KR860006266A - 지효성(持效性) 미크로 캡슐의 제조방법 - Google Patents

지효성(持效性) 미크로 캡슐의 제조방법 Download PDF

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KR860006266A
KR860006266A KR1019860000872A KR860000872A KR860006266A KR 860006266 A KR860006266 A KR 860006266A KR 1019860000872 A KR1019860000872 A KR 1019860000872A KR 860000872 A KR860000872 A KR 860000872A KR 860006266 A KR860006266 A KR 860006266A
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emulsion
water
temperature
viscosity
phase
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KR1019860000872A
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KR920007831B1 (ko
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마사끼 야마모또
마사끼 야마모또 (외 2)
시게유끼 다까다
야스아끼 오가와
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다께다야꾸힝 고오교 가부시끼사이샤
구라바야시 이꾸시로
다께다야꾸힝고오교 가부시끼 가이샤
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer
    • Y10T428/2987—Addition polymer from unsaturated monomers only

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Cosmetics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

내용 없음

Description

지효성(持效性) 미크로 캡슐의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 내부 수상으로서의 수용성 약제-함유 용액 및 오일상으로서의 중합제-함유 용액으로 구성된 W/O 유탁액을 제조하고, W/O/W 유탁액 제조에 사용되는 상기 W/O 유탁액의 점도를 약 150-10,000센티포이스로 조절한 후, 상기 유탁액을 수상내에 분산시키고, 이어서 생성된 W/O/W 유탁액에 대해 수-중 건조를 수행함을 특징으로 하는, 지효성 미크로캡슐의 제조방법.
  2. 제1항에 있어서, W/O/W 유탁액 제조시 W/O 유탁액의 점도를 약 150~5,000센티포이스로 조절하는 방법.
  3. 제1항에 있어서, 오일상내의 중합체농도를 증가시키는 방법; 수상과 오일상의 함량비를 조절하는 방법; 상기 W/O 유탁액의 온도를 조절하는 방법; 외부 수상의 온도를 조절하는 방법; W/O 유탁액을 외부 수상내에 부가할 때에 가선 가열기 또는 냉각기를 사용하여 W/O 유탁액의 온도를 조절하는 방법; 또는 상술한 방법들을 병행시켜 수행함으로써 W/O/W 유탁액제조시 W/O 유탁액의 점도를 약 150~10,000센티포이스로 조절하는 방법.
  4. 제1항에 있어서, (i) W/O 유탁액 또는 (ii) W/O 유탁액 및 외부 수상둘 다의 온도를 약 -20℃사용하는 유기용매의 비점으로 조절하는 방법에 의해 W/O/W 유탁액 제조시 W/O 유탁액의 점도를 약 150~10,000센티포이스로 조절하는 방법.
  5. 제4항에 있어서, 온도가 약 0℃~30℃인 방법.
  6. 제1항에 있어서, 수용성 약제가 생물학적 활성 폴리펩티드인 방법.
  7. 제6항에 있어서, 생물학적 활성 폴리펩티드가 (Pyr)Glu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NH-C2H5아세테이트인 방법.
  8. 제1항에 있어서, 중합체가 폴리락트산인 방법.
  9. 제1항에 있어서, 중합체가 락트산과 글리콜산의 공중합체인 방법.
  10. 제9항에 있어서, 공중합체의 락트산 : 글리콜산비율이 약 75±2몰% : 약 25±2몰%인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860000872A 1985-02-07 1986-02-07 지효성(持효性)미크로 캡슐의 제조방법 KR920007831B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2297885 1985-02-07
JP22978 1985-02-07
JP26797785 1985-11-27
JP267977 1985-11-27

Publications (2)

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KR860006266A true KR860006266A (ko) 1986-09-09
KR920007831B1 KR920007831B1 (ko) 1992-09-18

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KR1019860000872A KR920007831B1 (ko) 1985-02-07 1986-02-07 지효성(持효性)미크로 캡슐의 제조방법

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US (2) US4954298A (ko)
EP (1) EP0190833B1 (ko)
KR (1) KR920007831B1 (ko)
AT (1) ATE61935T1 (ko)
CA (1) CA1260395A (ko)
DE (1) DE3678308D1 (ko)
ES (1) ES8703739A1 (ko)
GR (1) GR860332B (ko)
HK (1) HK137793A (ko)
HU (1) HU196702B (ko)
IE (1) IE58930B1 (ko)
LV (1) LV5822B4 (ko)
PT (1) PT81980B (ko)

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CA1260395A (en) 1989-09-26
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EP0190833A3 (en) 1987-08-26
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HK137793A (en) 1993-12-24
GR860332B (en) 1986-06-05
HU196702B (en) 1989-01-30
PT81980A (en) 1986-03-01
ATE61935T1 (de) 1991-04-15
LV5822B4 (lv) 1997-12-20
ES8703739A1 (es) 1987-03-01
US4954298A (en) 1990-09-04
HUT45893A (en) 1988-09-28
ES551696A0 (es) 1987-03-01
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US5330767A (en) 1994-07-19

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