DD153372A5 - Verfahren zur herstellung von neuen ergolinderivaten - Google Patents

Verfahren zur herstellung von neuen ergolinderivaten Download PDF

Info

Publication number
DD153372A5
DD153372A5 DD80224224A DD22422480A DD153372A5 DD 153372 A5 DD153372 A5 DD 153372A5 DD 80224224 A DD80224224 A DD 80224224A DD 22422480 A DD22422480 A DD 22422480A DD 153372 A5 DD153372 A5 DD 153372A5
Authority
DD
German Democratic Republic
Prior art keywords
propyl
preparation
8alpha
prolactin
acid
Prior art date
Application number
DD80224224A
Other languages
German (de)
English (en)
Inventor
Edmund C Kornfeld
Nicholas J Bach
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DD153372A5 publication Critical patent/DD153372A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
DD80224224A 1979-10-01 1980-09-30 Verfahren zur herstellung von neuen ergolinderivaten DD153372A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/080,768 US4246265A (en) 1979-10-01 1979-10-01 6-n-Propyl-8α-methoxymethyl or methylmercaptomethylergolines and related compounds

Publications (1)

Publication Number Publication Date
DD153372A5 true DD153372A5 (de) 1982-01-06

Family

ID=22159504

Family Applications (1)

Application Number Title Priority Date Filing Date
DD80224224A DD153372A5 (de) 1979-10-01 1980-09-30 Verfahren zur herstellung von neuen ergolinderivaten

Country Status (32)

Country Link
US (1) US4246265A (ko)
EP (1) EP0026671B1 (ko)
JP (1) JPS5657787A (ko)
KR (1) KR830003478A (ko)
AT (1) AT373251B (ko)
AU (1) AU529508B2 (ko)
BE (1) BE885385A (ko)
BG (1) BG34908A3 (ko)
CA (1) CA1137079A (ko)
CH (1) CH645642A5 (ko)
CS (1) CS223834B2 (ko)
DD (1) DD153372A5 (ko)
DE (1) DE3069771D1 (ko)
DK (1) DK413780A (ko)
EG (1) EG14583A (ko)
ES (1) ES495520A0 (ko)
FI (1) FI803025A (ko)
FR (1) FR2466465A1 (ko)
GB (1) GB2058790B (ko)
GR (1) GR70067B (ko)
HU (1) HU181766B (ko)
IE (1) IE50429B1 (ko)
IL (1) IL61143A0 (ko)
IT (1) IT1133631B (ko)
NZ (1) NZ195053A (ko)
PH (1) PH15021A (ko)
PL (1) PL226917A1 (ko)
PT (1) PT71840B (ko)
RO (1) RO81115B (ko)
SU (1) SU976851A3 (ko)
YU (1) YU247280A (ko)
ZA (1) ZA805959B (ko)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH644606A5 (de) * 1980-09-23 1984-08-15 Sandoz Ag Verfahren zur isomerisierung von 9,10-dihydrolysergsaeurederivaten.
DE3216870A1 (de) * 1982-05-03 1983-11-03 Schering AG, 1000 Berlin und 4709 Bergkamen Pharmazeutische zubereitungen mit zytostatischer wirkung
US4675322A (en) * 1984-12-10 1987-06-23 Eli Lilly And Company 1-Substituted-6-n-propyl-8β-methylthio-methylergolines
US4683313A (en) * 1985-06-24 1987-07-28 Eli Lilly And Company 2-alkyl(or phenyl)thio-6-N alkyl ergolines and 4-dialkylaminotetrahydrobenz[c,d]indoles
US4782152A (en) * 1985-08-16 1988-11-01 Eli Lilly And Company Decyanation of pergolide intermediate
US4772709A (en) * 1985-10-01 1988-09-20 Eli Lilly And Company Process of making ketoalkanol esters of dihydrolysergic acid
FR2589734B1 (fr) * 1985-11-13 1988-09-02 Roussel Uclaf Utilisation de derives de l'ergoline a l'obtention d'un medicament a visee geriatrique
US5668155A (en) * 1988-05-10 1997-09-16 The General Hospital Corporation Administration of pirenzepine, methyl scopolamine and other muscarinic receptor antagonists for treatment of lipid metabolism disorders
DE3913756A1 (de) * 1989-04-21 1990-10-25 Schering Ag 8(beta)-substituierte ergoline, verfahren zu ihrer herstellung und ihre verwendung
IT1307934B1 (it) * 1999-01-27 2001-11-29 Poli Ind Chimica Spa Processo per la preparazione di derivati alchimercaptometilergolinici.
US6388079B1 (en) * 2000-08-29 2002-05-14 Scinopharm Singapore Pte Ltd. Process for preparing pergolide
DE60324776D1 (de) * 2002-03-15 2009-01-02 Antibioticos Spa Verfahren zur synthese von pergolid
US8821915B2 (en) 2002-08-09 2014-09-02 Veroscience, Llc Therapeutic process for the treatment of the metabolic syndrome and associated metabolic disorders
GB0409785D0 (en) * 2004-04-30 2004-06-09 Resolution Chemicals Ltd Preparation of cabergoline
US7339060B2 (en) 2005-03-23 2008-03-04 Resolution Chemicals, Ltd. Preparation of cabergoline
GB0505965D0 (en) * 2005-03-23 2005-04-27 Resolution Chemicals Ltd Preparation of cabergoline
US20070197576A1 (en) * 2006-02-08 2007-08-23 Resolution Chemicals Limited Production of Cabergoline and Novel Polymorphic Form Thereof
US20190374534A1 (en) 2018-06-08 2019-12-12 Boehringer Ingelheim Vetmedica Gmbh Liquid pharmaceutical compositions comprising pergolide

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3901894A (en) * 1974-06-06 1975-08-26 Lilly Co Eli 8-thiomethylergolines
DE2657771A1 (de) * 1976-01-02 1977-07-14 Sandoz Ag Neue organische verbindungen, ihre verwendung und herstellung
US4166182A (en) * 1978-02-08 1979-08-28 Eli Lilly And Company 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
US4202979A (en) * 1979-01-11 1980-05-13 Eli Lilly And Company 6-Ethyl(or allyl)-8-methoxymethyl or methylmercaptomethylergolines and related compounds

Also Published As

Publication number Publication date
EG14583A (en) 1985-03-31
CA1137079A (en) 1982-12-07
BG34908A3 (en) 1983-12-15
RO81115B (ro) 1983-02-28
DK413780A (da) 1981-04-02
EP0026671A1 (en) 1981-04-08
SU976851A3 (ru) 1982-11-23
BE885385A (fr) 1981-03-25
KR830003478A (ko) 1983-06-20
CS223834B2 (en) 1983-11-25
AU529508B2 (en) 1983-06-09
PT71840A (en) 1980-10-01
NZ195053A (en) 1983-07-29
PH15021A (en) 1982-05-13
ZA805959B (en) 1982-04-28
FR2466465B1 (ko) 1983-11-25
CH645642A5 (fr) 1984-10-15
HU181766B (en) 1983-11-28
RO81115A (ro) 1983-02-15
IT1133631B (it) 1986-07-09
PT71840B (en) 1981-06-09
ES8200697A1 (es) 1981-11-16
GR70067B (ko) 1982-07-26
IE50429B1 (en) 1986-04-16
IL61143A0 (en) 1980-11-30
ATA487480A (de) 1983-05-15
IE802036L (en) 1981-04-01
JPS5657787A (en) 1981-05-20
GB2058790A (en) 1981-04-15
AT373251B (de) 1984-01-10
DE3069771D1 (en) 1985-01-17
FR2466465A1 (fr) 1981-04-10
EP0026671B1 (en) 1984-12-05
ES495520A0 (es) 1981-11-16
US4246265A (en) 1981-01-20
YU247280A (en) 1983-02-28
FI803025A (fi) 1981-04-02
IT8025004A0 (it) 1980-09-29
PL226917A1 (ko) 1981-06-05
GB2058790B (en) 1983-06-08
AU6280780A (en) 1981-04-09

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