KR20220029757A - B-세포 성숙 항원을 표적화하는 키메라 항원 수용체 - Google Patents

B-세포 성숙 항원을 표적화하는 키메라 항원 수용체 Download PDF

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KR20220029757A
KR20220029757A KR1020227005825A KR20227005825A KR20220029757A KR 20220029757 A KR20220029757 A KR 20220029757A KR 1020227005825 A KR1020227005825 A KR 1020227005825A KR 20227005825 A KR20227005825 A KR 20227005825A KR 20220029757 A KR20220029757 A KR 20220029757A
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제임스 노블 코첸더퍼
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더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48045750&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR20220029757(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 filed Critical 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈
Priority to KR1020247025571A priority Critical patent/KR20240136359A/ko
Publication of KR20220029757A publication Critical patent/KR20220029757A/ko
Ceased legal-status Critical Current

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70517—CD8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

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  • Hematology (AREA)
  • Oncology (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020227005825A 2012-04-11 2013-03-15 B-세포 성숙 항원을 표적화하는 키메라 항원 수용체 Ceased KR20220029757A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020247025571A KR20240136359A (ko) 2012-04-11 2013-03-15 B-세포 성숙 항원을 표적화하는 키메라 항원 수용체

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261622600P 2012-04-11 2012-04-11
US61/622,600 2012-04-11
KR1020217007607A KR20210032014A (ko) 2012-04-11 2013-03-15 B-세포 성숙 항원을 표적화하는 키메라 항원 수용체
PCT/US2013/032029 WO2013154760A1 (en) 2012-04-11 2013-03-15 Chimeric antigen receptors targeting b-cell maturation antigen

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020217007607A Division KR20210032014A (ko) 2012-04-11 2013-03-15 B-세포 성숙 항원을 표적화하는 키메라 항원 수용체

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020247025571A Division KR20240136359A (ko) 2012-04-11 2013-03-15 B-세포 성숙 항원을 표적화하는 키메라 항원 수용체

Publications (1)

Publication Number Publication Date
KR20220029757A true KR20220029757A (ko) 2022-03-08

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ID=48045750

Family Applications (5)

Application Number Title Priority Date Filing Date
KR1020147031520A Active KR102086874B1 (ko) 2012-04-11 2013-03-15 B-세포 성숙 항원을 표적화하는 키메라 항원 수용체
KR1020247025571A Pending KR20240136359A (ko) 2012-04-11 2013-03-15 B-세포 성숙 항원을 표적화하는 키메라 항원 수용체
KR1020217007607A Ceased KR20210032014A (ko) 2012-04-11 2013-03-15 B-세포 성숙 항원을 표적화하는 키메라 항원 수용체
KR1020227005825A Ceased KR20220029757A (ko) 2012-04-11 2013-03-15 B-세포 성숙 항원을 표적화하는 키메라 항원 수용체
KR1020207006131A Active KR102229945B1 (ko) 2012-04-11 2013-03-15 B-세포 성숙 항원을 표적화하는 키메라 항원 수용체

Family Applications Before (3)

Application Number Title Priority Date Filing Date
KR1020147031520A Active KR102086874B1 (ko) 2012-04-11 2013-03-15 B-세포 성숙 항원을 표적화하는 키메라 항원 수용체
KR1020247025571A Pending KR20240136359A (ko) 2012-04-11 2013-03-15 B-세포 성숙 항원을 표적화하는 키메라 항원 수용체
KR1020217007607A Ceased KR20210032014A (ko) 2012-04-11 2013-03-15 B-세포 성숙 항원을 표적화하는 키메라 항원 수용체

Family Applications After (1)

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KR1020207006131A Active KR102229945B1 (ko) 2012-04-11 2013-03-15 B-세포 성숙 항원을 표적화하는 키메라 항원 수용체

Country Status (17)

Country Link
US (20) US9765342B2 (enExample)
EP (3) EP3689383B1 (enExample)
JP (6) JP6359520B2 (enExample)
KR (5) KR102086874B1 (enExample)
CN (3) CN110331154A (enExample)
AU (5) AU2013246443B2 (enExample)
BR (1) BR112014024893B8 (enExample)
CA (1) CA2869562C (enExample)
EA (2) EA201990959A1 (enExample)
HK (1) HK1203393A1 (enExample)
IL (4) IL234870B (enExample)
IS (1) IS9056A (enExample)
MX (3) MX394639B (enExample)
NZ (1) NZ700362A (enExample)
RU (2) RU2766608C2 (enExample)
SG (1) SG11201406414WA (enExample)
WO (1) WO2013154760A1 (enExample)

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