DK183583A - Fremgangsmaade til fremstilling af benzoazacycloalkyl-spiro-imidazolidiner - Google Patents
Fremgangsmaade til fremstilling af benzoazacycloalkyl-spiro-imidazolidiner Download PDFInfo
- Publication number
- DK183583A DK183583A DK183583A DK183583A DK183583A DK 183583 A DK183583 A DK 183583A DK 183583 A DK183583 A DK 183583A DK 183583 A DK183583 A DK 183583A DK 183583 A DK183583 A DK 183583A
- Authority
- DK
- Denmark
- Prior art keywords
- benzoazacycloalkyl
- imidazolidines
- spiro
- preparing
- procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8207203A FR2525603A1 (fr) | 1982-04-27 | 1982-04-27 | Benzoazacycloalkyl-spiro-imidazolinines, leur preparation et leur application en therapeutique |
FR8207203 | 1982-04-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
DK183583D0 DK183583D0 (da) | 1983-04-26 |
DK183583A true DK183583A (da) | 1983-10-28 |
Family
ID=9273425
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK183583A DK183583A (da) | 1982-04-27 | 1983-04-26 | Fremgangsmaade til fremstilling af benzoazacycloalkyl-spiro-imidazolidiner |
Country Status (22)
Country | Link |
---|---|
JP (1) | JPS5910584A (fr) |
KR (1) | KR840004428A (fr) |
AT (1) | ATA125383A (fr) |
AU (1) | AU1395383A (fr) |
BE (1) | BE896572A (fr) |
DD (1) | DD209833A5 (fr) |
DE (1) | DE3315106A1 (fr) |
DK (1) | DK183583A (fr) |
ES (1) | ES521895A0 (fr) |
FR (1) | FR2525603A1 (fr) |
GB (1) | GB2133401B (fr) |
GR (1) | GR78481B (fr) |
IL (1) | IL68497A0 (fr) |
IT (1) | IT1167123B (fr) |
LU (1) | LU84770A1 (fr) |
MA (1) | MA19783A1 (fr) |
NL (1) | NL8301476A (fr) |
NO (1) | NO831473L (fr) |
OA (1) | OA07412A (fr) |
PT (1) | PT76595B (fr) |
SE (1) | SE8302347L (fr) |
ZA (1) | ZA832927B (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU617541B2 (en) * | 1988-10-20 | 1991-11-28 | Wyeth | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors |
US4927831A (en) * | 1988-10-20 | 1990-05-22 | American Home Products | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors |
US6953787B2 (en) | 2002-04-12 | 2005-10-11 | Arena Pharmaceuticals, Inc. | 5HT2C receptor modulators |
EA016485B1 (ru) | 2003-06-17 | 2012-05-30 | Арена Фармасьютикалз, Инк. | Способы получения 3-бензазепинов |
EP2332920A3 (fr) | 2003-06-17 | 2011-12-21 | Arena Pharmaceuticals, Inc. | Procédés de préparation de 3-benzazepines |
CN102321023A (zh) | 2004-12-21 | 2012-01-18 | 艾尼纳制药公司 | (r)-8-氯-1-甲基-2,3,4,5-四氢-1h-3-苯并氮杂卓盐酸盐的晶型 |
EA201100129A1 (ru) | 2004-12-23 | 2011-10-31 | Арена Фармасьютикалз, Инк. | Композиции и способы применения модулятора рецептора 5ht-2c |
EP2518053A1 (fr) | 2006-04-03 | 2012-10-31 | Arena Pharmaceuticals, Inc. | Procédé de préparation de la 8-chloro-1-méthyl-2,3,4,5-tétrahydro-1H-3-benzazépine |
JP5404414B2 (ja) | 2006-12-05 | 2014-01-29 | アリーナ ファーマシューティカルズ, インコーポレイテッド | (r)−8−クロロ−1−メチル−2,3,4,5−テトラヒドロ−1h−3−ベンゾアゼピンおよびその中間体を調製するための方法 |
JP5491421B2 (ja) | 2008-03-04 | 2014-05-14 | アリーナ ファーマシューティカルズ, インコーポレイテッド | 5−ht2cアゴニストである(r)−8−クロロ−1−メチル−2,3,4,5−テトラヒドロ−1h−3−ベンゾアゼピンに関連する中間体の調製のためのプロセス |
WO2010148207A2 (fr) | 2009-06-18 | 2010-12-23 | Arena Pharmaceuticals, Inc. | Procédés pour la préparation d'agonistes du récepteur 5-ht2c |
KR20130112848A (ko) | 2010-06-02 | 2013-10-14 | 아레나 파마슈티칼스, 인크. | 5-ht2c 수용체 아고니스트의 제조 방법 |
EP2939677A1 (fr) | 2010-09-01 | 2015-11-04 | Arena Pharmaceuticals, Inc. | Administration de lorcasérine à des individus avec une insuffisance rénale |
WO2012030938A1 (fr) | 2010-09-01 | 2012-03-08 | Arena Pharmaceuticals, Inc. | Sels de lorcasérine dotés d'acides optiquement actifs |
KR20130101524A (ko) | 2010-09-01 | 2013-09-13 | 아레나 파마슈티칼스, 인크. | 5-ht2c 아고니스트의 비-흡습성 염 |
AU2011296003B2 (en) | 2010-09-01 | 2015-11-12 | Arena Pharmaceuticals, Inc. | Modified-release dosage forms of 5-HT2C agonist useful for weight management |
KR20190128001A (ko) | 2012-10-09 | 2019-11-13 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 체중 관리 방법 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4209630A (en) * | 1976-10-18 | 1980-06-24 | Pfizer Inc. | Hydantoin derivatives as therapeutic agents |
US4235911A (en) * | 1979-06-13 | 1980-11-25 | Pfizer Inc. | Hydantoin derivatives |
-
1982
- 1982-04-27 FR FR8207203A patent/FR2525603A1/fr active Granted
-
1983
- 1983-04-08 AT AT0125383A patent/ATA125383A/de not_active IP Right Cessation
- 1983-04-25 DD DD83250187A patent/DD209833A5/de unknown
- 1983-04-25 LU LU84770A patent/LU84770A1/fr unknown
- 1983-04-26 BE BE0/210633A patent/BE896572A/fr not_active IP Right Cessation
- 1983-04-26 AU AU13953/83A patent/AU1395383A/en not_active Abandoned
- 1983-04-26 NO NO831473A patent/NO831473L/no unknown
- 1983-04-26 SE SE8302347A patent/SE8302347L/xx not_active Application Discontinuation
- 1983-04-26 KR KR1019830001753A patent/KR840004428A/ko not_active Application Discontinuation
- 1983-04-26 ZA ZA832927A patent/ZA832927B/xx unknown
- 1983-04-26 IT IT48155/83A patent/IT1167123B/it active
- 1983-04-26 PT PT76595A patent/PT76595B/fr unknown
- 1983-04-26 IL IL68497A patent/IL68497A0/xx unknown
- 1983-04-26 DK DK183583A patent/DK183583A/da not_active Application Discontinuation
- 1983-04-26 NL NL8301476A patent/NL8301476A/nl not_active Application Discontinuation
- 1983-04-26 GR GR71214A patent/GR78481B/el unknown
- 1983-04-26 JP JP58073687A patent/JPS5910584A/ja active Pending
- 1983-04-27 MA MA20003A patent/MA19783A1/fr unknown
- 1983-04-27 GB GB08311508A patent/GB2133401B/en not_active Expired
- 1983-04-27 DE DE19833315106 patent/DE3315106A1/de not_active Withdrawn
- 1983-04-27 OA OA57984A patent/OA07412A/fr unknown
- 1983-04-27 ES ES521895A patent/ES521895A0/es active Granted
Also Published As
Publication number | Publication date |
---|---|
PT76595A (fr) | 1983-05-01 |
SE8302347D0 (sv) | 1983-04-26 |
AU1395383A (en) | 1983-11-03 |
ES8405796A1 (es) | 1984-06-16 |
IL68497A0 (en) | 1983-07-31 |
GB2133401A (en) | 1984-07-25 |
DE3315106A1 (de) | 1983-11-03 |
FR2525603A1 (fr) | 1983-10-28 |
KR840004428A (ko) | 1984-10-15 |
FR2525603B1 (fr) | 1984-09-14 |
GR78481B (fr) | 1984-09-27 |
ES521895A0 (es) | 1984-06-16 |
IT8348155A0 (it) | 1983-04-26 |
SE8302347L (sv) | 1983-10-28 |
OA07412A (fr) | 1984-11-30 |
IT1167123B (it) | 1987-05-13 |
LU84770A1 (fr) | 1984-11-28 |
PT76595B (fr) | 1986-01-21 |
MA19783A1 (fr) | 1983-12-31 |
DD209833A5 (de) | 1984-05-23 |
JPS5910584A (ja) | 1984-01-20 |
NL8301476A (nl) | 1983-11-16 |
ZA832927B (en) | 1984-06-27 |
DK183583D0 (da) | 1983-04-26 |
BE896572A (fr) | 1983-10-26 |
GB8311508D0 (en) | 1983-06-02 |
ATA125383A (de) | 1986-05-15 |
GB2133401B (en) | 1985-10-23 |
NO831473L (no) | 1983-10-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AHB | Application shelved due to non-payment |