KR860002464A - 프롤린유도체의 제조방법 - Google Patents
프롤린유도체의 제조방법 Download PDFInfo
- Publication number
- KR860002464A KR860002464A KR1019850006633A KR850006633A KR860002464A KR 860002464 A KR860002464 A KR 860002464A KR 1019850006633 A KR1019850006633 A KR 1019850006633A KR 850006633 A KR850006633 A KR 850006633A KR 860002464 A KR860002464 A KR 860002464A
- Authority
- KR
- South Korea
- Prior art keywords
- alk
- product
- pharmaceutically acceptable
- phenylpropyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/649,797 US4746676A (en) | 1984-09-12 | 1984-09-12 | Carboxyalkyl dipeptide compounds |
| US649..797 | 1984-09-12 | ||
| US06/752,695 US4749698A (en) | 1985-07-08 | 1985-07-08 | Antihypertensive derivatives |
| US752.695 | 1985-07-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR860002464A true KR860002464A (ko) | 1986-04-26 |
Family
ID=27095707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019850006633A Ceased KR860002464A (ko) | 1984-09-12 | 1985-09-11 | 프롤린유도체의 제조방법 |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0175266B1 (enExample) |
| KR (1) | KR860002464A (enExample) |
| AT (1) | ATE135711T1 (enExample) |
| AU (1) | AU578489B2 (enExample) |
| CA (1) | CA1288893C (enExample) |
| DE (1) | DE3588094T2 (enExample) |
| DK (1) | DK412985A (enExample) |
| ES (1) | ES8609364A1 (enExample) |
| FI (1) | FI89716C (enExample) |
| IL (1) | IL76345A (enExample) |
| IN (1) | IN164615B (enExample) |
| NO (1) | NO169442C (enExample) |
| NZ (1) | NZ213432A (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5629345A (en) * | 1993-07-23 | 1997-05-13 | Vide Pharmaceuticals | Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure |
| US5965620A (en) * | 1993-07-23 | 1999-10-12 | Vide Pharmaceuticals | Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure |
| JPH10501818A (ja) * | 1994-06-16 | 1998-02-17 | スミスクライン・ビーチャム・コーポレイション | 鋳型指向性環化 |
| CA2388468C (en) † | 1999-10-14 | 2011-01-25 | Curis, Inc. | Mediators of hedgehog signalling pathways, compositions and uses related thereto |
| ES2346399T3 (es) | 2000-09-21 | 2010-10-15 | Abb Schweiz Ag | Configuracion de un sistema de control de una instalacion electrica. |
| SG170767A1 (en) * | 2005-12-23 | 2011-05-30 | Zealand Pharma As | Modified lysine-mimetic compounds |
| EP2468724B1 (en) * | 2006-12-21 | 2015-11-18 | Zealand Pharma A/S | Synthesis of pyrrolidine compounds |
| WO2018202865A1 (en) | 2017-05-05 | 2018-11-08 | Zealand Pharma A/S | Gap junction intercellular communication modulators and their use for the treatment of diabetic eye disease |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5683483A (en) * | 1979-12-13 | 1981-07-08 | Santen Pharmaceut Co Ltd | Thiazolidine compound |
| US4350704A (en) * | 1980-10-06 | 1982-09-21 | Warner-Lambert Company | Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids |
| GR75019B (enExample) * | 1980-09-17 | 1984-07-12 | Univ Miami | |
| US4462943A (en) * | 1980-11-24 | 1984-07-31 | E. R. Squibb & Sons, Inc. | Carboxyalkyl amino acid derivatives of various substituted prolines |
| FR2501399B1 (fr) * | 1981-03-03 | 1987-06-19 | France Etat | Dispositif d'affichage de messages graphiques transmis par des systemes de videotex |
| EP0080822A1 (en) * | 1981-11-27 | 1983-06-08 | Beecham Group Plc | Anti-hypertensive prolinol-based peptides |
| EP0088350B1 (en) * | 1982-03-08 | 1985-02-20 | Schering Corporation | Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them |
| CA1258853A (en) * | 1982-04-30 | 1989-08-29 | Rudiger D. Haugwitz | Substituted 4-phenoxy prolines |
| AU1643283A (en) * | 1982-07-19 | 1984-01-26 | E.R. Squibb & Sons, Inc. | Substituted peptides |
| US4623729A (en) * | 1982-07-22 | 1986-11-18 | E. R. Squibb & Sons, Inc. | Acylalkylaminocarbonyl substituted amino and imino acid compounds |
| US4499079A (en) * | 1982-11-18 | 1985-02-12 | E. R. Squibb & Sons, Inc. | Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides |
| DK156484A (da) * | 1983-03-16 | 1984-09-17 | Usv Pharma Corp | Aminosyrederivater |
| ZA843899B (en) * | 1983-05-23 | 1984-12-24 | Usv Pharma Corp | Compounds for treating hypertension |
-
1985
- 1985-09-10 AU AU47331/85A patent/AU578489B2/en not_active Ceased
- 1985-09-10 AT AT85111454T patent/ATE135711T1/de not_active IP Right Cessation
- 1985-09-10 EP EP85111454A patent/EP0175266B1/en not_active Expired - Lifetime
- 1985-09-10 IL IL76345A patent/IL76345A/xx unknown
- 1985-09-10 DE DE3588094T patent/DE3588094T2/de not_active Expired - Fee Related
- 1985-09-11 NO NO853551A patent/NO169442C/no unknown
- 1985-09-11 KR KR1019850006633A patent/KR860002464A/ko not_active Ceased
- 1985-09-11 CA CA000490437A patent/CA1288893C/en not_active Expired - Lifetime
- 1985-09-11 DK DK412985A patent/DK412985A/da not_active Application Discontinuation
- 1985-09-11 ES ES546866A patent/ES8609364A1/es not_active Expired
- 1985-09-11 NZ NZ213432A patent/NZ213432A/xx unknown
- 1985-09-12 FI FI853494A patent/FI89716C/fi not_active IP Right Cessation
- 1985-09-16 IN IN652/CAL/85A patent/IN164615B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI89716C (fi) | 1993-11-10 |
| AU578489B2 (en) | 1988-10-27 |
| IN164615B (enExample) | 1989-04-22 |
| EP0175266A2 (en) | 1986-03-26 |
| FI89716B (fi) | 1993-07-30 |
| DK412985D0 (da) | 1985-09-11 |
| CA1288893C (en) | 1991-09-10 |
| NO169442B (no) | 1992-03-16 |
| NO169442C (no) | 1992-06-24 |
| ATE135711T1 (de) | 1996-04-15 |
| NO853551L (no) | 1986-03-13 |
| DE3588094D1 (de) | 1996-04-25 |
| EP0175266A3 (en) | 1988-08-03 |
| AU4733185A (en) | 1986-03-20 |
| EP0175266B1 (en) | 1996-03-20 |
| NZ213432A (en) | 1988-11-29 |
| FI853494L (fi) | 1986-03-13 |
| ES8609364A1 (es) | 1986-07-16 |
| IL76345A0 (en) | 1986-01-31 |
| ES546866A0 (es) | 1986-07-16 |
| DE3588094T2 (de) | 1996-08-22 |
| FI853494A0 (fi) | 1985-09-12 |
| IL76345A (en) | 1988-12-30 |
| DK412985A (da) | 1986-03-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR910000613A (ko) | 피발산의 p-치환된 페닐 에스테르 유도체, 그의 제조방법 및 이를 포함하는 조성물 | |
| KR840001952A (ko) | N-(4-(3-아미노프로필) 아미노부틸)-2-(ω)-과니디노-지방산-아미도)-2-치환된-에탄아미드 이들의 염 및 이들의 제조방법 | |
| KR960014094A (ko) | 아스파라긴산 프로테아제 기질 동배체의 항바이러스성 에테르 | |
| KR920021578A (ko) | 포스프노/비아릴 치환된 디펩티드 유도체 | |
| RU2008129204A (ru) | Применение ингибитора ibat для лечения или профилактики запора | |
| DK116480A (da) | Fremgangsmaade til fremstilling af substituerede chromoner | |
| DE69528437D1 (de) | Substituierte azaindolylidenderivate und verfahren zu ihrer herstellung | |
| KR860002464A (ko) | 프롤린유도체의 제조방법 | |
| RU2009124590A (ru) | Комбинация ингибиторов iap и flt3 | |
| CA2140598A1 (en) | Prolineamide derivatives | |
| RU92016217A (ru) | Двойные ингибиторы no синтазы и циклооксигеназы, способ их получения и фармацевтическая композиция на их основе | |
| KR860004081A (ko) | 폴리펩티드의 제조방법 | |
| ATE16805T1 (de) | Trifluoromethylphenyltetrahydropyridine mit appetithemmender wirkung, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. | |
| KR900004658A (ko) | 이치환 벤질아민, 그의 제조방법, 약제로서의 그의 용도 및 그의 합성 약제 | |
| FI895921A0 (fi) | Enzymhaemmande aminosyraderivat, foerfarande foer deras framstaellning, dessa innehaollande aemnen och deras anvaendning. | |
| RU2008122712A (ru) | Комбинация органических соединений | |
| DE3561819D1 (en) | Derivatives of methylenediphosphonic acid, process for their preparation and antirheumatic pharmaceutical compositions containing them | |
| DK0630231T3 (da) | Liposomer med negativ overskudsladning | |
| KR840007571A (ko) | 락탐 펩티드의 제조방법 | |
| RU2214404C2 (ru) | Тиазольные производные, способ получения и фармацевтическая композиция на их основе | |
| ATE271551T1 (de) | Verfahren zur herstellung von n-(1-(s)- ethoxycarbonyl-3-phenylpropyl)-l-alanin-n- carboxyanhydrid | |
| KR960703119A (ko) | 합성적 용도로 사용하기 위한 신규한 중간체 및 아미노피페라진 유도체를 제조하는 방법(Novel intermediate for synthetic use and process for producing amino-piperazine derivative) | |
| Merchán et al. | Determination of the absolute configuration of α-amino-2-alkylthiazoles by circular dichroism | |
| RU2220954C2 (ru) | ЗАМЕЩЕННЫЕ β-АЛАНИНЫ | |
| RU2201420C2 (ru) | Нитрилы дипептидов |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19850911 |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 19870928 Comment text: Request for Examination of Application Patent event code: PA02011R01I Patent event date: 19850911 Comment text: Patent Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 19900412 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 19900625 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 19900412 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |