KR840006659A - 6,7-디히드로-5,8-디메틸-9-플루오로-1-옥소-1H,5H-벤조[ij]퀴놀리진-2-카르복실산 및 그 유도체의 제조방법 - Google Patents

6,7-디히드로-5,8-디메틸-9-플루오로-1-옥소-1H,5H-벤조[ij]퀴놀리진-2-카르복실산 및 그 유도체의 제조방법 Download PDF

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Publication number
KR840006659A
KR840006659A KR1019830005376A KR830005376A KR840006659A KR 840006659 A KR840006659 A KR 840006659A KR 1019830005376 A KR1019830005376 A KR 1019830005376A KR 830005376 A KR830005376 A KR 830005376A KR 840006659 A KR840006659 A KR 840006659A
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KR
South Korea
Prior art keywords
fluoro
quinolizine
benzo
dihydro
oxo
Prior art date
Application number
KR1019830005376A
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English (en)
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KR890000864B1 (ko
Inventor
마아크 스턴 리챠드
Original Assignee
로날드 올리버 바우콜
라이커 레보러토리스 인코오포레이티드
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Publication date
Application filed by 로날드 올리버 바우콜, 라이커 레보러토리스 인코오포레이티드 filed Critical 로날드 올리버 바우콜
Publication of KR840006659A publication Critical patent/KR840006659A/ko
Priority to KR1019890000674A priority Critical patent/KR890000863B1/ko
Application granted granted Critical
Publication of KR890000864B1 publication Critical patent/KR890000864B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

내용 없음

Description

6,7-디히드로-5,8-디메틸-9-플루오로-1-옥소-1H, 5H-벤조[ij]퀴놀리진-2-카르복실산 및 그 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 하기 구조식의 화합물이나 염화아실, 에스테르, 알킬아미노알킬 에스테르염 및 약리적으로 알맞은 카르복실레이트염으로 구성된 기로부터 선택된 이것의 유도체의 유효량과 약리적으로 알맞은 담체가 함유된 제약조성물.
  2. 5-아미노-2-플루오로벤조산을 크로톤알데히드 또는 이것을 형성하는 크로톤알데히드의 전구체와 반응시켜 5-카르복시-6-플루오로퀴날딘을 산출하고, 이것을 환원시켜 6-플루오로-5-메틸-1,2,3,4-테트라히드로퀴날 딘을 산출하고, 이것을 알콕시메틸렌마론산의 디에스테르와 축합시켜 2-[N-(6-플루오로-5-메틸테트라히드로퀴날디닐)]메틸렌 마론산의 디에스테르를 산출하고, 이것을 환으로 형성하고 탈에스테르화하여 6,7-디히드로-5,8-디메틸-9-플루오로-1-옥소-1H,5H-벤조[ij]퀴놀리진-2-카르복실산을 제조하는 방법.
    ※참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019830005376A 1982-11-12 1983-11-12 6,7-디히드로-5,8-디메틸-9-플루오로-1-옥소-1H,5H-벤조[ij]퀴놀리진- 2-카르복실산, 그 유도체 및 제조방법 KR890000864B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019890000674A KR890000863B1 (ko) 1982-11-12 1989-01-21 퀴날딘 유도체

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/441,245 US4472405A (en) 1982-11-12 1982-11-12 Antimicrobial 6,7-dihydro-5,8-dimethyl-9 fluoro-1-oxo-1H, 5H-benzo (ij) quinolizine-2-carboxylic acid and derivatives
US441,245 1982-11-12
US441245 1982-11-12

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1019890000674A Division KR890000863B1 (ko) 1982-11-12 1989-01-21 퀴날딘 유도체

Publications (2)

Publication Number Publication Date
KR840006659A true KR840006659A (ko) 1984-12-01
KR890000864B1 KR890000864B1 (ko) 1989-04-11

Family

ID=23752110

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830005376A KR890000864B1 (ko) 1982-11-12 1983-11-12 6,7-디히드로-5,8-디메틸-9-플루오로-1-옥소-1H,5H-벤조[ij]퀴놀리진- 2-카르복실산, 그 유도체 및 제조방법

Country Status (22)

Country Link
US (1) US4472405A (ko)
EP (1) EP0109284B1 (ko)
JP (1) JPH0826017B2 (ko)
KR (1) KR890000864B1 (ko)
AT (1) ATE39926T1 (ko)
AU (1) AU568319B2 (ko)
CA (2) CA1254568A (ko)
CS (1) CS390391A3 (ko)
DE (1) DE3378912D1 (ko)
EG (1) EG16492A (ko)
ES (1) ES8504727A1 (ko)
FI (1) FI73213C (ko)
GR (1) GR79402B (ko)
IE (1) IE56232B1 (ko)
IL (1) IL70198A (ko)
IN (1) IN161391B (ko)
MX (1) MX7314E (ko)
NO (1) NO160782C (ko)
NZ (1) NZ206233A (ko)
OA (1) OA07586A (ko)
PT (1) PT77649B (ko)
ZA (1) ZA838436B (ko)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3519926A1 (de) * 1985-06-04 1986-12-04 Bayer Ag Indolinderivate, verfahren zu ihrer herstellung und diese indolinderivate enthaltende kosmetische lichtschutzmittel
CA1302413C (en) * 1986-01-22 1992-06-02 Bruce E. Williams Process for 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo- 1h,5h-benzo[ij]quinolizine-2-carboxylic acid
US4898945A (en) * 1986-01-22 1990-02-06 Minnesota Mining And Manufacturing Company Process for 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid
GB9827865D0 (en) * 1998-12-18 1999-02-10 Woodcock Fiona Medicament
DE10312346A1 (de) * 2003-03-20 2004-09-30 Bayer Healthcare Ag Kontrolliertes Freisetzungssystem
DE10351448A1 (de) 2003-11-04 2005-06-09 Bayer Healthcare Ag Geschmackstoffhaltige Arzneimittelformulierungen mit verbesserten pharmazeutischen Eigenschaften
DE102005055385A1 (de) * 2004-12-09 2006-06-14 Bayer Healthcare Ag Arzneimittel zur hygienischen Applikation im Ohr
DE102006010642A1 (de) * 2006-03-08 2007-09-27 Bayer Healthcare Aktiengesellschaft Arzneimittelformulierungen, enthaltend Fluorchinolone
DE102006010643A1 (de) 2006-03-08 2007-09-13 Bayer Healthcare Aktiengesellschaft Arzneimittel enthaltend Fluorchinolone
DE102007026550A1 (de) * 2007-06-08 2008-12-11 Bayer Healthcare Ag Extrudate mit verbesserter Geschmacksmaskierung
DE102007055341A1 (de) 2007-11-19 2009-05-20 Bayer Animal Health Gmbh Stabilisierung öliger Suspensionen enthaltend hydrophobe Kieselsäuren
AU2011315555B2 (en) 2010-10-12 2016-03-10 Elanco Animal Health Gmbh Non-starch based soft chewables
US10543170B2 (en) 2012-12-19 2020-01-28 Bayer Animal Health Gmbh Tablets with improved acceptance and good storage stability
MD4291C1 (ro) * 2013-12-27 2015-02-28 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Preparat medicamentos pentru tratamentul otitelor
CN114727622A (zh) * 2019-09-06 2022-07-08 礼蓝美国公司 适口颗粒状兽用药组合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE793524A (fr) * 1971-12-30 1973-06-29 Riker Laboratories Inc Acides benzoquinolizine-carboxyliques et leurs derives
ZA728444B (en) * 1971-12-30 1973-10-31 Riker Laboratories Inc Substituted benzo(ij)quinolizine-2-carboxylic acids and derivatives thereof
JPS5630964A (en) * 1979-08-22 1981-03-28 Kyorin Pharmaceut Co Ltd Novel substituted quinolinecarboxylic acid and its preparation
JPS5655388A (en) 1979-10-11 1981-05-15 Otsuka Pharmaceut Co Ltd Benzo ij quinolidine-2-carboxylic acid derivative, and its preparation
US4301289A (en) * 1980-02-19 1981-11-17 Minnesota Mining And Manufacturing Company Process for 6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxylic acid
JPS59155381A (ja) * 1983-02-22 1984-09-04 Kyorin Pharmaceut Co Ltd ベンゾキノリジンカルボン酸誘導体及びその製造法

Also Published As

Publication number Publication date
ATE39926T1 (de) 1989-01-15
EP0109284B1 (en) 1989-01-11
FI834147A (fi) 1984-05-13
IE56232B1 (en) 1991-05-22
IL70198A0 (en) 1984-02-29
JPH0826017B2 (ja) 1996-03-13
JPS59112969A (ja) 1984-06-29
US4472405A (en) 1984-09-18
PT77649B (en) 1986-03-19
CA1280755C (en) 1991-02-26
NO834093L (no) 1984-05-14
IN161391B (ko) 1987-11-28
EG16492A (en) 1994-11-30
FI73213B (fi) 1987-05-29
NO160782C (no) 1989-05-31
PT77649A (en) 1983-12-01
CS390391A3 (en) 1992-09-16
MX7314E (es) 1988-05-11
CA1254568A (en) 1989-05-23
FI73213C (fi) 1987-09-10
DE3378912D1 (de) 1989-02-16
IL70198A (en) 1988-11-15
ZA838436B (en) 1985-06-26
NZ206233A (en) 1986-10-08
IE832639L (en) 1984-05-12
FI834147A0 (fi) 1983-11-11
KR890000864B1 (ko) 1989-04-11
OA07586A (fr) 1985-03-31
EP0109284A1 (en) 1984-05-23
ES527163A0 (es) 1985-05-01
ES8504727A1 (es) 1985-05-01
AU2118183A (en) 1984-05-17
NO160782B (no) 1989-02-20
GR79402B (ko) 1984-10-22
AU568319B2 (en) 1987-12-24

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