AR230260A1 - Procedimiento para la preparacion de un compuesto d-(treo)-1-aril-2-acilamido-3-fluor-1-propanol - Google Patents

Procedimiento para la preparacion de un compuesto d-(treo)-1-aril-2-acilamido-3-fluor-1-propanol

Info

Publication number
AR230260A1
AR230260A1 AR279823A AR27982380A AR230260A1 AR 230260 A1 AR230260 A1 AR 230260A1 AR 279823 A AR279823 A AR 279823A AR 27982380 A AR27982380 A AR 27982380A AR 230260 A1 AR230260 A1 AR 230260A1
Authority
AR
Argentina
Prior art keywords
acilamido
aril
treo
fluor
propanol
Prior art date
Application number
AR279823A
Other languages
English (en)
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21736232&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR230260(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of AR230260A1 publication Critical patent/AR230260A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/28—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with modified 2-carboxyl group
    • C07D499/32—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
    • C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AR279823A 1979-02-05 1980-01-31 Procedimiento para la preparacion de un compuesto d-(treo)-1-aril-2-acilamido-3-fluor-1-propanol AR230260A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/009,207 US4235892A (en) 1979-02-05 1979-02-05 1-Aryl-2-acylamido-3-fluoro-1-propanols, methods for their use as antibacterial agents and compositions useful therefor

Publications (1)

Publication Number Publication Date
AR230260A1 true AR230260A1 (es) 1984-03-01

Family

ID=21736232

Family Applications (3)

Application Number Title Priority Date Filing Date
AR279823A AR230260A1 (es) 1979-02-05 1980-01-31 Procedimiento para la preparacion de un compuesto d-(treo)-1-aril-2-acilamido-3-fluor-1-propanol
AR286303A AR230427A1 (es) 1979-02-05 1981-07-31 Procedimiento para la preparacion de un compuesto d-(treo)-aril-2-acilamido-3-fluor-1-propanol
AR286304A AR230428A1 (es) 1979-02-05 1981-07-31 Procedimiento para la preparacion de un compuesto d-(treo)-aril-2-acilamido-3-fluor-1-propanol

Family Applications After (2)

Application Number Title Priority Date Filing Date
AR286303A AR230427A1 (es) 1979-02-05 1981-07-31 Procedimiento para la preparacion de un compuesto d-(treo)-aril-2-acilamido-3-fluor-1-propanol
AR286304A AR230428A1 (es) 1979-02-05 1981-07-31 Procedimiento para la preparacion de un compuesto d-(treo)-aril-2-acilamido-3-fluor-1-propanol

Country Status (18)

Country Link
US (1) US4235892A (es)
EP (1) EP0014437B1 (es)
JP (1) JPS5923300B2 (es)
KR (3) KR840001837B1 (es)
AR (3) AR230260A1 (es)
AT (1) ATE2616T1 (es)
AU (1) AU532879B2 (es)
CA (1) CA1137106A (es)
DE (1) DE3062094D1 (es)
DK (1) DK159264C (es)
HU (1) HU180555B (es)
IE (1) IE49740B1 (es)
IL (1) IL59288A (es)
MX (1) MX9203279A (es)
MY (1) MY8500051A (es)
NL (1) NL950004I2 (es)
NZ (1) NZ192774A (es)
ZA (1) ZA80478B (es)

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IT1173213B (it) * 1984-02-03 1987-06-18 Zambon Spa Procedimento per fluorurare alcuni derivati dall'1l-fenil-2-ammino-1,3-propandiolo e loro intermedi
US5105009A (en) * 1983-06-02 1992-04-14 Zambon S.P.A. Intermediates for the preparation of 1-(phenyl)-1-hydroxy-2-amino-3-fluoropropane derivatives
EP0678506A3 (en) 1983-06-02 1996-07-24 Zambon Spa Intermediates for the preparation of 1-phenyl-1-hydroxy-2-amino-3-fluoropropane derivatives.
GB8322983D0 (en) * 1983-08-26 1983-09-28 Pfizer Ltd Triazole antifungal agents
US5153328A (en) * 1984-02-03 1992-10-06 Zambon S.P.A. 2 Hydrocarbyl-4 substituted methyl 5 (4 substituted phenyl)-oxazolines
US5332835A (en) * 1984-02-03 1994-07-26 Zambon S.P.A. Process for fluorinating 1-phenyl-2-amino-1,3-propanediol compounds and new oxazoline compounds useful in this process
US4973750A (en) * 1984-09-19 1990-11-27 Schering Corporation Preparation of (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols
US4582918A (en) * 1984-09-19 1986-04-15 Schering Corporation Preparation of intermediates for (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols
DE3543021A1 (de) * 1985-12-05 1987-06-11 Boehringer Mannheim Gmbh Verbesserte verfahren zur herstellung von d-threo-1-(p-methylsulfonylphenyl) -2-dichloracetamido-propandiol-1,3-(thiamphenicol) sowie verwendung geeigneter zwischenprodukte
IT1197481B (it) * 1986-09-15 1988-11-30 Zambon Spa Preparazione farmaceutica per uso veterinario
IT1198238B (it) * 1986-12-23 1988-12-21 Zambon Spa Composti ad attivita' antibiotica
DE3800474A1 (de) * 1988-01-11 1989-07-20 Basf Lacke & Farben Verfahren und vorrichtung zum messen der viskositaet von stoffen
US5227494A (en) * 1988-09-14 1993-07-13 Schering Corporation Process for preparing oxazoline compounds
US4876352A (en) * 1988-09-14 1989-10-24 Schering Corporation Pressurized fluorination of hydroxy alkyl groups
IT1237798B (it) * 1989-10-20 1993-06-17 Zambon Spa Processo per l'inversione stereochimica di (2s,3s)-2-ammino-3-fenil-1 ,3-propandioli nei corrispondenti enantiomeri (2r,3r).
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AU646910B2 (en) * 1990-10-25 1994-03-10 Schering Corporation Process for preparing florfenicol, its analogs and oxazoline intermediates thereto
US5039666A (en) * 1990-10-30 1991-08-13 Hoechst-Roussel Pharmaceuticals Inc. Aminoglycoside composition having substantially reduced nephrotoxicity induced by the aminoglycoside
IT1249048B (it) 1991-02-21 1995-02-11 Zambon Spa Processo per la preparazione di trans-(5r)-2-ossazoline -2,4,5, trisostituite
US5346828A (en) * 1991-03-27 1994-09-13 Celgene Corporation Stereoisomeric enrichment of 2-amino-3-hydroxy-3-phenylpropionic acids using d-threonine aldolase
US5352832A (en) * 1992-12-18 1994-10-04 Schering Corporation Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates
DE4437932A1 (de) * 1994-10-24 1996-04-25 Bayer Ag Verfahren zur Herstellung von in einer Seitenkette fluorierten Alkyloxazolen und neue, in einer Seitenkette fluorierte Alkyloxazole
US6432203B1 (en) * 1997-03-17 2002-08-13 Applied Komatsu Technology, Inc. Heated and cooled vacuum chamber shield
US6150423A (en) 1998-10-15 2000-11-21 Phoenix Scientific, Inc. Propofol-based anesthetic and method of making same
US20030068339A1 (en) * 2001-10-02 2003-04-10 Phoenix Scientific, Inc. Veterinary florfenicol formulation that is syringeable under cold weather conditions
GB0205253D0 (en) * 2002-03-06 2002-04-17 Univ Gent Immediate release pharmaceutical granule compositions and a continuous process for making them
BR0308289A (pt) * 2002-03-08 2005-01-11 Schering Plough Ltd Antibióticos do tipo florfenicol
KR100896646B1 (ko) * 2002-08-21 2009-05-08 주식회사 포스코 스트립 산세조의 스트립 리프터를 이용한 염산액자동샘플링 장치
TW200505425A (en) * 2003-05-29 2005-02-16 Schering Plough Ltd Compositions and method for treating infection in cattle and swine
GB0315012D0 (en) * 2003-06-27 2003-07-30 Leuven K U Res & Dev Zeotiles
US8273371B2 (en) * 2003-06-27 2012-09-25 Johan Adriaan Martens Crystalline mesoporous oxide based materials useful for the fixation and controlled release of drugs
US7439268B2 (en) * 2003-07-18 2008-10-21 Idexx Laboratories Compositions containing prodrugs of florfenicol and methods of use
DK1502589T3 (da) * 2003-07-31 2006-09-25 Emdoka Bvba Drug Registration Veterinære, vandige injicerbare suspensioner indeholdende florfenicol
US20050049210A1 (en) * 2003-08-27 2005-03-03 Idexx Laboratories, Inc. Methods for the controlled delivery of pharmacologically active compounds
US7126005B2 (en) 2003-10-06 2006-10-24 Aurobindo Pharma Limited Process for preparing florfenicol
CN100579532C (zh) * 2003-12-23 2010-01-13 先灵-普劳有限公司 具有改善水溶性的氟苯尼考前药
US7361689B2 (en) * 2003-12-31 2008-04-22 Schering-Plough Animal Health Corporation Antibacterial 1-(4-mono- and di-halomethylsulphonylphenyl)-2-acylamino-3-fluoroproponals and preparation thereof
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BRPI0914687A2 (pt) 2008-06-24 2015-10-20 Intervet Int Bv preparação veterinária por derramamento, métodos para tratar condições inflamatórias e para administrar a preparação veterinária por derramamento, e, uso da preparação veterinária por derramamento
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CN102491953A (zh) * 2011-12-05 2012-06-13 江西日上化工有限公司 一种合成氟苯尼考中间体rt0131的方法
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CN103965085B (zh) * 2014-04-17 2016-02-24 上海恒晟药业有限公司 一种取代1,2-氨基醇药物的制备方法
CN106770599A (zh) * 2016-12-08 2017-05-31 哈尔滨工业大学 一种测定镀铬板裸露铁程度的方法

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Also Published As

Publication number Publication date
MY8500051A (en) 1985-12-31
AR230428A1 (es) 1984-04-30
NZ192774A (en) 1984-08-24
KR830001867A (ko) 1983-05-19
DK159264B (da) 1990-09-24
EP0014437A2 (en) 1980-08-20
HU180555B (en) 1983-03-28
DK159264C (da) 1991-02-18
KR840001963B1 (ko) 1984-10-26
KR830001869A (ko) 1983-05-19
NL950004I1 (nl) 1995-05-01
IE49740B1 (en) 1985-12-11
DK42480A (da) 1980-08-06
DE3062094D1 (en) 1983-03-31
NL950004I2 (nl) 1998-04-01
EP0014437B1 (en) 1983-02-23
KR840001964B1 (ko) 1984-10-26
US4235892A (en) 1980-11-25
AR230427A1 (es) 1984-04-30
CA1137106A (en) 1982-12-07
IL59288A0 (en) 1980-05-30
JPS5923300B2 (ja) 1984-06-01
AU532879B2 (en) 1983-10-20
IE800198L (en) 1980-08-05
AU5507880A (en) 1980-07-10
KR830001868A (ko) 1983-05-19
KR840001837B1 (ko) 1984-10-22
MX9203279A (es) 1992-07-31
EP0014437A3 (en) 1980-10-29
JPS55115855A (en) 1980-09-06
ATE2616T1 (de) 1983-03-15
ZA80478B (en) 1981-01-28
IL59288A (en) 1984-06-29

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