KR850001733A - 로이코트리엔 수용체에 길항 효과를 갖는 화합물의 제조방법 - Google Patents

로이코트리엔 수용체에 길항 효과를 갖는 화합물의 제조방법 Download PDF

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KR850001733A
KR850001733A KR1019840004617A KR840004617A KR850001733A KR 850001733 A KR850001733 A KR 850001733A KR 1019840004617 A KR1019840004617 A KR 1019840004617A KR 840004617 A KR840004617 A KR 840004617A KR 850001733 A KR850001733 A KR 850001733A
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hydrogen
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리챠드 베이커(외 2) 스테펜
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디. 알. 크라우터
릴리 인더스트리즈 리미티드
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Abstract

내용 없음

Description

로이코트리엔 수용체에 길항 효과를 갖는 화합물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 다음 일반식(Ⅱ)의 화합물을 일반식 R2SH의 티올과 반응시키고, 임의로 이어서 n이 1 또는 2인 화합물을 제조하려면 산화시키거나, R1이 임의로 치환된 알킬인 화합물을 제조하려면 환원시키거나, 어떠한 보호그룹도 제거하거나, R2,R3,R4또는 R5그룹을 상호 전환시킴을 특징으로 하여, 다음 일반식(Ⅰ)의 화합물 및 그의 염을제조하는 방법.
    상기식에서, n은 0,1 또는 2이며, R1은 임의로 치환된 페닐그룹으로 임의로 치환되는 탄소수 5 내지 30의 하이드로 카빌그룹이며, 단, 일반식(Ⅱ)에서 R1은 임의로 치환된 알케닐 또는 알키닐그룹이고, R2는 임의로 치환된 페닐이거나, 또는 임의로 보호된 하이드록실, 임의로 보호된 카복실, 니트릴, 임의로 보호된 테트라졸릴, -COR6[여기에서 R6는 C1-4 알킬, C1-4 알콕시, 임의로 보호된 아미노산 잔기 또는 -NR2 7(여기에서 각각의 R7은 수소 또는C1-4 알킬이다)이다] 및 NHR8[여기에서 R8은 수소, 보호그룹, 임의로 보호된 아미노산 잔기, C1-4 알킬 또는 -COR9(여기에서 각각의 R9은 C1-4 알킬 또는 C1-4 알콕시이다)이다]에서 선택한 하나 또는 그 이상의 치환체로 임의 치환된 C1-10 알킬이며, R3,R4및 R5는 각각 수소, 카복실, C2-5 알콕시카보닐, C1-4 알킬, C1-4 알콕시, 하이드록실, 임의로 보호된 테트라졸틸, 할로, 트리플루오로메틸, 니트릴, 니트로 및 - CONR10 2(여기에서 각각의 R10는 수소 또는 C1-4 알킬이다)에서 선택한다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840004617A 1983-08-03 1984-08-02 벤조산 유도체의 제조방법 KR920005382B1 (ko)

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GB83-20943 1983-08-03
GB8320943 1983-08-03
GB838320943A GB8320943D0 (en) 1983-08-03 1983-08-03 Organic compounds

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KR850001733A true KR850001733A (ko) 1985-04-01
KR920005382B1 KR920005382B1 (ko) 1992-07-02

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US (3) US4665189A (ko)
EP (2) EP0201823B1 (ko)
JP (1) JPS6064954A (ko)
KR (1) KR920005382B1 (ko)
AR (1) AR240796A1 (ko)
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CA (2) CA1297632C (ko)
CY (1) CY1539A (ko)
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ZA845923B (en) 1985-04-24
MY102762A (en) 1992-10-31
PL249009A1 (en) 1985-03-26
US4665189A (en) 1987-05-12
DE3483722D1 (de) 1991-01-17
PT79002B (en) 1986-10-23
ES8602641A1 (es) 1985-12-01
IE841989L (en) 1985-02-03
KR920005382B1 (ko) 1992-07-02
GB2144422A (en) 1985-03-06
FI843043A0 (fi) 1984-08-01
EP0134111A1 (en) 1985-03-13
AU3130484A (en) 1985-02-07
HU196956B (en) 1989-02-28
GR80015B (en) 1984-12-19
CA1301181C (en) 1992-05-19
ATE39110T1 (de) 1988-12-15
USRE33300E (en) 1990-08-14
PH21029A (en) 1987-06-30
GB2144422B (en) 1987-12-23
IL72539A (en) 1988-12-30
DK371384A (da) 1985-02-04
DE3475516D1 (en) 1989-01-12
EP0201823B1 (en) 1990-12-05
AR240796A2 (es) 1991-02-28
SU1402256A3 (ru) 1988-06-07
ATE58899T1 (de) 1990-12-15
CY1539A (en) 1990-11-16
US4963578A (en) 1990-10-16
EP0201823A3 (en) 1987-09-16
PT79002A (en) 1984-08-01
EP0134111B1 (en) 1988-12-07
JPH058698B2 (ko) 1993-02-02
DK167008B1 (da) 1993-08-16
IL72539A0 (en) 1984-11-30
JPS6064954A (ja) 1985-04-13
HUT37395A (en) 1985-12-28
DK371384D0 (da) 1984-07-31
CA1297632C (en) 1992-03-17
FI843043A (fi) 1985-02-04
FI81084C (fi) 1990-09-10
GB8419526D0 (en) 1984-09-05
SG28590G (en) 1990-07-13
IE57691B1 (en) 1993-03-10
GB8320943D0 (en) 1983-09-07
HK51090A (en) 1990-07-08
ES534825A0 (es) 1985-12-01
AU575575B2 (en) 1988-08-04
EP0201823A2 (en) 1986-11-20
EG16349A (en) 1987-09-30
PL144336B1 (en) 1988-05-31
HU199457B (en) 1990-02-28
AR240796A1 (es) 1991-02-28
NZ209050A (en) 1989-03-29
FI81084B (fi) 1990-05-31

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