ES410174A1 - Procedimiento para la preparacion de etambutol. - Google Patents

Procedimiento para la preparacion de etambutol.

Info

Publication number
ES410174A1
ES410174A1 ES410174A ES410174A ES410174A1 ES 410174 A1 ES410174 A1 ES 410174A1 ES 410174 A ES410174 A ES 410174A ES 410174 A ES410174 A ES 410174A ES 410174 A1 ES410174 A1 ES 410174A1
Authority
ES
Spain
Prior art keywords
buten
ethambutol
preparation
chloro
benzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES410174A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmaceutici Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia SpA filed Critical Farmaceutici Italia SpA
Publication of ES410174A1 publication Critical patent/ES410174A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/14—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic the nitrogen atom of the amino group being further bound to hydrocarbon groups substituted by amino groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Procedimiento para la preparación de etambutol, caracterizado porque se hace reaccionar 1,2- epoxi-3-buteno (I) con fosgeno , a una temperatura comprendida ente -40ºC y la temperatura ambiente, en presencia o no de pequeñas cantidades de una base de nitrógeno para obtener cloroformato de 2-cloro-3-buten-1-ol (II) que se hace reaccionar en frío con una bencilamina de estructura R-C6H4-CH2-NH2, en donde R representa un sustituyente elegido del grupo constituido por hidrógeno, metilo, halógeno, nitro y amino, para obtener N-benciluretano de 2-cloro-3-buten-1-ol (III), que se trata con un equivalente de hidróxido alcalino para obtener 4-vinil-3-bencil-oxazolidin-2-ona (IV) que a temperatura superior y en presencia de un exceso de hidróxido alcalino da 2-bencil-amino-3-buten-1-ol (V) que se resuelve en los antípodas ópticos en forma conocida y porque se condensa el antípoda dextrógiro con un derivado de etano elegido del grupo constituido por 1,2-haloetano y 1,2-ditosiloxietano para obtener (+)-2,2''-(N,N''-dibencil-etilendiimino)-di-3-buten-1-ol(VI) , que produce el etambutol por hidrogenación catalítica.
ES410174A 1971-12-30 1972-12-29 Procedimiento para la preparacion de etambutol. Expired ES410174A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT3311771 1971-12-30

Publications (1)

Publication Number Publication Date
ES410174A1 true ES410174A1 (es) 1975-12-16

Family

ID=11236499

Family Applications (1)

Application Number Title Priority Date Filing Date
ES410174A Expired ES410174A1 (es) 1971-12-30 1972-12-29 Procedimiento para la preparacion de etambutol.

Country Status (11)

Country Link
US (1) US3847991A (es)
AT (1) AT320604B (es)
DE (1) DE2263715C3 (es)
DK (1) DK135799B (es)
ES (1) ES410174A1 (es)
GB (1) GB1388510A (es)
HU (1) HU164598B (es)
NO (1) NO135285C (es)
SE (1) SE390633B (es)
SU (1) SU498902A3 (es)
YU (1) YU35869B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4370500A (en) * 1978-11-06 1983-01-25 American Cyanamid Company Compound: d-N-(2-amino-2-phenethyl)-2-methoxyethylamine and process for preparing the same by selective crystallization
US4272455A (en) * 1979-12-26 1981-06-09 The Dow Chemical Company Production of monoalkyleneglycols, monoalkanolamines and alkylenediamine
US7652039B2 (en) 2002-05-17 2010-01-26 Sequella, Inc. Methods of use and compositions for the diagnosis and treatment of infectious disease
US7456222B2 (en) * 2002-05-17 2008-11-25 Sequella, Inc. Anti tubercular drug: compositions and methods
US20040033986A1 (en) * 2002-05-17 2004-02-19 Protopopova Marina Nikolaevna Anti tubercular drug: compositions and methods
WO2005034857A2 (en) * 2003-09-05 2005-04-21 Sequella, Inc. Methods and compositions comprising diamines as new anti-tubercular therapeutics
US20090281054A1 (en) * 2008-05-06 2009-11-12 Venkata Reddy Compositions and methods comprising capuramycin analogues
US10806078B2 (en) 2017-05-12 2020-10-20 Deere & Company Control system for adjusting conditioning rollers of work vehicle
US10912255B2 (en) 2017-05-12 2021-02-09 Deere & Company Control system for adjusting forming shield of windrowing work vehicle
US10813287B2 (en) 2017-05-12 2020-10-27 Deere & Company Control system for adjusting swath flap of windrowing work vehicle
US11375663B2 (en) 2019-02-15 2022-07-05 Deere & Company Ground contour sensing system for crop mowing head
RU2712231C1 (ru) * 2019-07-30 2020-01-27 Федеральное государственное бюджетное учреждение науки Институт элементоорганических соединений им. А.Н. Несмеянова Российской академии наук (ИНЭОС РАН) Способ получения этамбутола

Also Published As

Publication number Publication date
NO135285B (es) 1976-12-06
SE390633B (sv) 1977-01-03
DE2263715B2 (de) 1977-08-11
AT320604B (de) 1975-02-25
YU35869B (en) 1981-08-31
DE2263715C3 (de) 1978-04-06
DK135799C (es) 1978-01-02
DE2263715A1 (de) 1973-07-05
DK135799B (da) 1977-06-27
GB1388510A (en) 1975-03-26
HU164598B (es) 1974-03-28
SU498902A3 (ru) 1976-01-05
YU323872A (en) 1981-02-28
US3847991A (en) 1974-11-12
NO135285C (es) 1977-03-16

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