KR880001852B1 - 항종양 퀴나졸린 화합물 및 그의 제조방법 - Google Patents

항종양 퀴나졸린 화합물 및 그의 제조방법 Download PDF

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Publication number
KR880001852B1
KR880001852B1 KR8200576A KR820000576A KR880001852B1 KR 880001852 B1 KR880001852 B1 KR 880001852B1 KR 8200576 A KR8200576 A KR 8200576A KR 820000576 A KR820000576 A KR 820000576A KR 880001852 B1 KR880001852 B1 KR 880001852B1
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KR
South Korea
Prior art keywords
methoxy
compound
methyl
ethyl
formula
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR8200576A
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English (en)
Korean (ko)
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KR830009050A (ko
Inventor
이.크레이바움 윌리암
티.코머 윌리암
Original Assignee
이삭 자코브스키
브리스톨-마이어스 컴페니
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Application filed by 이삭 자코브스키, 브리스톨-마이어스 컴페니 filed Critical 이삭 자코브스키
Publication of KR830009050A publication Critical patent/KR830009050A/ko
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Publication of KR880001852B1 publication Critical patent/KR880001852B1/ko
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR8200576A 1981-03-06 1982-02-09 항종양 퀴나졸린 화합물 및 그의 제조방법 Expired KR880001852B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US241317 1981-03-06
US06/241,317 US4343940A (en) 1979-02-13 1981-03-06 Anti-tumor quinazoline compounds

Publications (2)

Publication Number Publication Date
KR830009050A KR830009050A (ko) 1983-12-17
KR880001852B1 true KR880001852B1 (ko) 1988-09-22

Family

ID=22910195

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8200576A Expired KR880001852B1 (ko) 1981-03-06 1982-02-09 항종양 퀴나졸린 화합물 및 그의 제조방법

Country Status (31)

Country Link
US (1) US4343940A (cg-RX-API-DMAC7.html)
JP (1) JPS57158780A (cg-RX-API-DMAC7.html)
KR (1) KR880001852B1 (cg-RX-API-DMAC7.html)
AR (1) AR231138A1 (cg-RX-API-DMAC7.html)
AT (1) AT380476B (cg-RX-API-DMAC7.html)
AU (1) AU556099B2 (cg-RX-API-DMAC7.html)
BE (1) BE891936A (cg-RX-API-DMAC7.html)
CA (1) CA1163995A (cg-RX-API-DMAC7.html)
CH (1) CH647776A5 (cg-RX-API-DMAC7.html)
CY (1) CY1371A (cg-RX-API-DMAC7.html)
DE (1) DE3203770C2 (cg-RX-API-DMAC7.html)
DK (1) DK159442C (cg-RX-API-DMAC7.html)
ES (1) ES509434A0 (cg-RX-API-DMAC7.html)
FI (1) FI71559C (cg-RX-API-DMAC7.html)
FR (1) FR2501207B1 (cg-RX-API-DMAC7.html)
GB (1) GB2094295B (cg-RX-API-DMAC7.html)
GR (1) GR75903B (cg-RX-API-DMAC7.html)
HK (1) HK4588A (cg-RX-API-DMAC7.html)
HU (1) HU189997B (cg-RX-API-DMAC7.html)
IE (1) IE52385B1 (cg-RX-API-DMAC7.html)
IL (1) IL64875A0 (cg-RX-API-DMAC7.html)
IT (1) IT1154272B (cg-RX-API-DMAC7.html)
KE (1) KE3715A (cg-RX-API-DMAC7.html)
LU (1) LU83903A1 (cg-RX-API-DMAC7.html)
NL (1) NL8200473A (cg-RX-API-DMAC7.html)
NZ (1) NZ199576A (cg-RX-API-DMAC7.html)
PH (1) PH18529A (cg-RX-API-DMAC7.html)
PT (1) PT74394B (cg-RX-API-DMAC7.html)
SE (1) SE461732B (cg-RX-API-DMAC7.html)
SG (1) SG30787G (cg-RX-API-DMAC7.html)
YU (1) YU42031B (cg-RX-API-DMAC7.html)

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DE3131365A1 (de) * 1981-08-07 1983-02-24 Henkel KGaA, 4000 Düsseldorf Neue diglycidyl-substituierte heterocyclische verbindungen, verfahren zu ihrer herstellung und ihre verwendung in arzneimittelzubereitungen mit cytostatischer wirksamkeit
US4963554A (en) * 1990-02-14 1990-10-16 Ortho Pharmaceutical Corporation 6,7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides
US5030635A (en) * 1990-02-14 1991-07-09 Ortho Pharmaceutical Corporation 6-7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides
USRE37650E1 (en) 1991-05-10 2002-04-09 Aventis Pharmacetical Products, Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
US5714493A (en) * 1991-05-10 1998-02-03 Rhone-Poulenc Rorer Pharmaceuticals, Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
US5710158A (en) * 1991-05-10 1998-01-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US5480883A (en) * 1991-05-10 1996-01-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US6645969B1 (en) 1991-05-10 2003-11-11 Aventis Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
ATE188377T1 (de) * 1993-06-29 2000-01-15 Takeda Chemical Industries Ltd Chinoline oder chinazolin-derivate und deren verwendung zur herstellung eines medikaments für die behandlung von osteoporose
CA2183655C (en) * 1994-02-23 2001-03-06 Lee D. Arnold 4-polycyclic amino-substituted quinazoline derivatives
US5804396A (en) * 1994-10-12 1998-09-08 Sugen, Inc. Assay for agents active in proliferative disorders
TW321649B (cg-RX-API-DMAC7.html) * 1994-11-12 1997-12-01 Zeneca Ltd
GB9424233D0 (en) * 1994-11-30 1995-01-18 Zeneca Ltd Quinazoline derivatives
US5837815A (en) * 1994-12-15 1998-11-17 Sugen, Inc. PYK2 related polypeptide products
US5837524A (en) * 1994-12-15 1998-11-17 Sugen, Inc. PYK2 related polynucleotide products
EP0824525B1 (en) * 1995-04-27 2001-06-13 AstraZeneca AB Quinazoline derivatives
GB9508538D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
GB9508565D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
GB9508535D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivative
GB9508537D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
JPH11507052A (ja) * 1995-06-07 1999-06-22 スージェン・インコーポレーテッド キナゾリンおよび医薬組成物
DE69622183D1 (de) * 1995-11-07 2002-08-08 Kirin Brewery Chinolinderivate und chinazolinderivate welche die autophosphorylierung des von blutplättchen abstammenden wachstumsfaktorrezeptors inhibiren und sie enthaltende pharmazeutische zusammensetzungen
US7119174B2 (en) * 1995-12-18 2006-10-10 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
US6716575B2 (en) 1995-12-18 2004-04-06 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
CA2242425C (en) 1996-02-13 2006-07-18 Zeneca Limited Quinazoline derivatives as vegf inhibitors
GB9603097D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline compounds
GB9603095D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
NZ331191A (en) 1996-03-05 2000-03-27 Zeneca Ltd 4-anilinoquinazoline derivatives and pharmaceutical compositions thereof
GB9607729D0 (en) * 1996-04-13 1996-06-19 Zeneca Ltd Quinazoline derivatives
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
JP2001505779A (ja) * 1996-12-11 2001-05-08 スージェン・インコーポレーテッド Ｐｙｋ２関連産物および方法
US6818440B2 (en) * 1997-04-28 2004-11-16 Sugen, Inc. Diagnosis and treatment of alk-7 related disorders
US6228641B1 (en) 1997-05-20 2001-05-08 Sugen, Inc. Diagnosis and treatment of PTP04 related disorders
US6342593B1 (en) 1997-06-11 2002-01-29 Sugen, Inc. Diagnosis and treatment of ALP related disorders
US7115710B2 (en) * 1997-06-11 2006-10-03 Sugen, Inc. Diagnosis and treatment of PTP related disorders
US6388063B1 (en) 1997-06-18 2002-05-14 Sugen, Inc. Diagnosis and treatment of SAD related disorders
US6495353B1 (en) * 1998-01-21 2002-12-17 Sugen, Inc. Human orthologues of wart
AU3642499A (en) * 1998-04-14 1999-11-01 Sugen, Inc. Ste20-related protein kinases
HUP0102793A3 (en) 1998-05-28 2002-07-29 Parker Hughes Inst St Paul Quinazolines for treating brain tumor and medicaments containing them
US6800649B1 (en) * 1998-06-30 2004-10-05 Parker Hughes Institute Method for inhibiting c-jun expression using JAK-3 inhibitors
AU5682799A (en) * 1998-08-21 2000-03-14 Parker Hughes Institute Quinazoline derivatives
US6861442B1 (en) 1998-12-30 2005-03-01 Sugen, Inc. PYK2 and inflammation
US6080747A (en) * 1999-03-05 2000-06-27 Hughes Institute JAK-3 inhibitors for treating allergic disorders
US6258820B1 (en) 1999-03-19 2001-07-10 Parker Hughes Institute Synthesis and anti-tumor activity of 6,7-dialkoxy-4-phenylamino-quinazolines
US20030162223A1 (en) * 1999-10-22 2003-08-28 Lowery David E. Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
US7364866B2 (en) * 1999-10-22 2008-04-29 Pharmacia & Upjohn Company Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
EP1222273A2 (en) * 1999-10-22 2002-07-17 PHARMACIA & UPJOHN COMPANY Drosophila g protein coupled receptors, nucleic acids, and methods related to the same
PT1244647E (pt) * 1999-11-05 2006-10-31 Astrazeneca Ab Derivados de quinazolina como inibidores de vegf
CA2388865A1 (en) * 1999-11-16 2001-05-25 Pharmacia & Upjohn Company Novel g protein-coupled receptors
US20030082534A1 (en) * 1999-11-16 2003-05-01 Peter Lind Novel G protein-coupled receptors
EP1265925A2 (en) * 2000-02-23 2002-12-18 PHARMACIA & UPJOHN COMPANY G protein-coupled receptors
IL151626A0 (en) * 2000-04-07 2003-04-10 Astrazeneca Ab Quinazoline compounds
US20050069976A1 (en) * 2001-02-14 2005-03-31 Peter Lind Protein-coupled receptor
MXPA05001277A (es) 2002-08-02 2005-10-06 Ab Science 2-(3-aminoaril)amino-4-aril-tiazoles y su uso como inhibidores del c-kit.
US8450302B2 (en) * 2002-08-02 2013-05-28 Ab Science 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors
ATE465731T1 (de) * 2003-10-23 2010-05-15 Ab Science 2-aminoaryloxazol-verbindungen als tyrosinkinase- hemmer
MX2007012392A (es) 2005-04-04 2007-12-05 Ab Science Derivados de oxazol sustituidos y su uso como inhibidores de tirosina cinasa.
US8246966B2 (en) * 2006-08-07 2012-08-21 University Of Georgia Research Foundation, Inc. Trypanosome microsome system and uses thereof
CA2663436A1 (en) 2006-10-04 2008-04-10 Pfizer Products Inc. Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists
EP2088863A2 (en) 2006-11-22 2009-08-19 University Of Georgia Research Foundation, Inc. Tyrosine kinase inhibitors as anti-kinetolastid and anti-apicomplexan agents
US20110008347A1 (en) * 2006-12-01 2011-01-13 Agency For Science ,Technology And Research Cancer-related protein kinases
EP2680850B1 (en) 2011-03-04 2018-05-23 Newgen Therapeutics, Inc. Alkyne substituted quinazoline compound and methods of use

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US3298291A (en) * 1965-12-28 1967-01-17 Jack D Layton Paver screed assembly
US3455920A (en) * 1967-01-13 1969-07-15 Squibb & Sons Inc 2,3-dihydro-5 and 6-substituted-2-phenyl-4(1h)-quinazolinones
US3637693A (en) * 1968-07-12 1972-01-25 Du Pont Hydroxyarylquinazolines and their use as uv-absorbers
DE2050092C3 (de) 1970-10-13 1980-04-24 Bayer Ag, 5090 Leverkusen Chinazolondiurethane, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten
DE2162327C3 (de) * 1970-12-23 1975-09-18 Sumitomo Chemical Co., Ltd., Osaka (Japan) Verfahren zur Herstellung von 3,4-Oihydro-2(1 H)-chinazolinonen
JPS6011032B2 (ja) 1975-12-16 1985-03-22 大鵬薬品工業株式会社 ２―置換―５―フルオルピリミジン―４―オン誘導体の製造法
US4080455A (en) * 1975-12-16 1978-03-21 Taisho Pharmaceutical Company Limited 5-Fluoropyrimidin-4-one compositions

Also Published As

Publication number Publication date
DE3203770A1 (de) 1982-11-11
IT8247713A1 (it) 1983-08-03
CY1371A (en) 1987-08-07
AT380476B (de) 1986-05-26
KR830009050A (ko) 1983-12-17
BE891936A (fr) 1982-07-28
JPS57158780A (en) 1982-09-30
NL8200473A (nl) 1982-10-01
IE52385B1 (en) 1987-10-14
YU42031B (en) 1988-04-30
PT74394B (en) 1984-10-22
ES8304095A1 (es) 1983-02-16
PH18529A (en) 1985-08-02
GB2094295B (en) 1984-09-12
FI71559C (fi) 1987-01-19
AU556099B2 (en) 1986-10-23
PT74394A (en) 1982-03-01
IT8247713A0 (it) 1982-02-03
HK4588A (en) 1988-01-29
SG30787G (en) 1988-09-16
US4343940A (en) 1982-08-10
CA1163995A (en) 1984-03-20
GB2094295A (en) 1982-09-15
AR231138A1 (es) 1984-09-28
KE3715A (en) 1987-04-16
NZ199576A (en) 1986-05-09
IT1154272B (it) 1987-01-21
HU189997B (en) 1986-08-28
GR75903B (cg-RX-API-DMAC7.html) 1984-08-02
SE8200526L (sv) 1982-09-07
YU25682A (en) 1985-03-20
SE461732B (sv) 1990-03-19
FR2501207A1 (fr) 1982-09-10
ATA39582A (de) 1985-10-15
DK159442B (da) 1990-10-15
DE3203770C2 (de) 1993-11-04
DK159442C (da) 1991-03-18
AU7998182A (en) 1982-09-09
IL64875A0 (en) 1982-03-31
FR2501207B1 (fr) 1985-12-06
CH647776A5 (de) 1985-02-15
LU83903A1 (fr) 1982-09-13
ES509434A0 (es) 1983-02-16
FI71559B (fi) 1986-10-10
DK50482A (da) 1982-09-07
JPH0337552B2 (cg-RX-API-DMAC7.html) 1991-06-05
FI820399L (fi) 1982-09-07
IE820163L (en) 1982-09-06

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