KR830001867A - 신규 1-아릴-2-아실아미도-3-플루오로-1-프로판올, 그들의 제법 및 그들을 함유하는 약제학적 조성물 - Google Patents

신규 1-아릴-2-아실아미도-3-플루오로-1-프로판올, 그들의 제법 및 그들을 함유하는 약제학적 조성물

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KR830001867A
KR830001867A KR1019800000370A KR800000370A KR830001867A KR 830001867 A KR830001867 A KR 830001867A KR 1019800000370 A KR1019800000370 A KR 1019800000370A KR 800000370 A KR800000370 A KR 800000370A KR 830001867 A KR830001867 A KR 830001867A
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general formula
group
hydrogen
carbon atoms
formula
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KR1019800000370A
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KR840001837B1 (ko
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엘. 나가부산 타탄할리
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스타이나 칸스타트, 로즈마리 아이젠링
쉐링 코포레이션
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Application filed by 스타이나 칸스타트, 로즈마리 아이젠링, 쉐링 코포레이션 filed Critical 스타이나 칸스타트, 로즈마리 아이젠링
Priority to KR1019830000545A priority Critical patent/KR840001963B1/ko
Priority to KR1019830000546A priority patent/KR840001964B1/ko
Publication of KR830001867A publication Critical patent/KR830001867A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/28—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with modified 2-carboxyl group
    • C07D499/32—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
    • C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

내용 없음

Description

신규 1-아릴-2-아실아미도-3-플루오로-1-프로판올, 그들의 제법 및 그들을 함유하는 약제학적 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 일반식 Ⅱ의 아민을, 구조식 R, COOH의 유리산이나 이의 반응성 유도체로 N- 아실화 하거나, 일반식 Ⅳ의 옥사졸린을 개환시키는 동시에 프로판 부분의 3 위치를 불소화 하거나, 페닐부분의 하나 또는 양쪽의 파라 및 메타 위치에 X 또는 X′의 전구체인 X″를 갖는 점이 일반식 Ⅰ의 목적 생성물과 틀린 출발물질을 처리하여 X″를 X 또는 X′로 전환시키고
    R이일반식 Ⅰ의 출발물질을 중수소화 하여 R이구조식 Ⅰ의 상응 중수소 화합물을 얻고, 필요하면, 2-하이드록시 관능기를 에스테르화 하거나 가수분해하고, Z가 디카복실산이나 아미노산으로부터 유도된 아실라디칼인 약제학적으로 무독한 염을 형성하는 단계중 하나 또는 그 이상을 거치는 것을 특징으로 하여 일반식 Ⅰ 화합물을 제조하는 방법.
    상기 구조식에서
    R은 하나나 그 이상의 할로겐 원소로 치환될 수 있는 탄소수 하나 또는 둘의 알킬그룹을 나타내거나, 아자이도 메틸, 메틸설포닐메틸이나, Y가 -CH3, -CH2할(Hal)이나 할이고, 할은 할로겐 원소를 나타내는 할로듀테로 알킬그룹나타내고
    X 및 X′는 각각 수소나 할로겐원소, 니트로, 시아노 또는, 페닐그룹이 할로겐이나 저급알킬, 저급알콕시, 메틸설포닐이나 니트로로 치환될 수 있는 페닐그룹, 또는 그룹 R1(A)n을 나타내는데, n은 0 또는 1이고 A는 산소, 황, 카보닐, 설피닐이나 설포닐이고 R1은 저급알킬이거나, A가 설피닐이나 설포닐일 때는 R1도 아미노나 저급알킬아미노일 수 있고, 전기한 저급알킬이나 저급알콕시 그룹은 탄소수 1내지 3이며 는 수소거나, 탄소수 16까지의 카복실산의 아실라디칼인데 단 일반식 Ⅱ 및 Ⅳ에서는 수소인 것이 가장 바람직하다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019800000370A 1979-02-05 1980-01-31 1-아릴-2-아실아미도-3-플루오로-1-프로판올의 제조방법 KR840001837B1 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR1019830000545A KR840001963B1 (ko) 1979-02-05 1983-02-10 1-아릴-2-아실아미도-3-플루오로-1-프로판올의 제조방법
KR1019830000546A KR840001964B1 (ko) 1979-02-05 1983-02-10 1-아릴-2-아실아미도-3-플루오로-1-프로판올의 제조방법

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9207 1979-02-05
US06/009,207 US4235892A (en) 1979-02-05 1979-02-05 1-Aryl-2-acylamido-3-fluoro-1-propanols, methods for their use as antibacterial agents and compositions useful therefor
US009.207 1979-02-05

Related Child Applications (2)

Application Number Title Priority Date Filing Date
KR1019830000546A Division KR840001964B1 (ko) 1979-02-05 1983-02-10 1-아릴-2-아실아미도-3-플루오로-1-프로판올의 제조방법
KR1019830000545A Division KR840001963B1 (ko) 1979-02-05 1983-02-10 1-아릴-2-아실아미도-3-플루오로-1-프로판올의 제조방법

Publications (2)

Publication Number Publication Date
KR830001867A true KR830001867A (ko) 1983-05-19
KR840001837B1 KR840001837B1 (ko) 1984-10-22

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ID=21736232

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KR1019800000370A KR840001837B1 (ko) 1979-02-05 1980-01-31 1-아릴-2-아실아미도-3-플루오로-1-프로판올의 제조방법
KR1019830000546A KR840001964B1 (ko) 1979-02-05 1983-02-10 1-아릴-2-아실아미도-3-플루오로-1-프로판올의 제조방법
KR1019830000545A KR840001963B1 (ko) 1979-02-05 1983-02-10 1-아릴-2-아실아미도-3-플루오로-1-프로판올의 제조방법

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KR1019830000546A KR840001964B1 (ko) 1979-02-05 1983-02-10 1-아릴-2-아실아미도-3-플루오로-1-프로판올의 제조방법
KR1019830000545A KR840001963B1 (ko) 1979-02-05 1983-02-10 1-아릴-2-아실아미도-3-플루오로-1-프로판올의 제조방법

Country Status (18)

Country Link
US (1) US4235892A (ko)
EP (1) EP0014437B1 (ko)
JP (1) JPS5923300B2 (ko)
KR (3) KR840001837B1 (ko)
AR (3) AR230260A1 (ko)
AT (1) ATE2616T1 (ko)
AU (1) AU532879B2 (ko)
CA (1) CA1137106A (ko)
DE (1) DE3062094D1 (ko)
DK (1) DK159264C (ko)
HU (1) HU180555B (ko)
IE (1) IE49740B1 (ko)
IL (1) IL59288A (ko)
MX (1) MX9203279A (ko)
MY (1) MY8500051A (ko)
NL (1) NL950004I2 (ko)
NZ (1) NZ192774A (ko)
ZA (1) ZA80478B (ko)

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KR100896646B1 (ko) * 2002-08-21 2009-05-08 주식회사 포스코 스트립 산세조의 스트립 리프터를 이용한 염산액자동샘플링 장치

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KR840001964B1 (ko) 1984-10-26
IE800198L (en) 1980-08-05
KR830001869A (ko) 1983-05-19
EP0014437A2 (en) 1980-08-20
IE49740B1 (en) 1985-12-11
AU5507880A (en) 1980-07-10
DK159264B (da) 1990-09-24
EP0014437B1 (en) 1983-02-23
NL950004I2 (nl) 1998-04-01
HU180555B (en) 1983-03-28
AR230260A1 (es) 1984-03-01
MX9203279A (es) 1992-07-31
ZA80478B (en) 1981-01-28
ATE2616T1 (de) 1983-03-15
IL59288A (en) 1984-06-29
DE3062094D1 (en) 1983-03-31
JPS5923300B2 (ja) 1984-06-01
JPS55115855A (en) 1980-09-06
KR840001963B1 (ko) 1984-10-26
AR230427A1 (es) 1984-04-30
KR830001868A (ko) 1983-05-19
KR840001837B1 (ko) 1984-10-22
AR230428A1 (es) 1984-04-30
IL59288A0 (en) 1980-05-30
NZ192774A (en) 1984-08-24
CA1137106A (en) 1982-12-07
EP0014437A3 (en) 1980-10-29
AU532879B2 (en) 1983-10-20
MY8500051A (en) 1985-12-31
US4235892A (en) 1980-11-25
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DK42480A (da) 1980-08-06
DK159264C (da) 1991-02-18

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