ES8504727A1 - Procedimiento para la preparacion de acidos benzo(ij)-quinolizina-2-carboxilicos y sus derivados - Google Patents

Procedimiento para la preparacion de acidos benzo(ij)-quinolizina-2-carboxilicos y sus derivados

Info

Publication number
ES8504727A1
ES8504727A1 ES527163A ES527163A ES8504727A1 ES 8504727 A1 ES8504727 A1 ES 8504727A1 ES 527163 A ES527163 A ES 527163A ES 527163 A ES527163 A ES 527163A ES 8504727 A1 ES8504727 A1 ES 8504727A1
Authority
ES
Spain
Prior art keywords
quinolizine
benzo
dihydro
oxo
fluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES527163A
Other languages
English (en)
Other versions
ES527163A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Riker Laboratories Inc
Original Assignee
Riker Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riker Laboratories Inc filed Critical Riker Laboratories Inc
Publication of ES527163A0 publication Critical patent/ES527163A0/es
Publication of ES8504727A1 publication Critical patent/ES8504727A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Quinoline Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE ACIDOS BENZO IJ-QUINOLIZINA-2-CARBOXILICOS Y SUS DERIVADOS.COMPRENDE LAS SIGUIENTES ETAPAS: PRIMERA, SE HACE REACCIONAR ACIDO 5-AMINO-2-FLUORBENZOICO CON CROTONALDEHIDO O CON UN PRECURSOR DE CROTONALDEHIDO, PARA OBTENER 5-CARBOXI-6-FLUORQUINALDINA; SEGUNDA, SE REDUCE DICHA 5-CARBOXI-6-FLUORQUINALDINA PARA OBTENER 6-FLUOR-5-METIL-1,2,3,4-TETRAHIDROQUINALDINA; TERCERA, EL PRODUCTO OBTENIDO EN LA ETAPA ANTERIOR SE CONDENSA CON UN DIESTER DE UN ACIDO ALCOXIMETILENMALONICO; Y POR ULTIMO, EL PRODUCTO DE LA ETAPA ANTERIOR SE CICLIZA Y DESESTERIFICA PARA OBTENER EL ACIDO 6,7-DIHIDRO-5,8-DIMETIL-9-FLUOR-1-OXO-1H,5H-BENZO IJ QUINOLIZINA-2-CARBOXILICO.DE APLICACION COMO AGENTES ANTIMICROBIANOS PARA DESINFECTAR Y ESTERILIZAR.
ES527163A 1982-11-12 1983-11-10 Procedimiento para la preparacion de acidos benzo(ij)-quinolizina-2-carboxilicos y sus derivados Expired ES8504727A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/441,245 US4472405A (en) 1982-11-12 1982-11-12 Antimicrobial 6,7-dihydro-5,8-dimethyl-9 fluoro-1-oxo-1H, 5H-benzo (ij) quinolizine-2-carboxylic acid and derivatives

Publications (2)

Publication Number Publication Date
ES527163A0 ES527163A0 (es) 1985-05-01
ES8504727A1 true ES8504727A1 (es) 1985-05-01

Family

ID=23752110

Family Applications (1)

Application Number Title Priority Date Filing Date
ES527163A Expired ES8504727A1 (es) 1982-11-12 1983-11-10 Procedimiento para la preparacion de acidos benzo(ij)-quinolizina-2-carboxilicos y sus derivados

Country Status (22)

Country Link
US (1) US4472405A (es)
EP (1) EP0109284B1 (es)
JP (1) JPH0826017B2 (es)
KR (1) KR890000864B1 (es)
AT (1) ATE39926T1 (es)
AU (1) AU568319B2 (es)
CA (2) CA1254568A (es)
CS (1) CS390391A3 (es)
DE (1) DE3378912D1 (es)
EG (1) EG16492A (es)
ES (1) ES8504727A1 (es)
FI (1) FI73213C (es)
GR (1) GR79402B (es)
IE (1) IE56232B1 (es)
IL (1) IL70198A (es)
IN (1) IN161391B (es)
MX (1) MX7314E (es)
NO (1) NO160782C (es)
NZ (1) NZ206233A (es)
OA (1) OA07586A (es)
PT (1) PT77649B (es)
ZA (1) ZA838436B (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3519926A1 (de) * 1985-06-04 1986-12-04 Bayer Ag Indolinderivate, verfahren zu ihrer herstellung und diese indolinderivate enthaltende kosmetische lichtschutzmittel
US4898945A (en) * 1986-01-22 1990-02-06 Minnesota Mining And Manufacturing Company Process for 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid
CA1302413C (en) * 1986-01-22 1992-06-02 Bruce E. Williams Process for 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo- 1h,5h-benzo[ij]quinolizine-2-carboxylic acid
GB9827865D0 (en) * 1998-12-18 1999-02-10 Woodcock Fiona Medicament
DE10312346A1 (de) * 2003-03-20 2004-09-30 Bayer Healthcare Ag Kontrolliertes Freisetzungssystem
DE10351448A1 (de) 2003-11-04 2005-06-09 Bayer Healthcare Ag Geschmackstoffhaltige Arzneimittelformulierungen mit verbesserten pharmazeutischen Eigenschaften
DE102005055385A1 (de) * 2004-12-09 2006-06-14 Bayer Healthcare Ag Arzneimittel zur hygienischen Applikation im Ohr
DE102006010643A1 (de) 2006-03-08 2007-09-13 Bayer Healthcare Aktiengesellschaft Arzneimittel enthaltend Fluorchinolone
DE102006010642A1 (de) * 2006-03-08 2007-09-27 Bayer Healthcare Aktiengesellschaft Arzneimittelformulierungen, enthaltend Fluorchinolone
DE102007026550A1 (de) 2007-06-08 2008-12-11 Bayer Healthcare Ag Extrudate mit verbesserter Geschmacksmaskierung
DE102007055341A1 (de) 2007-11-19 2009-05-20 Bayer Animal Health Gmbh Stabilisierung öliger Suspensionen enthaltend hydrophobe Kieselsäuren
CA2814082A1 (en) 2010-10-12 2012-04-19 Bayer Intellectual Property Gmbh Non-starch based soft chewables
UA118748C2 (uk) 2012-12-19 2019-03-11 Байєр Енімал Хелс Гмбх Таблетки, що мають покращене сприйняття та хорошу стабільність при зберіганні
MD4291C1 (ro) * 2013-12-27 2015-02-28 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Preparat medicamentos pentru tratamentul otitelor
EP4025220A4 (en) * 2019-09-06 2023-10-04 Elanco US Inc. TASTY VETERINARY MEDICINAL COMPOSITIONS IN GRANULE FORM

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA728444B (en) * 1971-12-30 1973-10-31 Riker Laboratories Inc Substituted benzo(ij)quinolizine-2-carboxylic acids and derivatives thereof
BE793524A (fr) * 1971-12-30 1973-06-29 Riker Laboratories Inc Acides benzoquinolizine-carboxyliques et leurs derives
JPS5630964A (en) * 1979-08-22 1981-03-28 Kyorin Pharmaceut Co Ltd Novel substituted quinolinecarboxylic acid and its preparation
JPS5655388A (en) 1979-10-11 1981-05-15 Otsuka Pharmaceut Co Ltd Benzo ij quinolidine-2-carboxylic acid derivative, and its preparation
US4301289A (en) * 1980-02-19 1981-11-17 Minnesota Mining And Manufacturing Company Process for 6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxylic acid
JPS59155381A (ja) * 1983-02-22 1984-09-04 Kyorin Pharmaceut Co Ltd ベンゾキノリジンカルボン酸誘導体及びその製造法

Also Published As

Publication number Publication date
NZ206233A (en) 1986-10-08
CA1254568A (en) 1989-05-23
FI834147A0 (fi) 1983-11-11
ES527163A0 (es) 1985-05-01
DE3378912D1 (de) 1989-02-16
IL70198A0 (en) 1984-02-29
AU2118183A (en) 1984-05-17
EG16492A (en) 1994-11-30
FI73213B (fi) 1987-05-29
IE56232B1 (en) 1991-05-22
KR890000864B1 (ko) 1989-04-11
FI73213C (fi) 1987-09-10
EP0109284A1 (en) 1984-05-23
EP0109284B1 (en) 1989-01-11
IE832639L (en) 1984-05-12
MX7314E (es) 1988-05-11
IL70198A (en) 1988-11-15
IN161391B (es) 1987-11-28
ATE39926T1 (de) 1989-01-15
PT77649B (en) 1986-03-19
FI834147A (fi) 1984-05-13
PT77649A (en) 1983-12-01
KR840006659A (ko) 1984-12-01
NO834093L (no) 1984-05-14
NO160782C (no) 1989-05-31
NO160782B (no) 1989-02-20
ZA838436B (en) 1985-06-26
US4472405A (en) 1984-09-18
GR79402B (es) 1984-10-22
JPH0826017B2 (ja) 1996-03-13
OA07586A (fr) 1985-03-31
AU568319B2 (en) 1987-12-24
CS390391A3 (en) 1992-09-16
CA1280755C (en) 1991-02-26
JPS59112969A (ja) 1984-06-29

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20011110