ES8106702A1 - Un procedimiento para preparar nuevos acidos 2-amino-3-(al- cohiltiobenzoil)-fenilaceticos,sus esteres alcohilicos y sa-les metalicas - Google Patents

Un procedimiento para preparar nuevos acidos 2-amino-3-(al- cohiltiobenzoil)-fenilaceticos,sus esteres alcohilicos y sa-les metalicas

Info

Publication number
ES8106702A1
ES8106702A1 ES493880A ES493880A ES8106702A1 ES 8106702 A1 ES8106702 A1 ES 8106702A1 ES 493880 A ES493880 A ES 493880A ES 493880 A ES493880 A ES 493880A ES 8106702 A1 ES8106702 A1 ES 8106702A1
Authority
ES
Spain
Prior art keywords
amino
lower alkyl
alkylthiobenzoyl
esters
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES493880A
Other languages
English (en)
Other versions
ES493880A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AH Robins Co Inc
Original Assignee
AH Robins Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AH Robins Co Inc filed Critical AH Robins Co Inc
Publication of ES8106702A1 publication Critical patent/ES8106702A1/es
Publication of ES493880A0 publication Critical patent/ES493880A0/es
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • C07D209/34Oxygen atoms in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/24Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
    • C07C321/28Sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ACIDOS 2-AMINO-3-(ALCOHILTIOBENZOIL)-FENIL-ACETICOS, ESTERES ALCOHILICOS Y SALES DE METALES, DE FORMULA GENERAL (I). CONSISTENTE EN LA OBTENCION DE LA SAL ALCALINA DE (I) SOMETIENDO EL COMPUESTO DE FORMULA (II) A UNA REACCION DE HIDROLISIS CON UNA BASE DE METAL ALCALINO, PUDIENDOSE TRANSFORMAR LA SAL ASI OBTENIDA EN EL ACIDO LIBRE O EN EL ESTER ALCOHILICO DEL MISMO. EN LAS FORMULAS (I) Y (II) R ES HIDROGENO O ALCOHILO INFERIOR; R1 ES HIDROGENO, ALCOHILO INFERIOR O CATION METALICO FARMACEUTICAMENTE ACEPTABLE; R2 ES HIDROGENO, HALOGENO, ALCOHILO INFERIOR O ALCOXI INFERIOR; AM ES AMINO PRIMARIO (-NH2), METILAMINO O DIMETILAMINO. PARA PREPARAR LOS COMPUESTOS (II) SE PARTE DE FLUOROBENZOILINDOLIN-2-ONAS, QUE SE OBTIENEN POR METODOS CONOCIDOS. *FORMULA* S
ES493880A 1979-08-01 1980-07-31 Un procedimiento para preparar nuevos acidos 2-amino-3-(al- cohiltiobenzoil)-fenilaceticos,sus esteres alcohilicos y sa-les metalicas Granted ES493880A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6302979A 1979-08-01 1979-08-01

Publications (2)

Publication Number Publication Date
ES8106702A1 true ES8106702A1 (es) 1981-08-01
ES493880A0 ES493880A0 (es) 1981-08-01

Family

ID=22046443

Family Applications (1)

Application Number Title Priority Date Filing Date
ES493880A Granted ES493880A0 (es) 1979-08-01 1980-07-31 Un procedimiento para preparar nuevos acidos 2-amino-3-(al- cohiltiobenzoil)-fenilaceticos,sus esteres alcohilicos y sa-les metalicas

Country Status (37)

Country Link
JP (1) JPS5629568A (es)
KR (1) KR840000605B1 (es)
AR (1) AR226855A1 (es)
AT (1) AT369648B (es)
AU (1) AU532247B2 (es)
BE (1) BE884556A (es)
BR (1) BR8004546A (es)
CA (1) CA1147746A (es)
CH (1) CH648295A5 (es)
CS (1) CS214716B2 (es)
DE (1) DE3026964A1 (es)
DK (1) DK330380A (es)
EG (1) EG14771A (es)
ES (1) ES493880A0 (es)
FI (1) FI74457C (es)
FR (1) FR2463124A1 (es)
GB (2) GB2055820B (es)
GR (1) GR69714B (es)
HK (2) HK37584A (es)
HU (1) HU181728B (es)
IE (1) IE50293B1 (es)
IL (1) IL60444A (es)
IN (1) IN151542B (es)
IT (1) IT1132273B (es)
KE (2) KE3368A (es)
LU (1) LU82672A1 (es)
MX (1) MX6175E (es)
NL (1) NL8004397A (es)
NO (1) NO150080C (es)
NZ (1) NZ194515A (es)
PH (1) PH18030A (es)
PL (1) PL127122B1 (es)
PT (1) PT71632B (es)
SE (1) SE447247B (es)
SG (1) SG19884G (es)
YU (1) YU41725B (es)
ZA (1) ZA804703B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0723478U (ja) * 1993-10-08 1995-05-02 有限会社伊藤商店 衿カバー
FR2711076B1 (fr) * 1993-10-13 1995-12-08 Robatel Slpi Dispositif étanche et déformable élastiquement pour le débatissage de la couche résiduelle.
WO2002070478A1 (en) 2001-03-06 2002-09-12 Astrazeneca Ab Indolone derivatives having vascular-damaging activity

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH577461A5 (es) * 1975-08-13 1976-07-15 Robins Co Inc A H

Also Published As

Publication number Publication date
AT369648B (de) 1983-01-25
YU41725B (en) 1987-12-31
MX6175E (es) 1984-12-04
JPS5629568A (en) 1981-03-24
AU6084080A (en) 1981-02-05
FR2463124A1 (fr) 1981-02-20
PL127122B1 (en) 1983-09-30
CS214716B2 (en) 1982-05-28
DE3026964C2 (es) 1990-11-15
FI802282A (fi) 1981-02-02
SG19884G (en) 1985-01-04
FI74457C (fi) 1988-02-08
KR840000605B1 (ko) 1984-04-28
KE3368A (en) 1984-02-10
KR830003398A (ko) 1983-06-20
PH18030A (en) 1985-03-06
NO150080B (no) 1984-05-07
ATA403580A (de) 1982-06-15
LU82672A1 (fr) 1982-02-17
ZA804703B (en) 1981-07-29
IN151542B (es) 1983-05-14
FR2463124B1 (es) 1984-05-18
EG14771A (en) 1985-12-31
BE884556A (fr) 1980-11-17
IL60444A0 (en) 1980-09-16
IE50293B1 (en) 1986-03-19
CA1147746A (en) 1983-06-07
NZ194515A (en) 1984-05-31
IT1132273B (it) 1986-07-02
ES493880A0 (es) 1981-08-01
DE3026964A1 (de) 1981-02-26
NO802306L (no) 1981-02-02
HK37584A (en) 1984-05-11
PT71632B (en) 1981-12-17
CH648295A5 (fr) 1985-03-15
GB2105708A (en) 1983-03-30
IL60444A (en) 1985-03-31
SE8005425L (sv) 1981-02-02
AR226855A1 (es) 1982-08-31
SE447247B (sv) 1986-11-03
PT71632A (en) 1980-08-01
IE801537L (en) 1981-02-01
FI74457B (fi) 1987-10-30
NL8004397A (nl) 1981-02-03
JPH0314820B2 (es) 1991-02-27
GB2055820A (en) 1981-03-11
IT8023840A0 (it) 1980-07-31
NO150080C (no) 1984-08-15
YU187080A (en) 1983-09-30
PL225990A1 (es) 1982-02-01
GB2055820B (en) 1983-06-02
DK330380A (da) 1981-02-02
GR69714B (es) 1982-07-09
HK49084A (en) 1984-06-22
GB2105708B (en) 1983-09-14
KE3390A (en) 1984-05-25
AU532247B2 (en) 1983-09-22
BR8004546A (pt) 1981-04-28
HU181728B (en) 1983-11-28

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506