JOP20170103A1 - عملية لتحضير مشتقات 1-فنيل-1، 2، 4-تريازول مستبدلة بـ 5-هيدروكسي ألكيل - Google Patents

عملية لتحضير مشتقات 1-فنيل-1، 2، 4-تريازول مستبدلة بـ 5-هيدروكسي ألكيل

Info

Publication number
JOP20170103A1
JOP20170103A1 JOJO/P/2017/0103A JOP20170103A JOP20170103A1 JO P20170103 A1 JOP20170103 A1 JO P20170103A1 JO P20170103 A JOP20170103 A JO P20170103A JO P20170103 A1 JOP20170103 A1 JO P20170103A1
Authority
JO
Jordan
Prior art keywords
phenyl
triazole
preparation
hydroxyalkylated
preparing
Prior art date
Application number
JOJO/P/2017/0103A
Other languages
Arabic (ar)
English (en)
Inventor
Schirmer Heiko
Rubenbauer Philipp
Militzer Hans-Christian
Collin Marie-Pierre
Submeier Frank
Matthias Gericke Kersten
Neubauer Thomas
Furstner Chantal
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of JOP20170103A1 publication Critical patent/JOP20170103A1/ar

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
JOJO/P/2017/0103A 2016-05-03 2017-05-01 عملية لتحضير مشتقات 1-فنيل-1، 2، 4-تريازول مستبدلة بـ 5-هيدروكسي ألكيل JOP20170103A1 (ar)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP16168172 2016-05-03
EP16168163 2016-05-03
EP16168165 2016-05-03
EP16168166 2016-05-03
EP16168169 2016-05-03
EP17160086 2017-03-09

Publications (1)

Publication Number Publication Date
JOP20170103A1 true JOP20170103A1 (ar) 2017-11-03

Family

ID=58633014

Family Applications (1)

Application Number Title Priority Date Filing Date
JOJO/P/2017/0103A JOP20170103A1 (ar) 2016-05-03 2017-05-01 عملية لتحضير مشتقات 1-فنيل-1، 2، 4-تريازول مستبدلة بـ 5-هيدروكسي ألكيل

Country Status (19)

Country Link
US (2) US10703742B2 (https=)
EP (1) EP3452467A1 (https=)
JP (2) JP6921863B2 (https=)
KR (1) KR20190003536A (https=)
CN (2) CN109071500B (https=)
AU (2) AU2017259872B2 (https=)
BR (1) BR112018072528A2 (https=)
CA (1) CA3022789A1 (https=)
CL (1) CL2018003107A1 (https=)
CO (1) CO2018011948A2 (https=)
IL (1) IL262534B (https=)
JO (1) JOP20170103A1 (https=)
MX (2) MX391356B (https=)
PE (1) PE20190202A1 (https=)
RU (1) RU2742885C2 (https=)
SG (1) SG11201809672YA (https=)
TW (1) TWI755393B (https=)
UY (1) UY37222A (https=)
WO (1) WO2017191104A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20170103A1 (ar) * 2016-05-03 2017-11-03 Bayer Pharma AG عملية لتحضير مشتقات 1-فنيل-1، 2، 4-تريازول مستبدلة بـ 5-هيدروكسي ألكيل
US9988367B2 (en) * 2016-05-03 2018-06-05 Bayer Pharma Aktiengesellschaft Amide-substituted pyridinyltriazole derivatives and uses thereof
JP6911052B2 (ja) * 2016-05-03 2021-07-28 バイエル ファーマ アクチエンゲゼルシャフト オキソアルキル置換フェニルトリアゾール誘導体およびその使用
WO2021259852A1 (en) 2020-06-25 2021-12-30 Bayer Aktiengesellschaft Process for preparing 5-(alkoxycarbonyl)-and 5-(carboxamide)-1-aryl-1,2,4-triazole derivatives
CN118894815A (zh) * 2024-07-12 2024-11-05 西北师范大学 一种含三氟甲基的1,2,4-三氮唑啉类衍生物及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8183384B2 (en) * 2006-05-25 2012-05-22 Synta Pharmaceuticals Corp. Triazole compounds that modulate HSP90 activity
US20110237528A1 (en) * 2008-09-19 2011-09-29 Institute For Oneworld Health Compositions and methods comprising imidazole and triazole derivatives
DE102010001064A1 (de) 2009-03-18 2010-09-23 Bayer Schering Pharma Aktiengesellschaft Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung
EA023221B1 (ru) * 2010-02-27 2016-05-31 Байер Интеллектуэль Проперти Гмбх СВЯЗАННЫЕ БИС-АРИЛЬНЫЕ АРИЛ-ТРИАЗОЛОНЫ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ, ИХ ПРИМЕНЕНИЕ, ЛЕКАРСТВЕННОЕ СРЕДСТВО НА ИХ ОСНОВЕ И ДВОЙНОЙ АНТАГОНИСТ V1a/V2-РЕЦЕПТОРОВ
AU2013258107B2 (en) * 2012-05-08 2017-06-22 Bayer Pharma Aktiengesellschaft Method for the preparation of triazole compounds
UA121558C2 (uk) * 2014-11-03 2020-06-25 Баєр Фарма Актіенгезеллшафт Гідроксіалкілзаміщені фенілтриазольні похідні та їх застосування
JOP20170103A1 (ar) * 2016-05-03 2017-11-03 Bayer Pharma AG عملية لتحضير مشتقات 1-فنيل-1، 2، 4-تريازول مستبدلة بـ 5-هيدروكسي ألكيل
US9988367B2 (en) * 2016-05-03 2018-06-05 Bayer Pharma Aktiengesellschaft Amide-substituted pyridinyltriazole derivatives and uses thereof
JP6911052B2 (ja) * 2016-05-03 2021-07-28 バイエル ファーマ アクチエンゲゼルシャフト オキソアルキル置換フェニルトリアゾール誘導体およびその使用

Also Published As

Publication number Publication date
RU2742885C2 (ru) 2021-02-11
MX379555B (es) 2025-03-11
UY37222A (es) 2017-11-30
JP6921863B2 (ja) 2021-08-18
AU2017259872A1 (en) 2018-11-22
JP2021143193A (ja) 2021-09-24
RU2018142264A3 (https=) 2020-08-19
US20200299271A1 (en) 2020-09-24
AU2017259872B2 (en) 2021-06-24
JP2019514948A (ja) 2019-06-06
SG11201809672YA (en) 2018-11-29
MX2018013336A (es) 2019-05-09
PE20190202A1 (es) 2019-02-05
AU2021236502A1 (en) 2021-10-21
KR20190003536A (ko) 2019-01-09
CL2018003107A1 (es) 2019-02-22
CN113105403A (zh) 2021-07-13
CO2018011948A2 (es) 2018-11-22
BR112018072528A2 (pt) 2019-03-26
MX2020010365A (es) 2022-04-06
WO2017191104A1 (de) 2017-11-09
US20190144431A1 (en) 2019-05-16
RU2018142264A (ru) 2020-06-03
CA3022789A1 (en) 2017-11-09
TW201815782A (zh) 2018-05-01
MX391356B (es) 2025-03-19
US10703742B2 (en) 2020-07-07
IL262534B (en) 2021-04-29
TWI755393B (zh) 2022-02-21
EP3452467A1 (de) 2019-03-13
CN109071500A (zh) 2018-12-21
IL262534A (en) 2018-12-31
CN109071500B (zh) 2021-05-18

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