KR860002464A - 프롤린유도체의 제조방법 - Google Patents

프롤린유도체의 제조방법 Download PDF

Info

Publication number
KR860002464A
KR860002464A KR1019850006633A KR850006633A KR860002464A KR 860002464 A KR860002464 A KR 860002464A KR 1019850006633 A KR1019850006633 A KR 1019850006633A KR 850006633 A KR850006633 A KR 850006633A KR 860002464 A KR860002464 A KR 860002464A
Authority
KR
South Korea
Prior art keywords
alk
product
pharmaceutically acceptable
phenylpropyl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1019850006633A
Other languages
English (en)
Korean (ko)
Inventor
에스. 네이스 에드워드 (외 5)
Original Assignee
원본미기재
유 에스 브이 파마슈티칼 코포레이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/649,797 external-priority patent/US4746676A/en
Priority claimed from US06/752,695 external-priority patent/US4749698A/en
Application filed by 원본미기재, 유 에스 브이 파마슈티칼 코포레이션 filed Critical 원본미기재
Publication of KR860002464A publication Critical patent/KR860002464A/ko
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1019850006633A 1984-09-12 1985-09-11 프롤린유도체의 제조방법 Ceased KR860002464A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US06/649,797 US4746676A (en) 1984-09-12 1984-09-12 Carboxyalkyl dipeptide compounds
US649..797 1984-09-12
US06/752,695 US4749698A (en) 1985-07-08 1985-07-08 Antihypertensive derivatives
US752.695 1985-07-08

Publications (1)

Publication Number Publication Date
KR860002464A true KR860002464A (ko) 1986-04-26

Family

ID=27095707

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850006633A Ceased KR860002464A (ko) 1984-09-12 1985-09-11 프롤린유도체의 제조방법

Country Status (13)

Country Link
EP (1) EP0175266B1 (enExample)
KR (1) KR860002464A (enExample)
AT (1) ATE135711T1 (enExample)
AU (1) AU578489B2 (enExample)
CA (1) CA1288893C (enExample)
DE (1) DE3588094T2 (enExample)
DK (1) DK412985A (enExample)
ES (1) ES8609364A1 (enExample)
FI (1) FI89716C (enExample)
IL (1) IL76345A (enExample)
IN (1) IN164615B (enExample)
NO (1) NO169442C (enExample)
NZ (1) NZ213432A (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629345A (en) * 1993-07-23 1997-05-13 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
US5965620A (en) * 1993-07-23 1999-10-12 Vide Pharmaceuticals Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure
EP0765341A4 (en) * 1994-06-16 1998-09-16 Smithkline Beecham Corp CYCLISATION DIRECTED BY MATRIX
DE60027749T3 (de) † 1999-10-14 2012-01-19 Curis, Inc. Vermittler von "hedgehog" übermittelnden bahnen, dazugehörige zusammenetzungen und verwendungen
EP1191662B1 (de) 2000-09-21 2010-06-16 ABB Schweiz AG Konfiguration eines Leitsystems einer elektrischen Schaltanlage
CN101336229B (zh) 2005-12-23 2012-06-13 西兰岛药物有限公司 改性的拟赖氨酸化合物
US20080188545A1 (en) 2006-12-21 2008-08-07 Alimardanov Asaf R Synthesis of pyrrolidine compounds
US11324799B2 (en) 2017-05-05 2022-05-10 Zealand Pharma A/S Gap junction intercellular communication modulators and their use for the treatment of diabetic eye disease

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5683483A (en) * 1979-12-13 1981-07-08 Santen Pharmaceut Co Ltd Thiazolidine compound
US4350704A (en) * 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
EP0048159A3 (en) * 1980-09-17 1982-05-12 University Of Miami Novel carboxyalkyl peptides and thioethers and ethers of peptides as antihypertensive agents
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
FR2501399B1 (fr) * 1981-03-03 1987-06-19 France Etat Dispositif d'affichage de messages graphiques transmis par des systemes de videotex
EP0080822A1 (en) * 1981-11-27 1983-06-08 Beecham Group Plc Anti-hypertensive prolinol-based peptides
EP0088350B1 (en) * 1982-03-08 1985-02-20 Schering Corporation Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
ZA832762B (en) * 1982-04-30 1983-12-28 Squibb & Sons Inc Substituted 4-phenoxy prolines
AU1643283A (en) * 1982-07-19 1984-01-26 E.R. Squibb & Sons, Inc. Substituted peptides
US4623729A (en) * 1982-07-22 1986-11-18 E. R. Squibb & Sons, Inc. Acylalkylaminocarbonyl substituted amino and imino acid compounds
US4499079A (en) * 1982-11-18 1985-02-12 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
FI841052A7 (fi) * 1983-03-16 1984-09-17 Usv Pharma Corp Foereningar foer behandling av blodtryckssjukdomar.
ZA843899B (en) * 1983-05-23 1984-12-24 Usv Pharma Corp Compounds for treating hypertension

Also Published As

Publication number Publication date
FI89716B (fi) 1993-07-30
DE3588094T2 (de) 1996-08-22
ATE135711T1 (de) 1996-04-15
EP0175266A3 (en) 1988-08-03
AU578489B2 (en) 1988-10-27
FI853494A0 (fi) 1985-09-12
DK412985D0 (da) 1985-09-11
CA1288893C (en) 1991-09-10
NO853551L (no) 1986-03-13
FI853494L (fi) 1986-03-13
AU4733185A (en) 1986-03-20
ES546866A0 (es) 1986-07-16
NO169442C (no) 1992-06-24
ES8609364A1 (es) 1986-07-16
NZ213432A (en) 1988-11-29
DK412985A (da) 1986-03-13
IL76345A0 (en) 1986-01-31
IN164615B (enExample) 1989-04-22
EP0175266A2 (en) 1986-03-26
EP0175266B1 (en) 1996-03-20
NO169442B (no) 1992-03-16
DE3588094D1 (de) 1996-04-25
IL76345A (en) 1988-12-30
FI89716C (fi) 1993-11-10

Similar Documents

Publication Publication Date Title
KR910000613A (ko) 피발산의 p-치환된 페닐 에스테르 유도체, 그의 제조방법 및 이를 포함하는 조성물
KR840001952A (ko) N-(4-(3-아미노프로필) 아미노부틸)-2-(ω)-과니디노-지방산-아미도)-2-치환된-에탄아미드 이들의 염 및 이들의 제조방법
KR960014094A (ko) 아스파라긴산 프로테아제 기질 동배체의 항바이러스성 에테르
DK116480A (da) Fremgangsmaade til fremstilling af substituerede chromoner
ATE225348T1 (de) Substituierte azaindolylidenderivate und verfahren zu ihrer herstellung
KR860002464A (ko) 프롤린유도체의 제조방법
RU2009124590A (ru) Комбинация ингибиторов iap и flt3
RU92016217A (ru) Двойные ингибиторы no синтазы и циклооксигеназы, способ их получения и фармацевтическая композиция на их основе
ATE16805T1 (de) Trifluoromethylphenyltetrahydropyridine mit appetithemmender wirkung, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
KR900004658A (ko) 이치환 벤질아민, 그의 제조방법, 약제로서의 그의 용도 및 그의 합성 약제
RU2008122712A (ru) Комбинация органических соединений
HUP0001910A2 (hu) Eljárás 4'-trifluormetil-bifenil-2-karbonsav-(1,2,3,4-tetrahidroizokinolin-6-il)- amid előállítására, és az eljáráshoz felhasználható köztitermékek
CA2263362A1 (fr) Composes bi-aromatiques et compositions pharmaceutiques et cosmetiques les contenant
DE3561819D1 (en) Derivatives of methylenediphosphonic acid, process for their preparation and antirheumatic pharmaceutical compositions containing them
PT92558A (pt) Processo para a preparacao de derivados de aminoacidos inibidores de enzimas e de composicoes farmaceuticas que os contem
KR910000614A (ko) 신규 화합물
DE59301805D1 (de) Liposomen mit negativer überschussladung
ES2060079T3 (es) Procedimiento para la preparacion de un carboxialquil-eter de la 2-amino-7-hidroxitetralina.
KR890701571A (ko) 4h-3, 1-벤즈옥사진-4-온 화합물 및 세린 프로테아제 억제를 위한 그의 약학 조성물
NO874422D0 (no) Polyfluorforbindelser og deres fremstilling.
DE60104380D1 (de) Verfahren zur Herstellung von N-[1-(S)-Ethoxycarbonyl-3-phenylpropyl]-L-alanin-N-carboxyanhydrid
RU2220954C2 (ru) ЗАМЕЩЕННЫЕ β-АЛАНИНЫ
KR840001580A (ko) 6'-(2-아미노-2-〔4-아실욕시페닐〕아세트아미도페니실라노 일옥시메틸 페니실라네이트 1,1-디옥사이드 화합물의 제조방법
GB2092574A (en) Amide derivatives
RU2004125289A (ru) Способ получения производных морфолина и их промежуточных соединений

Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19850911

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 19870928

Comment text: Request for Examination of Application

Patent event code: PA02011R01I

Patent event date: 19850911

Comment text: Patent Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 19900412

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 19900625

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 19900412

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I