RO81115B - Procedeu pentru prepararea unor d-6-n-propilergoline - Google Patents
Procedeu pentru prepararea unor d-6-n-propilergolineInfo
- Publication number
- RO81115B RO81115B RO102217A RO10221780A RO81115B RO 81115 B RO81115 B RO 81115B RO 102217 A RO102217 A RO 102217A RO 10221780 A RO10221780 A RO 10221780A RO 81115 B RO81115 B RO 81115B
- Authority
- RO
- Romania
- Prior art keywords
- propylengolins
- preparing
- sodium
- propylglycines
- methyloxymethylergoline
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedeu pentru prepararea unor D-6-n-propilergoline cu formula generala I: (vezi formula) în care Y reprezinta oxigen sau sulf, caracterizat prin aceea ca se aduce în reactie D-6-n-propil-8-metiloximetilergolina cu metilmercaptanat de sodiu sau metilat de sodiu, la temepartura de 25...100 degree C, în solvent ales dintre dimetilformamida, metilacetamida si dimetilsulfoxid sub atmosfera de azot, apoi produsul de reactie este, eventual, trecut sub forma de sare acceptabila farmaceutic, în mod în sine cunoscut.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/080,768 US4246265A (en) | 1979-10-01 | 1979-10-01 | 6-n-Propyl-8α-methoxymethyl or methylmercaptomethylergolines and related compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
RO81115A RO81115A (ro) | 1983-02-15 |
RO81115B true RO81115B (ro) | 1983-02-28 |
Family
ID=22159504
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RO102217A RO81115B (ro) | 1979-10-01 | 1980-09-25 | Procedeu pentru prepararea unor d-6-n-propilergoline |
Country Status (32)
Country | Link |
---|---|
US (1) | US4246265A (ro) |
EP (1) | EP0026671B1 (ro) |
JP (1) | JPS5657787A (ro) |
KR (1) | KR830003478A (ro) |
AT (1) | AT373251B (ro) |
AU (1) | AU529508B2 (ro) |
BE (1) | BE885385A (ro) |
BG (1) | BG34908A3 (ro) |
CA (1) | CA1137079A (ro) |
CH (1) | CH645642A5 (ro) |
CS (1) | CS223834B2 (ro) |
DD (1) | DD153372A5 (ro) |
DE (1) | DE3069771D1 (ro) |
DK (1) | DK413780A (ro) |
EG (1) | EG14583A (ro) |
ES (1) | ES495520A0 (ro) |
FI (1) | FI803025A (ro) |
FR (1) | FR2466465A1 (ro) |
GB (1) | GB2058790B (ro) |
GR (1) | GR70067B (ro) |
HU (1) | HU181766B (ro) |
IE (1) | IE50429B1 (ro) |
IL (1) | IL61143A0 (ro) |
IT (1) | IT1133631B (ro) |
NZ (1) | NZ195053A (ro) |
PH (1) | PH15021A (ro) |
PL (1) | PL226917A1 (ro) |
PT (1) | PT71840B (ro) |
RO (1) | RO81115B (ro) |
SU (1) | SU976851A3 (ro) |
YU (1) | YU247280A (ro) |
ZA (1) | ZA805959B (ro) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH644606A5 (de) * | 1980-09-23 | 1984-08-15 | Sandoz Ag | Verfahren zur isomerisierung von 9,10-dihydrolysergsaeurederivaten. |
DE3216870A1 (de) * | 1982-05-03 | 1983-11-03 | Schering AG, 1000 Berlin und 4709 Bergkamen | Pharmazeutische zubereitungen mit zytostatischer wirkung |
US4675322A (en) * | 1984-12-10 | 1987-06-23 | Eli Lilly And Company | 1-Substituted-6-n-propyl-8β-methylthio-methylergolines |
US4683313A (en) * | 1985-06-24 | 1987-07-28 | Eli Lilly And Company | 2-alkyl(or phenyl)thio-6-N alkyl ergolines and 4-dialkylaminotetrahydrobenz[c,d]indoles |
US4782152A (en) * | 1985-08-16 | 1988-11-01 | Eli Lilly And Company | Decyanation of pergolide intermediate |
US4772709A (en) * | 1985-10-01 | 1988-09-20 | Eli Lilly And Company | Process of making ketoalkanol esters of dihydrolysergic acid |
FR2589734B1 (fr) * | 1985-11-13 | 1988-09-02 | Roussel Uclaf | Utilisation de derives de l'ergoline a l'obtention d'un medicament a visee geriatrique |
US5668155A (en) * | 1988-05-10 | 1997-09-16 | The General Hospital Corporation | Administration of pirenzepine, methyl scopolamine and other muscarinic receptor antagonists for treatment of lipid metabolism disorders |
DE3913756A1 (de) * | 1989-04-21 | 1990-10-25 | Schering Ag | 8(beta)-substituierte ergoline, verfahren zu ihrer herstellung und ihre verwendung |
IT1307934B1 (it) * | 1999-01-27 | 2001-11-29 | Poli Ind Chimica Spa | Processo per la preparazione di derivati alchimercaptometilergolinici. |
US6388079B1 (en) * | 2000-08-29 | 2002-05-14 | Scinopharm Singapore Pte Ltd. | Process for preparing pergolide |
AU2003221494A1 (en) | 2002-03-15 | 2003-09-29 | Antibioticos S.P.A. | Process for the synthesis of pergolide |
US8821915B2 (en) | 2002-08-09 | 2014-09-02 | Veroscience, Llc | Therapeutic process for the treatment of the metabolic syndrome and associated metabolic disorders |
GB0409785D0 (en) * | 2004-04-30 | 2004-06-09 | Resolution Chemicals Ltd | Preparation of cabergoline |
US7339060B2 (en) | 2005-03-23 | 2008-03-04 | Resolution Chemicals, Ltd. | Preparation of cabergoline |
GB0505965D0 (en) * | 2005-03-23 | 2005-04-27 | Resolution Chemicals Ltd | Preparation of cabergoline |
US20070197576A1 (en) * | 2006-02-08 | 2007-08-23 | Resolution Chemicals Limited | Production of Cabergoline and Novel Polymorphic Form Thereof |
AU2015320975B2 (en) | 2014-09-25 | 2020-10-08 | Boehringer Ingelheim Vetmedica Gmbh | Combination treatment of SGLT2 inhibitors and dopamine agonists for preventing metabolic disorders in equine animals |
WO2019234069A1 (en) | 2018-06-08 | 2019-12-12 | Boehringer Ingelheim Vetmedica Gmbh | Liquid pharmaceutical compositions comprising pergolide |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3901894A (en) * | 1974-06-06 | 1975-08-26 | Lilly Co Eli | 8-thiomethylergolines |
DE2657771A1 (de) * | 1976-01-02 | 1977-07-14 | Sandoz Ag | Neue organische verbindungen, ihre verwendung und herstellung |
US4166182A (en) * | 1978-02-08 | 1979-08-28 | Eli Lilly And Company | 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds |
US4202979A (en) * | 1979-01-11 | 1980-05-13 | Eli Lilly And Company | 6-Ethyl(or allyl)-8-methoxymethyl or methylmercaptomethylergolines and related compounds |
-
1979
- 1979-10-01 US US06/080,768 patent/US4246265A/en not_active Expired - Lifetime
-
1980
- 1980-09-25 PL PL22691780A patent/PL226917A1/xx unknown
- 1980-09-25 GR GR62959A patent/GR70067B/el unknown
- 1980-09-25 ZA ZA00805959A patent/ZA805959B/xx unknown
- 1980-09-25 FR FR8020639A patent/FR2466465A1/fr active Granted
- 1980-09-25 NZ NZ195053A patent/NZ195053A/xx unknown
- 1980-09-25 CA CA000361035A patent/CA1137079A/en not_active Expired
- 1980-09-25 BE BE1/9966A patent/BE885385A/fr not_active IP Right Cessation
- 1980-09-25 RO RO102217A patent/RO81115B/ro unknown
- 1980-09-25 FI FI803025A patent/FI803025A/fi not_active Application Discontinuation
- 1980-09-26 IL IL61143A patent/IL61143A0/xx unknown
- 1980-09-26 PT PT71840A patent/PT71840B/pt unknown
- 1980-09-26 CS CS806515A patent/CS223834B2/cs unknown
- 1980-09-27 EG EG80594A patent/EG14583A/xx active
- 1980-09-29 HU HU802373A patent/HU181766B/hu unknown
- 1980-09-29 JP JP13668780A patent/JPS5657787A/ja active Pending
- 1980-09-29 BG BG8049173A patent/BG34908A3/xx unknown
- 1980-09-29 IT IT25004/80A patent/IT1133631B/it active
- 1980-09-29 YU YU02472/80A patent/YU247280A/xx unknown
- 1980-09-30 AT AT0487480A patent/AT373251B/de not_active IP Right Cessation
- 1980-09-30 ES ES495520A patent/ES495520A0/es active Granted
- 1980-09-30 PH PH24648A patent/PH15021A/en unknown
- 1980-09-30 KR KR1019800003793A patent/KR830003478A/ko unknown
- 1980-09-30 DK DK413780A patent/DK413780A/da not_active Application Discontinuation
- 1980-09-30 AU AU62807/80A patent/AU529508B2/en not_active Ceased
- 1980-09-30 IE IE2036/80A patent/IE50429B1/en unknown
- 1980-09-30 GB GB8031440A patent/GB2058790B/en not_active Expired
- 1980-09-30 EP EP80303447A patent/EP0026671B1/en not_active Expired
- 1980-09-30 DE DE8080303447T patent/DE3069771D1/de not_active Expired
- 1980-09-30 DD DD80224224A patent/DD153372A5/de unknown
- 1980-09-30 CH CH730780A patent/CH645642A5/fr not_active IP Right Cessation
- 1980-10-01 SU SU802984351A patent/SU976851A3/ru active
Also Published As
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