KR830003478A - 6-N-프로필-8α-메톡시메틸 또는 메틸메르캅토메틸 에르골린 유도체의 제조방법 - Google Patents

6-N-프로필-8α-메톡시메틸 또는 메틸메르캅토메틸 에르골린 유도체의 제조방법 Download PDF

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Publication number
KR830003478A
KR830003478A KR1019800003793A KR800003793A KR830003478A KR 830003478 A KR830003478 A KR 830003478A KR 1019800003793 A KR1019800003793 A KR 1019800003793A KR 800003793 A KR800003793 A KR 800003793A KR 830003478 A KR830003478 A KR 830003478A
Authority
KR
South Korea
Prior art keywords
propyl
preparing
methoxymethyl
ergoline derivative
methyl mercaptomethyl
Prior art date
Application number
KR1019800003793A
Other languages
English (en)
Inventor
칼 콘펠드 에드먼드
제임스 배취 콜라스
Original Assignee
아더 알. 웨일
일라이 릴리 앤드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아더 알. 웨일, 일라이 릴리 앤드 캄파니 filed Critical 아더 알. 웨일
Publication of KR830003478A publication Critical patent/KR830003478A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8

Abstract

내용 없음

Description

6-N-프로필-8α-메톡시메틸 또는 메틸메르캅토메틸 에르골림 유도체의 제조방법.
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. D-6-n프로필-8α-메실옥시메틸에르골린을 메틸메르캅탄의 나트륨염이나 나트륨 메틸레이트와 반응시키고 임의로 약학적으로 무독한 산부가염을 유리시킴을 특징으로 하여 다음 구조식(Ⅰ)의 D-6-n-프로필 에르골린 및 이들의 약학적으로 무독한 산부가염을 제조하는 방법.
    상기 구조식에서
    Y는 산소 또는 황이며
    R1은 n-프로필을 나타낸다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019800003793A 1979-10-01 1980-09-30 6-N-프로필-8α-메톡시메틸 또는 메틸메르캅토메틸 에르골린 유도체의 제조방법 KR830003478A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80768 1979-10-01
US06/080,768 US4246265A (en) 1979-10-01 1979-10-01 6-n-Propyl-8α-methoxymethyl or methylmercaptomethylergolines and related compounds

Publications (1)

Publication Number Publication Date
KR830003478A true KR830003478A (ko) 1983-06-20

Family

ID=22159504

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019800003793A KR830003478A (ko) 1979-10-01 1980-09-30 6-N-프로필-8α-메톡시메틸 또는 메틸메르캅토메틸 에르골린 유도체의 제조방법

Country Status (32)

Country Link
US (1) US4246265A (ko)
EP (1) EP0026671B1 (ko)
JP (1) JPS5657787A (ko)
KR (1) KR830003478A (ko)
AT (1) AT373251B (ko)
AU (1) AU529508B2 (ko)
BE (1) BE885385A (ko)
BG (1) BG34908A3 (ko)
CA (1) CA1137079A (ko)
CH (1) CH645642A5 (ko)
CS (1) CS223834B2 (ko)
DD (1) DD153372A5 (ko)
DE (1) DE3069771D1 (ko)
DK (1) DK413780A (ko)
EG (1) EG14583A (ko)
ES (1) ES495520A0 (ko)
FI (1) FI803025A (ko)
FR (1) FR2466465A1 (ko)
GB (1) GB2058790B (ko)
GR (1) GR70067B (ko)
HU (1) HU181766B (ko)
IE (1) IE50429B1 (ko)
IL (1) IL61143A0 (ko)
IT (1) IT1133631B (ko)
NZ (1) NZ195053A (ko)
PH (1) PH15021A (ko)
PL (1) PL226917A1 (ko)
PT (1) PT71840B (ko)
RO (1) RO81115B (ko)
SU (1) SU976851A3 (ko)
YU (1) YU247280A (ko)
ZA (1) ZA805959B (ko)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH644606A5 (de) * 1980-09-23 1984-08-15 Sandoz Ag Verfahren zur isomerisierung von 9,10-dihydrolysergsaeurederivaten.
DE3216870A1 (de) * 1982-05-03 1983-11-03 Schering AG, 1000 Berlin und 4709 Bergkamen Pharmazeutische zubereitungen mit zytostatischer wirkung
US4675322A (en) * 1984-12-10 1987-06-23 Eli Lilly And Company 1-Substituted-6-n-propyl-8β-methylthio-methylergolines
US4683313A (en) * 1985-06-24 1987-07-28 Eli Lilly And Company 2-alkyl(or phenyl)thio-6-N alkyl ergolines and 4-dialkylaminotetrahydrobenz[c,d]indoles
US4782152A (en) * 1985-08-16 1988-11-01 Eli Lilly And Company Decyanation of pergolide intermediate
US4772709A (en) * 1985-10-01 1988-09-20 Eli Lilly And Company Process of making ketoalkanol esters of dihydrolysergic acid
FR2589734B1 (fr) * 1985-11-13 1988-09-02 Roussel Uclaf Utilisation de derives de l'ergoline a l'obtention d'un medicament a visee geriatrique
US5668155A (en) * 1988-05-10 1997-09-16 The General Hospital Corporation Administration of pirenzepine, methyl scopolamine and other muscarinic receptor antagonists for treatment of lipid metabolism disorders
DE3913756A1 (de) * 1989-04-21 1990-10-25 Schering Ag 8(beta)-substituierte ergoline, verfahren zu ihrer herstellung und ihre verwendung
IT1307934B1 (it) 1999-01-27 2001-11-29 Poli Ind Chimica Spa Processo per la preparazione di derivati alchimercaptometilergolinici.
US6388079B1 (en) * 2000-08-29 2002-05-14 Scinopharm Singapore Pte Ltd. Process for preparing pergolide
AU2003221494A1 (en) * 2002-03-15 2003-09-29 Antibioticos S.P.A. Process for the synthesis of pergolide
US8821915B2 (en) 2002-08-09 2014-09-02 Veroscience, Llc Therapeutic process for the treatment of the metabolic syndrome and associated metabolic disorders
GB0409785D0 (en) * 2004-04-30 2004-06-09 Resolution Chemicals Ltd Preparation of cabergoline
US7339060B2 (en) 2005-03-23 2008-03-04 Resolution Chemicals, Ltd. Preparation of cabergoline
GB0505965D0 (en) * 2005-03-23 2005-04-27 Resolution Chemicals Ltd Preparation of cabergoline
US20070197576A1 (en) * 2006-02-08 2007-08-23 Resolution Chemicals Limited Production of Cabergoline and Novel Polymorphic Form Thereof
US20190374534A1 (en) 2018-06-08 2019-12-12 Boehringer Ingelheim Vetmedica Gmbh Liquid pharmaceutical compositions comprising pergolide

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3901894A (en) * 1974-06-06 1975-08-26 Lilly Co Eli 8-thiomethylergolines
DE2657771A1 (de) * 1976-01-02 1977-07-14 Sandoz Ag Neue organische verbindungen, ihre verwendung und herstellung
US4166182A (en) * 1978-02-08 1979-08-28 Eli Lilly And Company 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
US4202979A (en) * 1979-01-11 1980-05-13 Eli Lilly And Company 6-Ethyl(or allyl)-8-methoxymethyl or methylmercaptomethylergolines and related compounds

Also Published As

Publication number Publication date
EP0026671B1 (en) 1984-12-05
FR2466465A1 (fr) 1981-04-10
GB2058790B (en) 1983-06-08
RO81115B (ro) 1983-02-28
AU529508B2 (en) 1983-06-09
PT71840A (en) 1980-10-01
IL61143A0 (en) 1980-11-30
ES8200697A1 (es) 1981-11-16
FR2466465B1 (ko) 1983-11-25
PT71840B (en) 1981-06-09
AT373251B (de) 1984-01-10
IE50429B1 (en) 1986-04-16
BE885385A (fr) 1981-03-25
US4246265A (en) 1981-01-20
CS223834B2 (en) 1983-11-25
DK413780A (da) 1981-04-02
EG14583A (en) 1985-03-31
EP0026671A1 (en) 1981-04-08
FI803025A (fi) 1981-04-02
CH645642A5 (fr) 1984-10-15
HU181766B (en) 1983-11-28
DD153372A5 (de) 1982-01-06
DE3069771D1 (en) 1985-01-17
IT1133631B (it) 1986-07-09
GB2058790A (en) 1981-04-15
JPS5657787A (en) 1981-05-20
CA1137079A (en) 1982-12-07
IE802036L (en) 1981-04-01
NZ195053A (en) 1983-07-29
IT8025004A0 (it) 1980-09-29
RO81115A (ro) 1983-02-15
ATA487480A (de) 1983-05-15
SU976851A3 (ru) 1982-11-23
AU6280780A (en) 1981-04-09
PL226917A1 (ko) 1981-06-05
ES495520A0 (es) 1981-11-16
BG34908A3 (en) 1983-12-15
ZA805959B (en) 1982-04-28
PH15021A (en) 1982-05-13
GR70067B (ko) 1982-07-26
YU247280A (en) 1983-02-28

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