KR910014123A - 여기 아미노산 신경전달체의 길항 물질로서 유용한 폴리아민 - Google Patents

여기 아미노산 신경전달체의 길항 물질로서 유용한 폴리아민 Download PDF

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Publication number
KR910014123A
KR910014123A KR1019900022585A KR900022585A KR910014123A KR 910014123 A KR910014123 A KR 910014123A KR 1019900022585 A KR1019900022585 A KR 1019900022585A KR 900022585 A KR900022585 A KR 900022585A KR 910014123 A KR910014123 A KR 910014123A
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KR
South Korea
Prior art keywords
amino acid
pharmaceutically acceptable
neurotransmitters
cell
acceptable salt
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KR1019900022585A
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English (en)
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KR930007250B1 (ko
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알렉스 사코마노 니콜라스
알프레드 볼크만 로버트
Original Assignee
제이. 트레보 럼브
화이자 인코포레이티드
헌터 잭슨
네츄럴 프로덕트 사이언시스, 인코포레이티드
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Publication of KR910014123A publication Critical patent/KR910014123A/ko
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Publication of KR930007250B1 publication Critical patent/KR930007250B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polyamides (AREA)
  • Indole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

내용 없음.

Description

여기 아미노산 신경전달체의 길항 물질로서 유용한 폴리아민
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 하기 일반식의 화합물로 이루어진 그룹중에서 선택된 거의 순수한 화합물 및 약제학적으로 허용되는 이의 염.
    상기식에서, R은 수소 또는 OH이다.
  2. 제1항에 있어서, R이 수소인 하기 일반식의 화합물 또는 약제학적으로 허용되는 이의 염.
  3. 제1항에 있어서, R이 OH인 하기 일반식의 화합물 또는 약제학적으로 허용되는 이의 염.
  4. 여기 아미노산 신경 전달체를 길항시키는 양의 제1항에 따른 화합물 또는 약제학적으로 허용되는 이의 염을 신경 전달체의 영향을 받는 세포에 투여함을 특징으로 하여 여기 아미노산 신경 전달체를 길항시키는 방법.
  5. 제4항에 있어서, 세포가 포유동물의 신경계내에 존재하는 세포인 방법.
  6. 제4항에 있어서, 세포가 무척추동물의 신경계내에 존재하는 세포인 방법.
  7. 여기 아미노산 신경 전달체를 길항시키는 양의 제1항에 따른 화합물 또는 약제학적으로 허용되는 이의 염 및 약제학적으로 허용되는 희석제 또는 담체를 포함하는 포유동물의 신경계내에 존재하는 세포에 영향을 미치는 아미노산 신경전달체를 길항시키기 위한 약제학적 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900022585A 1990-01-02 1990-12-31 여기 아미노산 신경전달체의 길항 물질로서 유용한 폴리아민 KR930007250B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US46020790A 1990-01-02 1990-01-02
US460,207 1990-01-02
US460207 1990-01-02
US560699 1990-07-31
US560,699 1990-07-31
US07/560,699 US5037846A (en) 1990-01-02 1990-07-31 Indolyl-3 polyamines and their use as antagonists of excitatory amino acid neurotransmitters

Publications (2)

Publication Number Publication Date
KR910014123A true KR910014123A (ko) 1991-08-31
KR930007250B1 KR930007250B1 (ko) 1993-08-04

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900022585A KR930007250B1 (ko) 1990-01-02 1990-12-31 여기 아미노산 신경전달체의 길항 물질로서 유용한 폴리아민

Country Status (23)

Country Link
US (1) US5037846A (ko)
EP (1) EP0436332B1 (ko)
JP (1) JPH0714913B2 (ko)
KR (1) KR930007250B1 (ko)
CN (1) CN1053059A (ko)
AT (1) ATE133941T1 (ko)
AU (2) AU619700B2 (ko)
CA (1) CA2033480C (ko)
DE (1) DE69025305T2 (ko)
DK (1) DK0436332T3 (ko)
ES (1) ES2083439T3 (ko)
FI (1) FI93644C (ko)
GR (1) GR3019487T3 (ko)
HU (1) HUT56063A (ko)
IE (1) IE70757B1 (ko)
IL (1) IL96793A0 (ko)
MY (1) MY104588A (ko)
NO (1) NO173733C (ko)
NZ (1) NZ236550A (ko)
PH (1) PH27608A (ko)
PL (1) PL165647B1 (ko)
PT (1) PT96389A (ko)
YU (1) YU247590A (ko)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5227397A (en) * 1989-04-28 1993-07-13 Pfizer Inc. Polyamines and polypeptides useful as antagonists of excitatory amino acid neuro-transmitters and/or as blockers of calcium channels
US5037846A (en) * 1990-01-02 1991-08-06 Pfizer Inc. Indolyl-3 polyamines and their use as antagonists of excitatory amino acid neurotransmitters
US5312928A (en) * 1991-02-11 1994-05-17 Cambridge Neuroscience Calcium channel antagonists and methodology for their identification
US5677288A (en) * 1991-05-15 1997-10-14 Cypros Pharmaceutical Corporation Use of aminoglycosides to protect against excitotoxic neuron damage
US5185369A (en) * 1991-08-23 1993-02-09 Pfizer Inc. Synthetic heteroaryl polyamines as excitatory amino acid neurotransmitter antagonists
CA2114798A1 (en) * 1991-08-23 1993-03-04 Nicholas A. Saccomano Synthetic aryl polyamines as excitatory amino acid neurotransmitter antagonists
US5763568A (en) * 1992-01-31 1998-06-09 Zeneca Limited Insecticidal toxins derived from funnel web (atrax or hadronyche) spiders
US6071970A (en) * 1993-02-08 2000-06-06 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US6211245B1 (en) 1993-02-08 2001-04-03 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US7087765B2 (en) 1995-06-07 2006-08-08 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US6017965A (en) * 1993-02-08 2000-01-25 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US6750244B2 (en) 1993-02-08 2004-06-15 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
RU2201224C2 (ru) 1994-02-08 2003-03-27 Эн-Пи-Эс Фармасьютикалз, Инк. Соединения, активные в новом сайте на рецептор-регулируемых кальциевых каналах и используемые для лечения неврологических расстройств и заболеваний
US5688764A (en) * 1995-02-17 1997-11-18 Nps Pharmaceuticals, Inc. Insecticidal peptides from spider venom
US5874298A (en) * 1995-02-17 1999-02-23 Nps Pharmaceuticals, Inc. Insecticidal toxins from Bracon hebetor nucleic acid encoding said toxin and methods of use
US5674846A (en) * 1996-09-04 1997-10-07 Nps Pharmaceuticals, Inc. Insecticidal peptides from Segestria sp. spider venom
WO1998036743A1 (en) * 1997-02-21 1998-08-27 Cypros Pharmaceutical Corporation Neuroprotective poly-guanidino compounds which block presynaptic n and p/q calcium channels
AU2003231670B2 (en) * 1997-10-27 2006-06-08 Slil Biomedical Corporation Methods for modulating macrophage proliferation using polyamine analogs
US8198334B2 (en) * 1997-10-27 2012-06-12 Pathologica Llc Methods for modulating macrophage proliferation in ocular disease using polyamine analogs
US7087648B1 (en) * 1997-10-27 2006-08-08 The Regents Of The University Of California Methods for modulating macrophage proliferation using polyamine analogs
WO2003043616A2 (en) * 2001-11-16 2003-05-30 Als Therapy Development Foundation, Inc. Treatment of neurodegenerative disorders through the modulation of the polyamine pathway
AU2002343609B2 (en) 2001-11-16 2008-12-11 Als Therapy Development Foundation, Inc. Treatment of neurodegenerative disorders through the modulation of the polyamine pathway
WO2006041805A1 (en) * 2004-10-04 2006-04-20 Cellgate, Inc. Polyamine analogs as therapeutic agents for ocular diseases
EP1937235B1 (en) * 2005-09-23 2015-07-01 Pathologica, LLC. Methods for treating viral infections using polyamine analogs

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925664A (en) * 1986-10-20 1990-05-15 University Of Utah Spider toxins and methods for their use as blockers of calcium channels and amino acid receptor function
IT1206078B (it) * 1987-06-03 1989-04-14 Polifarma Spa Procedimento per la produzione di acido 3-indolpiruvico e suoi derivati loro uso farmaceutico
US4950739A (en) * 1988-02-10 1990-08-21 New York University Membrane calcium channels and factors and methods for blocking, isolating and purifying calcium channels
DD298412A5 (de) * 1989-04-28 1992-02-20 ������@���Kk�� Verfahren zur herstellung von polypeptiden, die geeignet sind als antagonisten exzitatorischer aminosaeure-neurotransmitter und/oder blocker der calciumkanaele
US5037846A (en) * 1990-01-02 1991-08-06 Pfizer Inc. Indolyl-3 polyamines and their use as antagonists of excitatory amino acid neurotransmitters

Also Published As

Publication number Publication date
HUT56063A (en) 1991-07-29
EP0436332A2 (en) 1991-07-10
MY104588A (en) 1994-04-30
YU247590A (sh) 1993-10-20
CA2033480C (en) 1995-11-21
ATE133941T1 (de) 1996-02-15
JPH04210677A (ja) 1992-07-31
ES2083439T3 (es) 1996-04-16
PT96389A (pt) 1991-10-15
AU640565B2 (en) 1993-08-26
FI93644B (fi) 1995-01-31
PL165647B1 (pl) 1995-01-31
AU619700B2 (en) 1992-01-30
EP0436332B1 (en) 1996-02-07
GR3019487T3 (en) 1996-07-31
FI906466A0 (fi) 1990-12-31
NO173733C (no) 1994-01-26
FI906466A (fi) 1991-07-03
NO905616D0 (no) 1990-12-28
NZ236550A (en) 1992-05-26
JPH0714913B2 (ja) 1995-02-22
DE69025305T2 (de) 1996-06-27
AU1592692A (en) 1992-07-09
CN1053059A (zh) 1991-07-17
PH27608A (en) 1993-08-18
PL288490A1 (en) 1991-12-16
NO173733B (no) 1993-10-18
IE70757B1 (en) 1996-12-30
EP0436332A3 (en) 1991-09-25
DK0436332T3 (da) 1996-03-11
FI93644C (fi) 1995-05-10
NO905616L (no) 1991-07-03
IL96793A0 (en) 1991-09-16
KR930007250B1 (ko) 1993-08-04
US5037846A (en) 1991-08-06
AU6856190A (en) 1991-07-04
DE69025305D1 (de) 1996-03-21
IE904734A1 (en) 1991-07-17
CA2033480A1 (en) 1991-07-03

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