PT76595A - Procede de preparation de benzoazacycloalkyl-spiro-imidazolidines - Google Patents
Procede de preparation de benzoazacycloalkyl-spiro-imidazolidinesInfo
- Publication number
- PT76595A PT76595A PT76595A PT7659583A PT76595A PT 76595 A PT76595 A PT 76595A PT 76595 A PT76595 A PT 76595A PT 7659583 A PT7659583 A PT 7659583A PT 76595 A PT76595 A PT 76595A
- Authority
- PT
- Portugal
- Prior art keywords
- benzoazacycloalkyl
- imidazolidines
- spiro
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8207203A FR2525603A1 (fr) | 1982-04-27 | 1982-04-27 | Benzoazacycloalkyl-spiro-imidazolinines, leur preparation et leur application en therapeutique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT76595A true PT76595A (fr) | 1983-05-01 |
| PT76595B PT76595B (fr) | 1986-01-21 |
Family
ID=9273425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT76595A PT76595B (fr) | 1982-04-27 | 1983-04-26 | Procede de preparation de benzoazacycloalkyl-spiro-imidazolidines |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JPS5910584A (fr) |
| KR (1) | KR840004428A (fr) |
| AT (1) | ATA125383A (fr) |
| AU (1) | AU1395383A (fr) |
| BE (1) | BE896572A (fr) |
| DD (1) | DD209833A5 (fr) |
| DE (1) | DE3315106A1 (fr) |
| DK (1) | DK183583A (fr) |
| ES (1) | ES521895A0 (fr) |
| FR (1) | FR2525603A1 (fr) |
| GB (1) | GB2133401B (fr) |
| GR (1) | GR78481B (fr) |
| IL (1) | IL68497A0 (fr) |
| IT (1) | IT1167123B (fr) |
| LU (1) | LU84770A1 (fr) |
| MA (1) | MA19783A1 (fr) |
| NL (1) | NL8301476A (fr) |
| NO (1) | NO831473L (fr) |
| OA (1) | OA07412A (fr) |
| PT (1) | PT76595B (fr) |
| SE (1) | SE8302347L (fr) |
| ZA (1) | ZA832927B (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU617541B2 (en) * | 1988-10-20 | 1991-11-28 | Wyeth | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors |
| US4927831A (en) * | 1988-10-20 | 1990-05-22 | American Home Products | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors |
| US6953787B2 (en) | 2002-04-12 | 2005-10-11 | Arena Pharmaceuticals, Inc. | 5HT2C receptor modulators |
| EP2189448B1 (fr) | 2003-06-17 | 2014-01-29 | Arena Pharmaceuticals, Inc. | Procédés de séparation de racemates de 3-Benzazepines |
| CN101792417A (zh) | 2003-06-17 | 2010-08-04 | 艾尼纳制药公司 | 用于治疗5ht2c受体相关疾病的苯并氮杂卓衍生物 |
| KR101281919B1 (ko) | 2004-12-21 | 2013-07-03 | 아레나 파마슈티칼스, 인크. | (ｒ)-8-클로로-1-메틸-2,3,4,5-테트라히드로-1ｈ-3-벤즈아제핀 히드로클로라이드의 결정질 형태 |
| PT1833473E (pt) | 2004-12-23 | 2009-12-17 | Arena Pharm Inc | Composições de modulador de receptor 5ht2c e métodos de utilização |
| EP2001852A2 (fr) | 2006-04-03 | 2008-12-17 | Arena Pharmaceuticals, Inc. | Procédés de préparation de 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine et produits intermédiaires associés |
| CA2670285A1 (fr) | 2006-12-05 | 2008-06-12 | Arena Pharmaceuticals, Inc. | Procedes de preparation de (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine et intermediaires de celle-ci |
| JP5491421B2 (ja) | 2008-03-04 | 2014-05-14 | アリーナ ファーマシューティカルズ， インコーポレイテッド | ５−ｈｔ２ｃアゴニストである（ｒ）−８−クロロ−１−メチル−２，３，４，５−テトラヒドロ−１ｈ−３−ベンゾアゼピンに関連する中間体の調製のためのプロセス |
| CN102648170A (zh) | 2009-06-18 | 2012-08-22 | 艾尼纳制药公司 | 制备5-ht2c受体激动剂的方法 |
| US9045431B2 (en) | 2010-06-02 | 2015-06-02 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-HT2C receptor agonists |
| EP2939677A1 (fr) | 2010-09-01 | 2015-11-04 | Arena Pharmaceuticals, Inc. | Administration de lorcasérine à des individus avec une insuffisance rénale |
| CN103189360A (zh) | 2010-09-01 | 2013-07-03 | 艾尼纳制药公司 | 5-ht2c激动剂的非吸湿性盐 |
| ES2704455T3 (es) | 2010-09-01 | 2019-03-18 | Arena Pharm Inc | Formas farmacéuticas de liberación modificada de agonistas de 5-HT2C útiles para la gestión del peso |
| WO2012030938A1 (fr) | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | Sels de lorcasérine dotés d'acides optiquement actifs |
| AU2012392187B2 (en) | 2012-10-09 | 2018-07-12 | Arena Pharmaceuticals, Inc. | Method of weight management |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4209630A (en) * | 1976-10-18 | 1980-06-24 | Pfizer Inc. | Hydantoin derivatives as therapeutic agents |
| US4235911A (en) * | 1979-06-13 | 1980-11-25 | Pfizer Inc. | Hydantoin derivatives |
-
1982
- 1982-04-27 FR FR8207203A patent/FR2525603A1/fr active Granted
-
1983
- 1983-04-08 AT AT0125383A patent/ATA125383A/de not_active IP Right Cessation
- 1983-04-25 DD DD83250187A patent/DD209833A5/de unknown
- 1983-04-25 LU LU84770A patent/LU84770A1/fr unknown
- 1983-04-26 NO NO831473A patent/NO831473L/no unknown
- 1983-04-26 KR KR1019830001753A patent/KR840004428A/ko not_active Application Discontinuation
- 1983-04-26 JP JP58073687A patent/JPS5910584A/ja active Pending
- 1983-04-26 IL IL68497A patent/IL68497A0/xx unknown
- 1983-04-26 PT PT76595A patent/PT76595B/fr unknown
- 1983-04-26 GR GR71214A patent/GR78481B/el unknown
- 1983-04-26 ZA ZA832927A patent/ZA832927B/xx unknown
- 1983-04-26 DK DK183583A patent/DK183583A/da not_active Application Discontinuation
- 1983-04-26 SE SE8302347A patent/SE8302347L/xx not_active Application Discontinuation
- 1983-04-26 IT IT48155/83A patent/IT1167123B/it active
- 1983-04-26 NL NL8301476A patent/NL8301476A/nl not_active Application Discontinuation
- 1983-04-26 BE BE0/210633A patent/BE896572A/fr not_active IP Right Cessation
- 1983-04-26 AU AU13953/83A patent/AU1395383A/en not_active Abandoned
- 1983-04-27 OA OA57984A patent/OA07412A/fr unknown
- 1983-04-27 ES ES521895A patent/ES521895A0/es active Granted
- 1983-04-27 MA MA20003A patent/MA19783A1/fr unknown
- 1983-04-27 GB GB08311508A patent/GB2133401B/en not_active Expired
- 1983-04-27 DE DE19833315106 patent/DE3315106A1/de not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| ES8405796A1 (es) | 1984-06-16 |
| SE8302347L (sv) | 1983-10-28 |
| IT1167123B (it) | 1987-05-13 |
| ES521895A0 (es) | 1984-06-16 |
| GB2133401A (en) | 1984-07-25 |
| DK183583D0 (da) | 1983-04-26 |
| PT76595B (fr) | 1986-01-21 |
| DD209833A5 (de) | 1984-05-23 |
| ATA125383A (de) | 1986-05-15 |
| KR840004428A (ko) | 1984-10-15 |
| LU84770A1 (fr) | 1984-11-28 |
| JPS5910584A (ja) | 1984-01-20 |
| SE8302347D0 (sv) | 1983-04-26 |
| IL68497A0 (en) | 1983-07-31 |
| OA07412A (fr) | 1984-11-30 |
| NL8301476A (nl) | 1983-11-16 |
| ZA832927B (en) | 1984-06-27 |
| AU1395383A (en) | 1983-11-03 |
| IT8348155A0 (it) | 1983-04-26 |
| NO831473L (no) | 1983-10-28 |
| FR2525603B1 (fr) | 1984-09-14 |
| GB8311508D0 (en) | 1983-06-02 |
| DK183583A (da) | 1983-10-28 |
| GB2133401B (en) | 1985-10-23 |
| BE896572A (fr) | 1983-10-26 |
| DE3315106A1 (de) | 1983-11-03 |
| GR78481B (fr) | 1984-09-27 |
| FR2525603A1 (fr) | 1983-10-28 |
| MA19783A1 (fr) | 1983-12-31 |
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