KR830001889A - 7-아실인돌린-2-온류의 제조방법 - Google Patents

7-아실인돌린-2-온류의 제조방법

Info

Publication number
KR830001889A
KR830001889A KR1019800000617A KR800000617A KR830001889A KR 830001889 A KR830001889 A KR 830001889A KR 1019800000617 A KR1019800000617 A KR 1019800000617A KR 800000617 A KR800000617 A KR 800000617A KR 830001889 A KR830001889 A KR 830001889A
Authority
KR
South Korea
Prior art keywords
structural formula
acyl
lower alkyl
hydrogen
indoline
Prior art date
Application number
KR1019800000617A
Other languages
English (en)
Other versions
KR840001211B1 (ko
Inventor
로 영석
알란 월쉬 데비드
죤 웰스테드 제이알 윌리암
Original Assignee
로버트 피 울프
에이 에취 로번스 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 로버트 피 울프, 에이 에취 로번스 캄파니 filed Critical 로버트 피 울프
Publication of KR830001889A publication Critical patent/KR830001889A/ko
Application granted granted Critical
Publication of KR840001211B1 publication Critical patent/KR840001211B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

7-아실인돌린-2-온류의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 염화붕소 및 염화알미늄 존재하에서 구조식(Ⅰ)의 인돌린과 구조식 R1CN의 니트릴이 아실화반응(Acylation)으로 생성되는 구조식(Ⅱ)의 7-아실인돌린을 탈수소반응(Dehydrogenation)을 시켜 구조식(Ⅲ)의 7-아실인돌을 만들고 다시 이를 할로겐화반응(Halogen ation)을 시켜 생성되는 구조식(Ⅳ)의 7-아실-3-할로인돌을 인산존재하에서 가수분해(Hydrolysis)하여 구조식(Ⅴ)의 7-아실인돌린-2-온을 제조하는 방법.
    상기 구조식에서
    R은 수소, 할로겐, 저급알킬, 저급알콕시, 및 트리플루오로메틸이고
    R1은 저급알킬, 알킬페닐, 시클로알킬 및 아릴이고
    R2는 수소, 저급알킬 및 벤질이다.
  2. 특허청구의 범위 1의 제조방법에 따라 제조한 7-아실인돌린-2-온을 수용성 염기용액에서 가수분해하여 구조식(Ⅵ)의 2-아미노-3-아실페닐아세트산을 제조하는 방법.
    상기 구조식에서
    R, R1및 R2는 상기 정의와 동일하고
    R3는 수소 저급알킬 또는 양이온이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019800000617A 1979-02-16 1980-02-15 7-아실인돌린-2-온의 제조방법 KR840001211B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/012,698 US4221716A (en) 1979-02-16 1979-02-16 Intermediate and process for the preparation of 7-acylindolin-2-ones
US12698 1979-02-16

Publications (2)

Publication Number Publication Date
KR830001889A true KR830001889A (ko) 1983-05-19
KR840001211B1 KR840001211B1 (ko) 1984-08-21

Family

ID=21756265

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019800000617A KR840001211B1 (ko) 1979-02-16 1980-02-15 7-아실인돌린-2-온의 제조방법

Country Status (24)

Country Link
US (1) US4221716A (ko)
JP (2) JPS55111464A (ko)
KR (1) KR840001211B1 (ko)
AT (2) AT375914B (ko)
AU (2) AU538598B2 (ko)
BE (1) BE881632A (ko)
CA (1) CA1128529A (ko)
CH (1) CH648828A5 (ko)
DE (1) DE3005709A1 (ko)
DK (1) DK157850C (ko)
ES (2) ES8103040A1 (ko)
FI (1) FI75805C (ko)
FR (1) FR2449083A1 (ko)
GB (2) GB2098208B (ko)
IE (1) IE49384B1 (ko)
IL (1) IL59143A (ko)
IT (1) IT1128362B (ko)
MX (1) MX6151E (ko)
NL (1) NL190283C (ko)
NO (2) NO154837C (ko)
NZ (1) NZ192886A (ko)
PH (1) PH15317A (ko)
SE (3) SE447824B (ko)
ZA (1) ZA80889B (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4016580A (en) * 1975-04-21 1977-04-05 Polaroid Corporation Folding viewfinding and flash mounting assembly
IN163263B (ko) * 1984-02-07 1988-08-27 Pfizer
US4569942A (en) * 1984-05-04 1986-02-11 Pfizer Inc. N,3-Disubstituted 2-oxindole-1-carboxamides as analgesic and antiinflammatory agents
US4690943A (en) * 1984-09-19 1987-09-01 Pfizer Inc. Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds
CH687764A5 (de) * 1992-07-02 1997-02-14 Lonza Ag Gampel Wallis Geschof Verfahren zur Herstellung von 7-Acylindolen.
US7186745B2 (en) 2001-03-06 2007-03-06 Astrazeneca Ab Indolone derivatives having vascular damaging activity

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3597503A (en) * 1967-12-06 1971-08-03 Hooker Chemical Corp Cyclic phosphoroamidates and process for making same
US3975521A (en) * 1969-06-30 1976-08-17 Dow Corning Corporation Prostate carcinoma treatment
NL90149C (ko) * 1972-05-17
US3897451A (en) * 1973-04-27 1975-07-29 Univ Ohio State Res Found Synthesis of oxindoles from anilines and intermediates therein
US3975531A (en) * 1973-10-02 1976-08-17 A. H. Robins Company, Incorporated 4-(5- And 7-)benzoylindolin-2-ones and pharmaceutical uses thereof
SE400966B (sv) * 1975-08-13 1978-04-17 Robins Co Inc A H Forfarande for framstellning av 2-amino-3-(eller 5-)bensoyl-fenylettiksyror
AT339294B (de) * 1975-12-22 1977-10-10 Robins Co Inc A H Verfahren zur herstellung von 4-(5- oder 7-)-benzoylindolin-2-onen

Also Published As

Publication number Publication date
SE8001009L (sv) 1980-08-17
DE3005709A1 (de) 1980-08-28
JPH0325423B2 (ko) 1991-04-05
NL190283C (nl) 1994-01-03
AT375914B (de) 1984-09-25
NO154837C (no) 1987-01-07
DK67380A (da) 1980-08-17
IT1128362B (it) 1986-05-28
DE3005709C2 (ko) 1988-03-10
ES488622A0 (es) 1981-02-16
ES8103040A1 (es) 1981-02-16
AU538598B2 (en) 1984-08-23
GB2098208B (en) 1983-10-26
GB2098208A (en) 1982-11-17
FR2449083A1 (fr) 1980-09-12
IL59143A0 (en) 1980-05-30
IL59143A (en) 1983-12-30
NO861360L (no) 1980-08-18
ES8106703A1 (es) 1981-08-01
FI75805C (fi) 1988-08-08
NO166365C (no) 1991-07-10
PH15317A (en) 1982-11-18
BE881632A (fr) 1980-05-30
JPH01265074A (ja) 1989-10-23
MX6151E (es) 1984-11-28
ATA286983A (de) 1985-09-15
SE8405429D0 (sv) 1984-10-30
ES491847A0 (es) 1981-08-01
IE800234L (en) 1980-08-16
IE49384B1 (en) 1985-10-02
JPS55111464A (en) 1980-08-28
KR840001211B1 (ko) 1984-08-21
ATA80080A (de) 1984-02-15
SE8405430L (sv) 1984-10-30
AU564500B2 (en) 1987-08-13
SE8405429L (sv) 1984-10-30
FR2449083B1 (ko) 1983-07-29
GB2042541B (en) 1983-03-09
ZA80889B (en) 1981-05-27
SE447824B (sv) 1986-12-15
NO800399L (no) 1980-08-18
IT8067232A0 (it) 1980-02-15
JPH0379347B2 (ko) 1991-12-18
NO154837B (no) 1986-09-22
US4221716A (en) 1980-09-09
CH648828A5 (fr) 1985-04-15
NL190283B (nl) 1993-08-02
CA1128529A (en) 1982-07-27
AU2930984A (en) 1984-10-04
GB2042541A (en) 1980-09-24
NO166365B (no) 1991-04-02
FI75805B (fi) 1988-04-29
SE8405430D0 (sv) 1984-10-30
NL8000968A (nl) 1980-08-19
AU5487380A (en) 1980-08-21
FI800464A (fi) 1980-08-17
NZ192886A (en) 1982-09-14
AT380235B (de) 1986-04-25
SE451720B (sv) 1987-10-26
DK157850C (da) 1990-07-30
DK157850B (da) 1990-02-26

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