KR840000947B1 - 인슐린의 제조방법 - Google Patents

인슐린의 제조방법 Download PDF

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Publication number
KR840000947B1
KR840000947B1 KR1019810000990A KR810000990A KR840000947B1 KR 840000947 B1 KR840000947 B1 KR 840000947B1 KR 1019810000990 A KR1019810000990 A KR 1019810000990A KR 810000990 A KR810000990 A KR 810000990A KR 840000947 B1 KR840000947 B1 KR 840000947B1
Authority
KR
South Korea
Prior art keywords
insulin
chain
solution
sulfonate
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019810000990A
Other languages
English (en)
Korean (ko)
Other versions
KR830004855A (ko
Inventor
유겐 찬스 로날드
아더 호프만 제임스
Original Assignee
일라이 릴리 앤드 캄파니
아더 알 웨일
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 일라이 릴리 앤드 캄파니, 아더 알 웨일 filed Critical 일라이 릴리 앤드 캄파니
Publication of KR830004855A publication Critical patent/KR830004855A/ko
Application granted granted Critical
Publication of KR840000947B1 publication Critical patent/KR840000947B1/ko
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/067—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for sulfur-containing functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1019810000990A 1980-03-27 1981-03-26 인슐린의 제조방법 Expired KR840000947B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13439080A 1980-03-27 1980-03-27
US134,390 1980-03-27
US134390 1980-03-27

Publications (2)

Publication Number Publication Date
KR830004855A KR830004855A (ko) 1983-07-20
KR840000947B1 true KR840000947B1 (ko) 1984-07-01

Family

ID=22463156

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810000990A Expired KR840000947B1 (ko) 1980-03-27 1981-03-26 인슐린의 제조방법

Country Status (28)

Country Link
EP (1) EP0037256B1 (enExample)
JP (1) JPS56154443A (enExample)
KR (1) KR840000947B1 (enExample)
AR (1) AR227305A1 (enExample)
AT (1) ATE4638T1 (enExample)
AU (1) AU540645B2 (enExample)
CA (1) CA1155109A (enExample)
CS (1) CS236463B2 (enExample)
DD (1) DD157613A5 (enExample)
DE (1) DE3160862D1 (enExample)
DK (1) DK149756C (enExample)
EG (1) EG15248A (enExample)
ES (1) ES500750A0 (enExample)
FI (1) FI810918A7 (enExample)
GB (1) GB2072680B (enExample)
GR (1) GR73619B (enExample)
HU (1) HU185416B (enExample)
IE (1) IE51608B1 (enExample)
IL (1) IL62483A (enExample)
NO (1) NO151897C (enExample)
NZ (1) NZ196610A (enExample)
PH (1) PH16153A (enExample)
PL (1) PL128599B1 (enExample)
PT (1) PT72733B (enExample)
RO (1) RO81640B (enExample)
SU (1) SU1327790A3 (enExample)
YU (1) YU76981A (enExample)
ZA (1) ZA811970B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4451396A (en) * 1983-08-01 1984-05-29 Eli Lilly And Company Process for inhibiting undesired thiol reactions during cyanogen bromide cleavage of peptides
DE3501641A1 (de) * 1985-01-19 1986-07-24 Hoechst Ag, 6230 Frankfurt Verfahren zur gewinnung von insulin-vorlaeufern aus reaktionsgemischen, die bei der faltung von insulin-vorlaeufern aus den entsprechenden s-sulfonaten anfallen
US4835251A (en) * 1986-06-23 1989-05-30 Genetech, Inc. Method of chain combination
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
JP3406244B2 (ja) 1999-04-30 2003-05-12 伊藤ハム株式会社 新規な融合蛋白質からの組み換えインスリンの製造方法

Also Published As

Publication number Publication date
SU1327790A3 (ru) 1987-07-30
NO151897C (no) 1985-06-26
GB2072680A (en) 1981-10-07
JPS6318960B2 (enExample) 1988-04-20
RO81640A (ro) 1983-04-29
KR830004855A (ko) 1983-07-20
PT72733B (en) 1982-03-22
DK136581A (da) 1981-09-28
GB2072680B (en) 1983-09-21
IE51608B1 (en) 1987-01-21
IE810680L (en) 1981-09-27
CA1155109A (en) 1983-10-11
PL230295A1 (enExample) 1981-11-13
CS236463B2 (en) 1985-05-15
ZA811970B (en) 1982-11-24
RO81640B (ro) 1983-04-30
GR73619B (enExample) 1984-03-26
EG15248A (en) 1985-12-31
DK149756B (da) 1986-09-22
AU6884481A (en) 1981-10-01
DK149756C (da) 1987-06-15
JPS56154443A (en) 1981-11-30
AR227305A1 (es) 1982-10-15
PT72733A (en) 1981-04-01
DD157613A5 (de) 1982-11-24
YU76981A (en) 1983-09-30
EP0037256A1 (en) 1981-10-07
AU540645B2 (en) 1984-11-29
NZ196610A (en) 1984-03-16
PH16153A (en) 1983-07-12
NO151897B (no) 1985-03-18
IL62483A0 (en) 1981-05-20
FI810918L (fi) 1981-09-28
PL128599B1 (en) 1984-02-29
NO811038L (no) 1981-09-28
ES8207551A1 (es) 1982-09-16
HU185416B (en) 1985-02-28
ATE4638T1 (de) 1983-09-15
ES500750A0 (es) 1982-09-16
DE3160862D1 (en) 1983-10-20
IL62483A (en) 1984-05-31
EP0037256B1 (en) 1983-09-14
FI810918A7 (fi) 1981-09-28

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