KR890009845A - 아릴옥시페닐 프로필아민, 이의 제조방법 및 용도 - Google Patents

아릴옥시페닐 프로필아민, 이의 제조방법 및 용도 Download PDF

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KR890009845A
KR890009845A KR1019880015973A KR880015973A KR890009845A KR 890009845 A KR890009845 A KR 890009845A KR 1019880015973 A KR1019880015973 A KR 1019880015973A KR 880015973 A KR880015973 A KR 880015973A KR 890009845 A KR890009845 A KR 890009845A
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compound
alkyl
propylamine
methyl
alkenyl
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자콥슨 팔레
드레져 요르겐
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요르겐 부스라쎈
에이/에스 페로산
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
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    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
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    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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Abstract

내용 없음

Description

아릴옥시페닌 프로필아민, 이의 제조방법 및 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 일반식(Ⅰ)의 아릴옥시페닐프로필민 및 이의 약제학적으로 허용되는 산 염.
    상기식에서 R1은 C1-4-알콕시, 아릴옥시 또는 사이클로알킬 또는 사이클로알킬알킬로 치환되거나 비치환된 측쇄 또는 환상일 수 있는 알케닐 또는 C3-7-사이틀로알킬, C3-10-알킬이고, R2는 하나 이상의 시아노, 할로겐, C1-6-알킬, C1-6-알케닐, 프로플루오로메틸, C3-5-알킬렌, 아릴옥시 또는 아르알콕시로 임의로 치환된 3,4-메틸렌디옥시페닐, 아릴 또는 헤테로아릴이다.
  2. 제1항에 있어서, N-부틸-N-메틸-3-페닐-3-(4-트리를루오로메틸펜옥시)프로필아민인 화합물.
  3. 제1항에 있어서, N-사이클로프로필메틸-N-메틸-3-페닐-3-(4-트리플루오로메틸펜옥시)프로필아민인 화합물.
  4. 제1항에 있어서, N-부틸-N-메틸-3-페닐-3-(5,6,7,8,-테트라하이드로-2-나프톡시)프로필아민인 화합물.
  5. 제1항에 있어서, N-부틸-3-(5-인다닐옥시)-N-메틸-3-페닐프로필아민인 화합물.
  6. 제1항에 있어서, N-사이클로프로필-N-메틸-3-페닐-3-(3-트리플루오로메틸펜옥시)프로필아민인 화합물.
  7. 일반식(Ⅱ)의 화합물을 일반식 R1-X(여기에서, X는 할로겐과 같은 이탈기이고 R1은 상기 정의한 바와 같다)의 화합물과 반응시킴을 특징으로 하여, 제1항에 따른 화합물을 제조하는 방법.
    상기식에서, R2는 상기 정의한 바와 같다.
  8. 약제학적으로-허용되는 담체 또는 희석제와 함께 뇌 세포 내로의 칼슘 동화력을 억제하는데 유효한 량의 제1항의 화합물을 특징으로 하는, 인간을 포함하는 포유 동물의 뇌 세포 중의 칼슘 과부하를 방지하는데 사용하기에 적합한 약제학적 조성물.
  9. 제8항에 있어서, 활성 화합물 1 내지 100mg을 함유하는 경구 용량 단위 형태의 약제학적 조성물.
  10. 일반식(Ⅰ)의 피페리딘 화합물 및 이의 약제학적으로 허용되는 산 염을 이를 필요로 하는 대상으로 인간을 포함하는 포유 동물 뇌 세포 중에 투여함을 특징으로 하여, 상기 대상의 칼슘 과부하에 관련한 징후를 치료하는 방법.
    상기식에서, R1은 C1-4-알콕시, 아릴옥시 또는 사이클로알킬 또는 사이클로알킬알킬로 치환되거나 비치환된 직쇄, 측쇄 또는 환상일 수 있는 알케닐 또는 H9C3-7-사이클로알킬, C1-10-알킬이고, R2는 하나 이상의 시아노, 할로겐, C1-6-알킬, C1-6-알콕시, C1-6-알케닐, 트리플루오로메틸, C3-5-알킬렌, 알릴옥시 또는 아르알콕시에 의해 임의로 치환된, 3,4-메닐렌디옥시페닐, 아릴 또는 헤테로아릴이다.
    ※참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880015973A 1987-12-01 1988-12-01 아릴옥시페닐 프로필아민, 이의 제조방법 및 용도 KR890009845A (ko)

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DK6309/87 1987-12-01
DK630987A DK630987D0 (da) 1987-12-01 1987-12-01 Aryloxyphenylpropylaminer, deres fremstilling og anvendelse

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US (3) US4962122A (ko)
EP (1) EP0318727B1 (ko)
JP (1) JP2687977B2 (ko)
KR (1) KR890009845A (ko)
AT (1) ATE102600T1 (ko)
AU (1) AU610297B2 (ko)
CA (1) CA1336195C (ko)
DE (1) DE3888300T2 (ko)
DK (2) DK630987D0 (ko)
ES (1) ES2061605T3 (ko)
FI (1) FI885592A (ko)
IE (1) IE65810B1 (ko)
IL (1) IL88324A (ko)
NO (1) NO170849C (ko)
NZ (1) NZ227128A (ko)
PH (1) PH27498A (ko)
PT (1) PT89131B (ko)
ZA (1) ZA888559B (ko)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK258389D0 (da) * 1989-05-26 1989-05-26 Ferrosan As Aryloxyphenylpropylaminer, deres fremstilling og anvendelse
FI912280A (fi) * 1990-05-17 1991-11-18 Lilly Co Eli Kiral syntes av 1-aryl-3-aminopropan-1 -oler.
EP0576766A1 (en) * 1992-06-29 1994-01-05 Novo Nordisk A/S Propanolamine derivatives, their preparation and use
WO2000058262A1 (en) * 1999-03-29 2000-10-05 Eli Lilly And Company Stereospecific method for preparing tomoxetine and intermediates thereof
GB0004151D0 (en) 2000-02-23 2000-04-12 Astrazeneca Uk Ltd Novel use
GB0004153D0 (en) * 2000-02-23 2000-04-12 Astrazeneca Uk Ltd Novel use
GB0004152D0 (en) 2000-02-23 2000-04-12 Astrazeneca Uk Ltd Novel compounds
US7037932B2 (en) * 2001-05-18 2006-05-02 Eli Lilly And Company Heteroaryloxy 3-substituted propanamines as serotonin and norepinephrine reuptake inhibitors
SE0102640D0 (sv) 2001-07-31 2001-07-31 Astrazeneca Ab Novel compounds
CN100347262C (zh) * 2003-11-13 2007-11-07 同济大学 一种水溶性建筑粘结剂及其制备方法
US7439399B2 (en) * 2004-06-28 2008-10-21 Teva Pharmaceutical Fine Chemicals Processes for the preparation of atomoxetine hydrochloride
US7355078B2 (en) * 2004-06-28 2008-04-08 Teva Pharmaceutical Fine Chemicals S.R.L. Processes for the preparation of tomoxetine
ITMI20061987A1 (it) * 2006-10-16 2008-04-17 Archimica Srl Processo per la sintesi di arilossipropilammine ed eteroarilossipropilammine.
WO2008081477A1 (en) * 2007-01-04 2008-07-10 Natco Pharma Limited 3-aryloxy 3-substituted propanamines
CN101613347B (zh) * 2008-06-23 2012-07-04 中国人民解放军军事医学科学院毒物药物研究所 胺类化合物及其医药用途
CN110627664B (zh) * 2018-06-25 2022-07-29 北京安博睿达医药科技有限公司 一种新的氟西汀类似物及其制备方法和应用

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US3253040A (en) * 1962-12-10 1966-05-24 Union Carbide Corp Process for the production of primary 3-hydrocarbyloxypropylamines
GB1058822A (en) * 1963-07-30 1967-02-15 Ici Ltd 3-amino-2-hydroxypropoxy heterocyclic derivatives
CH609331A5 (en) * 1974-01-10 1979-02-28 Lilly Co Eli Process for the preparation of 3-aryloxy-3-phenyl-propylamines
US4018895A (en) * 1974-01-10 1977-04-19 Eli Lilly And Company Aryloxyphenylpropylamines in treating depression
FR2432500A1 (fr) * 1978-02-24 1980-02-29 Roussel Uclaf Nouveaux derives de la benzene propanamine et leurs sels, procede de preparation et application a titre de medicaments
GB2060622B (en) * 1979-09-14 1983-05-25 Wyeth John & Brother Ltd 3-aryl-3-aryloxyalkylamines
DE2950135A1 (de) * 1979-12-13 1981-06-19 Merck Patent Gmbh, 6100 Darmstadt Basischer aether, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung
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US4432995A (en) * 1980-12-22 1984-02-21 American Cyanamid Company 5-[2-(Ethylamino)-1-hydroxylethyl] anthranilonitrile and the use thereof in meat producing animals
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IL89854A (en) * 1988-04-08 1994-02-27 Lilly Co Eli Phenoxypropanamines, the process for their preparation and medicinal preparations containing them

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DE3888300T2 (de) 1994-06-16
JP2687977B2 (ja) 1997-12-08
FI885592A0 (fi) 1988-12-01
DK626188A (da) 1989-06-02
ATE102600T1 (de) 1994-03-15
AU2639788A (en) 1989-06-01
EP0318727A3 (en) 1990-09-12
AU610297B2 (en) 1991-05-16
DK626188D0 (da) 1988-11-10
PT89131A (pt) 1989-12-29
PT89131B (pt) 1993-05-31
IE883475L (en) 1989-06-01
DK165405B (da) 1992-11-23
IE65810B1 (en) 1995-11-15
US4970232A (en) 1990-11-13
CA1336195C (en) 1995-07-04
NO170849C (no) 1992-12-16
DK165405C (da) 1993-04-13
IL88324A0 (en) 1989-06-30
US4962122A (en) 1990-10-09
JPH02242A (ja) 1990-01-05
NO885346L (no) 1989-06-02
NO885346D0 (no) 1988-11-30
DE3888300D1 (de) 1994-04-14
EP0318727B1 (en) 1994-03-09
PH27498A (en) 1993-07-23
ES2061605T3 (es) 1994-12-16
ZA888559B (en) 1989-08-30
US5019592A (en) 1991-05-28
NZ227128A (en) 1991-04-26
FI885592A (fi) 1989-06-02
DK630987D0 (da) 1987-12-01
NO170849B (no) 1992-09-07
EP0318727A2 (en) 1989-06-07
IL88324A (en) 1993-04-04

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