KR870000920B1 - 벤조 치오펜 유도체의 제조 방법 - Google Patents

벤조 치오펜 유도체의 제조 방법 Download PDF

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Publication number
KR870000920B1
KR870000920B1 KR1019850001704A KR850001704A KR870000920B1 KR 870000920 B1 KR870000920 B1 KR 870000920B1 KR 1019850001704 A KR1019850001704 A KR 1019850001704A KR 850001704 A KR850001704 A KR 850001704A KR 870000920 B1 KR870000920 B1 KR 870000920B1
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KR
South Korea
Prior art keywords
dimethoxy
benzo
melting point
thiopene
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019850001704A
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English (en)
Korean (ko)
Other versions
KR850006391A (ko
Inventor
레드패드 제임스
토마스 로간 로버트
브룬톤 맥파젠 다비드
깁슨로이 로버트
Original Assignee
아크조 엔. 브이.
에이. 디. 도우마 프록시
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 아크조 엔. 브이., 에이. 디. 도우마 프록시 filed Critical 아크조 엔. 브이.
Publication of KR850006391A publication Critical patent/KR850006391A/ko
Application granted granted Critical
Publication of KR870000920B1 publication Critical patent/KR870000920B1/ko
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
KR1019850001704A 1984-03-16 1985-03-16 벤조 치오펜 유도체의 제조 방법 Expired KR870000920B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB84.06906 1984-03-16
GB848406906A GB8406906D0 (en) 1984-03-16 1984-03-16 Benzo-thiazole and benzothiophene derivatives

Publications (2)

Publication Number Publication Date
KR850006391A KR850006391A (ko) 1985-10-05
KR870000920B1 true KR870000920B1 (ko) 1987-05-07

Family

ID=10558202

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850001704A Expired KR870000920B1 (ko) 1984-03-16 1985-03-16 벤조 치오펜 유도체의 제조 방법

Country Status (14)

Country Link
US (2) US4665206A (https=)
EP (1) EP0158380B1 (https=)
JP (1) JPS60209577A (https=)
KR (1) KR870000920B1 (https=)
AU (1) AU568428B2 (https=)
CA (1) CA1254216A (https=)
DE (1) DE3567459D1 (https=)
DK (1) DK119285A (https=)
ES (4) ES8707223A1 (https=)
FI (1) FI80883C (https=)
GB (1) GB8406906D0 (https=)
HU (1) HU198030B (https=)
IE (1) IE57977B1 (https=)
ZA (1) ZA851807B (https=)

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IE58555B1 (en) * 1984-12-10 1993-10-06 Warner Almbert Company Novel benzothiophenes and benzofurans having antiallergy activity
EP0253650A3 (en) * 1986-07-18 1989-09-13 Eli Lilly And Company Improvements relating to benzothiophene derivatives
US4873259A (en) * 1987-06-10 1989-10-10 Abbott Laboratories Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds
US4822809A (en) * 1987-11-13 1989-04-18 Abbott Laboratories Benzazole lipoxygenase inhibiting compounds
US4882354A (en) * 1987-12-16 1989-11-21 Norwich Eaton Pharmaceuticals, Inc. N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents
DE68901424D1 (de) * 1988-07-05 1992-06-11 Akzo Nv Verbindungen mit bronchodilatatorischer aktivitaet.
IE913683A1 (en) * 1990-10-26 1992-05-22 Akzo Nv USE OF A BENZO[b]THIOPHENE-2-CARBOXIMIDAMIDE DERIVATIVE
US5276052A (en) * 1990-10-26 1994-01-04 Akzo N.V. Use of a benzo[b]thiopene-2-carboximidamide derivative
DE4128871A1 (de) * 1991-08-30 1993-03-04 Boehringer Mannheim Gmbh Benzo(b)thiophenderivate, verfahren zu ihrer herstellung und arzneimittel
US5340833A (en) * 1992-05-01 1994-08-23 Eisai Co., Ltd. Urokinase inhibitors
US5436246A (en) * 1992-09-17 1995-07-25 Merrell Dow Pharmaceuticals Inc. Serotonin receptor agents
DE69525763T2 (de) * 1994-04-11 2002-10-02 Chugai Seiyaku K.K., Tokio/Tokyo 4,6-DI-t-BUTYL-2,3-DIHYDROBENZOTHIOPHENE, DIE LDL OXIDATION HEMMEN
US5760062A (en) * 1995-04-18 1998-06-02 Geron Corporation Telomerase inhibitors
US5703116A (en) * 1995-04-18 1997-12-30 Geron Corporation Telomerase Inhibitors
US5656638A (en) * 1995-04-18 1997-08-12 Geron Corporation Telomerase inhibitors
US5863936A (en) * 1995-04-18 1999-01-26 Geron Corporation Telomerase inhibitors
US5770613A (en) * 1995-09-29 1998-06-23 Geron Corporation Telomerase inhibitors
US5767278A (en) * 1995-10-06 1998-06-16 Geron Corporation Telomerase inhibitors
CZ297324B6 (cs) * 1996-12-13 2006-11-15 Shionogi & Co., Ltd. Benzothiofenkarboxamidové deriváty a antagonisty PGD2, které je obsahují
US6362216B1 (en) 1998-10-27 2002-03-26 Array Biopharma Inc. Compounds which inhibit tryptase activity
EP1212089B1 (en) 1999-08-21 2006-03-22 ALTANA Pharma AG Synergistic combination of roflumilast and salmeterol
KR20040007596A (ko) 2001-05-23 2004-01-24 다나베 세이야꾸 가부시키가이샤 골절 치료 촉진용 조성물
ES2427930T3 (es) 2001-05-23 2013-11-04 Mitsubishi Tanabe Pharma Corporation Composición terapéutica para el tratamiento regenerativo de enfermedades de los cartílagos
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
MXPA05010373A (es) 2003-04-01 2005-12-05 Applied Research Systems Inhibidores de fosfodiesterasas en infertilidad.
WO2005034880A2 (en) 2003-10-09 2005-04-21 Aton Pharma, Inc. Thiophene and benzothiophene hydroxamic acid derivatives
WO2006101454A1 (en) * 2005-03-21 2006-09-28 S*Bio Pte Ltd Benzothiophene derivatives: preparation and pharmaceutical applications
MY148644A (en) * 2005-07-18 2013-05-15 Orion Corp New pharmaceutical compounds
CA2643012A1 (en) * 2006-02-21 2007-08-30 Trigen Limited Heterocyclic compounds and their use in the treatment of cardiovascular disease
CA2674237C (en) 2006-12-28 2015-11-24 Rigel Pharmaceuticals, Inc. N-substituted-heterocycloalkyloxybenzamide compounds and methods of use
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
ES2664873T3 (es) 2011-03-01 2018-04-23 Synergy Pharmaceuticals Inc. Proceso de preparación de agonistas de guanilato ciclasa C
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
SI3004138T1 (sl) 2013-06-05 2024-07-31 Bausch Health Ireland Limited Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo
KR102456567B1 (ko) 2013-08-09 2022-10-19 알데릭스, 인코포레이티드 인산염 수송을 억제하기 위한 화합물 및 방법
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient
CN111296447B (zh) * 2020-03-24 2021-09-17 东营施普瑞石油工程技术有限公司 一种油田用杀菌剂及其制备方法

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GB438211A (en) * 1934-06-01 1935-11-13 Ig Farbenindustrie Ag The manufacture of heterocyclic compounds
US2775593A (en) * 1948-10-01 1956-12-25 Schenley Ind Inc Thiosemicarbazones of aldehydes and ketones of the heterocyclic series
GB1229580A (https=) * 1967-12-15 1971-04-28
BE759237A (fr) * 1969-11-21 1971-05-01 Montedison Spa Procede de preparation d'amides a partir de composes heterocycliques azotes
BE786520A (fr) * 1971-07-23 1973-01-22 Bayer Ag Nouveaux benzothiazoles substitues, leur preparation et leur application comme fongicides et bactericides
DE2258036A1 (de) * 1972-11-27 1974-05-30 Goedecke Ag Verfahren zur herstellung von benzo eckige klammer auf b eckige klammer zu thiophen-derivaten
FR2305982A1 (fr) * 1975-04-03 1976-10-29 Innothera Lab Sa Nouvelles benzothienyl amino (propyl et butyl) cetones, leur procede de preparation et leur application en therapeutique
DE2834945A1 (de) * 1977-08-15 1979-03-01 Lilly Co Eli Thiadiazolylbenzamide, verfahren zu ihrer herstellung und sie enthaltende insektizide mittel
US4140785A (en) * 1978-05-08 1979-02-20 E. I. Du Pont De Nemours And Company N-(benzothienopyrazol)amide antirhinoviral agents
JPS5936670A (ja) * 1982-08-25 1984-02-28 Takeda Chem Ind Ltd ベンゾチアゾ−ル誘導体，その製造法およびそれを含有する摂食抑制剤

Also Published As

Publication number Publication date
HUT37410A (en) 1985-12-28
FI80883B (fi) 1990-04-30
FI851038A0 (fi) 1985-03-15
ES541336A0 (es) 1987-07-16
DK119285A (da) 1985-09-17
EP0158380B1 (en) 1989-01-11
ES551280A0 (es) 1987-04-16
KR850006391A (ko) 1985-10-05
ES8704924A1 (es) 1987-04-16
CA1254216A (en) 1989-05-16
ES551282A0 (es) 1987-04-16
ES8704925A1 (es) 1987-04-16
FI80883C (fi) 1990-08-10
AU3985285A (en) 1985-09-19
DE3567459D1 (en) 1989-02-16
ES8704926A1 (es) 1987-04-16
ZA851807B (en) 1985-10-30
EP0158380A1 (en) 1985-10-16
HU198030B (en) 1989-07-28
IE850592L (en) 1985-09-16
US4929636A (en) 1990-05-29
AU568428B2 (en) 1987-12-24
JPS60209577A (ja) 1985-10-22
FI851038L (fi) 1985-09-17
GB8406906D0 (en) 1984-04-18
IE57977B1 (en) 1993-06-02
US4665206A (en) 1987-05-12
ES551281A0 (es) 1987-04-16
DK119285D0 (da) 1985-03-15
ES8707223A1 (es) 1987-07-16
JPH0588232B2 (https=) 1993-12-21

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