fr) * | 1985-10-11 | 1986-07-01 | Pan Medica Sa | Alkylacarboxamides de pyridylalkylamines,leurs preparations et leurs utilisations |
-
1987
- 1987-02-24 US US07/017,960 patent/US4716175A/en not_active Expired - Lifetime
-
1988
- 1988-01-26 IE IE20488A patent/IE59998B1/en not_active IP Right Cessation
- 1988-01-27 CA CA000557467A patent/CA1336913C/en not_active Expired - Fee Related
- 1988-01-28 ZA ZA88604A patent/ZA88604B/xx unknown
- 1988-02-04 NZ NZ223410A patent/NZ223410A/xx unknown
- 1988-02-19 FI FI880796A patent/FI89593C/fi not_active IP Right Cessation
- 1988-02-23 ES ES88102644T patent/ES2056843T3/es not_active Expired - Lifetime
- 1988-02-23 JP JP63038777A patent/JPH07121895B2/ja not_active Expired - Lifetime
- 1988-02-23 DK DK094188A patent/DK165406C/da not_active IP Right Cessation
- 1988-02-23 EP EP88102644A patent/EP0283742B1/en not_active Expired - Lifetime
- 1988-02-23 PT PT86811A patent/PT86811B/pt not_active IP Right Cessation
- 1988-02-23 AT AT88102644T patent/ATE89814T1/de not_active IP Right Cessation
- 1988-02-23 DE DE8888102644T patent/DE3881249T2/de not_active Expired - Fee Related
- 1988-02-23 NO NO880774A patent/NO174043C/no unknown
- 1988-02-24 KR KR1019880001910A patent/KR880009933A/ko not_active IP Right Cessation
-
1992
- 1992-06-23 MX MX9203139A patent/MX9203139A/es unknown
-
1995
- 1995-09-14 HK HK148195A patent/HK148195A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HK148195A (en) | 1995-09-22 |
| EP0283742A3 (en) | 1989-07-26 |
| AU610558B2 (en) | 1991-05-23 |
| US4716175B1 (da) | 1993-06-22 |
| JPH07121895B2 (ja) | 1995-12-25 |
| CA1336913C (en) | 1995-09-05 |
| FI89593C (fi) | 1993-10-25 |
| FI880796A0 (fi) | 1988-02-19 |
| MX9203139A (es) | 1992-07-01 |
| IE59998B1 (en) | 1994-05-18 |
| PT86811A (pt) | 1988-03-01 |
| DE3881249D1 (en) | 1993-07-01 |
| ATE89814T1 (de) | 1993-06-15 |
| FI89593B (fi) | 1993-07-15 |
| NZ223410A (en) | 1989-11-28 |
| DK165406B (da) | 1992-11-23 |
| IE880204L (en) | 1988-08-24 |
| DK94188A (da) | 1988-08-25 |
| DK165406C (da) | 1993-04-13 |
| JPS63253060A (ja) | 1988-10-20 |
| DE3881249T2 (de) | 1993-09-16 |
| NO880774L (no) | 1988-08-25 |
| FI880796A (fi) | 1988-08-25 |
| NO174043B (no) | 1993-11-29 |
| US4716175A (en) | 1987-12-29 |
| NO880774D0 (no) | 1988-02-23 |
| EP0283742A2 (en) | 1988-09-28 |
| KR880009933A (ko) | 1988-10-05 |
| PT86811B (pt) | 1992-05-29 |
| ZA88604B (en) | 1989-09-27 |
| AU1135488A (en) | 1988-08-25 |
| NO174043C (no) | 1994-03-09 |
| EP0283742B1 (en) | 1993-05-26 |
| ES2056843T3 (es) | 1994-10-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK94188D0 (da) | Maettede fedtsyreamider som inhibitorer for kolesterol-acyltransferase | |
| MX9203150A (es) | Nuevos esteres de acidos tienilcarboxilicos de aminoalcoholes, sus productos de cuaternizacion y las composiciones farmaceuticas que los contienen. | |
| NO914092L (no) | Nye mercaptoacetylamid-derivater som er anvendbare som inhibitorer for enkefalinase og ace | |
| GR3001523T3 (en) | Substituted pyrimidine amides of oleic or linoleic acid as inhibitors of acyl-coa cholesterol acyltransferase | |
| IT8821542A0 (it) | Composti attivi come inibitori della biosintesi del colesterolo. | |
| DE3587230T2 (de) | Enzymatisches verfahren. | |
| NO930525L (no) | Framgangsmaate for utvikling av umettede fettsyrer | |
| ES544466A0 (es) | Procedimiento para la fabricacion de esteres de triterpenilode acidos organicos | |
| ES2025122B3 (es) | Procedimiento para obtencion de esteres de acidos alquencarboxilicos. | |
| NO891647D0 (no) | Fremgangsmaate for desodorisering av fettsyreesterblandinger. | |
| AR222747A1 (es) | Procedimiento para la produccion de enzima de fructosil transferasa | |
| PH23490A (en) | Substituted anilides of oleic,linoleic,or linolenic acid as inhibitors of acyl-coa: cholesterol acyl transferase | |
| IL84426A (en) | Process for the isolation of l-amino acids | |
| ES2107082T3 (es) | Acidos 6-piperazinil-1h-pirazolo(3,4-b)piridina-3-carboxilicos, esteres, amidas y compuestos relacionados, un procedimiento para su preparacion y su uso como medicamentos. | |
| EP0252524A3 (en) | Aryl- and aralkylamide- derivatives of omega- (substituted-phenyloxy)-alkanoic acids as inhibitors of acyl-coa: cholesterol acyltransferase and pharmaceuticals containing them | |
| IL87327A0 (en) | Aqueous enzyme compositions comprising proteolytic inhibitors as stabilizers | |
| FI103114B1 (fi) | Menetelmä proteolyyttisen entsyymin inhibiittoreina käyttökelpoisten sakkariinijohdannaisten valmistamiseksi | |
| ES544776A0 (es) | Procedimiento para la obtencion de esteres alquilicos de a- cidos bencimidazolcarbamicos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |