KR830009086A - 치환된 n-[4-(인돌릴)-피페리디노-알킬]-벤즈이미다졸론의 제조방법 - Google Patents

치환된 n-[4-(인돌릴)-피페리디노-알킬]-벤즈이미다졸론의 제조방법 Download PDF

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KR830009086A
KR830009086A KR1019820000868A KR820000868A KR830009086A KR 830009086 A KR830009086 A KR 830009086A KR 1019820000868 A KR1019820000868 A KR 1019820000868A KR 820000868 A KR820000868 A KR 820000868A KR 830009086 A KR830009086 A KR 830009086A
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formula
alkyl
benzimidazolone
indolyl
piperidino
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KR1019820000868A
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KR890000008B1 (ko
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프레터 커트
폭스 빅토르
티이. 올리버 제임스
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피이. 브라이언 스튜워트
베링거 인겔하임 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Immunology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Plural Heterocyclic Compounds (AREA)
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Abstract

내용 없음

Description

치환된 N-[4-(인돌릴)-피페리디노-알킬]-벤즈이마다졸론의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 일반식(II)의 3-(1,2,5,6-테트라하이드로-4-피리딜)-인돌을 일반식(III)의 N-(ω-할로알킬)-벤즈이미다졸론으로 알킬화시켜 일반식(IV)의 중간체를 얻고 이 일반식(IV)의 중간체를 귀금속촉매 존재하에 수소로 수소첨가 반응시켜 일반식(I)의 치환된 N-[4-(인돌릴)-피페리디노-알킬]-벤즈이미다졸론 및 그 약리학적으로 무독한 산부가염을 제조하는 방법.
    상기식에서,
    R1은 수소, 할로겐 또는 메톡시이고, R2는 수소 또는 저급알킬이고, R3는 수소 또는 저급알킬이고, R4는 수소, 저급알킬 또는 저급알케닐이고, n은 2 내지 6의 정수이고, X는 염소, 브롬 또는 요드이다.
  2. 일반식(V)의 3-(4-피페리딜)-인돌을 일반식(III)의 N-(ω-할로-알킬)-벤즈이미다졸론으로 알킬화시켜 상기 1의 일반식(I)의 치환된 N-[4-(인돌릴)-피페리디노-알킬]-벤즈이미다졸론 및 그 약리학적으로 무독한 산부가염을 제조하는 방법.
    상기식에서, R1, R2, R3, R4, n 및 X는 상기 1에서 정의된 바와 같다.
  3. 일반식(VI)의 4-피페리돈을 일반식(III)의 N-(ω-할로-알킬)-벤즈이미다졸론으로 알킬화시켜 일반식(VII)의 중간체를 얻은후 이 중간체를 산수용액중에서 일반식(VIII)의 인돌과 반응시켜 일반식(IV)의 상응하는 중간체를 얻은다음 이 일반식(IV)의 중간체를 귀금속 촉매하에 수소로 수소첨가반응시켜 상기 1의 일반식(I)의 치환된 N-[4-(인돌릴)-피페리디노-알킬]-벤즈이미다졸론 및 그 약리학적으로 무독한 산부가염을 제조하는 방법.
    상기식에서, R1, R2, R3, R4, n 및 X는 상기 1에서 정의된 바와 같다.
  4. 일반식(V)의 3-(4-피페리딜)-인돌일 일반식(IX)의 α,ω-디할로-알칸으로 알킬화시켜 일반식(X)의 중간체를 얻고 이 일반식(X)의 중간체를 일반식(XI)의 벤즈이미다졸론으로 알킬화시켜 상기 1의 일반식(I)의 치환된 N-[4-(인돌릴)-피페리디노-알킬]-벤즈이미다졸론 및 그 약리학적으로 무독한 산부가염을 제조하는 방법.
    상기식에서,
    R1, R2, R3, R4, n 및 X는 상기 1에서 정의된 바와 같다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8200868A 1981-02-25 1982-02-25 치환된 n-[4-(인돌릴)-피페리디노-알킬]-벤즈이미다졸론 및 이의 제조방법 KR890000008B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/237,966 US4359468A (en) 1981-02-25 1981-02-25 Antiallergic N-[4-(indolyl)-piperidino-alkyl]-benzimidazolones
US237,966 1981-02-25
US237.966 1981-02-25

Publications (2)

Publication Number Publication Date
KR830009086A true KR830009086A (ko) 1983-12-17
KR890000008B1 KR890000008B1 (ko) 1989-03-02

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KR8200868A KR890000008B1 (ko) 1981-02-25 1982-02-25 치환된 n-[4-(인돌릴)-피페리디노-알킬]-벤즈이미다졸론 및 이의 제조방법

Country Status (28)

Country Link
US (1) US4359468A (ko)
EP (1) EP0058975B1 (ko)
JP (1) JPS57156484A (ko)
KR (1) KR890000008B1 (ko)
AR (1) AR228475A1 (ko)
AT (1) ATE10742T1 (ko)
AU (1) AU543948B2 (ko)
CA (1) CA1191137A (ko)
CS (1) CS227343B2 (ko)
DD (1) DD202562A5 (ko)
DE (1) DE3261497D1 (ko)
DK (1) DK151017C (ko)
ES (2) ES509871A0 (ko)
FI (1) FI71558C (ko)
GB (1) GB2093455B (ko)
GR (1) GR74778B (ko)
HU (1) HU187652B (ko)
IE (1) IE52562B1 (ko)
IL (1) IL65097A0 (ko)
NO (1) NO157296C (ko)
NZ (1) NZ199822A (ko)
PH (1) PH17889A (ko)
PL (1) PL135472B1 (ko)
PT (1) PT74481B (ko)
SU (1) SU1088665A3 (ko)
UA (1) UA7228A1 (ko)
YU (1) YU42758B (ko)
ZA (1) ZA821196B (ko)

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US4548939A (en) * 1984-10-01 1985-10-22 Janssen Pharmaceutica N. V. 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
US4742057A (en) * 1985-12-05 1988-05-03 Fujisawa Pharmaceutical Co., Ltd. Antiallergic thiazole compounds
FR2613222B1 (fr) * 1987-04-03 1991-06-14 Guigon Nadine Composition pour les soins locaux de l'epiderme, notamment du cuir chevelu
DK733788A (da) * 1988-01-14 1989-07-15 Fujisawa Pharmaceutical Co Indolylpiperidinderivater og fremgangsmaade til fremstilling deraf
GB8908085D0 (en) * 1989-04-11 1989-05-24 Lundbeck & Co As H New therapeutic use
US5238945A (en) * 1989-04-11 1993-08-24 H. Lundbeck A/S Method of treating psychoses
FR2658823B1 (fr) * 1990-02-27 1992-04-30 Adir Nouveaux derives d'aminomethylpiperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent .
TW203049B (ko) * 1990-04-13 1993-04-01 Yamanouchi Pharma Co Ltd
DE4414113A1 (de) * 1994-04-22 1995-10-26 Merck Patent Gmbh 3-Indolylpiperidine
US5965582A (en) * 1994-08-03 1999-10-12 Asta Medica Aktiengesellschaft N-benzylindole and benzopyrazole derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunemodulating effect
US5521196A (en) * 1994-10-05 1996-05-28 Eli Lilly And Company 5-HT1F agonists for the treatment of migraine
US5521197A (en) * 1994-12-01 1996-05-28 Eli Lilly And Company 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
KR19980703048A (ko) * 1995-03-20 1998-09-05 피터쥐.스트링거 5-치환-3-(1,2,3,6-테트라히드로피리딘-4-일)- 및 3-(피페리딘-4-일)-1ｈ-인돌: 신규한 5-ｈｔ1ｆ 아고니스트
GB9825413D0 (en) 1998-11-19 1999-01-13 Lilly Co Eli Pharmaceutical compounds
GB9903784D0 (en) * 1999-02-18 1999-04-14 Lilly Co Eli Pharmaceutical compounds
AU2003297597A1 (en) * 2002-11-26 2004-06-18 Isis Pharmaceuticals, Inc. Benzimidazoles and analogs thereof as antibacterials
WO2006117314A2 (en) * 2005-04-30 2006-11-09 Boehringer Ingelheim International Gmbh Novel piperidin- substituted indoles and their use as ccr-3 modulators
WO2007050381A2 (en) * 2005-10-24 2007-05-03 Janssen Pharmaceutica, N.V. 3-piperidin-4-yl-indole orl-1 receptor modulators
US8462477B2 (en) 2010-09-13 2013-06-11 Analog Devices, Inc. Junction field effect transistor for voltage protection

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BE794333A (fr) * 1972-01-20 1973-07-19 Wyeth John & Brother Ltd Composes heterocycliques azotes therapeutiques
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DK79882A (da) 1982-08-26
DK151017B (da) 1987-10-12
ES8401961A1 (es) 1984-01-01
FI71558C (fi) 1987-01-19
ZA821196B (en) 1983-10-26
CS227343B2 (en) 1984-04-16
YU42758B (en) 1988-12-31
JPS57156484A (en) 1982-09-27
PL235187A1 (en) 1984-03-26
SU1088665A3 (ru) 1984-04-23
FI71558B (fi) 1986-10-10
KR890000008B1 (ko) 1989-03-02
EP0058975A1 (de) 1982-09-01
ES517988A0 (es) 1984-01-01
UA7228A1 (uk) 1995-06-30
FI820594L (fi) 1982-08-26
GB2093455A (en) 1982-09-02
US4359468A (en) 1982-11-16
PT74481B (de) 1984-10-09
JPH0318637B2 (ko) 1991-03-13
ES8306142A1 (es) 1983-05-01
GB2093455B (en) 1984-06-13
PL135472B1 (en) 1985-10-31
AU543948B2 (en) 1985-05-09
YU41082A (en) 1985-03-20
PT74481A (de) 1982-03-01
AR228475A1 (es) 1983-03-15
DD202562A5 (de) 1983-09-21
NO157296C (no) 1988-02-24
CA1191137A (en) 1985-07-30
NZ199822A (en) 1985-01-31
EP0058975B1 (de) 1984-12-12
HU187652B (en) 1986-02-28
GR74778B (ko) 1984-07-12
AU8078382A (en) 1982-09-02
ATE10742T1 (de) 1984-12-15
PH17889A (en) 1985-01-21
NO820583L (no) 1982-08-26
DE3261497D1 (en) 1985-01-24
IE820401L (en) 1982-08-25
IL65097A0 (en) 1982-04-30
ES509871A0 (es) 1983-05-01
NO157296B (no) 1987-11-16
IE52562B1 (en) 1987-12-09
DK151017C (da) 1988-06-13

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