ES2149354T3 - Solucion acuosa, estable de folinato. - Google Patents

Solucion acuosa, estable de folinato.

Info

Publication number
ES2149354T3
ES2149354T3 ES95913428T ES95913428T ES2149354T3 ES 2149354 T3 ES2149354 T3 ES 2149354T3 ES 95913428 T ES95913428 T ES 95913428T ES 95913428 T ES95913428 T ES 95913428T ES 2149354 T3 ES2149354 T3 ES 2149354T3
Authority
ES
Spain
Prior art keywords
stable
aqueous
folinate
folinate solution
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95913428T
Other languages
English (en)
Inventor
Alfred James Nijkerk
Johanna Maria Pieterne Vermeer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmachemie BV
Original Assignee
Pharmachemie BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmachemie BV filed Critical Pharmachemie BV
Application granted granted Critical
Publication of ES2149354T3 publication Critical patent/ES2149354T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

LA INVENCION PROPORCIONA UN SOLUCION ACUOSA DE FOLINATO APROPIADA PARA APLICACIONES MEDICAS EN FORMA DE SOLUCION DE FOLINATO SODICO QUE ES ESTABLE CUANDO ES ALMACENADA A TEMPERATURAS DE REFRIGERADOR, P.E. NO CRISTALIZA
ES95913428T 1994-04-05 1995-04-04 Solucion acuosa, estable de folinato. Expired - Lifetime ES2149354T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL9400530A NL9400530A (nl) 1994-04-05 1994-04-05 Stabiele waterige folinaatoplossing.

Publications (1)

Publication Number Publication Date
ES2149354T3 true ES2149354T3 (es) 2000-11-01

Family

ID=19864026

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95913428T Expired - Lifetime ES2149354T3 (es) 1994-04-05 1995-04-04 Solucion acuosa, estable de folinato.

Country Status (15)

Country Link
US (1) US6613767B1 (es)
EP (1) EP0755396B1 (es)
JP (1) JPH09510989A (es)
AT (1) ATE194346T1 (es)
AU (1) AU684350B2 (es)
DE (1) DE69517806T2 (es)
DK (1) DK0755396T3 (es)
ES (1) ES2149354T3 (es)
FI (1) FI120039B (es)
GR (1) GR3033863T3 (es)
NL (1) NL9400530A (es)
NO (1) NO314039B1 (es)
PT (1) PT755396E (es)
WO (1) WO1995026963A1 (es)
ZA (1) ZA952805B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH687062A5 (de) * 1994-02-14 1996-09-13 Cerbios Pharma Sa Konzentrierte Injektionsloesung von Alkalimetallsalzen von reduzierten Folaten.
NL9400530A (nl) 1994-04-05 1995-11-01 Pharmachemie Bv Stabiele waterige folinaatoplossing.
CH697021A5 (de) * 2003-06-26 2008-03-31 Merck Eprova Ag Stabile pharmazeutische Zusammensetzungen von 5, 10-Methylentetrahydrofolat.
CH696717A5 (de) * 2004-02-20 2007-10-31 Cerbios Pharma Sa Konzentrierte, stabile Losung, insbesondere eine Injektionslosung oder Infusionslosung, welche nebst Wasser entweder (6S)-Natrium-Folinat oder (6S)-Kalium-Folinat entholt
CN102258463A (zh) * 2011-07-18 2011-11-30 重庆煜澍丰医药有限公司 一种稳定的亚叶酸钠注射液
ES2414557B1 (es) * 2012-01-16 2014-06-10 Novocat Farma, S.A. Composición acuosa de paracetamol para inyección
WO2014025807A1 (en) 2012-08-06 2014-02-13 Spectrum Pharmaceuticals, Inc. Pharmaceutical compositions comprising l-leucovorin
US10059710B2 (en) 2016-02-17 2018-08-28 Merck & Cie Stable formulations of 5,10-methylene-(6R)-tetrahydrofolic acid

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2695860A (en) * 1952-04-29 1954-11-30 American Cyanamid Co Stabilized pteroyl solutions
CH673459A5 (es) 1987-05-15 1990-03-15 Eprova Ag
WO1990010460A1 (en) 1989-03-13 1990-09-20 Kenneth Naoyuki Matsumura Method for reducing side effects of a drug
NL8901432A (nl) * 1989-06-06 1991-01-02 Pharmachemie Bv Bij koelkasttemperatuur stabiele waterige folinaatoplossing, alsmede werkwijze ter bereiding daarvan.
US5173488A (en) * 1989-08-21 1992-12-22 American Cyanamid Company Stable injectable pharmaceutical formulation for folic acid and leucovorin salts and method
CH687062A5 (de) 1994-02-14 1996-09-13 Cerbios Pharma Sa Konzentrierte Injektionsloesung von Alkalimetallsalzen von reduzierten Folaten.
NL9400530A (nl) 1994-04-05 1995-11-01 Pharmachemie Bv Stabiele waterige folinaatoplossing.

Also Published As

Publication number Publication date
GR3033863T3 (en) 2000-10-31
DK0755396T3 (da) 2000-11-13
NO964231D0 (no) 1996-10-04
WO1995026963A1 (en) 1995-10-12
FI963972A (fi) 1996-10-03
ZA952805B (en) 1995-12-19
NO964231L (no) 1996-10-04
PT755396E (pt) 2000-10-31
US6613767B1 (en) 2003-09-02
EP0755396A1 (en) 1997-01-29
AU684350B2 (en) 1997-12-11
AU2086295A (en) 1995-10-23
JPH09510989A (ja) 1997-11-04
DE69517806T2 (de) 2001-11-08
EP0755396B1 (en) 2000-07-05
FI120039B (fi) 2009-06-15
DE69517806D1 (de) 2000-08-10
ATE194346T1 (de) 2000-07-15
NL9400530A (nl) 1995-11-01
NO314039B1 (no) 2003-01-20
FI963972A0 (fi) 1996-10-03

Similar Documents

Publication Publication Date Title
ES2136103T3 (es) Procedimiento para la preparacion de derivados de estaurosporina.
TNSN92022A1 (fr) Procede de preparation de nouveaux derives de l'indole
ES2149354T3 (es) Solucion acuosa, estable de folinato.
DK113183D0 (da) Kroneetherforbindelser, deres fremstilling og anvendelse
DK0474037T3 (da) Fremgangsmåde til fremstilling af 3-methyl-pyrazol
KR830004320A (ko) 퀴나졸린 유도체의 제조방법
FI95777C (fi) Menetelmä 8-N-(dietyyliaminoetyyli)rebekkamysiinin stabiilin vesiliuoksen valmistamiseksi
HRP20000749B1 (en) Purification of carboxaldehyde
ES532698A0 (es) Un procedimiento para preparar 1, 2, 3-triazino-(4', 5' : 4 ; 5) tieno (2, 3-b)-quinolin-4 (3h)-onas.
SE7907815L (sv) Cefalosporinforeningar
EP0490224A3 (de) Salicylaldehyd- und Salicylsäurederivate sowie deren Schwefelanaloge, Verfahren und Zwischenprodukte zu ihrer Herstellung
SE8206352D0 (sv) Sett att framstella bensylalkoholderivat
UA6327A1 (uk) Спосіб одержання похідних галоідпірідіна
ES481295A1 (es) Un procedimiento para preparar la forma cristalina metanola-to de cefamandol sodico.
ES2006164A6 (es) Un metodo para preparar derivados de acido benzoico
KR830003398A (ko) 2-아미노-3-(알킬티오벤조일)-페닐아세트산
GB1496100A (en) Ureidoacetic acid derivatives
KR860009020A (ko) 히드록시메틸세펨 화합물의 제조방법
KR860004015A (ko) 아릴 치환된 아미디노 우레아 유도체의 제조방법
KR860004008A (ko) 부타놀유도체의 제법
ES2091007T3 (es) Procedimiento para la obtencion de 5-dicloroacetil-3,3,6-trimetil-9-oxo-1,5-diazabiciclo(4,3,0)nonano.
JPS6468354A (en) Novel indoleacetic acid derivative
KR830001230A (ko) 글라우신 포스페이트 염류
ES2084757T3 (es) Procedimiento para la preparacion de derivados de piperazinilpirimidina.
GB1359425A (en) 2,4-diamino-5- -3,4,5-trimethoxybenzyl- -6-arylsulphonyloxypyri midines

Legal Events

Date Code Title Description
FC2A Grant refused

Effective date: 19981020

FG2A Definitive protection

Ref document number: 755396

Country of ref document: ES