KR20210055733A - 핵염기 편집 시스템을 전달하기 위한 조성물 및 방법 - Google Patents

핵염기 편집 시스템을 전달하기 위한 조성물 및 방법 Download PDF

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KR20210055733A
KR20210055733A KR1020217009863A KR20217009863A KR20210055733A KR 20210055733 A KR20210055733 A KR 20210055733A KR 1020217009863 A KR1020217009863 A KR 1020217009863A KR 20217009863 A KR20217009863 A KR 20217009863A KR 20210055733 A KR20210055733 A KR 20210055733A
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cas9
terminal fragment
deaminase
polynucleotide
fused
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데이비드 브라이슨
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빔 테라퓨틱스, 인크.
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
    • C12Y305/04002—Adenine deaminase (3.5.4.2)
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    • C12Y305/04004—Adenosine deaminase (3.5.4.4)
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites

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  • Wood Science & Technology (AREA)
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  • Crystallography & Structural Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020217009863A 2018-09-07 2019-09-07 핵염기 편집 시스템을 전달하기 위한 조성물 및 방법 Ceased KR20210055733A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862728703P 2018-09-07 2018-09-07
US62/728,703 2018-09-07
US201862779404P 2018-12-13 2018-12-13
US62/779,404 2018-12-13
PCT/US2019/050111 WO2020051561A1 (en) 2018-09-07 2019-09-07 Compositions and methods for delivering a nucleobase editing system

Publications (1)

Publication Number Publication Date
KR20210055733A true KR20210055733A (ko) 2021-05-17

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KR1020217009863A Ceased KR20210055733A (ko) 2018-09-07 2019-09-07 핵염기 편집 시스템을 전달하기 위한 조성물 및 방법

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US (1) US12529041B2 (https=)
EP (1) EP3847254A4 (https=)
JP (2) JP7657711B2 (https=)
KR (1) KR20210055733A (https=)
CN (1) CN112969790B (https=)
AU (1) AU2019336245B2 (https=)
CA (1) CA3112011A1 (https=)
WO (1) WO2020051561A1 (https=)

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CN112969790B (zh) 2024-07-05
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CA3112011A1 (en) 2020-03-12
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