KR830003398A - 2-아미노-3-(알킬티오벤조일)-페닐아세트산 - Google Patents

2-아미노-3-(알킬티오벤조일)-페닐아세트산 Download PDF

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Publication number
KR830003398A
KR830003398A KR1019800003043A KR800003043A KR830003398A KR 830003398 A KR830003398 A KR 830003398A KR 1019800003043 A KR1019800003043 A KR 1019800003043A KR 800003043 A KR800003043 A KR 800003043A KR 830003398 A KR830003398 A KR 830003398A
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KR
South Korea
Prior art keywords
lower alkyl
hydrogen
alkylthiobenzoyl
amino
alkali metal
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KR1019800003043A
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English (en)
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KR840000605B1 (ko
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알란 월쉬 데비드
알렌 샴블리 드와이트
Original Assignee
알. 피. 울프
에이. 에이치. 로빈스 캄파니 인코포레이티드
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Application filed by 알. 피. 울프, 에이. 에이치. 로빈스 캄파니 인코포레이티드 filed Critical 알. 피. 울프
Publication of KR830003398A publication Critical patent/KR830003398A/ko
Application granted granted Critical
Publication of KR840000605B1 publication Critical patent/KR840000605B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/24—Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
    • C07C321/28—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

2-아미노-3-(알킬티오벤조일)-페닐아세트산
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 플루오로벤조일 인돌린-2-온을 알칼리금속 알킬설파이드와 반응시키고 산 가수분해시켜 7-(알킬티오벤조일)인돌린-2-온을 얻은후 이를 알칼리금속 염기와 가수분해하여 2-아미노-3-(알킬티오벤조일)폐닐아세트산의 금속염을 얻고, 필요한 경우 상기 알칼리 금속염의 수용액에 아세트산을 가하여 R'이 수소인 유리산을 얻고, 필요한 경우 상기 금속염을 적당한 용매내에서 저급알킬 요오다이드로 처리하여 R'이 저급알킬인 에스테르를 얻음을 특징으로하여 다음 구조식(I)의 화합물을 제조하는 방법.
    상기 구조식에서
    R은 수소 또는 저급알킬이고
    R1은 수소, 저급알킬 또는 약학적으로 허용되는 금속양이온이고
    R2는 수소, 할로겐, 저급알킬 또는 저급알콕시이고
    Am은 1급 아미노(-NH2), 메틸아미노 또는 디메틸아미노이다.
    * 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019800003043A 1979-08-01 1980-07-30 2-아미노-3-(알킬티오벤조일)-페닐아세트산유도체의 제조방법 KR840000605B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6302979A 1979-08-01 1979-08-01
US63029 1979-08-01
US063,029 1979-08-01

Publications (2)

Publication Number Publication Date
KR830003398A true KR830003398A (ko) 1983-06-20
KR840000605B1 KR840000605B1 (ko) 1984-04-28

Family

ID=22046443

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019800003043A KR840000605B1 (ko) 1979-08-01 1980-07-30 2-아미노-3-(알킬티오벤조일)-페닐아세트산유도체의 제조방법

Country Status (37)

Country Link
JP (1) JPS5629568A (ko)
KR (1) KR840000605B1 (ko)
AR (1) AR226855A1 (ko)
AT (1) AT369648B (ko)
AU (1) AU532247B2 (ko)
BE (1) BE884556A (ko)
BR (1) BR8004546A (ko)
CA (1) CA1147746A (ko)
CH (1) CH648295A5 (ko)
CS (1) CS214716B2 (ko)
DE (1) DE3026964A1 (ko)
DK (1) DK330380A (ko)
EG (1) EG14771A (ko)
ES (1) ES493880A0 (ko)
FI (1) FI74457C (ko)
FR (1) FR2463124A1 (ko)
GB (2) GB2055820B (ko)
GR (1) GR69714B (ko)
HK (2) HK37584A (ko)
HU (1) HU181728B (ko)
IE (1) IE50293B1 (ko)
IL (1) IL60444A (ko)
IN (1) IN151542B (ko)
IT (1) IT1132273B (ko)
KE (2) KE3368A (ko)
LU (1) LU82672A1 (ko)
MX (1) MX6175E (ko)
NL (1) NL8004397A (ko)
NO (1) NO150080C (ko)
NZ (1) NZ194515A (ko)
PH (1) PH18030A (ko)
PL (1) PL127122B1 (ko)
PT (1) PT71632B (ko)
SE (1) SE447247B (ko)
SG (1) SG19884G (ko)
YU (1) YU41725B (ko)
ZA (1) ZA804703B (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0723478U (ja) * 1993-10-08 1995-05-02 有限会社伊藤商店 衿カバー
FR2711076B1 (fr) * 1993-10-13 1995-12-08 Robatel Slpi Dispositif étanche et déformable élastiquement pour le débatissage de la couche résiduelle.
US7186745B2 (en) 2001-03-06 2007-03-06 Astrazeneca Ab Indolone derivatives having vascular damaging activity

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH577461A5 (ko) * 1975-08-13 1976-07-15 Robins Co Inc A H

Also Published As

Publication number Publication date
HU181728B (en) 1983-11-28
EG14771A (en) 1985-12-31
NO150080B (no) 1984-05-07
AT369648B (de) 1983-01-25
CA1147746A (en) 1983-06-07
SE447247B (sv) 1986-11-03
PL127122B1 (en) 1983-09-30
ATA403580A (de) 1982-06-15
YU41725B (en) 1987-12-31
HK49084A (en) 1984-06-22
GB2055820B (en) 1983-06-02
IN151542B (ko) 1983-05-14
DE3026964C2 (ko) 1990-11-15
YU187080A (en) 1983-09-30
NO802306L (no) 1981-02-02
PT71632B (en) 1981-12-17
IT8023840A0 (it) 1980-07-31
SG19884G (en) 1985-01-04
NO150080C (no) 1984-08-15
KR840000605B1 (ko) 1984-04-28
ZA804703B (en) 1981-07-29
IL60444A0 (en) 1980-09-16
AU532247B2 (en) 1983-09-22
IE801537L (en) 1981-02-01
NL8004397A (nl) 1981-02-03
CH648295A5 (fr) 1985-03-15
FI802282A (fi) 1981-02-02
FI74457C (fi) 1988-02-08
FR2463124A1 (fr) 1981-02-20
AU6084080A (en) 1981-02-05
MX6175E (es) 1984-12-04
GB2055820A (en) 1981-03-11
FR2463124B1 (ko) 1984-05-18
FI74457B (fi) 1987-10-30
ES8106702A1 (es) 1981-08-01
KE3390A (en) 1984-05-25
IT1132273B (it) 1986-07-02
DE3026964A1 (de) 1981-02-26
JPS5629568A (en) 1981-03-24
IE50293B1 (en) 1986-03-19
GR69714B (ko) 1982-07-09
GB2105708A (en) 1983-03-30
DK330380A (da) 1981-02-02
LU82672A1 (fr) 1982-02-17
GB2105708B (en) 1983-09-14
PL225990A1 (ko) 1982-02-01
NZ194515A (en) 1984-05-31
HK37584A (en) 1984-05-11
BE884556A (fr) 1980-11-17
KE3368A (en) 1984-02-10
JPH0314820B2 (ko) 1991-02-27
PT71632A (en) 1980-08-01
PH18030A (en) 1985-03-06
ES493880A0 (es) 1981-08-01
BR8004546A (pt) 1981-04-28
SE8005425L (sv) 1981-02-02
AR226855A1 (es) 1982-08-31
CS214716B2 (en) 1982-05-28
IL60444A (en) 1985-03-31

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