JP2013532727A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013532727A5 JP2013532727A5 JP2013523213A JP2013523213A JP2013532727A5 JP 2013532727 A5 JP2013532727 A5 JP 2013532727A5 JP 2013523213 A JP2013523213 A JP 2013523213A JP 2013523213 A JP2013523213 A JP 2013523213A JP 2013532727 A5 JP2013532727 A5 JP 2013532727A5
- Authority
- JP
- Japan
- Prior art keywords
- substituent
- amino
- alkyl
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001424 substituent group Chemical group 0.000 claims 45
- 125000000217 alkyl group Chemical group 0.000 claims 22
- 150000003839 salts Chemical class 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 18
- 125000005466 alkylenyl group Chemical group 0.000 claims 16
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 16
- 125000001931 aliphatic group Chemical group 0.000 claims 13
- -1 amino, hydroxy Chemical group 0.000 claims 11
- 125000000623 heterocyclic group Chemical group 0.000 claims 10
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 150000002367 halogens Chemical class 0.000 claims 7
- 239000004480 active ingredient Substances 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 125000004103 aminoalkyl group Chemical group 0.000 claims 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 102100024299 Maternal embryonic leucine zipper kinase Human genes 0.000 claims 3
- 101710154611 Maternal embryonic leucine zipper kinase Proteins 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 3
- 230000002018 overexpression Effects 0.000 claims 3
- 230000000069 prophylactic effect Effects 0.000 claims 3
- 125000004548 quinolin-3-yl group Chemical group N1=CC(=CC2=CC=CC=C12)* 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- NBBJYMSMWIIQGU-UHFFFAOYSA-N Propionic aldehyde Chemical compound CCC=O NBBJYMSMWIIQGU-UHFFFAOYSA-N 0.000 claims 2
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 125000003107 substituted aryl group Chemical group 0.000 claims 2
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 1
- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 claims 1
- UFJXIZSDRSWGHH-UHFFFAOYSA-N 1-[4-[[6-(3-aminopiperidin-1-yl)pyridin-3-yl]amino]-6-(3,5-dichloro-4-hydroxyphenyl)quinolin-3-yl]ethanone Chemical compound CC(=O)C1=CN=C2C=CC(C=3C=C(Cl)C(O)=C(Cl)C=3)=CC2=C1NC(C=N1)=CC=C1N1CCCC(N)C1 UFJXIZSDRSWGHH-UHFFFAOYSA-N 0.000 claims 1
- DLMHQUGZXIWVLQ-UHFFFAOYSA-N 1-[4-[[6-(3-aminopiperidin-1-yl)pyridin-3-yl]amino]-6-(3,5-dichloro-4-hydroxyphenyl)quinolin-3-yl]propan-1-one Chemical compound CCC(=O)C1=CN=C2C=CC(C=3C=C(Cl)C(O)=C(Cl)C=3)=CC2=C1NC(C=N1)=CC=C1N1CCCC(N)C1 DLMHQUGZXIWVLQ-UHFFFAOYSA-N 0.000 claims 1
- DLMHQUGZXIWVLQ-SFHVURJKSA-N 1-[4-[[6-[(3s)-3-aminopiperidin-1-yl]pyridin-3-yl]amino]-6-(3,5-dichloro-4-hydroxyphenyl)quinolin-3-yl]propan-1-one Chemical compound CCC(=O)C1=CN=C2C=CC(C=3C=C(Cl)C(O)=C(Cl)C=3)=CC2=C1NC(C=N1)=CC=C1N1CCC[C@H](N)C1 DLMHQUGZXIWVLQ-SFHVURJKSA-N 0.000 claims 1
- DKZYXHCYPUVGAF-UHFFFAOYSA-N 1-[6-(3,5-dichloro-4-hydroxyphenyl)-4-[[4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridin-3-yl]ethanone Chemical compound CN(C)CC1CCC(CC1)Nc1c(cnc2ccc(nc12)-c1cc(Cl)c(O)c(Cl)c1)C(C)=O DKZYXHCYPUVGAF-UHFFFAOYSA-N 0.000 claims 1
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 claims 1
- PEAZQTKOWOEYCZ-UKIBZPOASA-N C1C[C@@H](CN(C)C)CC[C@@H]1NC1=C(C(=O)C2CC2)C=NC2=CC=C(C=3C=C(Cl)C(O)=C(Cl)C=3)C=C12 Chemical compound C1C[C@@H](CN(C)C)CC[C@@H]1NC1=C(C(=O)C2CC2)C=NC2=CC=C(C=3C=C(Cl)C(O)=C(Cl)C=3)C=C12 PEAZQTKOWOEYCZ-UKIBZPOASA-N 0.000 claims 1
- YFBRRBWSRJPOIT-RUCARUNLSA-N C1C[C@@H](CN(C)C)CC[C@@H]1NC1=C(C(C)=O)C=NC2=CC=C(C=3C=C(Cl)C(O)=C(Cl)C=3)C=C12 Chemical compound C1C[C@@H](CN(C)C)CC[C@@H]1NC1=C(C(C)=O)C=NC2=CC=C(C=3C=C(Cl)C(O)=C(Cl)C=3)C=C12 YFBRRBWSRJPOIT-RUCARUNLSA-N 0.000 claims 1
- UYIMHVQEXCPIKN-RUCARUNLSA-N C1C[C@@H](CN(C)C)CC[C@@H]1NC1=C(C(C)=O)C=NC2=CC=C(C=3C=C(Cl)C(O)=C(F)C=3)C=C12 Chemical compound C1C[C@@H](CN(C)C)CC[C@@H]1NC1=C(C(C)=O)C=NC2=CC=C(C=3C=C(Cl)C(O)=C(F)C=3)C=C12 UYIMHVQEXCPIKN-RUCARUNLSA-N 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 229940124787 MELK inhibitor Drugs 0.000 claims 1
- 241001024304 Mino Species 0.000 claims 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- LCFDWDAPNUMZKM-UHFFFAOYSA-N [4-[[6-(3-aminopiperidin-1-yl)pyridin-3-yl]amino]-6-(3,5-dichloro-4-hydroxyphenyl)quinolin-3-yl]-cyclopropylmethanone Chemical compound C1C(N)CCCN1C(N=C1)=CC=C1NC1=C(C(=O)C2CC2)C=NC2=CC=C(C=3C=C(Cl)C(O)=C(Cl)C=3)C=C12 LCFDWDAPNUMZKM-UHFFFAOYSA-N 0.000 claims 1
- LCFDWDAPNUMZKM-LJQANCHMSA-N [4-[[6-[(3r)-3-aminopiperidin-1-yl]pyridin-3-yl]amino]-6-(3,5-dichloro-4-hydroxyphenyl)quinolin-3-yl]-cyclopropylmethanone Chemical compound C1[C@H](N)CCCN1C(N=C1)=CC=C1NC1=C(C(=O)C2CC2)C=NC2=CC=C(C=3C=C(Cl)C(O)=C(Cl)C=3)C=C12 LCFDWDAPNUMZKM-LJQANCHMSA-N 0.000 claims 1
- LCFDWDAPNUMZKM-IBGZPJMESA-N [4-[[6-[(3s)-3-aminopiperidin-1-yl]pyridin-3-yl]amino]-6-(3,5-dichloro-4-hydroxyphenyl)quinolin-3-yl]-cyclopropylmethanone Chemical compound C1[C@@H](N)CCCN1C(N=C1)=CC=C1NC1=C(C(=O)C2CC2)C=NC2=CC=C(C=3C=C(Cl)C(O)=C(Cl)C=3)C=C12 LCFDWDAPNUMZKM-IBGZPJMESA-N 0.000 claims 1
- 125000005236 alkanoylamino group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 201000011199 bladder lymphoma Diseases 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 125000004431 deuterium atom Chemical group 0.000 claims 1
- 230000014509 gene expression Effects 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- WSFSSNUMVMOOMR-BJUDXGSMSA-N methanone Chemical compound O=[11CH2] WSFSSNUMVMOOMR-BJUDXGSMSA-N 0.000 claims 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36951910P | 2010-07-30 | 2010-07-30 | |
| US61/369,519 | 2010-07-30 | ||
| PCT/US2011/045792 WO2012016082A1 (en) | 2010-07-30 | 2011-07-28 | Quinoline derivatives and melk inhibitors containing the same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013532727A JP2013532727A (ja) | 2013-08-19 |
| JP2013532727A5 true JP2013532727A5 (https=) | 2014-09-11 |
| JP5849303B2 JP5849303B2 (ja) | 2016-01-27 |
Family
ID=45530500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013523213A Active JP5849303B2 (ja) | 2010-07-30 | 2011-07-28 | キノリン誘導体および同一物を含むｍｅｌｋ阻害剤 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9120749B2 (https=) |
| EP (1) | EP2597955B1 (https=) |
| JP (1) | JP5849303B2 (https=) |
| KR (1) | KR101826382B1 (https=) |
| CN (1) | CN103153063B (https=) |
| AU (1) | AU2011282588B2 (https=) |
| BR (1) | BR112013002182B8 (https=) |
| CA (1) | CA2806332C (https=) |
| DK (1) | DK2597955T3 (https=) |
| ES (1) | ES2565627T3 (https=) |
| IL (1) | IL223871A (https=) |
| MX (1) | MX342879B (https=) |
| RU (1) | RU2582610C2 (https=) |
| SG (2) | SG187633A1 (https=) |
| TW (1) | TWI532483B (https=) |
| WO (1) | WO2012016082A1 (https=) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012061557A2 (en) * | 2010-11-05 | 2012-05-10 | Glaxosmithkline Llc | Chemical compounds |
| EP2753329B1 (en) * | 2012-01-19 | 2017-08-09 | OncoTherapy Science, Inc. | 1,5-naphthyridine derivatives as melk inhibitors |
| US9745319B2 (en) | 2013-03-15 | 2017-08-29 | Araxes Pharma Llc | Irreversible covalent inhibitors of the GTPase K-Ras G12C |
| UY35464A (es) | 2013-03-15 | 2014-10-31 | Araxes Pharma Llc | Inhibidores covalentes de kras g12c. |
| TWI659021B (zh) | 2013-10-10 | 2019-05-11 | 亞瑞克西斯製藥公司 | Ｋｒａｓ ｇ１２ｃ之抑制劑 |
| US10254283B2 (en) | 2013-11-12 | 2019-04-09 | Dana-Farber Cancer Institute, Inc. | Biomarker for MELK activity and methods of using same |
| US9840489B2 (en) | 2013-12-20 | 2017-12-12 | Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China | Piperidine carboxamide compound, preparation method, and usage thereof |
| JO3556B1 (ar) | 2014-09-18 | 2020-07-05 | Araxes Pharma Llc | علاجات مدمجة لمعالجة السرطان |
| ES2826443T3 (es) | 2014-09-25 | 2021-05-18 | Araxes Pharma Llc | Inhibidores de proteínas mutantes KRAS G12C |
| US10011600B2 (en) | 2014-09-25 | 2018-07-03 | Araxes Pharma Llc | Methods and compositions for inhibition of Ras |
| CA2969974C (en) * | 2014-12-15 | 2020-08-04 | The Regents Of The University Of Michigan | Small molecule inhibitors of egfr and pi3k |
| CN107530353A (zh) | 2015-03-04 | 2018-01-02 | 丹娜法伯癌症研究院 | Melk的三环激酶抑制剂和使用方法 |
| JP2018513853A (ja) | 2015-04-10 | 2018-05-31 | アラクセス ファーマ エルエルシー | 置換キナゾリン化合物およびその使用方法 |
| JP6789239B2 (ja) | 2015-04-15 | 2020-11-25 | アラクセス ファーマ エルエルシー | Ｋｒａｓの縮合三環系インヒビターおよびその使用の方法 |
| MX388781B (es) * | 2015-07-22 | 2025-03-20 | Araxes Pharma Llc | Compuestos de quinazolina sustituido y su uso como inhibidores de proteínas kras, hras y/o nras mutantes g12c. |
| US10144724B2 (en) | 2015-07-22 | 2018-12-04 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use thereof |
| CN108026046B (zh) * | 2015-07-22 | 2021-12-21 | 亚瑞克西斯制药公司 | 取代的喹唑啉化合物及其作为g12c突变体kras、hras和/或nras蛋白质的抑制剂的用途 |
| PE20181366A1 (es) * | 2015-08-03 | 2018-08-27 | Bristol Myers Squibb Co | Compuestos heterociclicos utiles como moduladores de factor de necrosis tumoral (tnf) alfa |
| WO2017058915A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| US10882847B2 (en) | 2015-09-28 | 2021-01-05 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| US10647703B2 (en) | 2015-09-28 | 2020-05-12 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| EP3356354A1 (en) | 2015-09-28 | 2018-08-08 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
| WO2017058902A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| EP3356353A1 (en) | 2015-09-28 | 2018-08-08 | Araxes Pharma LLC | Inhibitors of kras g12c mutant proteins |
| WO2017058807A1 (en) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibitors of kras g12c mutant proteins |
| JP2018533939A (ja) | 2015-10-19 | 2018-11-22 | アラクセス ファーマ エルエルシー | Ｒａｓの阻害剤をスクリーニングするための方法 |
| KR20180081596A (ko) | 2015-11-16 | 2018-07-16 | 아락세스 파마 엘엘씨 | 치환된 헤테로사이클릭 그룹을 포함하는 2-치환된 퀴나졸린 화합물 및 이의 사용 방법 |
| WO2017100546A1 (en) | 2015-12-09 | 2017-06-15 | Araxes Pharma Llc | Methods for preparation of quinazoline derivatives |
| AU2016378579A1 (en) * | 2015-12-22 | 2018-06-14 | Vitae Pharmaceuticals, Inc. | Inhibitors of the menin-MLL interaction |
| WO2017172979A1 (en) | 2016-03-30 | 2017-10-05 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use |
| US10646488B2 (en) | 2016-07-13 | 2020-05-12 | Araxes Pharma Llc | Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof |
| HRP20221279T1 (hr) * | 2016-07-14 | 2022-12-23 | Crinetics Pharmaceuticals, Inc. | Modulatori somatostatina i njihove uporabe |
| KR102579047B1 (ko) | 2016-08-31 | 2023-09-14 | 온코세라피 사이언스 가부시키가이샤 | MELK에 대한 단클론 항체(monoclonal antibody) 및 그 사용 |
| US10280172B2 (en) | 2016-09-29 | 2019-05-07 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
| EP3523289A1 (en) | 2016-10-07 | 2019-08-14 | Araxes Pharma LLC | Heterocyclic compounds as inhibitors of ras and methods of use thereof |
| EP4183786A1 (en) * | 2016-12-23 | 2023-05-24 | Felicitex Therapeutics, Inc. | Derivatives of quinolines as inhibitors of dyrk1a and/or dyrk1b kinases |
| WO2018140514A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | 1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer |
| WO2018140513A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer |
| EP3573954A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | Fused bicyclic benzoheteroaromatic compounds and methods of use thereof |
| WO2018140599A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | Benzothiophene and benzothiazole compounds and methods of use thereof |
| CN110382482A (zh) | 2017-01-26 | 2019-10-25 | 亚瑞克西斯制药公司 | 稠合的杂-杂二环化合物及其使用方法 |
| JP2020521741A (ja) | 2017-05-25 | 2020-07-27 | アラクセス ファーマ エルエルシー | がんの処置のための化合物およびその使用の方法 |
| US11639346B2 (en) | 2017-05-25 | 2023-05-02 | Araxes Pharma Llc | Quinazoline derivatives as modulators of mutant KRAS, HRAS or NRAS |
| AU2018271990A1 (en) | 2017-05-25 | 2019-12-12 | Araxes Pharma Llc | Covalent inhibitors of KRAS |
| US11028068B2 (en) | 2017-07-25 | 2021-06-08 | Crinetics Pharmaceuticals, Inc. | Somatostatin modulators and uses thereof |
| EP3740475B1 (en) | 2018-01-17 | 2022-04-20 | Crinetics Pharmaceuticals, Inc. | Process of making somatostatin modulators |
| WO2019229765A1 (en) * | 2018-05-29 | 2019-12-05 | Council Of Scientific & Industrial Research, India | Bicycle topoisomerase i inhibiting compounds, process for preparation and use thereof |
| MX2021000887A (es) | 2018-08-01 | 2021-03-31 | Araxes Pharma Llc | Compuestos espiroheterociclicos y metodos de uso de los mismos para el tratamiento de cancer. |
| CN109705037A (zh) * | 2019-01-24 | 2019-05-03 | 广西师范大学 | 4-氨基喹啉-3-甲酸酯衍生物及其制备方法和应用 |
| CN109651355A (zh) * | 2019-01-24 | 2019-04-19 | 广西师范大学 | 3-(2-苯并五元杂环)-4-(3-二甲胺丙氨基)喹啉衍生物及其制备方法和应用 |
| US12486234B2 (en) | 2019-04-24 | 2025-12-02 | Children's Medical Center Corporation | PAPD5 inhibitors and methods of use thereof |
| US11926632B2 (en) * | 2020-06-22 | 2024-03-12 | Pmv Pharmaceuticals, Inc. | Methods and compounds for restoring mutant p53 function |
| US20240246941A1 (en) * | 2020-07-15 | 2024-07-25 | St. Jude Children's Research Hospital, Inc. | Substituted 4-(3-aminoprop-1-yl)aminoquinoline analogs as modulators of melanoma-associated antigen 11 ubiquitin ligase |
| FI4210700T3 (fi) | 2020-09-09 | 2025-09-16 | Crinetics Pharmaceuticals Inc | Somatostatiinimodulaatorin formulaatioita |
| EP4232042A1 (en) * | 2020-10-21 | 2023-08-30 | Escient Pharmaceuticals, Inc. | Modulators of mas-related g-protein receptor x2 and related products and their use |
| WO2022140456A1 (en) | 2020-12-22 | 2022-06-30 | Mekanistic Therapeutics Llc | Substituted aminobenzyl heteroaryl compounds as egfr and/or pi3k inhibitors |
| WO2024220236A2 (en) * | 2023-04-21 | 2024-10-24 | University Of Georgia Research Foundation, Inc. | Hydroxylamine-based bcr-abl1 inhibitors for treatment of cancer |
| US20250092031A1 (en) * | 2023-09-20 | 2025-03-20 | Momentum Therapeutics, Inc. | Ripk3 inhibitors and methods of use |
| WO2025147609A1 (en) * | 2024-01-05 | 2025-07-10 | Dewpoint Therapeutics, Inc. | Amino quinoline compounds and uses thereof |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1168801A (en) | 1966-05-13 | 1969-10-29 | May & Baker Ltd | Quinoline Derivatives |
| US6521618B2 (en) * | 2000-03-28 | 2003-02-18 | Wyeth | 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors |
| SE0101675D0 (sv) | 2001-05-11 | 2001-05-11 | Astrazeneca Ab | Novel composition |
| TW200413725A (en) | 2002-09-30 | 2004-08-01 | Oncotherapy Science Inc | Method for diagnosing non-small cell lung cancers |
| US20060024692A1 (en) | 2002-09-30 | 2006-02-02 | Oncotherapy Science, Inc. | Method for diagnosing non-small cell lung cancers |
| TW200423938A (en) | 2003-02-21 | 2004-11-16 | Wyeth Corp | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-alkoxy-3-quinolinecarbonitriles for the treatment of ischemic injury |
| CA2527017A1 (en) * | 2003-05-27 | 2004-12-09 | Pfizer Products Inc. | Quinazolines and pyrido [3,4-d] pyrimidines as receptor tyrosine kinase inhibitors |
| DE602005025231D1 (de) | 2004-08-10 | 2011-01-20 | Oncotherapy Science Inc | Gene und polypeptide in verbindung mit brustkrebserkrankungen |
| EP1856278A2 (en) | 2005-02-10 | 2007-11-21 | Oncotherapy Science, Inc. | Method of diagnosing bladder cancer |
| CN101283106A (zh) | 2005-07-27 | 2008-10-08 | 肿瘤疗法科学股份有限公司 | 小细胞肺癌的诊断方法 |
| EP1954277B1 (en) * | 2005-11-03 | 2017-01-18 | Vertex Pharmaceuticals Incorporated | Aminopyrimidines useful as kinase inhibitors |
| SI2010496T1 (sl) | 2006-04-14 | 2010-11-30 | Astrazeneca Ab | anilinokinolin karboksamidi kot inhibitorji CSF R kinaze |
| WO2007139496A1 (en) | 2006-05-30 | 2007-12-06 | Clanotech Ab | Quinoline derivatives acting as tyrosine kinase inhibitors |
| WO2008023841A1 (en) | 2006-08-25 | 2008-02-28 | Oncotherapy Science, Inc. | Breast cancer-associated gene, melk, and its interactions with bcl-g |
| TW200829555A (en) * | 2006-11-10 | 2008-07-16 | Astrazeneca Ab | Chemical compounds |
| EP2099796B1 (en) | 2006-11-30 | 2011-06-01 | Genentech, Inc. | Aza-indolyl compounds and methods of use |
| CN100540551C (zh) * | 2007-02-01 | 2009-09-16 | 中国药科大学 | 喹啉衍生物、其制备方法及其医药用途 |
| PE20090717A1 (es) * | 2007-05-18 | 2009-07-18 | Smithkline Beecham Corp | Derivados de quinolina como inhibidores de la pi3 quinasa |
| WO2009122180A1 (en) * | 2008-04-02 | 2009-10-08 | Medical Research Council | Pyrimidine derivatives capable of inhibiting one or more kinases |
| EP2303890A4 (en) | 2008-06-19 | 2012-04-11 | Progenics Pharm Inc | INHIBITORS OF PHOSPHATIDYLINOSITE-3-KINASE |
| PE20121148A1 (es) * | 2009-08-17 | 2012-09-07 | Intellikine Llc | Compuestos heterociclicos y usos de los mismos |
| EP2753329B1 (en) * | 2012-01-19 | 2017-08-09 | OncoTherapy Science, Inc. | 1,5-naphthyridine derivatives as melk inhibitors |
-
2011
- 2011-07-28 ES ES11813209.1T patent/ES2565627T3/es active Active
- 2011-07-28 DK DK11813209.1T patent/DK2597955T3/en active
- 2011-07-28 SG SG2013006903A patent/SG187633A1/en unknown
- 2011-07-28 CA CA2806332A patent/CA2806332C/en active Active
- 2011-07-28 WO PCT/US2011/045792 patent/WO2012016082A1/en not_active Ceased
- 2011-07-28 AU AU2011282588A patent/AU2011282588B2/en active Active
- 2011-07-28 RU RU2013108865/04A patent/RU2582610C2/ru active
- 2011-07-28 CN CN201180047405.5A patent/CN103153063B/zh active Active
- 2011-07-28 SG SG10201505951VA patent/SG10201505951VA/en unknown
- 2011-07-28 KR KR1020137005377A patent/KR101826382B1/ko active Active
- 2011-07-28 MX MX2013001201A patent/MX342879B/es active IP Right Grant
- 2011-07-28 EP EP11813209.1A patent/EP2597955B1/en active Active
- 2011-07-28 JP JP2013523213A patent/JP5849303B2/ja active Active
- 2011-07-28 BR BR112013002182A patent/BR112013002182B8/pt active IP Right Grant
- 2011-07-28 US US13/813,134 patent/US9120749B2/en active Active
- 2011-07-29 TW TW100126942A patent/TWI532483B/zh active
-
2012
- 2012-12-25 IL IL223871A patent/IL223871A/en active IP Right Grant
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013532727A5 (https=) | ||
| RU2013108865A (ru) | Производные хинолина и содержащие их ингибиторы melk | |
| CN109983007A (zh) | 酰胺类衍生物抑制剂及其制备方法和应用 | |
| JP2019517487A5 (https=) | ||
| SA520411325B1 (ar) | مشتقات 3-(1- أوكسو أيزو إندولين -2- يل) بيبريدين -2، 6-دايون واستخداماتها | |
| CA2687265A1 (en) | P70 s6 kinase inhibitors | |
| US20170172989A1 (en) | Treatment of cancers having resistance to chemotherapeutic agents | |
| RU2017145026A (ru) | Соединение, ингибирующее brk | |
| JP2009541223A5 (https=) | ||
| JP2014520898A5 (https=) | ||
| JP2014521725A (ja) | ＪＡＫＰＩ３Ｋ／ｍＴＯＲ併用療法 | |
| JP2021501145A5 (https=) | ||
| CA3019450A1 (en) | Indoleamine 2,3-dioxygenase inhibitor, preparation method therefor, and application | |
| JP2013528204A5 (https=) | ||
| CA2493225A1 (en) | Quinoline derivatives and their use as mycobacterial inhibitors | |
| CA2566544A1 (en) | Use of substituted quinoline derivatives for the treatment of drug resistant mycobacterial diseases | |
| MX356411B (es) | Derivados del tipo del azaindazol o diazaindazol como medicamento. | |
| CA2966303A1 (en) | Substituted pyridines as bromodomain inhibitors | |
| JP2014513110A5 (https=) | ||
| JP2016525076A5 (https=) | ||
| MX2013008296A (es) | Diarilacetileno hidracido que contiene inhibidores de tirosina quinasa. | |
| JP2017501237A5 (https=) | ||
| TN2017000158A1 (en) | Carbazole derivatives | |
| JP2015529194A5 (https=) | ||
| JP2015524843A5 (https=) |