KR840004428A - 벤조 아자시클로 알킬-스피로-이미다졸리딘의 제조방법 - Google Patents
벤조 아자시클로 알킬-스피로-이미다졸리딘의 제조방법 Download PDFInfo
- Publication number
- KR840004428A KR840004428A KR1019830001753A KR830001753A KR840004428A KR 840004428 A KR840004428 A KR 840004428A KR 1019830001753 A KR1019830001753 A KR 1019830001753A KR 830001753 A KR830001753 A KR 830001753A KR 840004428 A KR840004428 A KR 840004428A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- hydrogen
- spiro
- carried out
- acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (4)
- 다음 구조식(Ⅱ)의 케톤 유도체를 암모니움 산 또는 암모니움 염의 존재하에 알칼리 금속 시안화물과 축합시켜 다음 구조식(I´)의 스피로 히단토인을 얻고 필요하다면 R2가 수소인 다음 구조식(Ⅰ)의 화합물로 탈 벤질화 시키고 나머지를 저급 알카노인 산 할리드 또는 P-톨루엔 설포닐 할리드에 의해 아실화시켜 R2가 저급 알카노일 기 또는 P-톨루엔을 나타내는 구조식(Ⅰ)의 상응하는 화합물을 얻음을 특징으로 하는 다음 구조식(Ⅰ)의 벤조 아자시클로 알킬-스피로-이미다졸리딘 뿐만 아니라 약제학적으로 수용 가능한 무기 또는 유기 기재로 얻어지는 그것의 염 또는 약제학적으로 수용 가능한 무기산으로 얻어지는 그것의 염들(R2가 알카노일 또는 P-톨루엔 설포닐은 제외)의 제조방법.상기 구조식에서 R1은 수소나 할로겐 원자, 히드록시 또는 메톡시기를 나타내고 R2는 수소원자, 저급알킬기, 페닐저급-알킬기, 저급 알카닐기 또는 P-톨루엔 설포닐 기를 나타내고, n는 1 또는 2이고 R´2는 수소를 제외하고 상기한 R2의 의미와 같다.
- 상기 1항에 있어, 축합은 비점에서 극성용해중에 필요하다면 가압하에 암모니움 산 또는 암모니움염의 존재하에 수행됨을 특징으로 하는 상기의 제조방법.
- 상기 1항에 있어, 탈벤질화는 극성용매중 촉매 Pd/C의 존재하에 수행됨을 특징으로 하는 상기의 제조방법.
- 상기 1항에 있어, 아실화는 산수용체의 존재하에 수행됨을 특징으로 하는 상기의 제조방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR82.07203 | 1982-04-27 | ||
| FR8207203A FR2525603A1 (fr) | 1982-04-27 | 1982-04-27 | Benzoazacycloalkyl-spiro-imidazolinines, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR840004428A true KR840004428A (ko) | 1984-10-15 |
Family
ID=9273425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019830001753A KR840004428A (ko) | 1982-04-27 | 1983-04-26 | 벤조 아자시클로 알킬-스피로-이미다졸리딘의 제조방법 |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JPS5910584A (ko) |
| KR (1) | KR840004428A (ko) |
| AT (1) | ATA125383A (ko) |
| AU (1) | AU1395383A (ko) |
| BE (1) | BE896572A (ko) |
| DD (1) | DD209833A5 (ko) |
| DE (1) | DE3315106A1 (ko) |
| DK (1) | DK183583A (ko) |
| ES (1) | ES521895A0 (ko) |
| FR (1) | FR2525603A1 (ko) |
| GB (1) | GB2133401B (ko) |
| GR (1) | GR78481B (ko) |
| IL (1) | IL68497A0 (ko) |
| IT (1) | IT1167123B (ko) |
| LU (1) | LU84770A1 (ko) |
| MA (1) | MA19783A1 (ko) |
| NL (1) | NL8301476A (ko) |
| NO (1) | NO831473L (ko) |
| OA (1) | OA07412A (ko) |
| PT (1) | PT76595B (ko) |
| SE (1) | SE8302347L (ko) |
| ZA (1) | ZA832927B (ko) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU617541B2 (en) * | 1988-10-20 | 1991-11-28 | Wyeth | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors |
| US4927831A (en) * | 1988-10-20 | 1990-05-22 | American Home Products | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors |
| US6953787B2 (en) | 2002-04-12 | 2005-10-11 | Arena Pharmaceuticals, Inc. | 5HT2C receptor modulators |
| EP2189448B1 (en) | 2003-06-17 | 2014-01-29 | Arena Pharmaceuticals, Inc. | Processes for the Separation of 3-Benzazepine Racemates |
| CN101792417A (zh) | 2003-06-17 | 2010-08-04 | 艾尼纳制药公司 | 用于治疗5ht2c受体相关疾病的苯并氮杂卓衍生物 |
| KR101281919B1 (ko) | 2004-12-21 | 2013-07-03 | 아레나 파마슈티칼스, 인크. | (ｒ)-8-클로로-1-메틸-2,3,4,5-테트라히드로-1ｈ-3-벤즈아제핀 히드로클로라이드의 결정질 형태 |
| PT1833473E (pt) | 2004-12-23 | 2009-12-17 | Arena Pharm Inc | Composições de modulador de receptor 5ht2c e métodos de utilização |
| EP2001852A2 (en) | 2006-04-03 | 2008-12-17 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates related thereto |
| CA2670285A1 (en) | 2006-12-05 | 2008-06-12 | Arena Pharmaceuticals, Inc. | Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof |
| JP5491421B2 (ja) | 2008-03-04 | 2014-05-14 | アリーナ ファーマシューティカルズ， インコーポレイテッド | ５−ｈｔ２ｃアゴニストである（ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピンに関連する中間体の調製のためのプロセス |
| CN102648170A (zh) | 2009-06-18 | 2012-08-22 | 艾尼纳制药公司 | 制备5-ht2c受体激动剂的方法 |
| US9045431B2 (en) | 2010-06-02 | 2015-06-02 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-HT2C receptor agonists |
| EP2939677A1 (en) | 2010-09-01 | 2015-11-04 | Arena Pharmaceuticals, Inc. | Administration of lorcaserin to indviduals with renal impairment |
| CN103189360A (zh) | 2010-09-01 | 2013-07-03 | 艾尼纳制药公司 | 5-ht2c激动剂的非吸湿性盐 |
| ES2704455T3 (es) | 2010-09-01 | 2019-03-18 | Arena Pharm Inc | Formas farmacéuticas de liberación modificada de agonistas de 5-HT2C útiles para la gestión del peso |
| WO2012030938A1 (en) | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | Salts of lorcaserin with optically active acids |
| AU2012392187B2 (en) | 2012-10-09 | 2018-07-12 | Arena Pharmaceuticals, Inc. | Method of weight management |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4209630A (en) * | 1976-10-18 | 1980-06-24 | Pfizer Inc. | Hydantoin derivatives as therapeutic agents |
| US4235911A (en) * | 1979-06-13 | 1980-11-25 | Pfizer Inc. | Hydantoin derivatives |
-
1982
- 1982-04-27 FR FR8207203A patent/FR2525603A1/fr active Granted
-
1983
- 1983-04-08 AT AT0125383A patent/ATA125383A/de not_active IP Right Cessation
- 1983-04-25 DD DD83250187A patent/DD209833A5/de unknown
- 1983-04-25 LU LU84770A patent/LU84770A1/fr unknown
- 1983-04-26 NO NO831473A patent/NO831473L/no unknown
- 1983-04-26 KR KR1019830001753A patent/KR840004428A/ko not_active Application Discontinuation
- 1983-04-26 JP JP58073687A patent/JPS5910584A/ja active Pending
- 1983-04-26 IL IL68497A patent/IL68497A0/xx unknown
- 1983-04-26 PT PT76595A patent/PT76595B/pt unknown
- 1983-04-26 GR GR71214A patent/GR78481B/el unknown
- 1983-04-26 ZA ZA832927A patent/ZA832927B/xx unknown
- 1983-04-26 DK DK183583A patent/DK183583A/da not_active Application Discontinuation
- 1983-04-26 SE SE8302347A patent/SE8302347L/xx not_active Application Discontinuation
- 1983-04-26 IT IT48155/83A patent/IT1167123B/it active
- 1983-04-26 NL NL8301476A patent/NL8301476A/nl not_active Application Discontinuation
- 1983-04-26 BE BE0/210633A patent/BE896572A/fr not_active IP Right Cessation
- 1983-04-26 AU AU13953/83A patent/AU1395383A/en not_active Abandoned
- 1983-04-27 OA OA57984A patent/OA07412A/xx unknown
- 1983-04-27 ES ES521895A patent/ES521895A0/es active Granted
- 1983-04-27 MA MA20003A patent/MA19783A1/fr unknown
- 1983-04-27 GB GB08311508A patent/GB2133401B/en not_active Expired
- 1983-04-27 DE DE19833315106 patent/DE3315106A1/de not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| ES8405796A1 (es) | 1984-06-16 |
| SE8302347L (sv) | 1983-10-28 |
| IT1167123B (it) | 1987-05-13 |
| ES521895A0 (es) | 1984-06-16 |
| GB2133401A (en) | 1984-07-25 |
| DK183583D0 (da) | 1983-04-26 |
| PT76595B (fr) | 1986-01-21 |
| DD209833A5 (de) | 1984-05-23 |
| ATA125383A (de) | 1986-05-15 |
| LU84770A1 (fr) | 1984-11-28 |
| JPS5910584A (ja) | 1984-01-20 |
| PT76595A (fr) | 1983-05-01 |
| SE8302347D0 (sv) | 1983-04-26 |
| IL68497A0 (en) | 1983-07-31 |
| OA07412A (fr) | 1984-11-30 |
| NL8301476A (nl) | 1983-11-16 |
| ZA832927B (en) | 1984-06-27 |
| AU1395383A (en) | 1983-11-03 |
| IT8348155A0 (it) | 1983-04-26 |
| NO831473L (no) | 1983-10-28 |
| FR2525603B1 (ko) | 1984-09-14 |
| GB8311508D0 (en) | 1983-06-02 |
| DK183583A (da) | 1983-10-28 |
| GB2133401B (en) | 1985-10-23 |
| BE896572A (fr) | 1983-10-26 |
| DE3315106A1 (de) | 1983-11-03 |
| GR78481B (ko) | 1984-09-27 |
| FR2525603A1 (fr) | 1983-10-28 |
| MA19783A1 (fr) | 1983-12-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR840004428A (ko) | 벤조 아자시클로 알킬-스피로-이미다졸리딘의 제조방법 | |
| KR860004060A (ko) | 티에닐 축합 피라졸 유도체의 제조방법 | |
| KR850006939A (ko) | 아실트리펩타이드의 제조방법 | |
| KR890004201A (ko) | 포지티브 방사선-감수성 혼합물 | |
| KR860008160A (ko) | 아닐리노 벤조디옥솔 화합물의 제조방법 | |
| KR830006198A (ko) | 시클로헥산 유도체의 제조방법 | |
| KR840004422A (ko) | 사이프로헵타딘-3-카복실산의 에스테르 및 관련 화합물의 제조방법 | |
| KR830004320A (ko) | 퀴나졸린 유도체의 제조방법 | |
| KR830005168A (ko) | 5-(디하이드록시페녹시)테트라졸의 제조방법 | |
| KR830006302A (ko) | 신규 피리미딘 유도체의 제조방법 | |
| KR840002000A (ko) | 8-[3-(6-플루오로-1,2-벤즈이속사졸-3-일)프로필]-1-페닐-1,3,8-트리아자스피로[4,5] 데칸-4-온의 제조방법 | |
| KR830005191A (ko) | 푸란유도체의 제조방법 | |
| KR850004470A (ko) | 유기 화합물의 제조방법 | |
| KR840001160A (ko) | 벤조디옥산-이미다졸린 유도체의 제조방법 | |
| KR840009086A (ko) | 1-치환아제티딘-3-올 유도체의 제법 | |
| KR830009077A (ko) | 푸란 유도체의 제조방법 | |
| KR830006176A (ko) | 치환된 펜옥시-아미노프로판올 유도체의 제조방법 | |
| KR830009043A (ko) | 4-(1-이미다졸일메틸)신남산 하이드로클로라이드 모노하이드레이트의 제조방법 | |
| KR830010094A (ko) | 크로몬의 제조방법 | |
| KR850004760A (ko) | 이미다조 퀴놀린 유도체의 제조방법 | |
| KR840003639A (ko) | 이속사졸로피리미딘 유도체의 제조방법 | |
| KR840002853A (ko) | 아미노프로필아미노 블레오마이신 유도체류와 그 제조방법 | |
| KR830003398A (ko) | 2-아미노-3-(알킬티오벤조일)-페닐아세트산 | |
| KR850004581A (ko) | α,α-디메틸페닐아세트아닐리드 유도체의 제조방법 | |
| KR830010097A (ko) | 2,4-디옥사 사이클로헥사논 유도체의 제조방법 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |