KR20190003536A - 5-히드록시알킬-치환된 1-페닐-1,2,4-트리아졸 유도체의 제조 방법 - Google Patents

5-히드록시알킬-치환된 1-페닐-1,2,4-트리아졸 유도체의 제조 방법 Download PDF

Info

Publication number
KR20190003536A
KR20190003536A KR1020187031568A KR20187031568A KR20190003536A KR 20190003536 A KR20190003536 A KR 20190003536A KR 1020187031568 A KR1020187031568 A KR 1020187031568A KR 20187031568 A KR20187031568 A KR 20187031568A KR 20190003536 A KR20190003536 A KR 20190003536A
Authority
KR
South Korea
Prior art keywords
compound
formula
methyl
mixture
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020187031568A
Other languages
English (en)
Korean (ko)
Inventor
하이코 쉬르머
필리프 루벤바우어
한스-크리스티안 밀리처
마리에-피에르 콜린-크뢰펠린
프랑크 쥐스마이어
커스텐 마티아스 게릭
토마스 노이바우어
샹탈 휘르스트너
Original Assignee
바이엘 파마 악티엔게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 바이엘 파마 악티엔게젤샤프트 filed Critical 바이엘 파마 악티엔게젤샤프트
Publication of KR20190003536A publication Critical patent/KR20190003536A/ko
Ceased legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020187031568A 2016-05-03 2017-05-02 5-히드록시알킬-치환된 1-페닐-1,2,4-트리아졸 유도체의 제조 방법 Ceased KR20190003536A (ko)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
EP16168165 2016-05-03
EP16168169.7 2016-05-03
EP16168166.3 2016-05-03
EP16168163.0 2016-05-03
EP16168163 2016-05-03
EP16168172.1 2016-05-03
EP16168172 2016-05-03
EP16168166 2016-05-03
EP16168169 2016-05-03
EP16168165.5 2016-05-03
EP17160086 2017-03-09
EP17160086.9 2017-03-09
PCT/EP2017/060367 WO2017191104A1 (de) 2016-05-03 2017-05-02 Verfahren zur herstellung von 5-hydroxyalkyl-substituierten 1-phenyl-1,2,4-triazolderivativen

Publications (1)

Publication Number Publication Date
KR20190003536A true KR20190003536A (ko) 2019-01-09

Family

ID=58633014

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020187031568A Ceased KR20190003536A (ko) 2016-05-03 2017-05-02 5-히드록시알킬-치환된 1-페닐-1,2,4-트리아졸 유도체의 제조 방법

Country Status (19)

Country Link
US (2) US10703742B2 (https=)
EP (1) EP3452467A1 (https=)
JP (2) JP6921863B2 (https=)
KR (1) KR20190003536A (https=)
CN (2) CN109071500B (https=)
AU (2) AU2017259872B2 (https=)
BR (1) BR112018072528A2 (https=)
CA (1) CA3022789A1 (https=)
CL (1) CL2018003107A1 (https=)
CO (1) CO2018011948A2 (https=)
IL (1) IL262534B (https=)
JO (1) JOP20170103A1 (https=)
MX (2) MX391356B (https=)
PE (1) PE20190202A1 (https=)
RU (1) RU2742885C2 (https=)
SG (1) SG11201809672YA (https=)
TW (1) TWI755393B (https=)
UY (1) UY37222A (https=)
WO (1) WO2017191104A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20170103A1 (ar) * 2016-05-03 2017-11-03 Bayer Pharma AG عملية لتحضير مشتقات 1-فنيل-1، 2، 4-تريازول مستبدلة بـ 5-هيدروكسي ألكيل
US9988367B2 (en) * 2016-05-03 2018-06-05 Bayer Pharma Aktiengesellschaft Amide-substituted pyridinyltriazole derivatives and uses thereof
JP6911052B2 (ja) * 2016-05-03 2021-07-28 バイエル ファーマ アクチエンゲゼルシャフト オキソアルキル置換フェニルトリアゾール誘導体およびその使用
WO2021259852A1 (en) 2020-06-25 2021-12-30 Bayer Aktiengesellschaft Process for preparing 5-(alkoxycarbonyl)-and 5-(carboxamide)-1-aryl-1,2,4-triazole derivatives
CN118894815A (zh) * 2024-07-12 2024-11-05 西北师范大学 一种含三氟甲基的1,2,4-三氮唑啉类衍生物及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8183384B2 (en) * 2006-05-25 2012-05-22 Synta Pharmaceuticals Corp. Triazole compounds that modulate HSP90 activity
US20110237528A1 (en) * 2008-09-19 2011-09-29 Institute For Oneworld Health Compositions and methods comprising imidazole and triazole derivatives
DE102010001064A1 (de) 2009-03-18 2010-09-23 Bayer Schering Pharma Aktiengesellschaft Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung
EA023221B1 (ru) * 2010-02-27 2016-05-31 Байер Интеллектуэль Проперти Гмбх СВЯЗАННЫЕ БИС-АРИЛЬНЫЕ АРИЛ-ТРИАЗОЛОНЫ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ, ИХ ПРИМЕНЕНИЕ, ЛЕКАРСТВЕННОЕ СРЕДСТВО НА ИХ ОСНОВЕ И ДВОЙНОЙ АНТАГОНИСТ V1a/V2-РЕЦЕПТОРОВ
AU2013258107B2 (en) * 2012-05-08 2017-06-22 Bayer Pharma Aktiengesellschaft Method for the preparation of triazole compounds
UA121558C2 (uk) * 2014-11-03 2020-06-25 Баєр Фарма Актіенгезеллшафт Гідроксіалкілзаміщені фенілтриазольні похідні та їх застосування
JOP20170103A1 (ar) * 2016-05-03 2017-11-03 Bayer Pharma AG عملية لتحضير مشتقات 1-فنيل-1، 2، 4-تريازول مستبدلة بـ 5-هيدروكسي ألكيل
US9988367B2 (en) * 2016-05-03 2018-06-05 Bayer Pharma Aktiengesellschaft Amide-substituted pyridinyltriazole derivatives and uses thereof
JP6911052B2 (ja) * 2016-05-03 2021-07-28 バイエル ファーマ アクチエンゲゼルシャフト オキソアルキル置換フェニルトリアゾール誘導体およびその使用

Also Published As

Publication number Publication date
RU2742885C2 (ru) 2021-02-11
MX379555B (es) 2025-03-11
UY37222A (es) 2017-11-30
JP6921863B2 (ja) 2021-08-18
AU2017259872A1 (en) 2018-11-22
JP2021143193A (ja) 2021-09-24
RU2018142264A3 (https=) 2020-08-19
US20200299271A1 (en) 2020-09-24
AU2017259872B2 (en) 2021-06-24
JP2019514948A (ja) 2019-06-06
SG11201809672YA (en) 2018-11-29
MX2018013336A (es) 2019-05-09
PE20190202A1 (es) 2019-02-05
AU2021236502A1 (en) 2021-10-21
CL2018003107A1 (es) 2019-02-22
CN113105403A (zh) 2021-07-13
CO2018011948A2 (es) 2018-11-22
BR112018072528A2 (pt) 2019-03-26
MX2020010365A (es) 2022-04-06
WO2017191104A1 (de) 2017-11-09
JOP20170103A1 (ar) 2017-11-03
US20190144431A1 (en) 2019-05-16
RU2018142264A (ru) 2020-06-03
CA3022789A1 (en) 2017-11-09
TW201815782A (zh) 2018-05-01
MX391356B (es) 2025-03-19
US10703742B2 (en) 2020-07-07
IL262534B (en) 2021-04-29
TWI755393B (zh) 2022-02-21
EP3452467A1 (de) 2019-03-13
CN109071500A (zh) 2018-12-21
IL262534A (en) 2018-12-31
CN109071500B (zh) 2021-05-18

Similar Documents

Publication Publication Date Title
JP2021143193A (ja) ５−ヒドロキシアルキル置換１−フェニル−１，２，４−トリアゾール誘導体を生産する方法
HU220046B (hu) Pirazolo-pirimidinon-származékok, az ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
CA2138649A1 (en) Imidazole, triazole and tetrazole derivatives
CA2260900A1 (en) Substituted triazolo pyridazine derivatives as inverse agonists of the gabaa.alpha.5 receptor subtype
AU4269793A (en) Fused imidazole and triazole derivatives as 5-ht1 receptor agonists
WO1994020473A1 (fr) Compose avec action antagoniste de la vasopressine
CA2316352A1 (en) Acyl guanidine sodium/proton exchange inhibitors and method
WO2009082526A2 (en) Ortho pyrrolidine, benzyl-substituted heterocycle ccr1 antagonists for autoimmune diseases & inflammation
ZA200007485B (en) A substituted triazolo-pyridazine derivative, pharmaceutical compositions made therefrom.
TWI756418B (zh) 2-([1,2,3]三唑-2-基)-苯甲酸衍生物之製備
HUP0103075A2 (hu) Eljárás pirazolo[4,3-d]pirimidin-7-on-származékok és köztitermékeik előállítására
Bakavoli et al. Regioselective synthesis of [1, 2, 4] triazolo [3, 2-b][2, 4] benzothiazepin-10 (5H)-ones: a new heterocyclic ring system
HK40055792A (en) Method for producing 5-hydroxyalkyl-substituted 1-phenyl-1,2,4- triazole derivatives
HK1262153A1 (en) Method for producing 5-hydroxyalkyl-substituted 1-phenyl-1,2,4-triazole derivatives
CA2362400A1 (en) Triazolo-pyridazine derivatives as ligands for gaba receptors
Elgemeie et al. The reaction of dimethyl N-cyanodithioiminocarbonate with amino-and oxo-azoles: a new general synthesis of methylsulfanylazoloazines
HK1262153B (zh) 制备5-羟基烷基-取代的1-苯基-1，2，4-三唑衍生物的方法
US5552402A (en) Five-membered heteroaromatic compounds as 5-HT receptor agonists
KR100393744B1 (ko) 1,2,3,9-테트라하이드로-9-메틸-3-[(2-메틸-1ｈ-이미다졸-1-일)메틸]-4ｈ-카바졸-4-온의 제조방법
KR100368895B1 (ko) 1,2,3,9-테트라하이드로-9-메틸-3-[(2-메틸-1ｈ-이미다졸-1-일)메틸]-4ｈ-카바졸-4-온의 제조방법

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20181031

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20200429

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20211216

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20220627

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20211216

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I