KR850001202A - 아로일 벤조푸란 및 벤조티오펜 아세트산 및 프로피온산의 제조방법 - Google Patents

아로일 벤조푸란 및 벤조티오펜 아세트산 및 프로피온산의 제조방법 Download PDF

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KR850001202A
KR850001202A KR1019840004126A KR840004126A KR850001202A KR 850001202 A KR850001202 A KR 850001202A KR 1019840004126 A KR1019840004126 A KR 1019840004126A KR 840004126 A KR840004126 A KR 840004126A KR 850001202 A KR850001202 A KR 850001202A
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formula
hydrogen
furyl
compound
alkyl
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KR1019840004126A
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KR880002533B1 (ko
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패트릭 딘 제임스
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허윅 본 모즈
신텍스(유. 에스. 에이.) 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

아로일 벤조푸란 및 벤조티오펜 아세트산 및 프로피온산의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 일반식(II) 화합물을 아로일산 할라이드로 처리하거나, 일반식(III)의 화합물을 탈수소화제로 처리하거나, 일반식(IV)화합물을 에스-테르화하거나, 일반식(V) 화합물을 강염기 존재하에서 알킬화제로 알킬화하고, 임의로 계속하여 수득한 일반식(I)의 산을 약학적으로 허용되는 염으로 전환시키거나, 일반식(I)의 에스테르를 산으로 전환시키거나, 일반식(I)의 에스테르를 염으로 전환시키거나 약학적으로 허용되는 한 염을 약학적으로 허용되는 다른 염으로 전환시키거나, 한 에스테르를 또 다른 에스테르로 전환시킴을 특징으로 하여, 일반식(I) 화합물 또는 약학적으로 허용되는 그 염을 제조하는 방법.
    상기식에서, R1은 수소, 하이드록시, 저급알콕시, 또는 메틸이고, R2는 수소 또는 메틸이고, R3는 수소, 알킬, 페닐, 페닐저급알킬, 2-푸릴, 3-푸릴, 2-티에닐, 3-티에닐,H3C=CH-CH2-, 또는
    (상기식에서 R그룹은 동일하며, 저급알킬이다)이고, X1은 산소이거나, R1이 수소인 경우 황이고, X2는 산소 또는 황이고, Ar은 비치환된 페닐이거나, 저급알킬, 저급 알콕시, 할로, 저급알킬 설피닐, 저급알킬 설포닐, 저급알킬티오, 2-푸릴, 3-푸릴, 2-티에닐 및 3-티에닐 중에서 선택된 치환체 하나 이상으로 각기 치환된 페닐이고, 점선은 단일 결합 또는 이중결합을 나타내고, R3'는 에스테르 형성그룹이고, R3"는 수소 또는 알킬그룹이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840004126A 1983-07-14 1984-07-13 아로일 벤조푸란 및 벤조티오펜 아세트산 및 프로피온산의 제조방법 KR880002533B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51354583A 1983-07-14 1983-07-14
US513,545 1990-04-24

Publications (2)

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KR850001202A true KR850001202A (ko) 1985-03-16
KR880002533B1 KR880002533B1 (ko) 1988-11-28

Family

ID=24043724

Family Applications (1)

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KR1019840004126A KR880002533B1 (ko) 1983-07-14 1984-07-13 아로일 벤조푸란 및 벤조티오펜 아세트산 및 프로피온산의 제조방법

Country Status (22)

Country Link
EP (1) EP0132130B1 (ko)
JP (1) JPS6038376A (ko)
KR (1) KR880002533B1 (ko)
AR (1) AR240815A1 (ko)
AT (1) ATE50769T1 (ko)
AU (1) AU567953B2 (ko)
CA (1) CA1241008A (ko)
CS (1) CS252476B2 (ko)
DE (1) DE3481512D1 (ko)
DK (1) DK347484A (ko)
ES (2) ES8604554A1 (ko)
FI (1) FI842738A (ko)
GR (1) GR79949B (ko)
HU (1) HU200450B (ko)
IL (1) IL72409A (ko)
NO (1) NO842878L (ko)
NZ (1) NZ208894A (ko)
PH (1) PH20790A (ko)
PL (4) PL146833B1 (ko)
PT (1) PT78905B (ko)
SU (2) SU1409130A3 (ko)
ZA (1) ZA845445B (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0226670B1 (en) * 1985-12-04 1991-04-10 Imperial Chemical Industries Plc Process for hydroxyaraldehydes
GB8825505D0 (en) 1988-11-01 1988-12-07 Pfizer Ltd Therapeutic agents
US5656661A (en) * 1994-07-27 1997-08-12 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
JPH10506615A (ja) * 1994-07-27 1998-06-30 ザ、プロクター、エンド、ギャンブル、カンパニー 抗炎症剤として有用なジヒドロベンゾフラン及び関連化合物
US5684002A (en) * 1994-09-07 1997-11-04 The Procter & Gamble Company Dihydorbenzofuran and related compounds useful as anti-inflammatory agents
US5684031A (en) * 1996-02-01 1997-11-04 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5672620A (en) * 1996-02-01 1997-09-30 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
GB9814801D0 (en) * 1998-07-09 1998-09-09 Univ Strathclyde Integrin dependent cell adhesion inhibitors
EP2177511A2 (en) 2002-12-10 2010-04-21 Ranbaxy Laboratories Limited Process for preparing 3,6-disubstituted azabicyclo derivatives
TW202345792A (zh) * 2022-04-28 2023-12-01 日商第一三共股份有限公司 苯并噻吩化合物
CN115403544B (zh) * 2022-09-16 2024-05-31 台州永健医药科技有限公司 一种丹酚酸c的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2077733B1 (ko) * 1970-02-10 1973-03-16 Roussel Uclaf
DE2909754A1 (de) * 1979-03-13 1980-09-18 Thomae Gmbh Dr K Neue benzofuran- und benzothiophenderivate, deren herstellung und deren verwendung als arzneimittel
US4237144A (en) * 1979-06-21 1980-12-02 Merck & Co., Inc. 2,3-Dihydro-2,6,7-trisubstituted-5-acylbenzofurans
DE2931672A1 (de) * 1979-08-04 1981-02-26 Basf Ag Substituierte 2,3-dihydrobenzofurylmethylester, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung von schaedlingen
JPS5951275A (ja) * 1982-05-31 1984-03-24 Sumitomo Chem Co Ltd 新規な複素環化合物
EP0117675B1 (en) * 1983-02-19 1986-07-23 Beecham Group Plc Benzofuran and benzothiophene-carboxylic-acid derivatives

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AR240815A1 (es) 1991-02-28
ES8607960A1 (es) 1986-06-16
ZA845445B (en) 1986-02-26
CS252476B2 (en) 1987-09-17
NZ208894A (en) 1987-01-23
PL146523B1 (en) 1989-02-28
EP0132130A2 (en) 1985-01-23
IL72409A (en) 1988-05-31
HU200450B (en) 1990-06-28
AU3059384A (en) 1985-01-17
PL255162A1 (en) 1986-07-15
ES8604554A1 (es) 1986-02-16
PL248729A1 (en) 1986-06-17
PT78905B (en) 1986-07-22
PH20790A (en) 1987-04-14
KR880002533B1 (ko) 1988-11-28
GR79949B (ko) 1984-10-31
IL72409A0 (en) 1984-11-30
DK347484D0 (da) 1984-07-13
EP0132130A3 (en) 1986-12-10
AU567953B2 (en) 1987-12-10
ATE50769T1 (de) 1990-03-15
PL255163A1 (en) 1986-07-15
FI842738A0 (fi) 1984-07-09
NO842878L (no) 1985-01-15
JPS6038376A (ja) 1985-02-27
PL146833B1 (en) 1989-03-31
ES544539A0 (es) 1986-06-16
CS545984A2 (en) 1987-01-15
SU1614762A3 (ru) 1990-12-15
AR240815A2 (es) 1991-02-28
FI842738A (fi) 1985-01-15
CA1241008A (en) 1988-08-23
DK347484A (da) 1985-01-15
PT78905A (en) 1984-08-01
EP0132130B1 (en) 1990-03-07
SU1409130A3 (ru) 1988-07-07
HUT36108A (en) 1985-08-28
PL255164A1 (en) 1986-07-15
DE3481512D1 (de) 1990-04-12
ES534324A0 (es) 1986-02-16
PL145622B1 (en) 1988-10-31

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