KR20180137609A - Tfpi 억제제 및 사용 방법 - Google Patents

Tfpi 억제제 및 사용 방법 Download PDF

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KR20180137609A
KR20180137609A KR1020187036883A KR20187036883A KR20180137609A KR 20180137609 A KR20180137609 A KR 20180137609A KR 1020187036883 A KR1020187036883 A KR 1020187036883A KR 20187036883 A KR20187036883 A KR 20187036883A KR 20180137609 A KR20180137609 A KR 20180137609A
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미하엘 도칼
하르트무트 에흐를리히
프리드리히 샤이플링거
울프 라이머
울리히 라이네케
토마스 폴라코브스키
에베르하르트 슈나이더
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박스알타 인코퍼레이티드
박스앨타 게엠베하
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Abstract

본 발명에서는 조직 인자 경로 억제제 (TFPI)에 결합하는 펩티드, 예를 들어 TFPI-억제 펩티드, 및 그의 조성물을 제공한다. 펩티드는 TFPI를 억제하고/하거나, 응고 인자-결여 대상체에서 트롬빈 형성을 향상시키고/시키거나, 대상체에서 혈병 (blood clot) 형성을 증가시키고/시키거나, 대상체에서 혈액 응고 질환을 치료하기 위해 사용될 수 있다.

Description

TFPI 억제제 및 사용 방법{TFPI INHIBITORS AND METHODS OF USE}
본 발명은 일반적으로 조직 인자 경로 억제제 (TFPI)에 결합하는 펩티드 및 그의 용도에 관한 것이다.
관련 출원에 대한 교차 참조 및 참조에 의한 포함
본원은 2008년 12월 19일자 출원된 미국 특허 가출원 61/139,272에 대한 우선권을 주장하고, 상기 출원의 개시내용은 그 전문이 참고로 포함된다.
지혈은 복잡한 응고 케스케이드에 의존하고, 여기서 혈액 응고 인자에 의해 매개된 일련의 사건은 프로트롬빈의 트롬빈으로의 전환을 일으킨다. 인자 X (FX) 활성화는 고유 및 외인성 경로의 응고 케스케이드 모두의 중심 사건이다. 외인성 경로는 응고 케스케이드의 1차 활성제로서 제안되었다 (Mackman et al., Arterioscler. Thromb. Casc. Biol, 27, 1687-1693 (2007)). 순환 조직 인자 (TF) 및 활성화된 인자 VII (FVIIa)는 상호작용하여 "외인성 복합체"를 형성하고, 이는 FX의 활성화를 매개한다. 응고 케스케이드는 고유 경로에 의해 증폭되고, 그 동안 인자 XII, XI, IX, 및 VIII의 연속적인 활성화는 또한 FX 활성화를 매개하는 "고유" FIXa-FVIIIa 복합체의 형성을 일으킨다. 활성화된 FX는 트롬빈 형성을 촉진하고, 이것은 신체가 섬유소 (fibrin)를 생성하고 출혈을 효과적으로 제한하기 위해 요구된다.
혈우병과 같은 중증 출혈 질환은 혈액 응고 케스케이드의 파괴로부터 기인한다. 가장 일반적인 유형의 혈우병인 혈우병 A는 인자 VIII의 결핍에서 기인하는 반면, 혈우병 B는 인자 IX (FIX)의 결핍과 연관된다. 혈우병 C는 인자 XI (FXI)의 결핍에 의해 야기된다 (Cawthern et al., Blood, 91(12), 4581-4592 (1998)). 현재 혈우병 및 다른 응고 질병에 대한 치유법은 없다. 인자 대체 요법이 혈액 응고 질환에 대한 가장 일반적인 치료법이다. 그러나, 혈액 응고 인자는 대개 투여 직후에 혈류로부터 청소된다. 효과적이기 위해서는 환자는 혈장-유래 또는 재조합 인자 농축물의 빈번한 정맥내 주입을 받아야 하고, 이것은 불편하고, 임상 환경을 필요로 하고, 비싸고, 시간 소모적이다. 또한, 인자 대체 요법의 치료 효능은 억제 항체의 형성 시에 대폭 감소될 수 있다. 중증 혈우병 A 환자의 약 30%가 인자 VIII (FVIII)를 중화시키는 억제 항체를 발생시킨다 (Peerlinck and Hermans, Haemophilia, 12, 579-590 (2006)). 항-인자 항체를 가진 환자에게는 치료 옵션 (option)이 거의 없다.
따라서, 당업계에서는 혈액 응고 질환을 치료하기 위한 조성물 및 방법이 필요하다. 본 발명은 그러한 조성물 및 방법을 제공한다.
발명의 개요
본 발명은 조직 인자 경로 억제제 (TFPI)에 결합하는 펩티드, 예를 들어 혈액 응고 케스케이드를 조정하는 능력을 갖는 TFPI 길항성 펩티드를 제공한다. 예를 들어, 본 발명은 다음 아미노산 서열을 포함하는 펩티드를 제공한다:
X7X8X9X10X11X12X13X14X15X16X17X18X19X20X21 (서열 3109)
여기서,
X7은 L, P, K, S, W, V, N, 및 Q로 이루어진 군 중에서 선택되고;
X8은 L, R, N, F, 및 I로 이루어진 군 중에서 선택되고;
X9는 Y, V, P, 및 C로 이루어진 군 중에서 선택되고;
X10은 F, L, 및 G로 이루어진 군 중에서 선택되고;
X11은 L, W, V, A, M, T, 및 S로 이루어진 군 중에서 선택되고;
X12는 T, F, V, R, A, D, L, E, S, 및 Y로 이루어진 군 중에서 선택되고;
X13은 I, M, G, Q, D, 및 R로 이루어진 군 중에서 선택되고;
X14는 G, W, Y, L, M, 및 H로 이루어진 군 중에서 선택되고;
X15는 N, P, F, H, K, 및 Y로 이루어진 군 중에서 선택되고;
X16은 M, D, E, V, G, 및 K로 이루어진 군 중에서 선택되고;
X17은 G, I, R, S, T, 및 L로 이루어진 군 중에서 선택되고;
X18은 M, K, L, 및 I로 이루어진 군 중에서 선택되고;
X19는 Y, G, R, 및 S로 이루어진 군 중에서 선택되고;
X20은 A, E, S, C, 및 Y로 이루어진 군 중에서 선택되고;
X21은 A, V, K, 및 E로 이루어진 군 중에서 선택된다.
하나의 측면에서, 펩티드는 X7에 직접 연결된 하나 이상의 N-말단 아미노산(들)을 포함하고, 여기서 N-말단 아미노산(들)은
X6,
X5X6,
X4X5X6,
X3X4X5X6 (서열 3110),
X2X3X4X5X6 (서열 3111), 및
X1X2X3X4X5X6 (서열 3112)로 이루어진 군 중에서 선택된 아미노산 서열을 포함하고, 여기서
X1은 T 및 G로 이루어진 군 중에서 선택되고; X2는 F 및 V로 이루어진 군 중에서 선택되고; X3은 V, W, Y, 및 F로 이루어진 군 중에서 선택되고; X4는 D, Q, 및 S로 이루어진 군 중에서 선택되고; X5는 E, T, N, 및 S로 이루어진 군 중에서 선택되고; X6은 R, H, K, 및 A로 이루어진 군 중에서 선택된다.
별법으로 또는 추가로, 펩티드는 X21에 직접 연결된 하나 이상의 C-말단 아미노산을 포함하고, 여기서 C-말단 아미노산(들)은
X22,
X22X23,
X22X23X24,
X22X23X24X25 (서열 3113),
X22X23X24X25X26 (서열 3114), 및
X22X23X24X25X26X27 (서열 3115)로 이루어진 군 중에서 선택된 아미노산 서열을 포함하고, 여기서
X22는 Q, I, E, W, R, L, 및 N으로 이루어진 군 중에서 선택되고; X23은 L, V, M, 및 R로 이루어진 군 중에서 선택되고; X24는 K, L, A, 및 Y로 이루어진 군 중에서 선택되고; X25는 F이고; X26은 G이고; X27은 T이다.
하나의 측면에서, 본 발명은 서열 1-7에 제시된 아미노산 서열을 포함하는 펩티드, 예를 들어 JBT0132, JBT0303, JBT0193, JBT0178, JBT0120, 및 JBT0224 중 임의의 하나에 제시된 아미노산 서열을 포함하는 펩티드를 제공하고, 이는 혈액 응고 케스케이드 내에서 TFPI 활성을 억제한다. 본 발명은 Phe-Gln-Ser-Lys-Gly-Asn-Val-Phe-Val-Asp-Gly-Tyr-Phe-Glu-Arg-Leu-Arg-Ala-Lys-Leu (FQSKGNVFVDGYFERLRAKL) (서열 32)의 서열에 적어도 60% 동일성의 아미노산 서열을 포함하는, TFPI에 결합하는 펩티드를 또한 제공한다.
또한, 본 발명은 TFPI에 결합하는 펩티드를 제공하고, 여기서 펩티드는 화학식 I의 구조를 포함한다: X1001-X1002-X1003-X1004-X1005-X1006-X1007-X1008-X1009-X1010-X1011-X1012-X1013-X1014-X1015-X1016-X1017-X1018-X1019-X1020 (I) (서열 3116).
화학식 I에서,
X1001은 Bhf, C, D, F, G, H, I, K, L, M, N, Nmf, Q, R, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X1002는 G, K 및 Q로 이루어진 군 중에서 선택되는 아미노산이고;
X1003은 A, Aib, Bhs, C, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X1004는 A, Aib, Bhk, C, D, E, F, G, H, I, K, k, L, M, N, Nmk, P, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X1005는 a, A, Aib, Bal, C, D, d, E, F, G, H, K, k, L, M, N, Nmg, p, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X1006은 A, Aib, Btq, C, D, E, F, G, H, I, K, L, M, N, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X1007은 A, F, G, I, K, L, Nmv, P, Q, S, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X1008은 F, H, K, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X1009는 A, Aib, f, I, K, S, T 및 V로 이루어진 군 중에서 선택되는 아미노산이고;
X1010은 A, Aib, C, D, E, F, G, H, I, K, L, M, N, Nmf, P, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X1011은 Aib, C, K, G 및 Nmg로 이루어진 군 중에서 선택되는 아미노산이고;
X1012는 Y이고;
X1013은 A, Aib, C, E, F, G, H, K, L, M, Q, R, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X1014는 A, Aib, Bhe, C, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X1015는 (오메가-메틸)-R, D, E, K 및 R로 이루어진 군 중에서 선택되는 아미노산이고;
X1016은 L이고;
X1017은 (오메가-메틸)-R, A, Aib, Bhr, C, Cha, Cit, D, Dab, Dap, E, Eag, Eew, F, G, H, Har, Hci, Hle, I, K, L, M, N, Nle, Nva, Opa, Orn, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X1018은 A, Bal, C, D, E, F, G, H, I, K, L, M, N, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X1019는 Bhk, K, R 및 V로 이루어진 군 중에서 선택되는 아미노산이고;
X1020은 존재하거나 부재하고, 존재할 때 X1020은 Aib, Bhl, C, F, G, H, I, K, L, Nml, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이다.
하나의 측면에서, TFPI에 결합하는 펩티드는 하기 화학식 III의 구조를 포함한다: X1001-Q-X1003-X1004-X1005-X1006-I/V-X1008-V-X1010-G-Y-C/F-X1014-R-L-X1017-X1018-K-K/L (III) (서열 3117). 화학식 III에서, X1001, X1003, X1004, X1005, X1006, X1008, X1010, X1014, X1017 및 X1018은 각각 독립적으로 임의의 아미노산 중에서 선택된다.
본 발명은 하기 화학식 V의 구조를 포함하는 TFPI-결합 펩티드를 추가로 제공한다: X2001-X2002-X2003-X2004-X2005-X2006-[X2007-X2008-X2009-X2010-X2011-X2012-X2013-X2014-X2015-X2016-X2017-X2018]-X2019-X2020-X2021-X2022-X2023 (V) (서열 3118). 화학식 V에서, X2001, X2002, 및 X2023은 독립적으로 존재하거나 부재한다. 존재할 때, X2001은 A, D, E, F, G, H, I, K, L, P, R, S, T, V 및 W로 이루어진 군 중에서 선택되는 아미노산이고; X2002는 A, D, E, F, G, H, I, K, L, M, P, R, S, T, V 및 W로 이루어진 군 중에서 선택되는 아미노산이다. 추가로,
X2003은 A, F, I, K, L, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X2004는 A, D, E, F, G, I, K, L, R, S, T, V 및 W로 이루어진 군 중에서 선택되는 아미노산이고;
X2005는 W이고;
X2006은 F, H, I, K, L, R, V 및 W로 이루어진 군 중에서 선택되는 아미노산이고;
X2007은 C, Hcy, Dap 및 K로 이루어진 군 중에서 선택되는 아미노산, 바람직하게는 C 및 Hcy로 이루어진 군 중에서 선택되는 아미노산이고;
X2008은 A, G, R, S 및 T로 이루어진 군 중에서 선택되는 아미노산이고;
X2009는 a, A, I, K, L, M, m, Nle, p, R, 및 V로 이루어진 군 중에서 선택되는 아미노산이고;
X2010은 A, G, I, K, L, P, R, S, T 및 V로 이루어진 군 중에서 선택되는 아미노산이고;
X2011은 D, E, G, S 및 T로 이루어진 군 중에서 선택되는 아미노산이고;
X2012는 A, a, D, d, E, e, F, f, G, I, K, k, L, l, M, m, Nle, nle, P, p, R, r, S, s, T, t, V, v, W 및 w로 이루어진 군 중에서 선택되는 아미노산이고;
X2013은 A, D, d, E, e, F, G, I, K, L, R, S, s, T, V 및 W로 이루어진 군 중에서 선택되는 아미노산이고;
X2014는 A, D, E, F, G, I, K, L, M, R, S, T, V 및 W로 이루어진 군 중에서 선택되는 아미노산이고;
X2015는 A, D, E, F, G, I, K, L, M, Nle, R, S, T, V 및 W로 이루어진 군 중에서 선택되는 아미노산이고;
X2016은 A, D, E, F, I, K, L, M, Nle, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X2017은 A, D, E, F, G, I, K, L, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X2018은 C 및 D로 이루어진 군 중에서 선택되는 아미노산이고 (바람직하게는 X2018은 C이다);
X2019는 A, F, I, L, S, T, V 및 W로 이루어진 군 중에서 선택되는 아미노산이고;
X2020은 F 및 W로 이루어진 군 중에서 선택되는 아미노산이고;
X2021은 I, L 및 V로 이루어진 군 중에서 선택되는 아미노산이고;
X2022는 A, D, E, F, G, I, K, L, P, R, S, T, V, 및 W로 이루어진 군 중에서 선택되는 아미노산이다.
X2023이 펩티드 내에 존재할 때, X2023은 A, D, E, F, G, I, K, L, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이다. 펩티드는 화학식 V에서 괄호로 나타낸, X2007과 X2018 사이의 연결에 의해 생성된 고리 구조체를 포함한다.
본 발명은 또한 TFPI에 결합하는 펩티드를 제공하고, 여기서 펩티드는 하기 화학식 VI의 구조를 포함한다: X2001-X2002-F/Y-K-W-F/H-[C-X2008-M/V-X2010-D-X2012-X2013-G-I/T-X2016-S/T-C]-A/V-W-V-X2022-X2023 (VI) (서열 3119). 화학식 VI에서, X2001, X2002 및 X2023은 각각 독립적으로 존재하거나 부재한다. X2008, X2010, X2012, X2013, X2016 및 X2022뿐만 아니라 X2001, X2002 및 X2023 (존재할 때)은 각각 독립적으로 임의의 아미노산으로부터 선택된다. 펩티드는 화학식 VI에서 괄호로 나타낸, X2007과 X2018 사이의 연결에 의해 생성된 고리 구조체를 포함한다.
하나의 측면에서, 본 발명은 TFPI에 결합하는 펩티드를 제공하고, 여기서 펩티드는 하기 화학식 VIII의 구조를 포함한다: X3001-X3002-X3003-X3004-X3005-X3006-X3007-X3008-X3009-X3010-X3011-X3012-X3013-X3014-X3015-X3016-X3017-X3018-X3019-X3020-X3021 (VIII) (서열 3120). 화학식 VIII에서, X3001 및 X3002는 각각 독립적으로 존재하거나 부재한다. 존재할 때, X3001은 A, C, D, F, G, I, K, L, M, N, P, Q, R, S, T, W, E, H 및 Y로 이루어진 군 중에서 선택되는 아미노산이고; X3002는 A, C, D, F, H, K, M, N, P, R, S, T, W, Y, G, I 및 L로 이루어진 군 중에서 선택되는 아미노산이다. 화학식 VIII의 나머지에 관하여,
X3003은 A, C, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X3004는 A, C, D, E, F, G, H, I, K, L, M, N, Q, R, S, T, V, W, Y 및 P로 이루어진 군 중에서 선택되는 아미노산이고;
X3005는 C, D, F, G, H, I, K, L, M, N, P, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X3006은 A, W, C, K, P, R 및 H로 이루어진 군 중에서 선택되는 아미노산이고;
X3007은 Q, A, C, F, G, H, I, K, L, N, R, S, T, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X3008은 A, C, F, G, H, K, L, M, N, P, Q, R, S, T, V, W, Y 및 I로 이루어진 군 중에서 선택되는 아미노산이고;
X3009는 A, C, F, G, H, I, L, M, R, S, T, V, W, Y 및 K로 이루어진 군 중에서 선택되는 아미노산이고;
X3010은 A, C, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X3011은 A, G, I, K, L, M, N, Q, R, S, T, V, W, Y, C, F 및 H로 이루어진 군 중에서 선택되는 아미노산이고;
X3012는 A, C, H, I, K, L 및 R로 이루어진 군 중에서 선택되는 아미노산이고;
X3013은 A, C, F, G, H, K, L, M, R, S, V, W, Y 및 I로 이루어진 군 중에서 선택되는 아미노산이고;
X3014는 A, C, F, G, H, I, L, M, N, Q, R, S, T, V, W, Y 및 K로 이루어진 군 중에서 선택되는 아미노산이고;
X3015는 A, K 및 R로 이루어진 군 중에서 선택되는 아미노산이고;
X3016은 A, F, K 및 R로 이루어진 군 중에서 선택되는 아미노산이고;
X3017은 A, C, F, G, I, K, L, N, Q, R, S, T, V, W, Y, H, A 및 M으로 이루어진 군 중에서 선택되는 아미노산이고;
X3018은 A, C, F, I, K, L, M, Q, R, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X3019는 A, C, D, E, F, G, H, K, L, N, P, Q, R, V, W, Y 및 I로 이루어진 군 중에서 선택되는 아미노산이고;
X3020은 A, C, F, G, H, K, L, M, N, Q, R, V, W, Y, I 및 P로 이루어진 군 중에서 선택되는 아미노산이고;
X3021은 A, C, H, I, K, L, M, N, P, Q, R, T, V, W, Y, F 및 G로 이루어진 군 중에서 선택되는 아미노산이다.
추가로, 본 발명은 하기 화학식 IX의 구조를 포함하는, TFPI-결합 펩티드를 제공한다: X3001-X3002-X3003-X3004-X3005-X3006-X3007-X3008-X3009-X3010-X3011-H-X3013-X3014-K/R-R-X3017-X3018-X3019-X3020-X3021 (IX) (서열 3121). 여기서, X3001, X3002, X3003, X3004, X3005, X3006, X3007, X3008, X3009, X3010, X3011, X3013, X3014, X3017, X3018, X3019, X3020 및 X3021은 각각 독립적으로 임의의 아미노산으로부터 선택된다. 또한, 본 발명은 TFPI에 결합하는 펩티드를 포함하고, 여기서 펩티드는 다음 화학식 X의 서열에 적어도 60% 동일성을 갖는 아미노산 서열을 포함한다: Ac-GYASFPWFVQLHVHKRSWEMA-NH2 (서열 2023). 본원의 문맥에서, 화학식 I 내지 X 중 임의의 것에 포함된 임의의 펩티드 및 본원에 기재된 임의의 TFPI-결합 펩티드는 또한 "본 발명의 펩티드" 및 "본원에 기재된 펩티드"로서 칭해진다.
일부 실시양태에서, 본 발명의 펩티드는 TFPI-1 (예를 들어, TFPI-1α)에 결합하고, 임의로 FVIII, FIX, 및/또는 FXI의 부재 하에 TFPI-조절된 트롬빈 생성을 개선한다. 펩티드를 포함하는 조성물 (예를 들어, 제약 조성물)을 또한 제공한다.
또한, 본 발명은 본 발명의 펩티드의 사용 방법을 제공한다. 예를 들어, 본 발명은 TFPI를 본원에 기재된 펩티드와 접촉시키는 것을 포함하는, TFPI의 억제 방법을 제공한다. 본 발명은 또한 응고 인자-결여 대상체에서 트롬빈 형성을 향상시키는 방법, 대상체에서 혈병 (blood clot) 형성을 증가시키는 방법, 및 대상체에서 혈액 응고 질환을 치료하는 방법을 제공한다. 상기 방법들은 그 전체를 또한 본원에서 예를 들어, "본 발명의 방법"으로서 칭한다. 방법은 대상체에게 본원에 기재된 펩티드를 대상체에서 트롬빈 형성을 향상시키기 위해 효과적인 양, 혈병 형성을 향상시키기 위해 효과적인 양, 또는 혈액 응고 질환을 치료하기 위해 효과적인 양으로 투여하는 것을 포함한다. 명백하게 반대로 나타내지 않으면, 본 발명의 하나의 펩티드 또는 본 발명의 방법에 관하여 본원에서 제공되는 설명은 본 발명의 각각의 및 모든 펩티드 및 본 발명의 방법에 각각 적용된다. 본 발명의 추가의 측면은 의약의 제조를 위한 본 발명의 펩티드의 용도, TFPI를 디스플레이하는 세포를 표적화하는 방법, 질병에 걸린 또는 질병에 걸릴 위험이 있는 대상체의 치료 또는 진단 방법, 및 TFPI를 정제하는 방법을 포함한다. 선행 방법은 그 전체가 또한 본원에서 예를 들어, "본 발명의 방법"으로서 칭해진다.
도 1은 혈액 응고 케스케이드의 도면이다.
도 2는 조직 인자 경로 억제제-1의 2차 구조의 도면이다.
도 3은 조직 인자, 인자 Xa (FXa), 인자 VIIa (FVIIa), 및 TFPI를 포함하는 4원 복합체의 형성의 도면이다.
도 4는 펩티드 JBT0293에 관하여 아미노산 치환 (굵고 밑줄친)을 나타내는 다양한 TFPI-억제 펩티드의 아미노산 서열의 목록이다.
도 5는 TFPI-억제제 펩티드의 mRNA 디스플레이 선택의 도면이다.
도 6A는 EC50 결합 ELISA의 도면이고, 도 6B는 실시예 1에 기재된 IC50 ELISA의 도면이다.
도 7은 비오티닐화 펩티드 JBT0132에 대한 % OD (y축) 및 농도 [nM] (x-축)를 비교하는 결합 ELISA 곡선이다.
도 8A-8D는 본 발명의 예시적인 펩티드에 대한 % OD (y축) 및 농도 [nM] (x축)를 비교하는 경쟁 ELISA 곡선이다.
도 9A 및 9B는 펩티드 JBT0120 및 JBT0132에 대해 RU (y축)를 시간 (초) (x축)에 대해 플로팅한 센소그램 (sensorgram)이다.
도 10A 및 10B는 조직 인자 경로 억제제-1 및 조직 인자 경로 억제제-2와 펩티드 JBT0120 상호작용에 대해 RU (y축)를 시간 (초) (x축)에 대해 플로팅한 센소그램이다.
도 11A 및 11B는 혈장-기반 분석에서 펩티드 JBT0120 및 펩티드 JBT0132에 대해 생성된 트롬빈의 양 (nM) (y축) 및 시간 (분) (x축)을 비교하는 그래프이다.
도 12-18은 다양한 TFPI-억제 펩티드의 아미노산 서열; FXa 억제 분석에서 관찰된 TFPI의 EC50 및 % 억제; 외인성 테나제 (tenase) 억제 분석에서 관찰된 TFPI의 EC50 및 % 억제; 및 혈장-기반 분석에서 FEIBA, 인자 VIII (FVIII) 이뮤네이트 (Immunate), 또는 인자 IX (FIX) 등가 활성 (mU/mL)을 나열하는 표이다. "*"는 음성 대조군을 나타낸다.
도 19-21은 몇몇 TFPI-결합 펩티드의 BIAcore 분석의 결과를 나열하는 표이다. "*"는 음성 대조군을 나타낸다.
도 22-30은 다양한 TFPI-결합 펩티드의 아미노산 서열; FXa 억제 분석에서 관찰된 TFPI의 EC50 및 % 억제; 외인성 테나제 억제 분석에서 관찰된 TFPI의 EC50 및 % 억제; 및 혈장-기반 분석에서 FEIBA, FVIII 이뮤네이트, 또는 FIX 등가 활성 (mU/mL)을 나열하는 표이다. "*"는 음성 대조군을 나타낸다.
도 31은 PEG화된 TFPI-결합 펩티드의 약동학 특징 (펩티드의 농도 (y축) 대 투여 후 시간 (x축))을 PEG가 결핍되는 동일한 펩티드의 약동학 특징에 비교하는 그래프이다. 펩티드를 C57B16 마우스에 10 mg/kg의 용량으로 정맥내 투여하였다. 3개의 생물학적 샘플을 각각의 시점에서 펩티드의 존재에 대해 분석하였다.
도 32-39는 본 발명의 다양한 펩티드의 아미노산 서열 및 IC50 또는 EC50 값을 나열하는 표이다. "*"는 음성 대조군을 나타낸다.
본 발명은 혈액 응고 케스케이드 내에서 조직 인자 경로 억제제-1 (본원에서 TFPI로서 칭함)의 억제 활성을 차단하는 펩티드를 제공한다. 혈관 손상 시에, 조직 인자 (TF) 복합체는 인자 VIIa와 함께 "외인성 복합체" 또는 "외인성 테나제 복합체"를 형성하고, 이는 인자 IX 및 X를 활성화시킨다 (도 1). TFPI는 TF/FVIIa 외인성 복합체 활성의 주요 천연 조절물질이고, 연장에 의해, 트롬빈 생성을 제어하는데 일정 역할을 한다 (Panteleev et al., Eur. J. Biochem., 249, 2016-2031 (2002)). TFPI는 3개의 쿠니츠 (Kunitz)-형 억제 도메인을 포함하는 43 kDa 세린 프로테아제 억제제이다 (도 2). TFPI의 쿠니츠 도메인 1은 FVIIa에 결합하고, 쿠니츠 도메인 2는 FXa에 결합하여, 억제제가 TF/FVIIa 외인성 복합체의 활성을 차단하는 4원 FXa-TFPI-FVIIa-TF 복합체를 형성하도록 허용한다 (도 3). FXa의 TFPI 결합은 또한 응고 케스케이드의 공통 경로를 하향조절하고, 그 동안 FXa는 프로트롬빈을 트롬빈으로 전환시킨다 (Audu et al., Anesth. Analg., 103(4), 841-845 (2006)). 본 발명은 예를 들어, 혈액 응고 케스케이드에 대한 TFPI의 억제 작용을 차단하여 트롬빈 형성을 향상시키는 TFPI-억제 펩티드를 제공한다.
몇몇 TFPI-결합 펩티드의 아미노산 서열을 본원에서 제공한다. 통상적인 아미노산은 표 1에 제시된 바와 같이 그들의 표준 1-문자 또는 3-문자 코드에 따라 확인된다.
3-문자 코드 1-문자 코드 아미노산 3-문자 코드 1-문자 코드 아미노산
Ala A 알라닌 Met M 메티오닌
Cys C 시스테인 Asn N 아스파라긴
Asp D 아스파르트산 Pro P 프롤린
Glu E 글루탐산 Gln Q 글루타민
Phe F 페닐알라닌 Arg R 아르기닌
Gly G 글라이신 Ser S 세린
His H 히스티딘 Thr T 트레오닌
Ile I 이소류신 Val V 발린
Lys K 라이신 Trp W 트립토판
Leu L 류신 Tyr Y 티로신
비-통상적인 아미노산 및 추가의 펩티드 빌딩 블록 (building block)은 표 2에 제공된 3-문자 코드 (일반적인 4-문자 약어인 Ttds 제외)에 따라 확인된다.
Figure pat00001
Figure pat00002
Figure pat00003
Figure pat00004
Figure pat00005
Figure pat00006
Figure pat00007
본원에서 제공되는 펩티드의 아미노산 서열은 당업자가 이해할 바와 같이 전형적인 펩티드 서열 형식으로 도시된다. 예를 들어, 통상적인 아미노산의 3-문자 코드 또는 1-문자 코드, 또는 비-통상적인 아미노산에 대한 3-문자 코드 또는 약어는 펩티드 서열 내에서 명시된 위치에서 아미노산의 존재를 나타낸다. 각각의 비-통상적인 아미노산에 대한 코드는 서열 내의 다음 및/또는 선행 아미노산에 대한 코드에 하이픈 (hyphen)에 의해 연결된다. 인접한 아미노산은 화학 결합 (대개 아미드 결합)에 의해 연결된다. 화학 결합의 형성은 인접한 아미노산의 좌측에 위치할 때 아미노산 (예를 들어, Hle-인접한 아미노산)의 1-카르복실기로부터 히드록실기를 제거하고, 인접한 아미노산의 우측에 위치할 때 아미노산 (예를 들어, 인접한 아미노산-Hle)의 아미노기로부터 수소를 제거한다. 두 변형이 모두 동일한 아미노산에 적용되고, 하이픈으로 명백하게 예시하지 않으면서 아미노산 서열 내에 존재하는 인접한 통상적인 아미노산에 적용될 수 있음이 이해된다. 아미노산이 아미노산 측쇄 내에 1개 초과의 아미노 및/또는 카르복시기를 함유하는 경우에, 2- 또는 3-아미노기 및/또는 1-카르복시기가 일반적으로 펩티드 결합의 형성을 위해 사용된다. 비-통상적인 아미노산에 대해, 3-문자 코드가 사용되었고, 여기서 첫 번째 문자는 C-α-원자의 입체화학을 나타낸다. 예를 들어, 대문자 첫 번째 문자는 L-형의 아미노산이 펩티드 서열 내에 존재하는 것을 나타내는 반면, 소문자 첫 번째 문자는 D-형의 대응 아미노산이 펩티드 서열 내에 존재하는 것을 나타낸다. 1-문자 코드가 사용될 때, 소문자는 D-아미노산을 나타내는 반면, 대문자는 L-아미노산을 나타낸다. 반대로 지시하지 않는 한, 아미노산 서열은 본원에서 N-에서 C-말단 방향으로 제시한다.
본원에 기재된 몇몇 TFPI-결합 펩티드 서열의 C-말단은 OH, NH2, 또는 C-말단 아미노산 코드에 하이픈을 통해 연결된 구체적인 종결 아민에 대한 약어를 포함시킴으로써 명백하게 예시된다. 본원에 기재된 몇몇 펩티드의 N-말단은 수소 (유리 N-말단에 대해), 또는 N-말단 아미노산 코드에 하이픈을 통해 연결된 구체적인 종결 카르복실산 또는 다른 화학기에 대한 약어를 포함시킴으로써 명백하게 예시된다.
본 발명은 하기 아미노산 서열을 포함하는 펩티드를 제공한다:
X7X8X9X10X11X12X13X14X15X16X17X18X19X20X21 (서열 3109)
여기서 (아미노산에 대한 단일 문자 코드를 이용하여),
X7은 L, P, K, S, W, V, N, 및 Q로 이루어진 군 중에서 선택되고;
X8은 L, R, N, F, 및 I로 이루어진 군 중에서 선택되고;
X9는 Y, V, P, 및 C로 이루어진 군 중에서 선택되고;
X10은 F, L, 및 G로 이루어진 군 중에서 선택되고;
X11은 L, W, V, A, M, T, 및 S로 이루어진 군 중에서 선택되고;
X12는 T, F, V, R, A, D, L, E, S, 및 Y로 이루어진 군 중에서 선택되고;
X13은 I, M, G, Q, D, 및 R로 이루어진 군 중에서 선택되고;
X14는 G, W, Y, L, M, 및 H로 이루어진 군 중에서 선택되고;
X15는 N, P, F, H, K, 및 Y로 이루어진 군 중에서 선택되고;
X16은 M, D, E, V, G, 및 K로 이루어진 군 중에서 선택되고;
X17은 G, I, R, S, T, 및 L로 이루어진 군 중에서 선택되고;
X18은 M, K, L, 및 I로 이루어진 군 중에서 선택되고;
X19는 Y, G, R, 및 S로 이루어진 군 중에서 선택되고;
X20은 A, E, S, C, 및 Y로 이루어진 군 중에서 선택되고;
X21은 A, V, K, 및 E로 이루어진 군 중에서 선택된다.
상기한 코어 구조 (X7-X21)에 추가로, 구체적으로 고려되는 다른 구조는 하나 이상의 추가의 아미노산이 코어 구조에 부착된 (예를 들어, 아미노산 서열 X7-X21의 N-말단 또는 C-말단에 연결된) 구조이다. 따라서, 본 발명은 코어 구조를 포함하고 다음으로 이루어진 군 중에서 선택된 아미노산 서열을 포함하는 하나 이상의 N-말단 아미노산(들)을 추가로 포함하는 펩티드를 포함한다:
X6,
X5X6,
X4X5X6,
X3X4X5X6 (서열 3110),
X2X3X4X5X6 (서열 3111), 및
X1X2X3X4X5X6 (서열 3112)
여기서, X6은 코어 구조 아미노산 서열의 X7에 직접 연결되고,
X1은 T 및 G로 이루어진 군 중에서 선택되고;
X2는 F 및 V로 이루어진 군 중에서 선택되고;
X3은 V, W, Y, 및 F로 이루어진 군 중에서 선택되고;
X4는 D, Q, 및 S로 이루어진 군 중에서 선택되고;
X5는 E, T, N, 및 S로 이루어진 군 중에서 선택되고;
X6은 R, H, K, 및 A로 이루어진 군 중에서 선택된다.
본 발명의 펩티드는 하나의 측면에서 아미노산 서열 QSKKNVFVFGYFERLRAK (서열 1)을 포함하거나 그로 이루어진다.
또 다른 실시양태에서, 코어 구조를 포함하는 본 발명의 펩티드는 다음으로 이루어진 군 중에서 선택된 아미노산 서열을 포함하는 하나 이상의 C-말단 아미노산(들)을 포함한다:
X22,
X22X23,
X22X23X24,
X22X23X24X25 (서열 3113),
X22X23X24X25X26 (서열 3114), 및
X22X23X24X25X26X27 (서열 3115)
여기서, X22는 코어 구조 아미노산 서열의 X21에 직접 연결되고,
X22는 Q, I, E, W, R, L, 및 N으로 이루어진 군 중에서 선택되고;
X23은 L, V, M, 및 R로 이루어진 군 중에서 선택되고;
X24는 K, L, A, 및 Y로 이루어진 군 중에서 선택되고;
X25는 F이고;
X26은 G이고;
X27은 T이다.
하나의 측면에서, 본 발명의 펩티드는 아미노산 서열 VIVFTFRHNKLIGYERRY (서열 4)를 포함하거나 그로 이루어진다. 본 발명의 펩티드가 코어 구조의 N-말단 및 C-말단 모두에서 추가의 아미노산을 포함하는 것이 또한 고려된다. 상기 측면에서, 펩티드는 아미노산 서열 TFVDERLLYFLTIGNMGMYAAQLKF (서열 3), GVWQTHPRYFWTMWPDIKGEVIVLFGT (서열 5), KWFCGMRDMKGTMSCVWVKF (서열 6), 또는 ASFPLAVQLHVSKRSKEMA (서열 7)을 포함하거나 그로 이루어진다.
본 발명은 아미노산 서열 X3X4X5-F-X7-NVF-X11X12-GY-X15X16-RLRAK-X22 (서열 2)를 포함하는 펩티드를 추가로 포함하고, 여기서 X3은 Y 또는 F이고; X4는 Q 또는 S이고; X5는 N 또는 S이고; X7은 K, N, 또는 Q이고; X11은 V, A, S, 또는 T이고; X12는 F, A, D, L, Q, S, 또는 Y이고; X15는 F, K, 또는 Y이고; X16은 E 또는 D이고; X22는 L 또는 N이다.
또한, 본 발명은 TFPI에 결합하는 펩티드를 제공하고, 여기서 펩티드는 하기 화학식 I의 구조를 포함한다: X1001-X1002-X1003-X1004-X1005-X1006-X1007-X1008-X1009-X1010-X1011-X1012-X1013-X1014-X1015-X1016-X1017-X1018-X1019-X1020 (I) (서열 3116). 화학식 I에서,
X1001은 Bhf, C, D, F, G, H, I, K, L, M, N, Nmf, Q, R, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X1002는 G, K 및 Q로 이루어진 군 중에서 선택되는 아미노산이고;
X1003은 A, Aib, Bhs, C, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X1004는 A, Aib, Bhk, C, D, E, F, G, H, I, K, k, L, M, N, Nmk, P, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X1005는 a, A, Aib, Bal, C, D, d, E, F, G, H, K, k, L, M, N, Nmg, p, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X1006은 A, Aib, Btq, C, D, E, F, G, H, I, K, L, M, N, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X1007은 A, F, G, I, K, L, Nmv, P, Q, S, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X1008은 F, H, K, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X1009는 A, Aib, f, I, K, S, T 및 V로 이루어진 군 중에서 선택되는 아미노산이고;
X1010은 A, Aib, C, D, E, F, G, H, I, K, L, M, N, Nmf, P, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X1011은 Aib, C, K, G 및 Nmg로 이루어진 군 중에서 선택되는 아미노산이고;
X1012는 Y이고;
X1013은 A, Aib, C, E, F, G, H, K, L, M, Q, R, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X1014는 A, Aib, Bhe, C, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X1015는 (오메가-메틸)-R, D, E, K 및 R로 이루어진 군 중에서 선택되는 아미노산이고;
X1016은 L이고;
X1017은 (오메가-메틸)-R, A, Aib, Bhr, C, Cha, Cit, D, Dab, Dap, E, Eag, Eew, F, G, H, Har, Hci, Hle, I, K, L, M, N, Nle, Nva, Opa, Orn, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X1018은 A, Bal, C, D, E, F, G, H, I, K, L, M, N, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X1019는 Bhk, K, R 및 V로 이루어진 군 중에서 선택되는 아미노산이다.
X1020은 화학식 I 내에서 존재하거나 부재한다 (즉, 일부 경우에, 본 발명의 펩티드는 구조 X1001-X1002-X1003-X1004-X1005-X1006-X1007-X1008-X1009-X1010-X1011-X1012-X1013-X1014-X1015-X1016-X1017-X1018-X1019-X1020 (서열 3116)을 포함한다). X1020이 존재하는 경우에는 Aib, Bhl, C, F, G, H, I, K, L, Nml, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이다.
예를 들어, 본 발명의 펩티드는 화학식 I의 구조를 포함하고, 여기서 X1001은 C, F, I, K, L, Nmf, V, M, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고; X1002는 Q이고; X1003은 A, C, D, E, H, K, M, I, N, Q, R, S, T 및 V로 이루어진 군 중에서 선택되는 아미노산이고; X1004는 A, Aib, C, D, E, G, H, F, I, K, k, L, M, N, Nmk, P, Q, R, S, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고; X1005는 a, A, Aib, Bal, C, d, E, D, F, G, H, K, k, L, M, N, Nmg, p, Q, R, S, T 및 Y로 이루어진 군 중에서 선택되는 아미노산이고; X1006은 A, Btq, C, D, G, I, K, H, L, M, N, Q, R, S, V 및 Y로 이루어진 군 중에서 선택되는 아미노산이고; X1007은 I, K, L, Q, V 및 Y로 이루어진 군 중에서 선택되는 아미노산이고; X1008은 F, H 및 Y로 이루어진 군 중에서 선택되는 아미노산이고; X1009는 f, I 및 V로 이루어진 군 중에서 선택되는 아미노산이고; X1010은 A, D, E, F, G, H, K, L, M, N, P, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고; X1011은 G 및 Nmg로 이루어진 군 중에서 선택되는 아미노산이고; X1012는 Y이고; X1013은 Aib, C, F, H, L, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고; X1014는 A, Aib, Bhe, C, D, E, H, I, K, L, M, N, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고; X1015는 E 및 R로 이루어진 군 중에서 선택되는 아미노산이고; X1016은 L이고; X1017은 (오메가-메틸)-R, A, Aib, Bhr, C, Cha, Cit, Dab, Dap, Eag, Eew, F, H, Har, Hci, Hle, I, K, L, M, N, Nle, Nva, Opa, Orn, R, S, T, V 및 Y로 이루어진 군 중에서 선택되는 아미노산이고; X1018은 A, C, D, E, F, I, K, L, M, N, Q, R, V 및 W로 이루어진 군 중에서 선택되는 아미노산이고; X1019는 K 및 R로 이루어진 군 중에서 선택되는 아미노산이고; X1020은 Aib, Bhl, F, K, L, R 및 W로 이루어진 군 중에서 선택되는 아미노산이다 (X1020이 펩티드 내에 존재할 때).
하나의 측면에서, 본 발명의 펩티드는 화학식 I의 구조를 포함하고, 여기서 X1001은 F, L, Y 및 M으로 이루어진 군 중에서 선택되는 아미노산이고; X1002는 Q이고; X1003은 M, Q, R, S, T 및 C로 이루어진 군 중에서 선택되는 아미노산이고; X1004는 Aib, K, L, P, R, E, G, I, Y, M 및 W로 이루어진 군 중에서 선택되는 아미노산이고; X1005는 a, Aib, D, d, G, H, K, k, N, Nmg, p, Q, R, A, E, C 및 M으로 이루어진 군 중에서 선택되는 아미노산이고; X1006은 A, C, D, G, H, K, N, Q, R, S 및 M으로 이루어진 군 중에서 선택되는 아미노산이고; X1007은 I 및 V로 이루어진 군 중에서 선택되는 아미노산이고; X1008은 F, H 및 Y로 이루어진 군 중에서 선택되는 아미노산이고; X1009는 V이고; X1010은 A, D, E, K, M, N, Q, R, F, H, P, S, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고; X1011은 G이고; X1012는 Y이고; X1013은 C 또는 F이고; X1014는 A, C, D, E, K, L, M, N, Q, R, T, V 및 Aib로 이루어진 군 중에서 선택되는 아미노산이고; X1015는 R이고; X1016은 L이고; X1017은 A, Aib, C, Cha, Dab, Dap, Eag, Eew, H, Har, Hci, Hle, K, Nle, Nva, Opa, Orn, R, I, L, S 및 M으로 이루어진 군 중에서 선택되는 아미노산이고; X1018은 A, L, N, M 및 R로 이루어진 군 중에서 선택되는 아미노산이고; X1019는 K이고; X1020은 K 또는 L이다.
아미노산 X1020이 화학식 I에서 부재할 때, 본 발명의 펩티드는 하나의 측면에서 화학식 I의 N-말단에서 아미노산 X1000을 추가로 포함하여, 펩티드는 다음 화학식 II의 구조를 포함하거나 그로 이루어진다: X1000-X1001-X1002-X1003-X1004-X1005-X1006-X1007-X1008-X1009-X1010-X1011-X1012-X1013-X1014-X1015-X1016-X1017-X1018-X1019 (II) (서열 3122). X1000이 펩티드 내에 존재할 때, X1000은 A, E, 및 P로 이루어진 군 중에서 선택되는 아미노산인 반면, X1001-X1019의 아미노산은 상기 규정한 바와 같다.
추가의 측면에서, 본 발명의 TFPI-결합 펩티드는 다음 화학식 III의 구조를 포함한다: X1001-Q-X1003-X1004-X1005-X1006-I/V-X1008-V-X1010-G-Y-C/F-X1014-R-L-X1017-X1018-K-K/L (III) (서열 3117). 화학식 III 내의 X1001, X1003, X1004, X1005, X1006, X1008, X1010, X1014, X1017 및 X1018은 각각 독립적으로 임의의 아미노산으로부터 선택된다. 예를 들어, 화학식 III에서,
X1001은 임의로 Bhf, C, D, F, G, H, I, K, L, M, N, Nmf, Q, R, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 C, F, I, K, L, Nmf, V, M, W 및 Y로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, F, L, Y 및 M으로 이루어진 군 중에서 선택되는 아미노산)이고/이거나;
X1003은 임의로 A, Aib, Bhs, C, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, C, D, E, H, K, M, I, N, Q, R, S, T 및 V로 이루어진 군 중에서 선택되는 아미노산이고/이거나 (예를 들어, 아미노산은 M, Q, R, S, T 또는 C이다);
X1004는 임의로 A, Aib, Bhk, C, D, E, F, G, H, I, K, k, L, M, N, Nmk, P, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, Aib, C, D, E, G, H, F, I, K, k, L, M, N, Nmk, P, Q, R, S, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, Aib, K, L, P, R, E, G, I, Y, M 및 W로 이루어진 군 중에서 선택되는 아미노산)이고/이거나;
X1005는 임의로 a, A, Aib, Bal, C, D, d, E, F, G, H, K, k, L, M, N, Nmg, p, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 a, A, Aib, Bal, C, d, E, D, F, G, H, K, k, L, M, N, Nmg, p, Q, R, S, T 및 Y로 이루어진 군 중에서 선택되는 아미노산이고/이거나 (예를 들어, 아미노산은 a, Aib, D, d, G, H, K, k, N, Nmg, p, Q, R, A, E, C 또는 M이다);
X1006은 임의로 A, Aib, Btq, C, D, E, F, G, H, I, K, L, M, N, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, Btq, C, D, G, I, K, H, L, M, N, Q, R, S, V 및 Y로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, A, C, D, G, H, K, N, Q, R, S 및 M으로 이루어진 군 중에서 선택되는 아미노산)이고/이거나;
X1008은 임의로 F, H, K, W 및 Y로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 F, H 및 Y로 이루어진 군 중에서 선택되는 아미노산이고/이거나;
X1010은 임의로 A, Aib, C, D, E, F, G, H, I, K, L, M, N, Nmf, P, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, D, E, F, G, H, K, L, M, N, P, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, A, D, E, K, M, N, Q, R, F, H, P, S, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산)이고/이거나;
X1014는 임의로 A, Aib, Bhe, C, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, Aib, Bhe, C, D, E, H, I, K, L, M, N, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, A, C, D, E, K, L, M, N, Q, R, T, V 또는 Aib)이고/이거나;
X1017은 임의로 (오메가-메틸)-R, A, Aib, Bhr, C, Cha, Cit, D, Dab, Dap, E, Eag, Eew, F, G, H, Har, Hci, Hle, I, K, L, M, N, Nle, Nva, Opa, Orn, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 (오메가-메틸)-R, A, Aib, Bhr, C, Cha, Cit, Dab, Dap, Eag, Eew, F, H, Har, Hci, Hle, I, K, L, M, N, Nle, Nva, Opa, Orn, R, S, T, V 및 Y로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, A, Aib, C, Cha, Dab, Dap, Eag, Eew, H, Har, Hci, Hle, K, Nle, Nva, Opa, Orn, R, I, L, S 및 M으로 이루어진 군 중에서 선택되는 아미노산)이고/이거나;
X1018은 임의로 A, Bal, C, D, E, F, G, H, I, K, L, M, N, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, C, D, E, F, I, K, L, M, N, Q, R, V 및 W로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, A, L, N, M 및 R로 이루어진 군 중에서 선택되는 아미노산)이다.
일부 실시양태에서, 본 발명의 펩티드는 아미노산 서열의 N- 또는 C-말단에 부착된 하나 이상의 추가의 아미노산 잔기를 포함한다. 예를 들어, 화학식 I-III 중 임의의 하나의 구조를 포함하는 펩티드는 일부 실시양태에서 X1001에 직접 연결된 하나 이상의 N-말단 아미노산(들)을 추가로 포함하고, 여기서 N-말단 아미노산(들)은 다음으로 이루어진 군 중에서 선택된 아미노산 서열을 포함한다
X1000,
X999-X1000,
X998-X999-X1000,
X997-X998-X999-X1000 (서열 3123),
X996-X997-X998-X999-X1000 (서열 3124),
X995-X996-X997-X998-X999-X1000 (서열 3125),
X994-X995-X996-X997-X998-X999-X1000 (서열 3126),
X993-X994-X995-X996-X997-X998-X999-X1000 (서열 3127),
X992-X993-X994-X995-X996-X997-X998-X999-X1000 (서열 3128),
X991-X992-X993-X994-X995-X996-X997-X998-X999-X1000 (서열 3129), 및
X990-X991-X992-X993-X994-X995-X996-X997-X998-X999-X1000 (서열 3130).
펩티드가 하나 이상의 N-말단 아미노산을 포함할 때, X1000은 A 또는 K이고; X999는 V 또는 K이고; X998은 Q 또는 K이고; X997은 L 또는 K이고; X996은 R 또는 K이고; X995는 G 또는 K이고; X994는 V 또는 K이고; X993은 G 또는 K이고; X992는 S 또는 K이고; X991은 K이고; X990은 K이다.
화학식 I-III에 기재된 코어 구조에 추가로, 구체적으로 고려되는 다른 구조는 하나 이상의 추가의 아미노산이 X1020에 직접 연결된 코어 구조의 C-말단에 부착되는 구조이다. 예를 들어, C-말단 첨가는 임의로 X1021, X1021-X1022, X1021-X1022-X1023, 및 X1021-X1022-X1023-X1024 (서열 3131)로 이루어진 군 중에서 선택된 아미노산 서열을 포함하고, 여기서 X1021은 T 또는 K이고; X1022는 S 또는 K이고; X1023 및 X1024는 K이다.
본 발명은 아미노산 서열 Ac-FQSK-Nmg-NVFVDGYFERL-Aib-AKL-NH2 (화학식 IV) (서열 164)에 적어도 60% 동일성 (예를 들어, 적어도 65%, 적어도 70%, 적어도 75%, 적어도 80%, 적어도 85%, 적어도 90%, 적어도 95% 또는 100% 동일성)을 갖는 아미노산 서열을 포함하거나 그로 이루어지는 TFPI-결합 펩티드를 추가로 포함한다. 일부 경우에, 펩티드는 본원에 설명된 바와 같이 임의의 하나의 화학식 I-III의 아미노산 서열을 포함하거나 그로 이루어진다. 본 발명은 서열 8-978로 이루어진 군 중에서 선택된 아미노산 서열을 포함하거나 그로 이루어지는 펩티드 (예를 들어, 서열 8-741 및 962-972 (예를 들어, 서열 8-741, 962-968, 971, 또는 972)로 이루어진 군 중에서 선택된 및/또는 서열 742-961 (예를 들어 서열 744-961)로 이루어진 군 중에서 선택된 및/또는 서열 973-978로 이루어진 군 중에서 선택된 아미노산 서열을 포함하거나 그로 이루어지는 펩티드)를 또한 포함한다.
본 발명의 펩티드는 일부 경우에 분자내 디술피드 결합을 포함한다. 이와 관련하여, 화학식 I-III의 구조를 포함하는 펩티드는 시스테인들이 분자내 디술피드 결합을 형성하도록 적어도 3개의 아미노산 잔기에 의해 이격되어 있는 적어도 2개의 시스테인 잔기를 함유한다 (예를 들어, 펩티드는 2개의 시스테인 잔기를 함유한다). 일부 경우에, 시스테인들은 3개 초과의 아미노산 잔기에 의해 이격되어 있다. 예를 들어, 화학식 I, II, 또는 III의 구조를 포함하는 펩티드에서, X1000, X1001, X1003, X1004, X1005, X1006, X1010, X1011, X1013, X1014, X1017, X1018, X1020 및 X1021 중 임의의 2개는 임의로 디술피드 다리를 형성할 수 있는 시스테인이다. 따라서, 일부 측면에서, 펩티드는 2개의 시스테인 잔기를 함유하고, X1000, X1005, X1010 및 X1014 중 하나는 시스테인이고, X1006, X1010, X1017 및 X1021 중 하나는 시스테인이다. 본 발명에서는 시스테인 쌍의 모든 가능한 조합을 고려하고, 예를 들어, X1000 및 X1006은 C이거나; X1000 및 X1010은 C이거나; X1000 및 X1017은 C이거나; X1005 및 X1017은 C이거나; X1010 및 X1017은 C이거나; X1010 및 X1021은 C이거나; X1014 및 X1021은 C이다.
본 발명은 TFPI에 결합하는 펩티드를 추가로 제공하고, 상기 펩티드는 다음 화학식 V의 구조를 포함한다: X2001-X2002-X2003-X2004-X2005-X2006-[X2007-X2008-X2009-X2010-X2011-X2012-X2013-X2014-X2015-X2016-X2017-X2018]-X2019-X2020-X2021-X2022-X2023 (V) (서열 3118). 여기서 펩티드는 X2007과 X2018 사이의 연결 (화학식 V 내에 괄호로서 나타냄), 예를 들어, 디술피드 결합에 의해 생성된 고리 구조체를 형성한다. 화학식 V에서, X2001, X2002, 및 X2023은 독립적으로 존재하거나 부재한다. 존재할 때, X2001은 A, D, E, F, G, H, I, K, L, P, R, S, T, V 및 W로 이루어진 군 중에서 선택되는 아미노산이고; X2002는 A, D, E, F, G, H, I, K, L, M, P, R, S, T, V 및 W로 이루어진 군 중에서 선택되는 아미노산이고, X2023은 A, D, E, F, G, I, K, L, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이다. 또한, X2003은 A, F, I, K, L, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X2004는 A, D, E, F, G, I, K, L, R, S, T, V 및 W로 이루어진 군 중에서 선택되는 아미노산이고;
X2005는 W이고;
X2006은 F, H, I, K, L, R, V 및 W로 이루어진 군 중에서 선택되는 아미노산이고;
X2007은 C, Hcy, Dap 및 K로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, C 또는 Hcy)이고;
X2008은 A, G, R, S 및 T로 이루어진 군 중에서 선택되는 아미노산이고;
X2009는 a, A, I, K, L, M, m, Nle, p, R, Sem, 및 V로 이루어진 군 중에서 선택되는 아미노산이고;
X2010은 A, G, I, K, L, P, R, S, T 및 V로 이루어진 군 중에서 선택되는 아미노산이고;
X2011은 D, E, G, S 및 T로 이루어진 군 중에서 선택되는 아미노산이고;
X2012는 A, a, D, d, E, e, F, f, G, I, K, k, L, l, M, m, Nle, nle, P, p, R, r, S, s, Sem, T, t, V, v, W 및 w로 이루어진 군 중에서 선택되는 아미노산이고;
X2013은 A, D, d, E, e, F, G, I, K, L, R, S, s, T, V 및 W로 이루어진 군 중에서 선택되는 아미노산이고;
X2014는 A, D, E, F, G, I, K, L, M, R, S, T, V 및 W로 이루어진 군 중에서 선택되는 아미노산이고;
X2015는 A, D, E, F, G, I, K, L, M, Nle, R, S, T, V 및 W로 이루어진 군 중에서 선택되는 아미노산이고;
X2016은 A, D, E, F, I, K, L, M, Nle, R, S, Sem, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X2017은 A, D, E, F, G, I, K, L, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X2018은 C 및 D로 이루어진 군 중에서 선택되는 아미노산이고 (예를 들어, X2018은 C이다);
X2019는 A, F, I, L, S, T, V 및 W로 이루어진 군 중에서 선택되는 아미노산이고;
X2020은 F 및 W로 이루어진 군 중에서 선택되는 아미노산이고;
X2021은 I, L 및 V로 이루어진 군 중에서 선택되는 아미노산이고;
X2022는 A, D, E, F, G, I, K, L, P, R, S, T, V, 및 W로 이루어진 군 중에서 선택되는 아미노산이다.
일부 경우에, 화학식 V의 구조를 포함하는 본 발명의 펩티드에서,
X2001은 임의로 A, D, F, G, H, K, L, P 및 S로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, D, F, G, H, K, L 및 S로 이루어진 군 중에서 선택되는 아미노산이고 (X2001이 존재할 때);
X2002는 임의로 A, D, F, G, H, K, L, P, R 및 S로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, F, H, K, L, M, R 및 S로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, H, F, M 또는 R)이고 (X2002이 존재할 때);
X2003은 임의로 A, F, K, L, S 및 Y로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 F, S 및 Y로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, F 또는 Y)이고;
X2004는 임의로 A, D, F, G, K, L 및 S로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, K)이고;
X2005는 임의로 W이고;
X2006은 임의로 F, H, K 및 L로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, F 또는 H)이고;
X2007은 임의로 C 및 HcY로 이루어진 군 중에서 선택되는 아미노산이고 (예를 들어, X2007은 C이고);
X2008은 임의로 A, G 및 S로 이루어진 군 중에서 선택되는 아미노산이고;
X2009는 임의로 a, A, K, L, V, M, m, Nle, Sem, 및 p로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 M, Nle, p 및 V로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, M, Sem, 또는 V)이고;
X2010은 임의로 A, G, K, L, P, R 및 S로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, K, L, P, R 및 S로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, K, P, 또는 R)이고;
X2011은 임의로 D, G 및 S로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, D 또는 S)이고;
X2012는 임의로 A, a, D, d, F, f, G, K, k, L, l, M, m, Nle, P, S 및 s로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 D, d, F, f, G, K, k, L, l, M, Nle, P, S, 및 Sem으로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, F, L, l, Sem, 및 M으로 이루어진 군 중에서 선택되는 아미노산)이고;
X2013은 임의로 A, D, d, F, G, K, L, S 및 s로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, D, F, G, K, L 및 S로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, D, G, K, 또는 S)이고;
X2014는 임의로 D, F, G, K, L 및 S로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, D 또는 G)이고;
X2015는 임의로 A, D, F, G, I, K, L, M, Nle, S 및 T로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, I 또는 T)이고;
X2016은 임의로 D, F, K, L, M, Nle, S, 및 Y로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 D, F, K, L, M, Nle, S, Sem, 및 Y로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, D, F, M, Sem, 또는 Y)이고;
X2017은 임의로 A, D, F, G, K, L, S, T 및 Y로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, S 또는 T)이고;
X2018은 임의로 C이고;
X2019는 임의로 A, F, L, S 및 V로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, A 또는 V)이고;
X2020은 임의로 F 및 W로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, W)이고;
X2021은 임의로 L 및 V로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, V)이고;
X2022는 임의로 A, D, F, G, K, L, P, R, S 및 W로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, F, G, K, L, P, R, S 및 W로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, F, L, K, R, P 및 W로 이루어진 군 중에서 선택되는 아미노산)이고;
X2023은 임의로 A, D, F, G, K, L, M, S 및 Y로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, D, F, G, L, M, S 및 Y로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, A, D, F, M, S 및 Y로 이루어진 군 중에서 선택되는 아미노산 서열)이다 (X2023이 존재할 때).
본 발명은 TFPI에 결합하는 펩티드를 추가로 포함하고, 여기서 펩티드는 다음 화학식 VI의 구조를 포함한다: X2001-X2002-F/Y-K-W-F/H-[C-X2008-M/V-X2010-D-X2012-X2013-G-I/T-X2016-S/T-C]-A/V-W-V-X2022-X2023 (VI) (서열 3119). 화학식 VI의 구조를 포함하는 펩티드에서, X2001, X2002 및 X2023은 각각 독립적으로 존재하거나 부재한다. X2001, X2002, 및/또는 X2023이 존재하는 경우에, X2001, X2002 및 X2023 중 임의의 것은 임의의 아미노산으로부터 독립적으로 선택된다. 또한, X2008, X2010, X2012, X2013, X2016, 및 X2022는 각각 독립적으로 임의의 아미노산으로부터 선택된다.
일부 측면에서, 화학식 VI의 펩티드에서,
X2001은 임의로 A, D, E, F, G, H, I, K, L, P, R, S, T, V 및 W로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, D, F, G, H, K, L, P 및 S로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, A, D, F, G, H, K, L 및 S로 이루어진 군 중에서 선택되는 아미노산)이고/이거나 (X2001이 존재할 때);
X2002는 임의로 A, D, E, F, G, H, I, K, L, M, P, R, S, T, V 및 W로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, D, F, G, H, K, L, M, P, R 및 S로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, A, F, H, K, L, M, R 및 S로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 H, F, M, 또는 R)이고/이거나 (X2002이 존재할 때);
X2008은 임의로 A, G, R, S 및 T로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, G 및 S로 이루어진 군 중에서 선택되는 아미노산이고/이거나;
X2010은 임의로 A, G, I, K, L, P, R, S, T 및 V로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, G, K, L, P, R 및 S로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, A, K, L, P, R 및 S로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 K, P 또는 R)이고/이거나;
X2012는 임의로 A, a, D, d, E, e, F, f, G, I, I, K, k, L, l, M, m, Nle, nle, P, p, R, r, S, s, Sem, T, t, V, v, W 및 w로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, a, D, d, F, f, G, K, k, L, l, M, m, Nle, P, S, s, 및 Sem으로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, D, d, F, f, G, K, k, L, l, M, Nle, P, S, 및 Sem으로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 F, L, l, Sem, 또는 M)이고/이거나;
X2013은 임의로 A, D, d, E, e, F, G, I, K, L, R, S, s, T, V 및 W로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, D, d, F, G, K, L, S 및 s로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, A, D, F, G, K, L 및 S로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 D, G, K 또는 S)이고/이거나;
X2016은 임의로 A, D, E, F, I, K, L, M, Nle, R, S, Sem, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 D, F, K, L, M, Nle, S Sem, 및 Y로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, D, F, K, L, M, Nle, S, Sem으로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 F, Sem, 또는 M)이고/이거나;
X2022는 임의로 A, D, E, F, G, I, K, L, P, R, S, T, V, 및 W로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, D, F, G, K, L, P, R, S 및 W로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, A, F, G, K, L, P, R, S 및 W로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 F, L, K, R, P 또는 W)이고/이거나;
X2023은 임의로 A, D, E, F, G, I, K, L, R, M, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, D, F, G, K, L, M, S 및 Y로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, A, D, F, G, L, M, S 및 Y로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, D, F, M, S 또는 Y)이다 (X2023이 존재할 때).
본 발명의 TFPI-결합 펩티드는 하나의 측면에서, 다음 화학식 VII의 서열에 적어도 60% 동일성 (예를 들어, 적어도 60%, 적어도 65%, 적어도 70%, 적어도 75%, 적어도 80%, 적어도 85%, 적어도 90%, 적어도 95% 또는 100% 동일성)을 갖는 아미노산 서열을 포함한다: Ac-FYYKWH[CGMRDMKGTMSC]AWVKF-NH2 (VII) (서열 1040). 임의로, 펩티드는 본원에 규정된 바와 같은 화학식 V-VII의 아미노산 서열을 포함하거나 그로 이루어진다. 본 발명은 서열 1001-1293으로 이루어진 군 중에서 선택된 아미노산 서열을 포함하거나 그로 이루어지는 펩티드 (예를 들어, 서열 1001-1212 및 1290-1291 (예를 들어 서열 1001-120, 1290, 또는 1291)로 이루어진 군 중에서 선택된 및/또는 서열 1213-1289로 이루어진 군 중에서 선택된 및/또는 서열 1292 및 1293으로 이루어진 군 중에서 선택된 아미노산 서열을 포함하거나 그로 이루어지는 펩티드)를 또한 포함한다.
본 발명은 다음 화학식 VIII의 구조를 포함하는 TFPI-결합 펩티드를 추가로 제공한다: X3001-X3002-X3003-X3004-X3005-X3006-X3007-X3008-X3009-X3010-X3011-X3012-X3013-X3014-X3015-X3016-X3017-X3018-X3019-X3020-X3021 (VIII) (서열 3120). 화학식 VIII에서, X3001 및 X3002는 독립적으로 펩티드 내에 존재하거나 부재한다. 존재하는 경우에, X3001은 A, C, D, F, G, I, K, L, M, N, P, Q, R, S, T, W, E, H 및 Y로 이루어진 군 중에서 선택되는 아미노산이고; X3002는 A, C, D, F, H, K, M, N, P, R, S, T, W, Y, G, I 및 L로 이루어진 군 중에서 선택되는 아미노산이다. 또한, X3003은 A, C, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X3004는 A, C, D, E, F, G, H, I, K, L, M, N, Q, R, S, T, V, W, Y 및 P로 이루어진 군 중에서 선택되는 아미노산이고;
X3005는 C, D, F, G, H, I, K, L, M, N, P, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X3006은 A, W, C, K, P, R 및 H로 이루어진 군 중에서 선택되는 아미노산이고;
X3007은 Q, A, C, F, G, H, I, K, L, N, R, S, T, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X3008은 A, C, F, G, H, K, L, M, N, P, Q, R, S, T, V, W, Y 및 I로 이루어진 군 중에서 선택되는 아미노산이고;
X3009는 A, C, F, G, H, I, L, M, R, S, T, V, W, Y 및 K로 이루어진 군 중에서 선택되는 아미노산이고;
X3010은 A, C, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X3011은 A, G, I, K, L, M, N, Q, R, S, T, V, W, Y, C, F 및 H로 이루어진 군 중에서 선택되는 아미노산이고;
X3012는 A, C, H, I, K, L 및 R로 이루어진 군 중에서 선택되는 아미노산이고;
X3013은 A, C, F, G, H, K, L, M, R, S, V, W, Y 및 I로 이루어진 군 중에서 선택되는 아미노산이고;
X3014는 A, C, F, G, H, I, L, M, N, Q, R, S, T, V, W, Y 및 K로 이루어진 군 중에서 선택되는 아미노산이고;
X3015는 A, K 및 R로 이루어진 군 중에서 선택되는 아미노산이고;
X3016은 A, F, K 및 R로 이루어진 군 중에서 선택되는 아미노산이고;
X3017은 A, C, F, G, I, K, L, N, Q, R, S, T, V, W, Y, H, A 및 M으로 이루어진 군 중에서 선택되는 아미노산이고;
X3018은 A, C, F, I, K, L, M, Q, R, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
X3019는 A, C, D, E, F, G, H, K, L, N, P, Q, R, V, W, Y 및 I로 이루어진 군 중에서 선택되는 아미노산이고;
X3020은 A, C, F, G, H, K, L, M, N, Q, R, V, W, Y, I 및 P로 이루어진 군 중에서 선택되는 아미노산이고;
X3021은 A, C, H, I, K, L, M, N, P, Q, R, T, V, W, Y, F 및 G로 이루어진 군 중에서 선택되는 아미노산이다.
본 발명의 일부 측면에서, 펩티드는 화학식 VIII의 서열을 포함하고, 여기서
X3001은 임의로 A, C, D, G, I, K, L, M, N, P, Q, R, S, T, W, E, H 및 Y로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, C, D, G, K, L, M, N, P, R, S, T, E, H 및 Y로 이루어진 군 중에서 선택되는 아미노산이고 (X3001이 존재할 때);
X3002는 C, F, H, K, R, S, W, Y, G, I 및 L로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 C, K, R, W, Y, G, I 및 L로 이루어진 군 중에서 선택되는 아미노산이고 (X3002가 존재할 때);
X3003은 임의로 A, C, D, F, G, H, I, K, L, M, N, P, Q, R, S, T 및 W로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, C, G, H, I, K, L, M, R, S, T 및 W로 이루어진 군 중에서 선택되는 아미노산이고;
X3004는 임의로 A, C, D, G, H, I, K, L, M, N, R, S, T, V 및 P로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, C, G, H, I, K, L, M, N, R, S, T 및 P로 이루어진 군 중에서 선택되는 아미노산이고;
X3005는 임의로 C, F, H, I, K, M, R, T, W 및 Y로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 C, F, H, K, R 및 W로 이루어진 군 중에서 선택되는 아미노산이고;
X3006은 임의로 P, H 및 A로 이루어진 군 중에서 선택되는 아미노산이고;
X3007은 임의로 C, G, R, W, A 및 L로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 L, C, R 및 W로 이루어진 군 중에서 선택되는 아미노산이고;
X3008은 임의로 A, C, F, G, H, K, L, M, N, Q, R, T, V, W, Y 및 I로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, C, F, H, K, R, V, W, Y 및 I로 이루어진 군 중에서 선택되는 아미노산이고;
X3009는 임의로 C, I, R, V 및 K로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 C, R, V 및 K로 이루어진 군 중에서 선택되는 아미노산이고;
X3010은 임의로 A, C, G, H, I, K, L, M, Q, R, S 및 T로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, C, K, L, Q, R 및 S로 이루어진 군 중에서 선택되는 아미노산이고;
X3011은 임의로 A, I, K, L, M, R, S, V, W, C, F 및 H로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 I, K, L, M, R, V, W, C, F 및 H로 이루어진 군 중에서 선택되는 아미노산이고;
X3012는 임의로 H 및 R로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, H)이고;
X3013은 임의로 C, F, K, L, M, R, V 및 I로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 C, K, R, V 및 I로 이루어진 군 중에서 선택되는 아미노산이고;
X3014는 임의로 A, M, C, F, H, I, L, N, R, S, V, W 및 K로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, S, C, F, H, I, R 및 K로 이루어진 군 중에서 선택되는 아미노산이고;
X3015는 임의로 K 또는 R이고;
X3016은 임의로 K 또는 R이고;
X3017은 임의로 A, C, F, G, I, K, L, N, Q, R, S, T, V, W, H, A 및 M으로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 C, G, I, K, L, N, Q, R, S, T, V, H, A 및 M으로 이루어진 군 중에서 선택되는 아미노산이고;
X3018은 임의로 A, K, C, I, L, R 및 W로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, K, C, I, R, 또는 W)이고;
X3019는 임의로 A, C, E, H, K, N, Q, R 및 I로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 C, E, H, K, R 및 I로 이루어진 군 중에서 선택되는 아미노산이고;
X3020은 임의로 C, H, L, M, R, V, I 및 P로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, C, M, I, 또는 P)이고;
X3021은 임의로 A, C, H, I, K, L, M, N, Q, R, V, W, Y, F 및 G로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, C, H, I, K, L, M, N, Q, R, V, W, F 및 G로 이루어진 군 중에서 선택되는 아미노산이다.
본 발명은 TFPI에 결합하고 다음 화학식 IX의 구조를 포함하는 펩티드를 추가로 제공한다: X3001-X3002-X3003-X3004-X3005-X3006-X3007-X3008-X3009-X3010-X3011-H-X3013-X3014-K/R-R-X3017-X3018-X3019-X3020-X3021 (IX) (서열 3121). 화학식 IX에서, X3001 및 X3002는 독립적으로 펩티드 내에 존재하거나 부재한다. 존재하는 경우에, X3001 및/또는 X3002는 독립적으로 임의의 아미노산으로부터 선택된다. 마찬가지로, X3003, X3004, X3005, X3006, X3007, X3008, X3009, X3010, X3011, X3013, X3014, X3017, X3018, X3019, X3020 및 X3021은 각각 독립적으로 임의의 아미노산으로부터 선택된다. 존재할 때, X3001은 임의로 A, C, D, F, G, I, K, L, M, N, P, Q, R, S, T, W, E, H 및 Y로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, C, D, G, I, K, L, M, N, P, Q, R, S, T, W, E, H 및 Y로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, A, C, D, G, K, L, M, N, P, R, S, T, E, H 및 Y로 이루어진 군 중에서 선택되는 아미노산)이다. 마찬가지로, 존재할 때, X3002는 임의로 A, C, D, F, H, K, M, N, P, R, S, T, W, Y, G, I 및 L로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 C, F, H, K, R, S, W, Y, G, I 및 L로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, C, K, R, W, Y, G, I 및 L로 이루어진 군 중에서 선택되는 아미노산)이다. 또한 화학식 IX에 관하여,
X3003은 임의로 A, C, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, W, 및 Y로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, C, D, F, G, H, I, K, L, M, N, P, Q, R, S, T 및 W로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, A, C, G, H, I, K, L, M, R, S, T 및 W로 이루어진 군 중에서 선택되는 아미노산)이고/이거나;
X3004는 임의로 A, C, D, E, F, G, H, I, K, L, M, N, Q, R, S, T, V, W, Y 및 P로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, C, D, G, H, I, K, L, M, N, R, S, T, V 및 P로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, A, C, G, H, I, K, L, M, N, R, S, T 및 P로 이루어진 군 중에서 선택되는 아미노산)이고/이거나;
X3005는 임의로 C, D, F, G, H, I, K, L, M, N, P, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 C, F, H, I, K, M, R, T, W 및 Y로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, C, F, H, K, R 및 W로 이루어진 군 중에서 선택되는 아미노산)이고/이거나;
X3006은 임의로 A, W, C, K, P, R 및 H로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 P, H 및 A로 이루어진 군 중에서 선택되는 아미노산이고/이거나;
X3007은 임의로 Q, A, C, F, G, H, I, K, L, N, R, S, T, W 및 Y로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 C, G, R, W, A 및 L로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, L, C, R 또는 W)이고/이거나;
X3008은 임의로 A, C, F, G, H, K, L, M, N, P, Q, R, S, T, V, W, Y 및 I로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, C, F, G, H, K, L, M, N, Q, R, T, V, W, Y 및 I로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, A, C, F, H, K, R, V, W, Y 및 I로 이루어진 군 중에서 선택되는 아미노산)이고/이거나;
X3009는 임의로 A, C, F, G, H, I, L, M, R, S, T, V, W, Y 및 K로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 C, I, R, V 및 K로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, C, R, V 또는 K)이고/이거나;
X3010은 임의로 A, C, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, C, G, H, I, K, L, M, Q, R, S 및 T로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, A, C, K, L, Q, R 및 S로 이루어진 군 중에서 선택되는 아미노산)이고/이거나;
X3011은 임의로 A, G, I, K, L, M, N, Q, R, S, T, V, W, Y, C, F 및 H로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, I, K, L, M, R, S, V, W, C, F 및 H로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, I, K, L, M, R, V, W, C, F 및 H로 이루어진 군 중에서 선택되는 아미노산)이고/이거나;
X3013은 임의로 A, C, F, G, H, K, L, M, R, S, V, W, Y 및 I로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 C, F, K, L, M, R, V, 및 I로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, C, K, R, V, 또는 I)이고/이거나;
X3014는 임의로 A, C, F, G, H, I, L, M, N, Q, R, S, T, V, W, Y 및 K로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, M, C, F, H, I, L, N, R, S, V, W 및 K로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, A, S, C, F, H, I, R 및 K로 이루어진 군 중에서 선택되는 아미노산)이고/이거나;
X3017은 임의로 A, C, F, G, I, K, L, N, Q, R, S, T, V, W, Y, H, A 및 M으로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, C, F, G, I, K, L, N, Q, R, S, T, V, W, H, A 및 M으로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, C, G, I, K, L, N, Q, R, S, T, V, H, A 및 M으로 이루어진 군 중에서 선택되는 아미노산)이고/이거나;
X3018은 임의로 A, C, F, I, K, L, M, Q, R, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, K, C, I, L, R 및 W로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, K, C, I, R, 또는 W)이고/이거나;
X3019는 임의로 A, C, D, E, F, G, H, K, L, N, P, Q, R, V, W, Y 및 I로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, C, E, H, K, N, Q, R 및 I로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, C, E, H, K, R, 또는 I)이고/이거나;
X3020은 임의로 A, C, F, G, H, K, L, M, N, Q, R, V, W, Y, I 및 P로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 C, H, L, M, R, V, I 및 P로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, C, M, I, 또는 P)이고/이거나;
X3021은 임의로 A, C, H, I, K, L, M, N, P, Q, R, T, V, W, Y, F 및 G로 이루어진 군 중에서 선택되는 아미노산, 예를 들어 A, C, H, I, K, L, M, N, Q, R, V, W, Y, F 및 G로 이루어진 군 중에서 선택되는 아미노산 (예를 들어, A, C, H, I, K, L, M, N, Q, R, V, W, F 및 G로 이루어진 군 중에서 선택되는 아미노산)이다.
본 발명의 TFPI-결합 펩티드는 일부 측면에서, 다음 화학식 X의 서열에 적어도 60% 동일성 (예를 들어, 적어도 65%, 적어도 70%, 적어도 75%, 적어도 80%, 적어도 85%, 적어도 90%, 적어도 95% 또는 100% 동일성)을 갖는 아미노산 서열을 포함한다: Ac-GYASFPWFVQLHVHKRSWEMA-NH2 (X) (서열 2023). 임의로, 펩티드는 본원에서 규정되는 화학식 VIII-IX의 아미노산 서열을 포함하거나 그로 이루어진다. 본원에서 사용될 때, "적어도 60% 동일성" 및 유사한 용어는 예를 들어, 60% 내지 100%로부터의 임의의 정수, 예를 들어 60%, 61%, 62% 등을 포함한다. 또한, 용어 "적어도 [%] 동일성"은 동일한 아미노산의 수/본 발명의 펩티드의 아미노산의 총 수 이상인 임의의 백분율을 포함한다 ([적어도 % 동일성] ≥ [동일한 아미노산의 수] / [본 발명의 펩티드의 아미노산의 총 수]).
본 발명은 서열 2001-2498로 이루어진 군 중에서 선택되는 아미노산 서열을 포함하거나 그로 이루어지는 펩티드 (예를 들어, 서열 2001-2296 및 2498 (예를 들어, 서열 2001-2126, 2128-2296, 또는 2498)로 이루어진 군 중에서 선택되는 및/또는 서열 2297-2497 (예를 들어, 서열 2298-2497)로 이루어진 군 중에서 선택되는 아미노산 서열을 포함하거나 그로 이루어지는 펩티드)를 또한 포함한다. 본 발명은 서열 3001-3108로 이루어진 군 중에서 선택되는 아미노산 서열을 포함하거나 그로 이루어지는 펩티드 (예를 들어, 서열 3001-3064 (예를 들어, 서열 3001-3048, 3051-3053, 3055, 또는 3057-3064)로 이루어진 군 중에서 선택되는 및/또는 서열 3065-3084 (예를 들어, 서열 3066-3084)로 이루어진 군 중에서 선택되는 및/또는 서열 3085-3108로 이루어진 군 중에서 선택되는 아미노산 서열을 포함하거나 그로 이루어지는 펩티드)를 추가로 제공한다.
서열 1-7의 펩티드는 또한 일부 측면에서 서열 1-7의 N- 또는 C-말단에 부착된 하나 이상의 아미노산을 포함한다. 예를 들어, 본 발명은 JBT0047, JBT0051, JBT0055, JBT0131, JBT0132, JBT0133, JBT0155, JBT0158, JBT0162, JBT0163, JBT0164, JBT0166, JBT0169, JBT0170, JBT0171, JBT0174, JBT0175, 또는 JBT0293 (이들 모두는 서열 1의 아미노산 서열을 포함한다)의 아미노산 서열을 포함하거나 그로 이루어지는 펩티드를 포함한다. 서열 2의 아미노산 서열을 포함하는 예시적인 펩티드는 JBT0294, JBT0295, JBT0296, JBT0297, JBT0298, JBT0299, JBT0300, JBT0301, JBT0302, JBT0303, JBT0304, JBT0305, JBT0306, JBT0307, JBT0308, JBT0309, JBT0310, 또는 JBT0311의 아미노산 서열을 포함하거나 그로 이루어지는 펩티드를 포함한다. 서열 3의 아미노산 서열을 포함하는 예시적인 펩티드는 JBT0049, JBT0053, JBT0057, JBT0190, JBT0193, 또는 JBT0197의 아미노산 서열을 포함하거나 그로 이루어진다. 본 발명은 JBT0050, JBT0054, JBT0058, JBT0129, JBT0130, JBT0205, JBT0208, JBT0211, JBT0212, JBT0217, JBT0218, 또는 JBT0219 (이들은 모두 서열 4의 아미노산 서열을 포함한다)의 아미노산 서열을 포함하거나 그로 이루어지는 펩티드를 추가로 포함한다. 서열 5를 포함하는 예시적인 펩티드는 JBT0101, JBT0052, JBT0103, JBT0178, 또는 JBT0182의 아미노산 서열을 포함하거나 그로 이루어지는 펩티드를 포함한다. 본 발명은 JBT0120, JBT0124, JBT0247, JBT0248, JBT0251, 또는 JBT0252 (이들은 각각 서열 6의 아미노산 서열을 포함한다)의 아미노산 서열을 포함하거나 그로 이루어지는 펩티드를 추가로 포함한다. 서열 7의 아미노산 서열을 포함하는 펩티드, 예를 들어, JBT0122, JBT0126. JBT0221, JBT0224, JBT0225, JBT0226, JBT0228, JBT0232, 또는 JBT0233의 아미노산 서열을 포함하거나 그로 이루어지는 펩티드를 또한 본 발명에서 제공한다. 본원에 기재된 펩티드는 실시예 1의 표 5 및 도 12-18에 제시되어 있다.
특정 실시양태에서, 본 발명의 펩티드는 JBT0047, JBT0049, JBT0101, JBT0120, 또는 JBT0122의 아미노산 서열, 또는 본원에 기재된 임의의 본 발명의 펩티드 (예를 들어, 임의의 하나의 서열 1-3108의 아미노산 서열을 포함하거나 그로 이루어지는 펩티드, 예를 들어 임의의 하나의 서열 8-741, 744-968, 971-978, 1001-1210, 1213-1289, 1290-1293, 2001-2126, 2128-2296, 2298-2498, 3001-3048, 3051-3053, 3055, 3057-3064, 및 3067-3108의 아미노산 서열을 포함하거나 그로 이루어지는 펩티드), 또는 임의의 상기 서열의 변이체를 포함하거나 그로 이루어진다. "변이체"는 모 아미노산 서열에 대해 하나 이상의 아미노산 치환, 아미노산 결실, 또는 아미노산 부가를 포함하는 펩티드를 의미한다. 변이체는 TFPI에 결합하고/하거나 TFPI 활성을 억제하는 능력을 보유하면서 본원에서 제공되는 임의의 아미노산 서열에 적어도 60%, 65%, 70%, 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% 또는 99% 동일한 아미노산 서열을 갖는 펩티드를 포함하고 이로 제한되지 않는다. 하나의 실시양태에서, 펩티드는 JBT0132, JBT0303, JBT0193, JBT0178, JBT0120, 또는 JBT0224의 아미노산 서열을 포함하거나 그로 이루어진다.
하나의 측면에서, 본 발명의 펩티드는 40개 이하의 아미노산, 예를 들어 35개 이하의 아미노산으로 이루어진다. 임의로, 본 발명의 펩티드는 25개 이하의 아미노산, 또는 10개 이하의 아미노산으로 이루어진다. 다양한 실시양태에서, 펩티드는 15-35개의 아미노산 잔기 (예를 들어, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 또는 35개의 아미노산 잔기)를 포함한다. 그러나, 펩티드가 응고 케스케이드의 TFPI 억제를 차단하고 임의로 TFPI에 결합하는 한, 하나 이상의 결실을 포함하는 본원에 기재된 펩티드가 본 발명의 문맥에서 적합한 것이 또한 고려된다. 하나의 측면에서, 펩티드가 TFPI에 결합하고 임의로 응고 케스케이드의 TFPI 억제를 차단하는 한, 하나 이상의 결실을 포함하는 펩티드가 본 발명의 문맥에서 적합하다. 일부 측면에서, 아미노산은 아미노산 서열 내로부터 N-말단에서 및/또는 C-말단에서 제거된다. 그러한 펩티드 단편은 3-14개의 아미노산 잔기 (예를 들어, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 또는 14개의 아미노산 잔기)를 포함할 수 있다.
임의로, 본 발명의 펩티드는 TFPI에 결합하고/하거나 억제하는 펩티드의 능력을 파괴하지 않는 하나 이상의 아미노산 치환 (본원에서 제공되는 임의의 아미노산 서열에 대해)을 포함한다. 예를 들어, JBT0294, JBT0295, JBT0296, JBT0297, JBT0298, JBT0299, JBT0300, JBT0301, JBT0302, JBT0303, JBT0304, JBT0305, JBT0306, JBT0307, JBT0308, JBT0309, JBT0310, 또는 JBT0311로 이루어진 군 중에서 선택되는 아미노산 서열을 포함하거나 그로 이루어지는 펩티드는 JBT0293의 아미노산 서열의 치환 돌연변이체이다 (N-말단에서 페닐알라닌 잔기 및 C-말단에서 라이신 잔기에 직접 연결된 서열 1의 아미노산 서열) (도 4 참조). 아미노산 치환은 (1) 단백질분해에 대한 감수성을 감소시키고/시키거나, (2) 산화에 대한 감수성을 감소시키고/시키거나, (3) 결합 친화도를 변경하고/하거나, (4) 펩티드에 대해 다른 물리화학적 또는 기능적 특성을 부여하거나 변형하는 것을 포함하고 이로 제한되지 않는다. 하나의 측면에서, 치환은 보존적 치환이고, 여기서 아미노산 잔기는 유사한 측쇄를 갖는 아미노산 잔기로 교체된다. 유사한 측쇄를 갖는 아미노산 잔기의 패밀리는 당업계에 규정되어 있고, 염기성 측쇄 (예를 들어, 라이신, 아르기닌, 및 히스티딘), 산성 측쇄 (예를 들어, 아스파르트산 및 글루탐산), 비하전 극성 측쇄 (예를 들어, 글라이신, 아스파라긴, 글루타민, 세린, 트레오닌, 티로신, 및 시스테인), 비극성 측쇄 (예를 들어, 알라닌, 발린, 류신, 이소류신, 프롤린, 페닐알라닌, 메티오닌, 및 트립토판), 베타-분지형 측쇄 (예를 들어, 트레오닌, 발린, 및 이소류신) 및 방향족 측쇄 (예를 들어, 티로신, 페닐알라닌, 트립토판, 및 히스티딘)를 갖는 아미노산을 포함한다. 그러나, 당업자는 생성되는 펩티드가 TFPI 활성을 전적으로 또는 부분적으로 하향조절하는 능력을 보유하는 한 보존적 치환을 생성하는 것에 제한되지 않음이 이해될 것이다. 본 발명은 당업계에 공지되어 있는 비전형적인, 비-천연 아미노산을 포함하는 TFPI-억제 펩티드를 또한 포함한다. 예시적인 비-천연 아미노산은 오르니틴, 시트룰린, 히드록시프롤린, 호모세린, 페닐글라이신, 타우린, 요오도티로신, 2,4-디아미노부티르산, α-아미노 이소부티르산, 4-아미노부티르산, 2-아미노 부티르산, y-아미노 부티르산, 2-아미노 이소부티르산, 3-아미노 프로피온산, 노르류신, 노르발린, 사르코신, 호모시트룰린, 시스테인산, t-부틸글라이신, t-부틸알라닌, 페닐글라이신, 시클로헥실알라닌, β-알라닌, 플루오로-아미노산, 3-메틸 아미노산, α-C-메틸 아미노산, N-메틸 아미노산, 2-아미노-이소부티르산, β-호모글루탐산, β-호모페닐알라닌, β-호모라이신, β-호모류신, β-호모아스파라긴, β-호모글루타민, β-호모아르기닌, β-호모세린, β-호모티로신, β-호모아스파르트산, β-호모발린, β-호모아스파라긴, (S)-시클로헥실알라닌, (S)-시트룰린, (S)-2,4-디아미노부티르산, (S)-2,4-디아미노부티르산, (S)-디아미노프로피온산, (S)-2-프로파르길글라이신, (S)-N(오메가)-니트로-아르기닌, L-호모페닐알라닌, (S)-호모-아르기닌, (S)-호모-시트룰린, (S)-호모-시스테인, (S)-2-아미노-5-메틸-헥산산, (S)-호모-라이신, (S)-노르류신, (S)-N-메틸알라닌, (S)-N-메틸-아스파르트산, (S)-N-메틸-글루탐산, (S)-N-메틸-페닐알라닌, N-메틸-글라이신, (S)-N-메틸-라이신, (S)-N-메틸-류신, (S)-N-메틸-아르기닌, (S)-N-메틸-세린, (S)-N-메틸-발린, (S)-N-메틸-티로신, (S)-2-아미노-펜탄산, (S)-2-피리딜-알라닌, (S)-오르니틴, L-페닐글라이신, 4-페닐-부티르산 및 셀레노메티오닌을 포함한다. 개별 아미노산은 적절한 경우에 L 또는 D 입체화학을 가질 수 있지만, L 입체화학이 펩티드 내에서 모든 아미노산에 대해 일반적으로 사용된다.
본 발명은 본원에서 제공되는 아미노산 서열 내에 삽입되고/되거나 N-말단 또는 C-말단에 부착된 하나 이상의 아미노산을 포함하는 TFPI-억제 펩티드 변이체를 추가로 포함한다. 하나의 측면에서, 펩티드는 펩티드의 용해도를 증가시키기 위해 N-말단 및/또는 C-말단에서 1 또는 2개의 라이신을 포함하고 이로 제한되지 않는, 펩티드의 합성, 취급, 또는 사용을 용이하게 하는 하나 이상의 아미노산을 추가로 포함한다. 적합한 융합 단백질은 단백질 서열의 일부인 것으로 일반적으로 인정되지 않는 하나 이상의 폴리펩티드, 폴리펩티드 단편, 또는 아미노산에 연결된 TFPI-억제 펩티드를 포함하는 단백질을 포함하고 이로 제한되지 않는다. 하나의 측면에서, 융합 펩티드는 2개 이상의 펩티드의 전체 아미노산 서열을 포함하거나, 별법으로 2개 이상의 펩티드의 일부 (단편)를 포함한다. 본원에 기재된 TFPI-억제 펩티드의 전부 또는 일부에 추가로, 융합 단백질은 임의로 목적하는 생물학적 활성/기능을 포함하는 임의의 적합한 펩티드의 전부 또는 일부를 포함한다. 실제로, 일부 측면에서, TFPI-억제 펩티드는 예를 들어 순환 반감기가 긴 펩티드, 마커 단백질, TFPI-억제 펩티드의 정제를 용이하게 하는 펩티드, 다량체 단백질의 형성을 촉진하는 펩티드 서열, 또는 임의의 상기한 것의 단편 중 하나 이상에 작동가능하게 연결된다. 하나의 실시양태에서, 2개 이상의 TFPI-억제 펩티드는 함께 융합되거나, 다량체화 도메인에 의해 연결되거나, 화학 연결을 통해 부착되어 TFPI-억제 펩티드 복합체를 생성한다. TFPI-억제제 펩티드들은 동일하거나 상이할 수 있다.
"유도체"가 본 발명에 포함되고, 이는 아미노산의 부가, 결실 또는 치환과 구분되는 일부 방식으로 화학적으로 변형된 TFPI-억제 펩티드를 포함한다. 이와 관련하여, 본원에서 제공되는 본 발명의 펩티드는 중합체, 지질, 다른 유기 모이어티 (moiety), 및/또는 무기 모이어티와 화학적으로 결합된다. 펩티드 및 단백질 변형의 예는 문헌 [Hermanson, Bioconjugate Techniques, Academic Press, (1996)]에 제시되어 있다. 유도체는 용해도, 안정성, 흡수, 또는 순환 반감기를 증가시키기 위해 일부 상황에서 제조된다. 다양한 화학적 변형은 물질의 임의의 바람직하지 않은 부작용을 제거하거나 약화시킨다. 이와 관련하여, 본 발명은 하나 이상의 수용성 중합체 부착을 포함하도록 공유 변형된 TFPI-억제 펩티드를 포함한다. 당업계에 공지된 유용한 중합체는 폴리에틸렌 글리콜 (PEG) (예를 들어, 크기가 약 40 kD 또는 1 kD인 PEG), 폴리옥시에틸렌 글리콜, 폴리프로필렌 글리콜, 모노메톡시-폴리에틸렌 글리콜, 덱스트란, 셀룰로스, 폴리-(N-비닐 피롤리돈)-폴리에틸렌 글리콜, 프로필렌 글리콜 동종중합체, 폴리프로필렌 옥시드/에틸렌 옥시드 공-중합체, 폴리옥시에틸화 폴리올 (예를 들어, 글리세롤) 및 폴리비닐 알콜, 및 임의의 상기 물질들의 혼합물을 포함하고 이로 제한되지 않는다. 하나의 측면에서, 본 발명의 펩티드는 PEG화된 펩티드이다. 수용성 중합체 부착에 대한 추가의 논의에 대해서는 미국 특허 4,640,835; 4,496,689; 4,301,144; 4,670,417; 4,791,192; 및 4,179,337을 참조한다. 다른 측면에서, 펩티드 유도체는 특정 세포 종류, 조직, 및/또는 장기에 특이적인 표적화 모이어티를 포함한다. 별법으로, 펩티드는 정제, 검출, 다량체화 및 펩티드 활성의 특성 결정을 용이하게 하는 하나 이상의 화학적 모이어티에 연결된다. 예시적인 화학적 모이어티는 비오틴이다. 또한, 하나의 측면에서, 본 발명의 펩티드는 펩티드의 N-말단 아미노산에서 아실화된다. 다른 측면에서, 본 발명의 펩티드는 펩티드의 C-말단 아미노산에서 아미드화된다. 또 다른 추가의 측면에서, 본 발명의 펩티드는 펩티드의 N-말단 아미노산에서 아실화되고 펩티드의 C-말단 아미노산에서 아미드화된다.
유도체는 변형된 또는 비-단백질구성 아미노산 또는 변형된 링커기를 포함하는 펩티드를 또한 포함한다 (예를 들어, 문헌 [Grant, Synthetic Peptides: A User's Guide, Oxford University Press (1992)] 참조). 변형된 아미노산은 예를 들어 아미노 및/또는 카르복실기가 다른 기로 교체된 아미노산을 포함한다. 비-제한적인 예는 티오아미드, 우레아, 티오우레아, 아실히드라지드, 에스테르, 올레핀, 술폰아미드, 인산 아미드, 케톤, 알콜, 붕산 아미드, 벤조디아제핀 및 다른 방향족 또는 비-방향족 헤테로사이클을 포함하는 변형된 아미노산을 포함한다 (문헌 [Estiarte et al., Burgers Medicinal Chemistry, 6th edition, Volume 1, Part 4, John Wiley & Sons, New York (2002)] 참조). 변형된 아미노산은 아미드 결합 대신에 상기 언급한 관능기 중의 적어도 하나를 갖는 펩티드에 종종 연결된다. 비-단백질구성 아미노산은 β-알라닌 (Bal), 노르발린 (Nva), 노르류신 (Nle), 4-아미노부티르산 (γ-Abu), 2-아미노이소부티르산 (Aib), 6-아미노헥산산 (ε-Ahx), 오르니틴 (Orn), 히드록시프롤린 (Hyp), 타우린, 사르코신, 시트룰린 (Cit), 시스테인산 (Coh), 시클로헥실알라닌 (Cha), 메티오닌술폭시드 (Meo), 메티오닌술폰 (Moo), 호모세린메틸에스테르 (Hsm), 프로파르길글라이신 (Eag), 5-플루오로트립토판 (5Fw), 6-플루오로트립토판 (6Fw), 3',4'-디메톡시페닐-알라닌 (Ear), 3',4'-디플루오로페닐알라닌 (Dff), 4'-플루오로페닐-알라닌 (Pff), 1-나프틸-알라닌 (1Ni), 1-메틸트립토판 (1Mw), 페니실라민 (Pen), 호모세린 (Hse), t-부틸글라이신, t-부틸알라닌, 페닐글라이신 (Phg), 벤조티에닐알라닌 (Bta), L-호모-시스테인 (Hcy), N-메틸-페닐알라닌 (Nmf), 2-티에닐알라닌 (Thi), 3,3-디페닐알라닌 (Ebw), 호모페닐알라닌 (Hfe) 및 S-벤질-L-시스테인 (Ece)을 포함하고 이로 제한되지 않는다. 상기 및 다른 비-단백질구성 아미노산은 D- 또는 L-이성질체로서 존재할 수 있다. 변형된 링커의 예는 가요성 링커 4,7,10-트리옥사-1,13-트리데칸디아민 (Ttds), 글라이신, 6-아미노헥산산, 베타-알라닌 (Bal), 및 Ttds, 글라이신, 6-아미노헥산산 및 Bal의 조합물을 포함하고 이로 제한되지 않는다.
본 발명의 펩티드를 구성하는 아미노산의 상동체는 표 3에 제시된 바와 같을 수 있다.
<표 3>
Figure pat00008
일부 실시양태에서, 본 발명의 펩티드 내에서 아미노산들을 연결하는 펩티드 (CO-NH) 연결기는 "레트로 (retro)-변형된" 펩티드, 즉, 참조 펩티드에 비해 반대 방향 (NH-CO 결합)으로 회합된 아미노산 잔기를 포함하는 펩티드를 생성하기 위해 반전된다. 레트로-변형된 펩티드는 참조 펩티드와 동일한 아미노산 키랄성 (chirality)을 포함한다. "인버소 (inverso)-변형된" 펩티드는 참조 펩티드와 동일한 방향으로 회합된 아미노산 잔기를 포함하는 본 발명의 펩티드이지만, 아미노산의 키랄성이 역전된다. 따라서, 참조 펩티드가 L-아미노산을 포함할 경우, "인버소-변형된" 펩티드는 D-아미노산을 포함하고, 그 반대의 경우도 가능하다. 인버소-변형된 펩티드는 CO-NH 펩티드 결합을 포함한다. "레트로-인버소 변형된" 펩티드는 반대 방향으로 회합되고 역전된 키랄성을 갖는 아미노산 잔기를 포함하는 펩티드를 의미한다. 레트로-인버소 유사체는 참조 펩티드에서 발견되는 측쇄 토폴로지 (topology)를 거의 유지하면서 펩티드 결합 (즉, NH-CO)의 반전된 말단 및 반전된 방향을 갖는다. 레트로-인버소 펩티드모방체는 본원에 참고로 포함된 문헌 [Meziere et al., Immunol., 159, 3230-3237 (1997)]에 기재된 방법을 포함하는 표준 방법을 사용하여 제조된다. 부분적인 레트로-인버소 펩티드는 단지 일부의 아미노산 서열만이 반전되고 에난티오머성 아미노산 잔기로 교체된 펩티드이다.
본 발명의 TFPI-결합 펩티드 (예를 들어, TFPI 억제제 펩티드)는 다양한 방식으로 제조된다. 하나의 측면에서, 펩티드는 문헌 [Merrifield, J. Am. Chem. Soc, 85, 2149 (1963)]; [Davis et al., Biochem. Intl., 10, 394-414 (1985)]; [Larsen et al., J. Am. Chem. Soc, 115, 6247 (1993)]; [Smith et al., J. Peptide Protein Res., 44, 183 (1994)]; [O'Donnell et al., J. Am. Chem. Soc, 118, 6070 (1996)]; [Stewart and Young, Solid Phase Peptide Synthesis, Freeman (1969)]; [Finn et al., The Proteins, 3rd ed., vol. 2, pp. 105-253 (1976)]; 및 [Erickson et al., The Proteins, 3rd ed., vol. 2, pp. 257-527 (1976)]에 기재된 것을 포함한 고체상 합성 기술에 의해 합성된다. 별법으로, TFPI-결합 펩티드 (예를 들어, TFPI-억제 펩티드)는 TFPI-결합 펩티드 (예를 들어, TFPI-억제 펩티드)를 코딩하는 핵산을 숙주 세포 (이는 펩티드를 발현시키도록 배양된다)에 도입함으로써 재조합 방식으로 발현된다. 그러한 펩티드는 표준 단백질 정제 기술을 이용하여 세포 배양액으로부터 정제된다.
본 발명은 본 발명의 TFPI-억제 펩티드를 코딩하는 핵산 서열을 포함하는 핵산을 또한 포함한다. DNA 및/또는 RNA 분자의 제조 방법은 당업계에 공지되어 있다. 하나의 측면에서, 본원에서 제공되는 펩티드를 코딩하는 DNA/RNA 분자는 화학 합성 기술 및/또는 중합효소 연쇄 반응 (PCR)을 이용하여 생성된다. 원하는 경우에, TFPI-억제 펩티드 코딩 서열은 발현 벡터 내로 도입된다. 당업자는 당업계에 공지된 임의의 많은 발현 벡터, 예를 들어 비제한적으로 플라스미드, 플라스미드-리포좀 복합체, 및 바이러스 벡터가 본 발명의 문맥에서 적합함을 알 것이다. 임의의 이들 발현 벡터는 예를 들어, 문헌 [Sambrook et al., Molecular Cloning, a Laboratory Manual, 2d edition, Cold Spring Harbor Press, Cold Spring Harbor, N.Y. (1989)] 및 [Ausubel et al., Current Protocols in Molecular Biology, Greene Publishing Associates and John Wiley & Sons, New York, N.Y. (1994)]에 기재된 표준 재조합 DNA 기술을 이용하여 제조된다. 임의로, 핵산은 하나 이상의 조절 서열, 예를 들어 프로모터, 활성제, 인핸서, cap 신호, 폴리아데닐화 신호, 또는 전사 또는 번역의 제어와 연관된 다른 신호에 작동가능하게 연결된다.
본 발명의 임의의 TFPI-억제 펩티드, 또는 펩티드를 코딩하는 핵산은 또한 조성물 (예를 들어, 제약 조성물) 내에 제공된다. 이와 관련하여, 펩티드는 본원에서 추가로 설명되는 생리학상 허용되는 (즉, 약물학상 허용되는) 담체, 버퍼, 부형제, 또는 희석제를 사용하여 제형화된다. 임의로, 펩티드는 생리학상 허용되는 염의 형태로 존재하고, 이는 본 발명에 포함된다. "생리학상 허용되는 염"은 제약상 허용되는 임의의 염을 의미한다. 적절한 염의 일부 예는 아세트산염, 염산염, 브롬화수소산염, 황산염, 시트레이트, 타르트레이트, 글리콜레이트, 및 옥살레이트를 포함한다. 원하는 경우에, 조성물은 하나 이상의 추가의 제약상 유효제를 포함한다.
본원에서 제공되는 펩티드는 임의로 적어도 하나의 조직 인자 경로 억제제-1 (예를 들어, TFPI-1α) 활성, 예를 들어 비제한적으로 혈액 응고 케스케이드를 하향조절하는 활성을 억제한다. 임의의 특정 작용 메카니즘에 매이지 않지만, 제안된 억제 메카니즘은 4원 TF-FVIIA-FXA-TFPI 복합체의 형성을 방지하는 것을 포함할 수 있다. 펩티드는 FXa (예를 들어, 인자 Xa에 대한 TFPI 쿠니츠 도메인 2의 결합을 억제한다), TF/FVIIa 복합체 (예를 들어, TF/FVIIa 복합체에 대한 TFPI 쿠니츠 도메인 1의 결합을 억제한다), TF 단독, 및/또는 FVIIa 단독에 대한 TFPI의 결합을 억제한다. TFPI 활성이 감쇄하면, TF 및 FVIIa는 유리되어 FX를 활성화시키고, 이는 차례로 프로트롬빈의 트롬빈으로의 전환을 향상시킨다.
하나의 측면에서, 본 발명의 펩티드는 모델 및/또는 혈장 시스템에서 TFPI 길항 활성을 보인다. TFPI-억제 활성을 결정하기 위한 예시적인 모델 시스템은 외인성 테나제 분석이고, 이는 TFPI (이는 FX 활성화 반응의 천연 억제제임)의 존재 하에 외인성 복합체-매개된 FX 활성화를 회복시키는 후보 펩티드의 능력을 시험한다 (예를 들어, 문헌 [Lindhout et al., Thromb. Haemost., 74, 910-915 (1995)] 참조). TFPI-억제 활성을 특성 결정하기 위한 또 다른 모델 시스템은 FXa 억제 분석이고, 여기서 FXa 활성을 TFPI의 존재 하에 측정한다 (문헌 [Sprecher et al., PNAS, 91, 3353-3357 (1994)] 참조). 외인성 테나제 분석 및 FXa 억제 분석은 실시예 3에 추가로 설명된다. 임의로, 본 발명의 펩티드는 TFPI의 존재 하에 1 x 10-4 M 이하, 1 x 10-5 M 이하, 1 x 10-6 M 이하, 또는 1 x 10-7 M 이하의 절반 최대 유효 농도 (EC50)로 FX 활성화를 향상시킨다.
하나의 측면에서, TFPI-길항 활성을 혈장-기반 분석으로 특성 결정한다. 트롬빈 형성은 후보 펩티드의 존재 하에 FVIII 또는 FIX 활성이 실질적으로 없는 혈장에서 촉발된다 (예를 들어, 잔류 응고 인자 활성은 1% 미만이다). 트롬빈 형성은 실시예 4에 기재된 바와 같이 형광 또는 발색 기질을 이용하여 검출할 수 있다. 트롬빈 활성을 측정하기 위한 시스템은 트롬비노스코프 비브이 (Thrombinoscope BV, 네덜란드 마스트리흐트)에 의해 제공된다. 프로트롬빈 전환은 예를 들어, 트롬보그래프 (Thrombograph)™ (써모 사이언티픽 (Thermo Scientific, 미국 매사추세츠주 월탬))를 이용하여 측정되고, 생성되는 데이타를 트롬비노스코프 비브이로부터 이용가능한 트롬비노스코프 (Thrombinoscope)™ 소프트웨어에 의해 생성된 교정된 자동 트롬보그램 (Calibrated Automatic Thrombogram)으로 컴파일링한다. 특정 실시양태에서, TFPI-억제 펩티드는 분석 동안 생성된 피크 트롬빈의 양을 증가시키고/시키거나 피크 트롬빈 형성을 달성하기 위해 요구되는 시간을 감소시킨다. 예를 들어, 펩티드는 FVIII의 부재 하에 (예를 들어, FVIII-결핍 혈장 내에서) TFPI-조절된 트롬빈 생성을, 정상 혈장 내에서 TFPI-의존 트롬빈 생성의 수준의 적어도 1%로 개선시킨다. 일반적으로, 정상 (이환되지 않은) 혈장은 약 0.5 U/mL 내지 약 2 U/mL 인자 VIII를 함유한다. 따라서, 일부 경우에, TFPI-억제제 펩티드는 FVIII의 부재 하에 트롬빈 형성을 0.5 U/mL 내지 2 U/mL FVIII의 존재 하에 관찰된 것의 적어도 약 1%로 향상시킬 것이다. 추가의 실시양태에서, 펩티드는 인자 VIII의 부재 하에 트롬빈 형성을, 정상 혈장 내에서, 즉, 생리학적 수준의 인자 VIII의 존재 하에 트롬빈 형성의 수준의 적어도 약 2%, 적어도 약 3%, 적어도 약 5%, 적어도 약 7%, 또는 적어도 약 10%로 향상시킨다. 다양한 측면에서, 펩티드는 생체 내에서 TFPI 억제 활성을 특성화하기 위해 트롬빈 결핍 또는 혈우병의 동물 모델에게 투여된다. 그러한 생체내 모델은 당업계에 공지되어 있고, 예를 들어, 혈우병 A를 유도하기 위해 항-FVIII 항체를 투여한 마우스 (Tranholm et al., Blood, 102, 3615-3620 (2003)); 응고 인자 낙-아웃 (knock-out) 모델, 예를 들어 비제한적으로 FVIII 낙-아웃 마우스 (Bi et al., Nat. Genet., 10(1), 119-121 (1995)) 및 FIX 낙-아웃 마우스 (Wang et al., PNAS, 94(21), 11563-66 (1997)); 토끼에서 유도된 혈우병-A (Shen et al., Blood, 42(4), 509-521 (1973)); 및 채플 힐 (Chapel Hill) HA 개 (Lozier et al., PNAS, 99, 12991-12996 (2002))를 포함한다.
임의의 특정 이론 또는 메카니즘에 매이지 않지만, 본원에서 제공되는 본 발명의 펩티드는 TFPI 및 FXa의 결합을 (경쟁적으로 또는 알로스테리 (allostery) 방식으로) 차단함으로써 TFPI 활성을 억제할 수 있다. 별법으로 또는 추가로, 펩티드는 조직 인자 (TF)/인자 VIIa 복합체와 TFPI의 결합을 억제할 수 있다. 따라서, 특정 측면에서, 펩티드는 TFPI에 특이적으로 결합한다. 비제한적으로 마우스, 래트, 토끼, 개, 고양이, 소, 말, 돼지, 기니 피그, 및 영장류를 포함한 임의의 공급원으로부터의 다양한 펩티드가 TFPI에 결합한다. 하나의 실시양태에서, 펩티드는 인간 TFPI에 결합한다. 임의로, TFPI-억제 펩티드는 하나 초과의 종으로부터의 TFPI에 결합한다 (즉, 펩티드는 다수의 종들 사이에서 교차반응성이다). 특정 측면에서, 펩티드는 1 x 10-4 M 이하, 1 x 10-5 M 이하, 1 x 10-6 M 이하, 또는 1 x 10-7 M 이하의 해리 상수 (KD)로 TFPI에 결합한다. 친화도는 예를 들어 비제한적으로 임의의 하나, 2 또는 그 이상의 다양한 기술, 예를 들어 친화도 ELISA 분석, 경쟁 ELISA 분석, 및/또는 표면 플라즈몬 공명 (BIAcore™) 분석을 이용하여 결정할 수 있다. 경쟁 (IC50) ELISA 분석을 이용하여 특성 결정할 때, 본 발명의 펩티드는 임의로 약 50,000 nM 이하의 IC50을 나타낸다. 예를 들어, 펩티드는 약 10,000 nM 이하의 IC50, 예를 들어 약 5,000 nM 이하, 약 1,000 nM 이하, 또는 약 500 nM 이하의 IC50을 나타낸다. 하나의 측면에서, 펩티드는 약 250 nM 이하, 약 100 nM 이하, 또는 약 50 nM 이하의 IC50을 나타낸다. 예시적인 펩티드 및 그들의 IC50 값을 도 32-39에 제공하고; 일부 경우에, 펩티드를 IC50 값에 기초하여 군 A, B, C, D, E, F, 및 G (실시예 1의 표 4 참조)로 분류한다. 다양한 측면에서, 본 발명은 표 4에 규정된 군 A, B, C, D, E, F, 및/또는 G에 속하는 펩티드를 제공한다. 친화도는 운동학 방법 또는 평형/용액 방법에 의해 또한 결정할 수 있다. 그러한 방법은 본원에서 추가로 상세히 설명되거나 당업계에 공지되어 있다.
모든 결합 물질 및 결합 분석과 마찬가지로, 당업자는 생물학상 (예를 들어, 치료상) 효과적이기 위해서 결합 물질이 검출가능하게 결합하지 않아야 하는 다양한 모이어티를 나열하는 것은 소모적이고 비실용적일 것임을 안다. 따라서, 용어 "특이적으로 결합하다"는 TFPI가 아닌 비관련 대조 단백질에 결합하는 것보다 더 큰 친화도로 TFPI에 결합하는 펩티드의 능력을 나타낸다. 예를 들어, 펩티드는 대조 단백질에 대한 친화도보다 적어도, 5, 10, 15, 25, 50, 100, 250, 500, 1000, 또는 10,000배 더 큰 친화도로 TFPI에 결합할 수 있다. 일부 실시양태에서, 펩티드는 "항-표적" (그에 대한 펩티드의 결합이 유해 효과를 일으킬 수도 있는 인간 내의 단백질 또는 다른 천연 발생 물질)에 결합하는 것보다 더 큰 친화도로 TFPI에 결합한다. 몇몇 클래스의 펩티드 또는 단백질은 잠재적인 항-표적이다. TFPI-억제 펩티드는 혈류 내에서 및/또는 내피에서 그들의 활성을 발휘하기 때문에, 혈장 단백질이 잠재적인 항-표적에 해당한다. 상이한 단백질의 KD는 유의한 유사성을 공유하므로 쿠니츠 도메인 (KD)을 함유하는 단백질은 잠재적인 항-표적이다. 조직 인자 경로 억제제-2 (TFPI-2)는 TFPI-1α에 매우 유사하고, TFPI-1α와 유사하게 KD를 함유한다 (Sprecher et al., PNAS, 91, 3353-3357 (1994)). 따라서, 하나의 측면에서, 본 발명의 펩티드는 항-표적, 예를 들어 TFPI-2에 대한 친화도보다 적어도 5, 10, 15, 25, 또는 50배 더 큰 친화도로 TFPI에 결합한다.
본 발명은 조직 인자 경로 억제제-1 (TFPI)의 억제 방법을 추가로 포함한다. 방법은 본원에 기재된 바와 같이 TFPI를 TFPI-결합 펩티드와 접촉시키는 것을 포함한다. 임의의 정도의 TFPI-활성 억제가 고려된다. 예를 들어, TFPI-억제 펩티드는 외인성 경로의 TFPI-억제를 적어도 약 5% (예를 들어, 적어도 약 10%, 적어도 약 25%, 또는 적어도 약 30%) 감소시킨다. 일부 실시양태에서, TFPI-억제 펩티드는 외인성 경로 내에서 TFPI 활성을, 펩티드의 부재 하에 TFPI 활성에 비해 적어도 약 50%, 적어도 약 75%, 또는 적어도 약 90% 감소시킨다.
본 발명은 TFPI가 위치하는 생물학적 구조 (예를 들어 비제한적으로 세포 표면 및 내피층 (lining))를 표적화하는 방법을 추가로 포함한다. 방법은 생물학적 구조 (예를 들어, 비제한적으로 세포 표면 상에서 TFPI를 디스플레이하는 세포를 포함함)를 임의로 펩티드에 추가의 기능성을 부여하는 모이어티에 접합된 본원에 기재된 TFPI-결합 펩티드와 접촉시키는 것을 포함한다. 모이어티는 염료 (예를 들어 형광 염료), 방사성 핵종 또는 방사성 핵종-함유 복합체, 단백질 (예를 들어, 효소, 독소, 또는 항체) 또는 세포독성제일 수 있다. 예를 들어, 펩티드는 펩티드 검출 및/또는 정제를 용이하게 하고/하거나 치료 특성을 포함하는 효과기 모이어티에 연결 또는 접합된다. 하나의 측면에서, TFPI-결합 펩티드 또는 펩티드 접합체는 포유동물 내에서 TFPI를 디스플레이하는 세포를 표적화하기 위해 포유동물에게 투여된다. 임의로, 방법은 TFPI에 대한 TFPI-결합 펩티드의 결합을 검출하는 것을 추가로 포함한다. 방법은 TFPI가 적합한 진단 마커이거나 TFPI-발현 세포가 치료 방안을 위한 표적인 질병의 치료 및 진단을 위해 유용하다.
일부 측면에서, 펩티드-TFPI 결합은 간접적으로 검출된다. 이와 관련하여, 펩티드는 펩티드-TFPI 결합을 유의하게 저해하지 않으면서 본 발명의 펩티드에 결합하는 상호작용 파트너 (partner)와 접촉되고, 상호작용 파트너가 검출된다. 예시적인 상호작용 파트너는 항체, 항원-결합 항체 단편, 안티칼린 및 항체 모방체, 앱타머 (aptamer) 및 스피겔머 (spiegelmer)를 포함하고 이로 제한되지 않는다. 임의로, 상호작용 파트너는 상호작용 파트너-펩티드 복합체의 검출을 용이하게 하기 위해 검출 모이어티를 포함한다. 예를 들어, 항체 및 그의 단편을 검출하는 방법은 당업계에서 잘 이해되고 있다. 유사하게, 검출 모이어티는 생물학적 물질의 확인을 위해 당업계에서 널리 사용되고, 예를 들어 염료 (예를 들어, 형광 염료), 방사성 핵종 및 방사성 핵종-함유 복합체, 및 효소를 포함한다.
따라서, 본 발명은 이상 TFPI 활성과 연관되거나 그에 의해 유발되는 질병 또는 질환에 걸린 또는 질병 또는 질환에 걸릴 위험이 있는 대상체를 진단하는 방법을 제공한다. 방법은 대상체에게 본 발명의 TFPI-결합 펩티드를 투여하고, TFPI-펩티드 복합체를 검출하는 것을 포함한다. 일부 경우에, 본 발명의 펩티드는 검출가능한 모이어티에 접합되고, 방법은 검출가능한 모이어티를 검출하는 것을 포함한다. 다른 경우에, 방법은 대상체에게 TFPI-결합 펩티드에 결합하는 TFPI-결합 펩티드 상호작용 파트너를 투여하고, 상호작용 파트너를 검출하는 것을 포함한다. 원하는 경우에, 상호작용 파트너는 검출가능한 모이어티를 포함하거나 그에 접합되고, 검출가능한 모이어티가 검출된다. 검출가능한 모이어티의 존재는 TFPI의 존재를 나타내고, 그에 의해 TFPI와 연관된 질병 또는 질환 (예를 들어, (i) TFPI를 억제함으로써 치료될 수 있거나, (ii) TFPI를 억제함으로써 개선 또는 예방될 수 있는 증상을 포함하는 질병 또는 질환)의 진단을 허용한다. 대상체에 대한 펩티드의 투여가 바람직하지 않은 경우에, 대상체로부터 생물학적 샘플을 얻고, 본원에 기재된 바와 같이 TFPI-결합 펩티드와 접촉시키고, TFPI-펩티드 복합체를 검출한다.
본 발명의 펩티드는 TFPI에 결합하고, 따라서, 생물학적 샘플 (예를 들어, 생물학적 유체, 예를 들어 혈청), 발효 추출물, 조직 제제, 배양 배지 등으로부터 TFPI 또는 재조합 TFPI를 정제하기 위해 유용하다. 본 발명은 TFPI의 상업적인 생산에서 또는 TFPI 분자의 특성 결정 방법에서 TFPI-결합을 이용하는 방법을 포함한다. 예를 들어, 본 발명은 TFPI를 정제하는 방법을 포함한다. 방법은 TFPI를 함유하는 샘플을 TFPI 및 펩티드 사이에서 복합체를 형성시키기 위해 적절한 조건 하에 본원에 규정된 펩티드와 접촉시키고; 샘플로부터 복합체를 제거하고; 임의로 복합체를 해리시켜 TFPI를 방출시키는 것을 포함한다. TFPI 및 펩티드 사이에 복합체를 형성하기 위해 적절한 예시적인 조건은 실시예에 개시되어 있고, 그러한 조건은 TFPI-펩티드 복합체를 해리시키기 위해 쉽게 변형될 수 있다. 일부 실시양태에서, TFPI의 회수를 용이하게 하기 위해 펩티드를 지지체, 예를 들어, 고체 지지체에 고정시킨다. 예를 들어, 하나의 실시양태에서, 펩티드를 크로마토그래피 정지상 (예를 들어, 실리카, 친화도 크로마토그래피 비드, 또는 크로마토그래피 수지)에 고정시키고, TFPI를 포함하는 샘플을 정지상에 적용하여 TFPI-펩티드 복합체를 형성시키고, 나머지 샘플을 정지상으로부터 제거하고, 정지상으로부터 TFPI를 용출시킨다. 이와 관련하여, 본 발명의 펩티드는 하나의 측면에서 친화도 크로마토그래피 기술에서 사용하기 위해 적합하다.
응고 인자-결여 대상체에서 트롬빈 형성을 향상시키는 방법을 또한 제공한다. 방법은 대상체에게 TFPI를 억제하기 위해 효과적인 조건 하에 본원에서 제공되는 펩티드를 투여하는 것을 포함한다. 이와 관련하여, TFPI-억제 펩티드는 대상체에서 트롬빈 형성을 향상시키기 위해 효과적인 양으로 효과적인 조건 하에 투여된다. "응고 인자-결여"는 대상체가 트롬빈 형성을 위해 요구되는 하나 이상의 혈액 인자, 예를 들어 FVIII, FIX, 또는 FXI의 결핍으로 고통받는 것을 의미한다. 실제로, 하나의 실시양태에서, 대상체는 FVIII가 결여된다. 별법으로 또는 추가로, 대상체는 인자 IX가 결여된다. 응고 인자 결핍은 임상 샘플 내의 인자의 양을 검사함으로써 확인된다. 당업자는 응고 인자 결핍의 규모에 따라 혈우병을 분류한다. 경증 혈우병에 걸린 대상체는 정상량 (1 U/ml)의 인자 VIII 또는 인자 IX의 약 5% 내지 30%를 갖는다. 중등도 혈우병은 정상 인자 VIII, 인자 IX, 또는 인자 XI 수준의 약 1% 내지 5%를 특징으로 하는 반면, 중증 혈우병이 있는 대상체는 정상량의 인자 VIII, 인자 IX, 또는 인자 XL의 1% 미만을 갖는다. 결핍은 활성화된 부분 트롬보플라스틴 시간 (APTT) 시험에 의해 간접적으로 확인할 수 있다. APTT 시험은 혈병이 형성하기 위해 요구되는 시간의 길이를 측정하고, 상기 시간은 정상 응고 인자 수준을 갖는 환자에 비해 인자 VIII 결핍 (혈우병 A), 인자 LX 결핍 (혈우병 B), 및 인자 XI 결핍 (혈우병 C)이 있는 환자에 대해 더 길다. 중증 및 중등도 인자 VIII 결핍이 있는 환자의 거의 100%는 APTT를 이용하여 진단될 수 있다. 본 발명은 응고 인자 결핍으로 고통받지 않는 대상체에서 트롬빈 형성을 향상시키는 것을 추가로 포함한다. 방법은 대상체 (예를 들어, 정상, 생리학적 수준의 응고 인자를 갖는 대상체)에게 본원에서 제공되는 펩티드를, 트롬빈 형성을 향상시키기 위해 효과적인 조건 하에 투여하는 것을 포함한다.
하나의 측면에서, TFPI-억제 펩티드는 대상체에서 혈병 형성을 증가시키기 위해 사용된다. 혈병 형성을 증가시키는 방법은 대상체에게 본원에 기재된 펩티드를, 혈병 형성을 증가시키기 위해 효과적인 양으로 효과적인 조건 하에 투여하는 것을 포함한다. 방법은 유익한 (예를 들어, 치료) 효과를 달성하기 위해 응고 케스케이드를 완전히 회복시킬 필요가 없음이 이해될 것이다. 응고 인자 결핍과 연관된 증상의 발병 또는 심도를 감소시키는, 트롬빈 또는 혈병 형성의 임의의 향상 또는 증가가 고려된다. 트롬빈 형성 및 혈액 응고를 촉진하는데 있어서 방법의 효능을 결정하는 방법은 당업계에 공지되고 본원에 기재되어 있다.
본 발명은 대상체에게 하나 이상의 TFPI-억제 펩티드, 예를 들어 임의의 하나 이상의 본원에 기재된 펩티드를, 대상체에서 혈액 응고 질환을 치료하기 위해 효과적인 양으로 효과적인 조건 하에 투여하는 것을 포함하는, 대상체에서 혈액 응고 질환을 치료하는 방법을 추가로 포함한다. 하나의 측면에서, 펩티드는 TFPI 활성을 억제하는 천연 펩티드가 아니다. "응고 질환"은 결여 혈액 응고 인자 활성 및 결여 혈소판 활성에 의해 유발된 출혈 질환을 포함한다. 혈액 응고 인자는 인자 V (FV), FVII, FVIII, FIX, FX, FXI, FXIII, FII (저프로트롬빈혈증의 원인), 및 폰 빌레브란트 (von Willebrand) 인자를 포함하고 이로 제한되지 않는다. 인자 결핍은 예를 들어, 인자의 단축된 생체내-반감기, 인자의 변경된 결합 특성, 인자의 유전자 결함, 및 인자의 감소된 혈장 농도에 의해 유발된다. 응고 질환은 선천성이거나 후천성일 수 있다. 잠재적인 유전자 결함은 응고 인자를 코딩하는 뉴클레오티드 서열 내의 결실, 부가 및/또는 치환을 포함하고, 그의 부재, 존재 및/또는 치환은 각각 응고 인자의 활성에 부정적인 영향을 미친다. 응고 질환은 또한 응고 인자에 대한 억제제 또는 자가면역성 (예를 들어, 항체)의 발생으로부터 기인한다. 한 예에서, 응고 질환은 혈우병 A이다. 별법으로, 응고 질환은 혈우병 B 또는 혈우병 C이다.
혈소판 질환은 순환계 내의 혈소판 기능 결여 또는 비정상적으로 낮은 혈소판 수치에 의해 유발된다. 낮은 혈소판 수치는 예를 들어 생산 부족, 혈소판 격리, 또는 비제어된 개방성 파괴 (patent destruction)에 의한 것일 수 있다. 혈소판감소증 (혈소판 결핍)은 화학요법 및 다른 약물 요법, 방사선요법, 수술, 사고에 의한 실혈, 및 다른 질병 상태를 포함한 다양한 이유로 존재할 수 있다. 혈소판감소증을 수반하는 예시적인 질병 상태는 다음과 같다: 재생불량성 빈혈; 유방암과 연관된 특발성 혈소판감소성 자색반증을 포함한 특발성 또는 면역 혈소판감소증 (ITP); HIV-연관 ITP 및 HIV-관련 혈전성 혈소판감소성 자색반증; 혈소판감소증을 야기하는 전이성 종양; 신생아 루푸스 증후군 비장 비대를 포함하는 전신 홍반 루푸스; 판코니 (Fanconi) 증후군; 비타민 B12 결핍; 엽산 결핍; 메이-헤글린 이상 (May-Hegglin anomaly); 비스코트-올드리치 (Wiskott-Aldrich) 증후군; 만성 간 질환; 혈소판감소증과 연관된 골수이형성 증후군; 발작성 야간 혈색소뇨증; C7E3 Fab (압식시맙 (Abciximab)) 요법 후의 급성 최중증 혈소판감소증; 모성 동종면역 혈소판감소증을 포함하는 동종면역 혈소판감소증; 항인지질 항체 및 혈전증과 연관된 혈소판감소증; 자가면역 혈소판감소증; 카르보플라틴-유도된 혈소판감소증 및 헤파린-유도된 혈소판감소증을 포함하는 약물-유도된 면역 혈소판감소증; 태아 혈소판감소증; 임신성 혈소판감소증; 휴스 (Hughes) 증후군; 루푸스양 혈소판감소증; 사고에 의한 및/또는 대량 실혈; 골수증식 질환; 악성종양이 있는 환자에서 혈소판감소증; 암 환자에서 혈전성 혈소판감소성 자색반증/용혈성 요독 증후군으로서 나타나는 혈전성 미세혈관병증을 포함하는 혈전성 혈소판감소증 자색반증; 수혈후 자색반증 (PTP); 자가면역 용혈성 빈혈; 육안으로 보이지 않는 공장 게실 천공; 진정 적혈구계 무형성증; 자가면역 혈소판감소증; 유행성 신장병증; 리팜피신-연관 급성 신 부전증; 파리-트루소 (Paris-Trousseau) 혈소판감소증; 신생아 동종면역 혈소판감소증; 발작성 야간 혈색소뇨증; 위암에서 혈액학적 변화; 용혈성 요독 증후군 (예를 들어, 아동의 요독성 병태); 및 A형 간염 바이러스를 포함한 바이러스 감염에 관련된 혈액학적 소견 및 CMV-연관 혈소판감소증. 혈소판 질환은 또한 폰 빌레브란트 질병, 부신생물 혈소판 기능이상, 글란즈만 (Glanzman) 혈소판 기능 저하증, 및 베르나르-술리에 (Bernard-Soulier) 질병을 포함하고 이로 제한되지 않는다. TFPI-억제 펩티드로 치료될 수 있는 추가의 출혈 질환은 외상에 의해 유발되는 출혈 병태; 하나 이상의 접촉 인자, 예를 들어 FXI, FXII, 프레칼리크레인 및 고분자량 키니노겐 (HMWK)의 결핍; 비타민 K 결핍; 섬유소원 (fibrinogen) 질환, 예를 들어 무섬유소원혈증, 저섬유소원혈증 및 이상섬유소원혈증; 및 알파2-항플라스민 결핍을 포함하고 이로 제한되지 않는다. 하나의 실시양태에서, TFPI-억제 펩티드는 과도한 출혈, 예를 들어 수술, 외상, 뇌내 출혈, 간 질병, 신장 질병, 혈소판감소증, 혈소판 기능이상, 혈종, 내부 출혈, 출혈성 관절증, 체온저하, 월경, 임신 및 뎅기 출혈열에 의해 유발된 과도한 출혈을 치료하기 위해 사용된다. 상기한 모든 질환은 본원의 개시내용의 문맥에서 "혈액 응고 질환"으로 간주된다.
하나의 측면에서, 본 발명의 TFPI-억제 펩티드는 대상체에서 하나 이상의 항응고제의 효과를 (전적으로 또는 부분적으로) 역전시키기 위해 사용된다. 수많은 항응고제가 당업계에 공지되어 있고, 예를 들어 헤파린; 쿠마린 유도체, 예를 들어 와파린 또는 디쿠마롤; TFPI; AT III; 루푸스 항응고제; 선충 항응고제 펩티드 (NAPc2); FVIIa 억제제; 활성-부위 차단된 FVIIa (FVIIai); 활성-부위 차단된 FIXa (FIXai); FIXa 억제제; FXa 억제제, 예를 들어 폰다파리눅스, 이드라파리눅스, DX-9065a, 및 라작사반 (DPC906); 활성-부위 차단된 FXa (FXai); FVa 또는 FVIIIa의 억제제, 예를 들어 활성화된 단백질 C (APC) 및 가용성 트롬보모둘린; 트롬빈 억제제, 예를 들어 히루딘, 비발리루딘, 아르가트로반 및 시멜라가트란 (ximelagatran); 및 응고 인자 (예를 들어, FV, FVII, FVIII, FIX, FX, FXIII, FII, FXI, FXII, 폰 빌레브란트 인자, 프레칼리크레인, 또는 고분자량 키니노겐 (HMWK))에 결합하는 항체 또는 항체 단편을 포함한다.
본원에서 사용될 때, "치료하는" 및 "치료"는 혈액 응고 질환과 연관된 증상의 심도 및/또는 발병의 임의의 감소를 나타낸다. 따라서, "치료하는" 및 "치료"는 치료 및 예방 조치를 포함한다. 당업자는 혈액 응고 질환 또는 그와 연관된 증상으로부터 임의의 정도의 보호 또는 그의 개선이 대상체, 예를 들어 인간 환자에게 유익함을 알 것이다. 환자의 삶의 질은 대상체에서 임의의 정도로 증상의 심도를 감소시킴으로써 및/또는 증상의 출현을 지연시킴으로써 개선된다. 따라서, 하나의 측면에서, 방법은 대상체가 혈액 응고 질환을 발병할 위험이 있는지 결정된 (예를 들어, 응고 인자 (예를 들어, FVIII, FIX, 또는 FXI)의 결핍이 검출된) 후 가능한 빨리 또는혈액 응고 질환 (예를 들어, 혈우병 A, 혈우병 B, 또는 혈우병 C)이 검출된 후 가능한 빨리 수행한다. 추가의 측면에서, 펩티드는 전적으로 또는 부분적으로 손상 또는 수술 동안 과도한 실혈에 대해 보호하기 위해 투여된다.
위와 관련하여, 본 발명은 대상체의 치료 방법, 예를 들어 TFPI의 억제가 유익한 질병의 치료를 위한 방법에서 사용하기 위한 펩티드를 제공한다. 하나의 측면에서, 질병 또는 질환은 혈액 응고 질환이다. 대상체는 질병 또는 질환에 걸리거나 질병 또는 질환 (또는 유해한 생물학적 사건, 예를 들어 과도한 실혈)에 걸릴 위험이 있다. 방법은 대상체에게 본 발명의 펩티드를, 질병 또는 질환을 전적으로 또는 부분적으로 치료 또는 예방하기 위해 효과적인 양으로 효과적인 조건 하에 투여하는 것을 포함한다. 본 발명은 의약의 제조에 사용하기 위한 펩티드를 추가로 제공한다. 예를 들어, 펩티드는 본원에 상세히 설명된 바와 같이 혈액 응고 질환의 치료용 의약의 제조에서 사용될 수 있다.
일부 실시양태에서, 대상체에게 본 발명의 TFPI-결합 펩티드 (예를 들어, TFPI-억제 펩티드)를 코딩하는 핵산 서열을 포함하는 핵산을 투여하는 것이 유리하다. 상기 핵산은 하나의 측면에서 TFPI-억제 펩티드 대신에 또는 그에 추가로 제공된다. 발현 벡터, 핵산 조절 서열, 투여 방법 등은 본원에서 추가로 설명되고 미국 특허 공개 20030045498에 기재되어 있다.
특정 대상체에 대한 특정 투여 요법은 부분적으로, 사용되는 본 발명의 TFPI-억제 펩티드, 투여되는 TFPI-결합 펩티드 (예를 들어, TFPI-억제 펩티드)의 양, 투여 경로, 치료되는 특정 질병, 수여체에 관련한 고려사항, 및 임의의 부작용의 원인 및 정도에 따라 결정될 것이다. 대상체 (예를 들어, 포유동물, 예를 들어 인간)에게 투여되는 펩티드의 양 및 투여의 조건 (예를 들어, 투여 시기, 투여 경로, 투여 요법)은 합리적인 시간 틀에 걸쳐 목적하는 생물학적 반응을 일으키기 위해 충분하다. 투여량은 대개 다양한 인자, 예를 들어 사용된 특정 TFPI-억제 펩티드, 대상체의 연령 및 체중, 및 대상체에서 임의의 질병 또는 질환의 존재 및 심도에 따라 결정된다. 용량의 크기는 또한 투여 경로, 시기 및 빈도에 의해 결정될 것이다. 따라서, 임상의는 최적 치료 효과를 얻기 위해 투여량을 적정하고 투여 경로를 변형할 수 있고, 통상적인 범위 탐색 기술은 당업자에게 공지되어 있다. 순수하게 예시로서, 하나의 측면에서, 방법은 상기 언급된 인자에 따라 예를 들어, 약 0.1 ㎍/kg 내지 약 100 mg/kg 이상을 투여하는 것을 포함한다. 다른 실시양태에서, 투여량은 1 ㎍/kg 내지 약 75 mg/kg; 또는 5 ㎍/kg 내지 약 50 mg/kg; 또는 10 ㎍/kg 내지 약 20 mg/kg 범위일 수 있다. 특정 실시양태에서, 용량은 약 0.5 mg/kg 내지 약 20 mg/kg (예를 들어, 약 1 mg/kg, 1.5 mg/kg, 2 mg/kg, 2.3 mg/kg, 2.5 mg/kg, 3 mg/kg, 3.5 mg/kg, 4 mg/kg, 4.5 mg/kg, 5 mg/kg, 5.5 mg/kg, 6 mg/kg, 6.5 mg/kg, 7 mg/kg, 8 mg/kg, 9 mg/kg, 또는 10 mg/kg)의 펩티드를 포함한다. 많은 혈액 응고 질환의 만성 성질을 감안하면, 대상체는 수주, 수개월, 또는 수년 지속하는 치료 과정에 걸쳐 TFPI-억제 펩티드를 투여받을 것이고 매일 또는 매주 1회 이상의 용량을 필요로 할 수 있을 것임이 생각된다. 다른 실시양태에서, TFPI-억제 펩티드는 급성 병태 (예를 들어, 수술 또는 외상에 의해 유발된 출혈, 또는 응고 대체 요법을 투여받는 대상체에서 인자 억제제/자가면역 에피소드)를 치료하기 위해 비교적 짧은 치료 기간, 예를 들어, 1 내지 14일 동안 투여된다.
본원에 기재된 펩티드를 포함하는 생리학상 허용되는 조성물, 예를 들어 제약 조성물을 투여하는 적합한 방법은 당업계에 공지되어 있다. 펩티드를 투여하기 위해 하나 초과의 경로가 사용될 수 있지만, 특정 경로가 다른 경로보다 더 즉각적이고 더 효과적인 반응을 제공할 수 있다. 환경에 따라, 제약 조성물을 체강 내로 적용 또는 주입하고/하거나, 피부 또는 점막을 통해 흡수시키고/시키거나, 섭취하고/하거나, 흡입하고/하거나 순환계 내로 도입시킨다. 하나의 측면에서, TFPI-억제 펩티드를 포함하는 조성물은 본 발명의 펩티드를 순환계 내로 도입하기 위해 정맥내, 동맥내, 또는 복강내 투여한다. 비-정맥내 투여가 또한 특히 저분자량 치료제에 관련하여 적절하다. 특정 환경에서, TFPI-억제 펩티드를 포함하는 제약 조성물을 경구로, 국소로, 설하로, 질로, 직장으로; 뇌내 (뇌실질내), 뇌실내, 근육내, 눈 안, 문맥내, 병변내, 골수내, 경막내, 심실내, 경피, 피하, 코 안, 요도, 또는 장관 수단에 의한 주사를 통해; 지연 방출 시스템에 의해; 또는 이식 장치에 의해 전달하는 것이 바람직하다. 원하는 경우에, TFPI-억제 펩티드를, 관심있는 구역에 공급하는 동맥내 또는 정맥내 투여를 통해, 예를 들어, 다리에 전달하기 위해 대퇴 동맥을 통해 영역별로 투여한다. 하나의 실시양태에서, 펩티드는 예를 들어, 미국 특허 5,439,686 및 5,498,421, 및 미국 특허 공개 2003/0059474, 2003/0064033, 2004/0043077, 2005/0048127, 2005/0170005, 2005/0142205, 2005/142201, 2005/0233945, 2005/0147689. 2005/0142206, 2006/0024379, 2006/0260777, 2007/0207210, 2007/0092452, 2007/0281031, 및 2008/0026068에 기재되어 있는 바와 같이 미세입자 내로 포함된다. 별법으로, 조성물은 그 위에 목적하는 분자가 흡수되거나 또는 캡슐화되어 있는 막, 스폰지, 또는 다른 적절한 물질의 이식을 통해 투여된다. 이식 장치가 사용되는 경우에, 장치는 하나의 측면에서 임의의 적합한 조직 내로 이식되고, 목적하는 분자의 전달은 다양한 측면에서 확산, 적기 (timed)-방출 볼러스, 또는 연속 투여를 통해 이루어진다. 다른 측면에서, TFPI-억제 펩티드는 수술 절차 또는 손상의 치료 동안 노출된 조직에 직접 투여되거나, 혈액 절차의 수혈을 통해 투여된다. 치료 전달 방안은 당업자에게 잘 공지되어 있고, 그 일부는 예를 들어 미국 특허 5,399,363에 추가로 기재되어 있다.
투여를 용이하게 하기 위해, TFPI-결합 펩티드 (예를 들어, TFPI-억제 펩티드)는 하나의 실시양태에서 담체 (즉, 비히클, 보조제, 버퍼 또는 희석제)를 포함하는 생리학상 허용되는 조성물 내로 제형화된다. 사용된 특정 담체는 단지 화학-물리학적 고려사항, 예를 들어 용해도 및 펩티드와의 반응성의 결핍에 의해, 및 투여 경로에 의해 제한된다. 생리학상 허용되는 담체는 당업계에 공지되어 있다. 주사가능한 용도에 적합한 예시적인 제약 형태는 비제한적으로 멸균 수성 용액 또는 분산액, 및 멸균 주사가능 용액 또는 분산액의 즉석 제조를 위한 멸균 분말을 포함한다 (예를 들어, 미국 특허 5,466,468 참조). 주사가능한 제형은 예를 들어 문헌 [Pharmaceutics and Pharmacy Practice, J.B. Lippincott Co., Philadelphia. Pa., Banker and Chalmers, eds., pages 238-250 (1982)], 및 [ASHP Handbook on Injectable Drugs, Toissel, 4th ed., pages 622-630 (1986)]에 추가로 기재되어 있다. 본원에서 제공되는 펩티드를 포함하는 제약 조성물은 임의로 그러한 제약 조성물의 사용에 관한 지시를 제공하는 충전 물질과 함께 용기 내에 배치된다. 일반적으로, 그러한 지시는 시약 농도를 설명하는 확실한 표현, 및 특정 실시양태에서 제약 조성물을 구성하기 위해 필요할 수 있는 부형제 성분 또는 희석제의 상대적인 양을 포함한다.
적절한 경우에, 본 발명의 TFPI-결합 펩티드 (예를 들어, TFPI-억제 펩티드)는 추가의 또는 증대된 생물학적 효과를 달성하기 위해 다른 물질 및/또는 다른 치료 양상과 조합으로 투여된다. 동시-치료제는 혈장-유래된 또는 재조합 응고 인자, 혈우병 예방 치료제, 면역억제제, 혈장 인자-억제 항체 길항제 (즉, 항-억제제), 항섬유소용해제, 항생제, 호르몬 요법, 소염제 (예를 들어, 비-스테로이드성 소염 약물 (NSAID) 또는 스테로이드성 소염 물질), 응고촉진제 및 진통제를 포함하고 이로 제한되지 않는다. 하나의 측면에서, 방법은 대상체에 대한 예를 들어, FXIII, FXII, FXI (예를 들어, 헤몰레벤 (HEMOLEVEN)® (라보라트와 프라세 디 프락시온먼 에 데 비오테크놀로지 (Laboratoire francais du Fractionnement et des Biotechnologies, 프랑스 레 쥘리)) 및 FXI 농축물 (바이오프로덕츠 래보러토리 (BioProducts Laboratory, 영국 허트포드셔 엘스트리)), FX, FIX (예를 들어, 베네픽스 (BENEFIX)® 응고 인자 IX (와이어쓰 (Wyeth, 미국 뉴저지주 메디슨); 알파닌 (ALPHANINE)® SD (그리폴스 (Grifols, 미국 캘리포니아주 로스앤젤레스)); 모노닌 (MONONINE)® (씨에스엘 베링 (CSL Behring, 미국 펜실베니아주 킹 오브 프러시아)); 베불린 (BEBULIN)-VH™ (박스터 (Baxter, 미국 일리노이주 디어필드)); 프로필린 (PROFILNINE)® SD (그리폴스, 미국 캘리포니아주 로스앤젤레스); 또는 프로플렉스 (PROPLEX) T™ (박스터, 미국 일리노이주 디어필드), FVIII (예를 들어, 애드베이트 (ADVATE)™ (박스터, 미국 일리노이주 디어필드); 헬릭세이트 (HELIXATE)® FS (씨에스엘 베링, 미국 펜실베니아주 킹 오브 프러시아); 레팍토 (REFACTO)® (와이어쓰, 미국 뉴저지주 메디슨), 진타 (XYNTHA)™ (와이어쓰, 미국 뉴저지주 메디슨), 코게네이트 (KOGENATE)® 및 코게네이트® FS (바이엘 (Bayer, 미국 펜실베니아주 피츠버그)); 알파네이트 (ALPHANATE)® (그리폴스, 미국 캘리포니아주 로스앤젤레스); 헤모필 (HEMOPHIL) M™ (박스터, 미국 일리노이주 디어필드); 코에이트 (K0ATE)®-DVI (탈레크리스 바이오써라퓨틱스-유에스에시 (Talecris Biotherapeutics-USA, 미국 노쓰캐롤라이나주 리써치 트라이앵글 파크)); 또는 모나크 (MONARC)-M™ (박스터, 미국 일리노이주 디어필드), FVIIa (예를 들어, 노보세븐 (NOVOSEVEN)® FVIIa (노보 노디스크 (Novo Nordisk, 미국 뉴저지주 프린스턴) 및 FVII 농축물 (박스터 바이오사이언스 (Baxter Bioscience, 오스트리아 비엔나), 또는 바이오프로덕츠 래보러토리 (영국 허트포드셔 엘스트리)), FV, FVa, FII, 및/또는 Fill의 투여를 수반하는 전통적인 대체 인자 치료 요법에 대한 부가 요법이다. 일부 경우에, 대상체는 또한 인자 VIII 억제제 우회 활성을 갖는 동결 건조된 멸균 인간 혈장 분획인 FEIBA VH Immuno™ (박스터 바이오사이언스, 오스트리아 비엔나)를 투여받는다. FEIBA VH Immuno™은 거의 동일한 단위의 인자 VIII 억제제 우회 활성 및 프로트롬빈 복합체 인자 (인자 II, VII, IX, 및 X와 단백질 C)를 함유한다. 다른 예시적인 동시-치료제는 프레칼리크레인, 고분자량 키니노겐 (HMWK), 폰 빌레브란트 인자, 조직 인자, 및 트롬빈을 포함하고 이로 제한되지 않는다. 별법으로 또는 추가로, TFPI-억제 펩티드는 하나 이상의 상이한 TFPI-억제 펩티드와 동시-제형화된다.
따라서, 본 발명은 대상체에게 본 발명의 TFPI-결합 펩티드 (예를 들어, TFPI-억제 펩티드) (또는 다수의 TFPI-억제 펩티드)를, 각각 그 의약에 대해 적합한 요법에 따라 투여되는 하나 이상의 추가의 적합한 물질(들)과 조합으로 투여하는 것을 포함한다. 투여 전략은 TFPI-억제 펩티드 및 하나 이상의 추가로 적합한 물질(들)의 동시 투여 (즉, 실질적인 동시 투여) 및 비-동시 투여 (즉, 상이한 시간에 임의의 순서로 (겹치든가 그렇지 않든가) 투여)를 포함한다. 상이한 성분들은 임의로 동일한 조성물 또는 별개의 조성물 내에서 및 동일한 또는 상이한 투여 경로에 의해 투여됨이 이해될 것이다.
일부 실시양태에서, 본 발명의 펩티드는 모이어티, 예를 들어, 치료 또는 진단 모이어티, 예를 들어 검출 모이어티 및 상기 설명된 동시-치료제에 접합된다. 별법으로 또는 추가로, 펩티드는 (a) 펩티드에 결합하고 (b) 치료 활성이고/이거나 상호작용 파트너 (예를 들어, 치료제, 진단제 또는 검출제)에 추가의 기능성을 제공하는 모이어티에 연결된 상호작용 파트너 (예를 들어, 항체, 항체 단편, 안티칼린, 앱타머, 또는 스피겔머)와 조합으로 투여된다. 적합한 모이어티는 염료, 방사성 핵종, 방사성 핵종-함유 복합체, 효소, 독소, 항체, 항체 단편, 및 세포독성제을 포함하고 이로 제한되지 않고, 일부 경우에 모이어티는 치료 활성을 갖는다 (즉, 유익한 또는 목적하는 생물학적 효과를 달성한다). 펩티드 접합체 또는 펩티드-상호작용 파트너 쌍은 본원에 기재된 임의의 방법, 예를 들어 질병 또는 질환에 걸린 또는 질병 또는 질환에 걸릴 위험이 있는 대상체의 치료 방법에 사용하기 위해 적합하다.
본 명세서에서 인용되는 모든 공개문, 특허 및 특허 출원은 각각의 개별 공개문 또는 특허 출원이 구체적으로 및 개별적으로 참고로 포함되는 것으로 지시되는 것처럼 본원에 참고로 포함된다. 또한, 전체 문서는 통합된 개시내용으로서 관련되는 것으로 의도되고, 본원에 기재된 특징의 모든 조합은 특징의 조합이 상기 문서의 동일한 문장, 또는 단락, 또는 절에서 함께 발견되지 않는 경우에도 고려됨을 이해하여야 한다. 예를 들어, 단백질 요법이 설명되는 경우, 폴리뉴클레오티드 요법 (단백질을 코딩하는 폴리뉴클레오티드/벡터를 사용)을 수반하는 실시양태가 구체적으로 고려되고, 그 반대의 경우도 고려된다. 상기한 발명을 명확한 이해를 위해 예시 및 예를 통해 다소 상세하게 설명하였지만, 본 발명의 교시내용에 비추어 첨부된 청구의 범위 또는 취지로부터 벗어나지 않으면서 본 발명에 대한 특정 변화 및 변형이 가능할 수 있음이 당업자에게 쉽게 자명해질 것이다. 본 발명은 예를 들어 상기 구체적으로 언급된 변동보다 임의의 방식으로 그 범위가 더 좁은 본 발명의 모든 실시양태를 포함한다. 속으로서 설명된 본 발명의 측면에 관하여, 모든 개별적인 종은 본 발명의 별개의 측면으로 개별적으로 간주된다. 단수 ("a" 또는 "an")를 설명하거나 그를 사용하여 청구된 본 발명의 측면에 관하여, 문맥이 보다 제한적인 의미를 분명하게 요구하지 않는다면, 이들 용어가 "하나 이상"을 의미함을 이해해야 한다. 세트 내의 하나 이상으로 설명된 요소에 관하여, 세트 내의 모든 조합이 고려됨을 이해해야 한다.
실시예
실시예 1
다음 실시예는 펩티드의 생산, 확인, 및 TFPI에 대한 결합에 대한 스크리닝을 설명한다.
펩티드 후보를 상업 공급자 (예를 들어, 폴리펩티드 래보래토리스 에스에이에스 (PolyPeptide Laboratories SAS, 프랑스 스트라스부르) 및 제이피티 펩티드 테크놀로지스 게엠베하 (JPT Peptide Technologies GmbH, 독일 베를린))로부터 입수하였다. 후보 펩티드의 합성 방법은 상기 제공된다. 후보 펩티드는 트리플루오로아세테이트 (TFA) 염으로서 순도 >90% 또는 >60%로 합성하였다. 모든 펩티드를 DMSO 내에 10 mM의 원액 농도로 용해시켰다. TFPI-결합 펩티드 서열은 mRNA 디스플레이 라이브러리를 이용하여 확인하였다. mRNA 디스플레이 기술은 출발 풀 (pool) 내에서 1014개의 상이한 서열의 다양성을 허용하고, 예를 들어, 파지 디스플레이를 위해 요구되는 생체내 단계를 피하므로 다른 라이브러리 스크리닝 기술보다 우월하다. 간단히 설명하면, 기술은 mRNA를 푸로마이신 분자를 통해 그의 코딩된 후보 펩티드에 직접 연결하는 것을 포함한다 (도 5). mRNA 디스플레이 방법은 국제 특허 출원 공개 WO 2005/051985 및 문헌 [Liu et al., Methods in Enzymology, 318, 268-293 (2000)]에 추가로 설명되어 있다. TFPI를 비오틴을 통해 고체 지지체에 고정시키고, 후보 펩티드-RNA 복합체에 노출시켰다. TFPI-결합된 후보 펩티드-RNA 복합체를 단리하고, RNA 역전사를 수행하여 코딩 DNA를 얻었다. 고친화도 바인더 (binder)는 경쟁적 회피 (elusion) 전략을 이용하여 6 내지 10회 선택 라운드 후에 얻었다. 많은 후보 펩티드는 길이가 31개 아미노산 (27개의 무작위로 선정된 아미노산 및 두 말단에 인접하는 2개의 아미노산)이었다.
선택된 펩티드를 합성하고, TFPI-결합 친화도를 보유하는 펩티드 단편을 확인하기 위해 미세어레이-기반 스캔 분석을 사용하여 펩티드 최적화에 적용하였다. 예를 들어, JBT0047의 미세어레이-기반 스캔은 그 서열이 19개 아미노산에 의해 중복되는 펩티드의 일련의 20개 아미노산 단편을 사용하여 수행하였다. N- 및 C-말단 절단 분석을 수행하여 스캔 분석을 보충하였다. 미세어레이 스캔 결과는 펩티드 JBT0293이 TFPI에 최고 친화도로 결합함을 보여주었다. JBT0293의 아미노산 서열에 기초한 일련의 치환 돌연변이체를 생성하고, TFPI 결합 특성에 대해 시험하였다.
TFPI에 대한 하위세트 펩티드의 친화도를 비오티닐화 펩티드를 사용하여 수행된 효소 연결 면역흡착 분석 (ELISA)-유사 분석 (결합 (EC50) ELISA)을 통해 입증하였다. 96 웰 맥시소프 (Maxisorp) 플레이트 (넝크 (Nunc))를 코팅 버퍼 (15 mM Na2CO3, 35 mM NaHCO3, pH 9.6) 중의 3 ㎍/mL TFPI로 밤새 코팅하였다. 플레이트를 350 ㎕ 세척 버퍼 (HNaT: 175 mM NaCl, 25 mM HEPES, 5 mM CaCl2, 0.1% Tween 80, pH 7.35)로 3회 세척하고, 후속적으로 2시간 동안 HNaT 중의 2% 효모 추출물 200 ㎕로 차단하였다. 이어서, 플레이트를 350 ㎕ HNaT로 3회 세척하였다. 비오티닐화된 후보 펩티드를 DMSO 원액으로부터 HNaT 중에 1/200로 희석하였다. 10 mM 펩티드 원액 용액의 1/200 희석 동안 침전물이 나타나지 않으면, 초기 펩티드 농도는 50 μM이었다. 침전물이 형성될 경우에, DMSO 중의 펩티드 원액의 예비-희석을 수행하였다. 희석된 펩티드를 맥시소프 플레이트에 적용하고, 연속 희석액 (1/3)을 생성하고, 희석액을 1.5시간 동안 실온에서 인큐베이팅하였다. 인큐베이션 후에 3회 세척 단계 (350 ㎕ HNaT)를 수행하였다. 결합된 펩티드는 호스래디시 (horseradish) 퍼옥시다제-접합된 스트렙타비딘과 함께 인큐베이션(1시간)한 후 HNaT를 사용한 3회의 세척 단계 및 첨가된 TMB (3,3',5,5'-테트라메틸벤지딘)의 후속적인 발색 전환에 의해 검출하였다. 분석을 도 6a에 예시한다.
일반적으로, 고정된 TFPI에 대한 펩티드 결합은 배경보다 유의하게 더 높았다. 비오티닐화 펩티드에 대한 EC50 값을 도 32-39에 제공한다. 하나의 TFPI-결합 펩티드, JBT0132의 결합 곡선을 도 7에 도시한다. JBT0132의 EC50은 약 2.2 nM인 것으로 계산되었다.
또한, 경쟁 (IC50) ELISA는 TFPI-결합을 위해 비-비오티닐화 후보 펩티드와 경쟁하도록 "추적자 (tracer)"로서 비오티닐화 TFPI-결합 펩티드를 사용하여 수행하였다. 분석 원리를 도 6b에 도시한다. 96 웰 맥시소프 플레이트 (넝크)를 코팅 버퍼 (15 mM Na2CO3, 35 mM NaHCO3, pH 9.6) 중의 3 ㎍/mL TFPI로 밤새 코팅하였다. 플레이트를 350 ㎕ 세척 버퍼 (HNaT: 175 mM NaCl, 25 mM HEPES, 5 mM CaCl2, 0.1% Tween 80, pH 7.35)로 3회 세척하고, 2시간 동안 HNaT 중의 2% 효모 추출물 200 ㎕로 차단하였다. 이어서, 플레이트를 350 ㎕ HNaT로 3회 세척하였다. 비오티닐화된 추적자 펩티드를 결합 ELISA에서 결정된 그의 각각의 EC90 값 (n > 2이면 중앙값)에 대응하는 농도로 적용하였다. 펩티드의 경쟁자 원액 용액 (10 mM)을 HSA가 없는 HNaT 중에 1/33.3으로 희석하고, 3% DMSO가 있는 HNaT로 연속 1/3 희석액을 제조하였다. 희석액을 비오티닐화 추적자 펩티드로 1:6의 비로 (20 ㎕ 경쟁자 희석액 및 100 ㎕ 추적자 펩티드) 추가로 희석하였다. 경쟁자 및 추적자 펩티드의 혼합물을 TFPI-코팅된 미세적정 플레이트에 적용하고, 1.5시간 동안 인큐베이팅하였다. 플레이트를 350 ㎕ HNaT로 3회 세척하였다. 펩티드-TFPI 결합은 HRP-접합된 스트렙타비딘을 미세적정 플레이트에 적용하고, 혼합물을 1시간 동안 인큐베이팅하고, 플레이트를 350 ㎕ HNaT로 3회 세척하고, TMB (3,3',5,5'-테트라메틸벤지딘)를 적용하고, HRP에 의한 TMB의 후속적인 발색 전환을 검출함으로써 검출하였다. 대표적인 비-비오티닐화 펩티드에 대한 IC50 그래프를 도 8a-8d에 제공한다. 펩티드 JBT0303, JBT0120 및 JBT0224의 IC50 측정치를 표 3에 제시한다.
펩티드 IC50 [μM] n SD 추적자 펩티드 추적자 농도 [μM]
JBT0303 0.119 2 0.064 JBT0131 0.0409
JBT0120 0.0189 3 0.0044 JBT0124 0.0718
JBT0224 n.a. 1 JBT0126 0.240
경쟁 ELISA (IC50) 분석에 추가로, 보다 많은 수의 펩티드를 평행하게 측정하기 위해 스크리닝 분석을 사용하였다. 스크리닝 ELISA는 단지 3개의 상이한 농도의 경쟁자 (JBT0047 클래스에 대해 300 nM, 100 nM 및 33.3 nM, 및 JBT0122 클래스에 대해 50000 nM, 16667 nM 및 5556 nM)를 사용한 것을 제외하고는 경쟁 IC50 ELISA와 유사하다. 일부 경우에, 스크리닝 결과는 경쟁적 펩티드에 관련한 추적자 신호의 % 억제로서 표현하였다 (JBT0047 패밀리에 대해 경쟁적 펩티드 JBT0477, 및 JBT0122 패밀리에 대해 경쟁적 펩티드 JBT1697). 본원에 제시된 방법에 따라 제조되고 스크리닝된 펩티드의 경쟁 IC50 분석 결과 및 스크리닝 분석 결과를 도 32-39에 제공한다. 도 32-39에 제시된 평균 IC50 값은 표 3에 제시된 값보다 더 많은 갯수의 분석에 기초한 것이고, 따라서, 값은 약간 다를 수 있다. 스크리닝 ELISA의 결과를 추적자 펩티드 JBT0131 결합의 % 억제로서 제시한다. IC50 ELISA를 이용하여 분석한 몇몇 펩티드를 표 4에 제시된 그의 결합 친화도에 따라 도 32-39에서 분류하였다.
TFPI 경쟁 ELISA IC50 [nM] 군
< 50 nM A
50 ≤ x < 100 nM B
100 ≤ x < 250 nM C
250 ≤ x < 1000 nM D
1000 ≤ x < 5000 nM E
5000 ≤ x < 10000 nM F
10000 ≤ x < 50000 nM G
본원에 기재된 방법을 이용하여 확인된 예시적인 TFPI-결합 펩티드를 표 5에 제시한다. 일부 펩티드는 비오티닐화되고, 많은 것은 용해도를 촉진하기 위해 N- 및 C-말단 라이신을 포함한다. 몇몇 펩티드는 아래 설명된 바와 같이 모델 및/또는 혈장 분석 시스템에서 TFPI-억제 활성을 보였다.
Figure pat00009
Figure pat00010
본 실시예는 TFPI-억제 펩티드를 생성하고 특성 결정하는 예시적인 방법을 제공한다. 표 5의 모든 펩티드는 인간 TFPI-1α에 결합하는 것으로 밝혀졌다. 돌연변이 분석으로 TFPI에 대한 친화도를 유지하면서 TFPI-결합 펩티드 내에서 적어도 하나의 아미노산이 치환될 수 있음을 입증하였다. ELISA 분석에서 시험된 표 5의 펩티드는 TFPI-1α에 10 μM (1 x 10-5 M) 미만의 EC50 및 50 μM 미만의 IC50으로 결합하였다.
실시예 2
선택된 TFPI-결합 펩티드를 "항-표적" 결합의 면에서 추가로 특성 결정하였다. 본 실시예는 TFPI-억제 펩티드가 비-TFPI-1 단백질에 대해 감소된 친화도를 보임을 입증한다.
TFPI-1에 대한 유사성 때문에 TFPI-2를 항-표적으로서 선택하였다. 인간 TFPI-1 (C-말단에서 10 His-태그에 융합된 잔기 29-282; MW 41 kDa (R&D 시스템즈 (R&D Systems, 미국 미네소타주 미네아폴리스); 카탈로그 번호 2974-PI)), 쥐 TFPI-1 (C-말단에서 10 His-태그에 융합된 잔기 29-289; MW 41 kDa (R&D 시스템즈; 카탈로그 번호 2975-PI)), 및 TFPI-2 (R&D 시스템즈, 미국 미네소타주 미네아폴리스)에 대한 TFPI-결합 펩티드의 결합 속도를 BIAcore 3000™ 표면 플라즈몬 공명 분석 (지이 헬쓰케어 (GE Healthcare, 영국 찰폰트 세인트 자일즈))을 이용하여 연구하였다. TFPI 단백질을 500 RU를 목표로 하는 아민 커플링 (coupling) 화학에 의해 C1 칩 (지이 헬쓰케어, Order Code: BR-1005-40) 상에 고정시켰다. 몇몇 TFPI-결합 펩티드를 고정된 TFPI 단백질과 상호작용하기 위한 분석물로서 사용하였다. 30 ㎕/min의 유속을 이용하였다. 180초 후에, 180 ㎕의 펩티드 용액을 3.84 nM 내지 656.25 nM 범위의 6개의 상이한 농도로 주입한 후, 480초의 해리 시간을 허용하였다. 45 ㎕ 10 mM NaOH를 사용하여 칩을 재생하였다. 각각의 결합 실험 전후에 HBS-P 버퍼 (10 mM HEPES, pH 7.4, 150 mM NaCl, 0.005% P20) + 1% DMSO 및 0.8% P80를 사용하여 4개의 측정치를 취하였다. BIAevaluation® Version 4.1 소프트웨어 (지이 헬쓰케어)를 이용하여 데이타를 분석하였다. 센소그램을 1:1 랭뮈어 (Langmuir) 결합 곡선에 피팅하여, kon 및 koff를 결정하고 KD를 계산하였다.
블랭크 (blank) 셀에 결합된 몇몇 시험된 펩티드, 예를 들어, JBT0050, JBT0121, JBT0205 및 JBT0211, 및 그의 센소그램으로부터의 결합 상수는 결정될 수 없었다. JBT0133은 TFPI-1에 대해 약한 결합을 보였다. 다른 펩티드로부터의 센소그램은 신뢰할 만한 결합 상수를 제공한다. 몇몇 TFPI-억제 펩티드의 BIAcore 분석의 결과를 표 6 및 도 19-21에 제공한다. 표 6에 나열된 각각의 펩티드는 10 μM 미만의 KD를 제시하였다. 펩티드 중 2개의 펩티드의 센소그램을 도 9a 및 9b로서 제공한다.
Figure pat00011
TFPI-2 항-표적과의 상호작용을 또한 검사하였다. 인간 TFPI-2와 후보 펩티드 상호작용으로부터 생성된 최대 신호는 상호작용 파트너로서 TFPI-1을 사용하여 얻은 신호보다 훨씬 더 낮았다. 낮은 TFPI-2 결합 신호에 대한 속도 분석은 오차 경향이 있었고; 따라서, 센소그램의 시각적 비교를 이용하여 결합 친화도를 추정하였다. TFPI-1 및 TFPI-2에 대한 JBT0120 결합을 설명하는 센소그램을 도 10a 및 10b로서 제공한다. JBT0120은 TFPI-1에 대한 그의 결합 친화도에 비해 10배 더 낮은 친화도로 TFPI-2에 결합한다. 또한, JBT0132는 TFPI-2보다 TFPI-1에 대해 적어도 10배 더 큰 친화도를 보이는 것으로 밝혀졌다.
본 실시예에 제공된 데이타는 TFPI-억제 펩티드가 TFPI-1에 특이적으로 결합함을 확인한다.
실시예 3
다음 실시예는 FXa 억제 및 외인성 테나제 억제 분석을 이용하여 실시예 1에서 확인된 선택된 펩티드의 TFPI-억제 활성의 특성 결정을 설명한다. 두 분석은 모두 혈장 시스템에서 활성을 예측한다. 외인성 테나제 분석은 (a) FXa 및 TFPI의 상호작용 및 (b) FXa-TFPI 복합체와 TF-FVIIa 복합체의 상호작용에 대한 펩티드의 영향에 대한 통찰을 제공한다. FXa 억제 분석은 FXa 및 TFPI의 상호작용에 대한 펩티드의 영향만을 측정한다.
외인성 테나제 복합체는 응고 과정의 개시 시에 FX 및 FIX 활성화를 담당한다. 외인성 복합체는 FVIIa, 조직 인자 (TF), 및 FX 기질로 이루어진다. 외인성 테나제 복합체의 TFPI-매개된 억제에 대한 펩티드의 영향을 결정하기 위해, 커플링된 효소 분석을 확립하였다. 펩티드를 10 mM 원액으로부터 (DMSO 중에) 1/6.25로 희석하고, 원치 않는 침전을 방지하기 위해 DMSO 중에 연속 1/4 희석에 의해 추가로 희석하였다. TFPI를 HNaCa-HSA (25mM HEPES; 175mM NaCl; 5mM CaCl2; 0.1% HSA; pH 7.35) 중에 희석하였다. FVIIa, 지질화 TF, 인지질 소포 (vesicle) (DOPC/POPS 80/20), 및 FXa에 특이적인 발색 기질 (S-2222 (다이아팜 (DiaPharma, 미국 오하이오주 웨스트체스터)로부터 입수가능함) (모두 HNaCa-HSA 중에 희석시킴)을 96-웰 플레이트에 첨가하였다. 인큐베이션 기간 후에, TFPI 및 펩티드 희석액을 첨가하여, 2.5% DMSO의 최종 농도로 하였다. FX를 웰에 첨가함으로써 FX 활성화를 개시시켰다. FXa-매개된 발색 기질 전환은 미세-플레이트 판독기를 이용하여 흡광도의 증가를 관찰함으로써 결정하였다. 특정 시점에 생성된 FXa의 양은 OD 판독치로부터 계산하였다. 반응 개시의 20분 후에 생성된 FXa를 펩티드 농도 대 TFPI의 억제 (%)의 플롯으로부터 EC50의 계산을 위해 고려하였다.
또한, TFPI의 기능적 억제를 FXa 억제 분석을 사용하여 조사하였다. FXa-특이적 발색 기질 (S-2222) 및 TFPI (둘 모두 HNaCa-HSA 중에 희석시킴)을 96 웰 플레이트에 첨가하였다. 펩티드를 10 mM 원액으로부터 (DMSO 중에) 1/6.25로 희석하고, 원치 않는 침전을 방지하기 위해 DMSO 중에 연속 1/4 희석에 의해 추가로 희석하였다. 펩티드 희석액 (2.5 ㎕)을 96 웰 플레이트에 첨가하여, 2.5% DMSO의 최종 농도로 하였다. 발색 기질의 전환은 FXa의 첨가에 의해 촉발시키고, 전환의 운동학은 미세-플레이트 판독기에서 측정하였다. TFPI는 FXa를 느리게 억제하므로, 115분 후의 OD 판독치를 펩티드 농도 대 TFPI의 억제 (%)의 플롯으로부터 EC50의 계산을 위해 고려하였다.
외인성 테나제 분석 및 FXa 억제 분석의 결과를 표 7 및 도 22-27에 제공한다.
FXa 억제 분석 외인성 테나제 분석
EC50 [μM] 2.5 μM에서 억제 % EC50 [μM] 2.5 μM에서 억제 %
JBT0120 0.9 45 0.9 45
JBT0132 1.2 36 0.1 10
JBT0224 n.a. 26 3.5 18
JBT0303 1.2 61 n.a. 8
표 7을 살펴보면, JBT0120, JBT0132, 및 JBT0224는 TFPI-1의 존재 하에 외인성 복합체-매개된 FX 활성화를 <2μM의 EC50으로 회복시켜, TFPI 활성을 약 20% 내지 약 60% 억제하였다. JBT0047 (EC50=1.4 μM), JBT0131 (EC50=2.2 μM), 및 JBT0293 (EC50=2.9 μM)도 또한 TFPI-1의 존재 하에 외인성 복합체 활성을 회복시켰다. 또한, JBT0120, JBT0132, JBT0224 및 JBT0303은 TFPI-1의 존재 하에 FXa 활성을 < 5 μM의 EC50으로 회복시켜, FXa 억제 분석에서 TFPI 활성을 약 5% 내지 약 50% 억제하였다. JBT0047 (EC50=0.7 μM), JBT0131 (EC50=8.2 μM), JBT0293 (EC50=1.3 μM), JBT0297 (EC50=0.6 μM), 및 JBT0305 (EC50=2.3 μM)도 또한 FXa 억제 분석에서 TFPI-1의 존재 하에 FXa의 활성을 회복시켰다. 본 실시예는 본 발명의 펩티드가 TFPI 길항제임을 확인한다.
실시예 4
본 실시예에서, 펩티드의 TFPI 억제 활성을 혈장-기반 분석을 이용하여 확립한다.
트롬빈 생성에 대한 펩티드의 영향을 Fluoroskan Ascent® 판독기 (써모 랩시스템즈 (Thermo Labsystems, 핀란드 헬싱키); 390 nm 여기 및 460 nm 방출의 필터)에서 교정된 자동화 트롬보그래피에 이어, 트롬빈-특이적 형광 기질 Z-Gly-Gly-Arg-AMC의 느린 절단 (Hemker, Pathophysiol. Haemost. Thromb., 33, 4-15 (2003))을 통해 이중으로 측정하였다. FVIII 또는 FIX 결핍이 있는 환자의 혈장 (조지 킹 바이오-메디칼 인크. (George King Bio-Medical Inc., 미국 캔사스주 오버랜드 파크))을 시험을 위해 입수하였다. 각각의 혈장에 대한 잔류 응고 인자 활성은 1% 미만이었다. 항체-매개된 FVIII 결핍에 대한 모델로서, 함께 모은 동결된 정상 혈장 (조지 킹 바이오-메디칼 인크., 미국 캔사스주 오버랜드 파크)을 염소에서 생성시킨 고역가의 열 불활성화된 항-인간 FVIII 혈장 (4490 BU/ml; 박스터 바이오사이언스, 오스트리아 비엔나)과 함께 50 BU/mL로 인큐베이팅하였다. 혈장을 인자 XIIa 오염을 억제하기 위해 옥수수 트립신 억제제 (CTI) (헤마톨로직 테크놀로지스, 인크. (Hematologic Technologies, Inc., 미국 버몬트주 에섹스 정션))와 혼합하여 40 ㎍/mL의 최종 농도로 하였다.
미리 가온한 (37℃) 혈장 (80 ㎕)을 96 웰 미세-플레이트 (이뮬론 (Immulon) 2HB, 투명한 U자형 바닥; 써모 일렉트론 (Thermo Electron, 미국 매사추세츠주 월탬))의 각각의 웰에 첨가하였다. 조직 인자에 의한 트롬빈 생성을 촉발하기 위해, 소량 (12 pM)의 재조합 인간 조직 인자, 및 포스파티딜세린, 포스파티딜콜린 및 포스파티딜에탄올아민으로 구성된 인지질 소포 (48 μM) (트롬비노 스코프 비브이, 네덜란드 마스트리흐트)를 함유하는 10 ㎕의 PPP 로우 (low) 시약을 첨가하였다. 펩티드를 10 mM 원액으로부터 DMSO로 1/7.5로 희석하고, Aqua-Dest로 1/8.33로 추가로 희석하여 12%의 DMSO 농도로 하여, 최종 분석 혼합물 내에 0.5% DMSO 농도를 제공하였다. 플레이트를 미리 가온한 (37℃) 판독기에 넣기 전에, 5 mg/mL 인간 혈청 알부민 (시그마-알드리치 코퍼레이션 (Sigma-Aldrich Corporation, 미국 미주리주 세인트루이스))을 함유하는 5 ㎕의 HEPES 완충 염수 또는 Aqua-Dest 중의 12% DMSO를 첨가한 후, 펩티드 희석액 또는 참조 단백질 (FVIII 이뮤네이트 참조 표준품 (박스터 바이오사이언스, 오스트리아 비엔나); 인자 VIII 억제제 우회 활성 (FEIBA) 참조 표준품 (박스터 바이오사이언스, 오스트리아 비엔나); 노보세븐 (노보 노디스크, 덴마크); 및 정제된 인간 혈장 FIX (엔자임 리서치 래보러토리즈 (Enzyme Research Laboratories, 미국 일리노이주 사우쓰 벤드))을 첨가하였다. 트롬빈 생성은 각각의 웰 내로 형광 기질 및 HEPES-완충 CaCl2 (100 mM)를 함유하는 20 ㎕의 FluCa 시약 (트롬비노 스코프 비브이, 네덜란드 마스트리흐트)을 분배함으로써 개시시켰다. 형광 강도를 37℃에서 기록하였다.
생성되는 트롬빈 생성 곡선의 파라미터는 트롬비노스코프™ 소프트웨어 (트롬비노스코프 비브이, 네덜란드 마스트리흐트) 및 내부 필터 및 기질 소모 효과에 대해 교정하기 위해 트롬빈 계산기를 이용하여 계산하였다 (Hemker, Pathophysiol. Haemost. Thromb., 33, 4-15 (2003)). 참조 단백질 (예를 들어, FVIII 이뮤네이트® 참조 표준품, FEIBA 참조 표준품)에 동등한 특정 펩티드 농도의 트롬빈 생성 활성을 계산하기 위해, 각각의 트롬빈 생성 곡선의 피크에서 트롬빈 양 (피크 트롬빈, nM)을 표준 농도에 대해 플로팅하고, 비-선형 알고리즘에 의해 피팅하였다. 상기 교정에 기초하여, FVIII 이뮤네이트, FIX, FEIBA 또는 노보세븐 등가 활성을 계산하였다. 다양한 펩티드에 대한 결과를 도 12-18 및 28-30에 제공한다. 대표적인 결과를 표 8에 제시한다 (*는 FVIII 결여 혈장을 상이한 공여자로부터 입수하였음을 나타낸다).
10 μM 펩티드에서 FVIII 결여 혈장 내의 % FVIII-등가 활성 10 μM 펩티드에서 FVIII 억제된 혈장 내의 FEIBA-등가 활성 [mU/ml]
JBT0120 37.4* 298
JBT0132 5.3 41
JBT0224 16.2 191
JBT0303 20.8 253
표 8을 살펴보면, JBT0120, JBT0132, JBT0224, 및 JBT0303은 FVIII-결핍 혈장 내에서 TFPI-의존 트롬빈 생성을, FVIII를 함유하는 혈장 내에서 트롬빈 생성의 수준 (% FVIII-등가 활성)의 1%를 초과하는 수준으로 개선시켰다. 시험된 펩티드는 FVIII-결여 혈장 내에서 약 5%-40% FVIII-등가 활성을 보였다. JBT0120 및 JBT0132는 도 11a 및 11b에 도시된 바와 같이 피크 트롬빈 및 피크 시간을 용량 의존적으로 개선시켰다.
실시예 5
다음 실시예는 본 발명의 펩티드가 펩티드의 물리화학적 또는 약동학 특성을 향상시키는 모이어티의 첨가에 의해 변형될 수 있음을 입증한다. 아래에 예시된 바와 같이, 본원에 기재된 펩티드에 대한 40 kDa PEG의 첨가는 펩티드의 약동학 거동을 극적으로 개선하였다.
화학적 또는 생물학적 모이어티를 펩티드에 접합시키는 방법은 당업계에 공지되어 있다. PEG (폴리에틸렌 글리콜)를 본원에서 설명되는 펩티드에 부가하기 위해서, 관능기 (AOA = 아미노옥시 아세테이트)를 알데히드 및 케톤에 커플링시키기 위해 펩티드의 N-말단에 첨가하였다. 별법으로, 시스테인을 말레이미드와 커플링시키기 위해 펩티드의 C-말단 부분에 첨가하였다 (Hermanson, Bioconjugate Techniques, Academic Press (1996)). 펩티드 (JBT1586) AOA-FQSKGNVFVDGYFERL-Aib-AKL-NH2 (서열 166) 및 (JBT1587) Ac-FQSKGNVFVDGYFERL-Aib-AKLC-NH2 (서열 167)을 각각 PEG를 사용한 N-말단 및 C-말단 변형을 위해 사용하였다. AOA-FQSKGNVFVDGYFERL-Aib-AKL-NH2 (서열 166) 및 Ac-FQSKGNVFVDGYFERL-Aib-AKLC-NH2 (서열 167)을 각각 과량의 40 kDa mPEG-프로피온알데히드 (SUNBRIGHT ME-400AL2, NOF, 일본) 및 40 kDa mPEG-말레이미드 (SUNBRIGHT ME-400MA, NOF, 일본)와 함께 인큐베이팅하였다. 생성되는 PEG화된 펩티드 JBT1853 및 JBT1855는 출발 구조 Ac-FQSKGNVFVDGYFERL-Aib-AKL-NH2 (JBT0740) (서열 66)에 비해 유사한 친화도를 보인다.
생성되는 PEG화된 펩티드는 마우스에서 유의하게 증가된 혈장 안정성 및 지속된 혈장 반감기를 나타냈다. 도 31은 C-말단에서 PEG화된 펩티드 JBT1855 (Ac-FQSKGNVFVDGYFERL-Aib-AKLC(PEG(40kD))-NH2) (서열 252)에 비해 유리 펩티드 JBT0740 (Ac-FQSKGNVFVDGYFERL-Aib-AKL-NH2) (서열 66)의 약동학 분석의 결과를 예시한다. 비PEG화된 펩티드와 달리, PEG화 펩티드는 투여의 100분 후에 마우스 혈장 내에 고농도로 존재한다. 비PEG화된 펩티드는 혈장으로부터 급속하게 청소된다.
SEQUENCE LISTING <110> Dockal, et al. <120> TFPI INHIBITORS AND METHODS OF USE <130> 31315/44241A <150> 61/139,272 <151> 2008-12-19 <160> 3145 <170> PatentIn version 3.5 <210> 1 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <400> 1 Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu Arg 1 5 10 15 Ala Lys <210> 2 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is selected from the group consisting of Val, Trp, Tyr, and Phe <220> <221> MOD_RES <222> (2)..(2) <223> Xaa is selected from the group consisting of Asp, Gln, and Ser <220> <221> MOD_RES <222> (3)..(3) <223> Xaa is selected from the group consisting of Glu, Thr, Ans, and Ser <220> <221> MOD_RES <222> (5)..(5) <223> Xaa is selected from the group consisting of Leu, Pro, Lys, Ser, Trp, Val, Asn and Gln <220> <221> MOD_RES <222> (9)..(9) <223> Xaa is selected from the group consisting of Leu, Trp, Val, Ala, Met, Thr, and Ser <220> <221> MOD_RES <222> (10)..(10) <223> Xaa is selected from the group consisting of Thr, Phe, Val, Arg, Ala, Asp, Leu, Glu, Ser, and Tyr <220> <221> MOD_RES <222> (13)..(13) <223> Xaa is selected from the group consisting of Asn, Pro, Phe, His, Lys, and Tyr <220> <221> MOD_RES <222> (14)..(14) <223> Xaa is selected from the group consisting of Met, Asp, Glu, Val, Gly, and Lys <220> <221> MOD_RES <222> (20)..(20) <223> Xaa is selected from the group consisting of Gln, Ile, Gle, Trp, Arg, Leu, and Asn <400> 2 Xaa Xaa Xaa Lys Xaa Asn Val Phe Xaa Xaa Gly Tyr Xaa Xaa Arg Leu 1 5 10 15 Arg Ala Lys Xaa 20 <210> 3 <211> 25 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <400> 3 Thr Phe Val Asp Glu Arg Leu Leu Tyr Phe Leu Thr Ile Gly Asn Met 1 5 10 15 Gly Met Tyr Ala Ala Gln Leu Lys Phe 20 25 <210> 4 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <400> 4 Val Ile Val Phe Thr Phe Arg His Asn Lys Leu Ile Gly Tyr Glu Arg 1 5 10 15 Arg Tyr <210> 5 <211> 27 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <400> 5 Gly Val Trp Gln Thr His Pro Arg Tyr Phe Trp Thr Met Trp Pro Asp 1 5 10 15 Ile Lys Gly Glu Val Ile Val Leu Phe Gly Thr 20 25 <210> 6 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <400> 6 Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met Ser Cys Val 1 5 10 15 Trp Val Lys Phe 20 <210> 7 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <400> 7 Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys Arg Ser Lys 1 5 10 15 Glu Met Ala <210> 8 <211> 35 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (35)..(35) <223> C-terminal amidation <400> 8 Lys Lys Ser Gly Val Gly Arg Leu Gln Val Ala Phe Gln Ser Lys Lys 1 5 10 15 Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu Arg Ala Lys Leu Thr 20 25 30 Ser Lys Lys 35 <210> 9 <211> 32 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (32)..(32) <223> C-terminal amidation <400> 9 Lys Lys Ser Gly Val Gly Arg Leu Gln Val Ala Phe Gln Ser Lys Lys 1 5 10 15 Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu Arg Ala Lys Lys Lys 20 25 30 <210> 10 <211> 32 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (32)..(32) <223> C-terminal amidation <400> 10 Lys Lys Gly Arg Leu Gln Val Ala Phe Gln Ser Lys Lys Asn Val Phe 1 5 10 15 Val Phe Gly Tyr Phe Glu Arg Leu Arg Ala Lys Leu Thr Ser Lys Lys 20 25 30 <210> 11 <211> 29 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (29)..(29) <223> C-terminal amidation <400> 11 Lys Lys Gln Val Ala Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly 1 5 10 15 Tyr Phe Glu Arg Leu Arg Ala Lys Leu Thr Ser Lys Lys 20 25 <210> 12 <211> 26 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (26)..(26) <223> C-terminal amidation <400> 12 Lys Lys Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu 1 5 10 15 Arg Leu Arg Ala Lys Leu Thr Ser Lys Lys 20 25 <210> 13 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 13 Lys Lys Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu 1 5 10 15 Arg Leu Arg Ala Lys Leu Lys Lys 20 <210> 14 <211> 25 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (25)..(25) <223> C-terminal amidation <400> 14 Lys Lys Ala Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe 1 5 10 15 Glu Arg Leu Arg Ala Lys Leu Lys Lys 20 25 <210> 15 <211> 36 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (2)..(2) <223> Xaa is Carboxyfluorescein <220> <221> MOD_RES <222> (36)..(36) <223> C-terminal amidation <400> 15 Lys Xaa Lys Ser Gly Val Gly Arg Leu Gln Val Ala Phe Gln Ser Lys 1 5 10 15 Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu Arg Ala Lys Leu 20 25 30 Thr Ser Lys Lys 35 <210> 16 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 16 Phe Gln Ser Lys Asn Asn Val Phe Val Asp Gly Tyr Phe Asp Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 17 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 17 Phe Gln Ser Lys Asn Asn Val Phe Val Gln Gly Tyr Phe Asp Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 18 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 18 Phe Gln Ser Lys Asn Asn Val Phe Val Ser Gly Tyr Phe Asp Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 19 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 19 Phe Gln Ser Lys Asn Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 20 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 20 Phe Gln Ser Lys Asp Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 21 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 21 Phe Gln Ser Lys Lys Asn Val Phe Val Glu Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 22 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 22 Phe Gln Ser Lys Lys Asn Val Phe Val Thr Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 23 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 23 Phe Gln Ser Lys Lys Asn Val Phe Val His Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 24 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 24 Phe Gln Ser Lys Lys Asn Val Phe Val Met Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 25 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 25 Phe Gln Ser Lys Lys Asn Val Phe Val Asn Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 26 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 26 Phe Gln Ser Lys Gly Asn Val Phe Val Thr Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 27 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 27 Phe Gln Ser Lys Gly Asn Val Phe Val Asn Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 28 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 28 Phe Gln Ser Lys Gly Asn Val Phe Val His Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 29 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 29 Phe Gln Ser Lys Gly Asn Val Phe Val Lys Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 30 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 30 Phe Gln Ser Lys Gly Asn Val Phe Val Glu Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 31 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 31 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Asp Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 32 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 32 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 33 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 33 Phe Gln Ser Lys Asp Asn Val Phe Val Thr Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 34 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 34 Phe Gln Ser Lys Asp Asn Val Phe Val Asn Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 35 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 35 Phe Gln Ser Lys Asp Asn Val Phe Val His Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 36 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 36 Phe Gln Ser Lys Asp Asn Val Phe Val Lys Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 37 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 37 Phe Gln Ser Lys Asp Asn Val Phe Val Glu Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 38 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 38 Phe Gln Ser Lys Asp Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 39 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 39 Phe Gln Ser Lys Asn Asn Val Phe Val Thr Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 40 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 40 Phe Gln Ser Lys Asn Asn Val Phe Val Asn Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 41 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 41 Phe Gln Ser Lys Asn Asn Val Phe Val His Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 42 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 42 Phe Gln Ser Lys Asn Asn Val Phe Val Lys Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 43 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 43 Phe Gln Ser Lys Asn Asn Val Phe Val Glu Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 44 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 44 Phe Gln Ser Lys Gln Asn Val Phe Val Thr Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 45 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 45 Phe Gln Ser Lys Gln Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 46 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> N-methyl-Gly <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 46 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 47 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> N-methyl-Gly <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 47 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 48 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 48 Phe Gln Ser Lys Gly Asn Val His Val Lys Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 49 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 49 Phe Gln Ser Lys Gly Asn Val His Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 50 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 50 Phe Gln Ser Pro Gly Asn Val His Val Lys Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 51 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 51 Phe Gln Ser Pro Gly Asn Val His Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 52 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 52 Phe Gln Ser Lys Gly Asn Ile Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 53 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> D-Ala <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 53 Phe Gln Ser Lys Ala Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 54 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> D-Ala <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 54 Phe Gln Ser Lys Ala Asn Val Phe Val Thr Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 55 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> N-methyl-Gly <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 55 Phe Gln Ser Lys Gly Ala Val Phe Val Asp Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 56 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is (S)-Diaminopropionic acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 56 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 57 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (1)..(1) <223> (S)-Ornithine <220> <221> misc_feature <222> (17)..(17) <223> Xaa can be any naturally occurring amino acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 57 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 58 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is (S)-2-Amino-pentanoic acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 58 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 59 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> D-Ala <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 59 Phe Gln Ser Lys Ala Asn Val Phe Val Ala Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 60 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> D-Ala <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 60 Phe Gln Ser Lys Ala Ala Val Phe Val Asp Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 61 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> N-methyl-Gly <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 61 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 62 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> N-methyl-Gly <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 62 Phe Gln Ser Lys Gly Asn Val Phe Val Thr Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 63 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (17)..(17) <223> (S)-Homo-Citrulline <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 63 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 64 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (17)..(17) <223> (S)-Homo-Arg <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 64 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 65 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (17)..(17) <223> (S)-2-Pyridyl-Ala <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 65 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 66 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is 2-Amino-isobutryic acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 66 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 67 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> N-methyl-Gly <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 67 Phe Gln Ser Lys Gly Ala Val Phe Val Thr Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 68 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (17)..(17) <223> (S)-N(omega)-nitro-Arg <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 68 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 69 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 69 Phe Gln Ser Lys Gly Asn Val Phe Val Thr Gly Tyr Phe Asp Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 70 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> N-methyl-Gly <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 70 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 71 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> N-methyl-Gly <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is (S)-Norleucine <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 71 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 72 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 72 Phe Gln Ser Lys Gly Ala Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 73 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 73 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 74 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> N-methyl-Gly <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 74 Phe Gln Ser Lys Gly Asn Val Phe Val Ala Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 75 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 75 Phe Gln Ser Glu Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 76 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 76 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 His Ala Lys Leu 20 <210> 77 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 77 Phe Gln Ser Ile Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 78 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 78 Phe Gln Ser Lys Gly Asn Ile Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 79 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> D-Ala <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 79 Phe Gln Ser Lys Ala Asn Val Phe Val Thr Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 80 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 80 Phe Gln Ser Lys Gly Lys Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 81 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 81 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Lys Ala Lys Leu 20 <210> 82 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (17)..(17) <223> (S)-2-Propargylglycine <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 82 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Gly Ala Lys Leu 20 <210> 83 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 83 Phe Gln Ser Leu Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 84 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 84 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Leu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 85 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is (S)-2,4-Diaminobutyric acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 85 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 86 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 86 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Leu Ala Lys Leu 20 <210> 87 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 87 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Leu Lys Leu 20 <210> 88 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 88 Met Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 89 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 89 Phe Gln Met Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 90 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 90 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Met Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 91 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 91 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Met Lys Leu 20 <210> 92 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (17)..(17) <223> (S)-Cyclohexylalanine <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 92 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 93 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 93 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Asn Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 94 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 94 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Asn Lys Leu 20 <210> 95 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 95 Phe Gln Ser Pro Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 96 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (17)..(17) <223> (S)-2-Amino-5-methyl-hexanoic acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 96 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 97 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 97 Phe Gln Gln Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 98 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 98 Phe Gln Ser Lys Gly Gln Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 99 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 99 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Gln Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 100 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 100 Phe Gln Arg Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 101 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 101 Phe Gln Ser Arg Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 102 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 102 Phe Gln Ser Lys Gly Arg Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 103 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 103 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Arg Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 104 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is Norleucine <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 104 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 105 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 105 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Arg Lys Leu 20 <210> 106 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> D-Ala <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is Norleucine <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 106 Phe Gln Ser Lys Ala Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 107 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 107 Phe Gln Ser Lys Gly Ser Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 108 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 108 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Thr Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 109 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> N-methyl-Gly <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 109 Phe Gln Ser Lys Gly Ala Val Phe Val Ala Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 110 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 110 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Val Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 111 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 111 Tyr Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 112 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 112 Phe Gln Ser Lys Gly Asn Val Tyr Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 113 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is Norleucine <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 113 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Ala Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 114 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Carboxyfluorescein <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 114 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 115 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> D-Lys <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 115 Phe Gln Ser Lys Lys Ala Val Phe Val Asp Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 116 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 116 Phe Gln Ser Lys Gly Ala Val Phe Val Asp Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 117 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> D-Asp <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 117 Phe Gln Ser Lys Asp Ala Val Phe Val Asp Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 118 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> D-Lys <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 118 Phe Gln Ser Lys Lys Ala Val Phe Val Ala Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 119 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> D-Lys <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 119 Phe Gln Ser Lys Asp Ala Val Phe Val Ala Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 120 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> D-Lys <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 120 Phe Gln Ser Lys Lys Ala Val Phe Val Lys Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 121 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> D-Lys <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 121 Phe Gln Ser Lys Asp Ala Val Phe Val Lys Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 122 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> D-Lys <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 122 Phe Gln Ser Lys Lys Ala Val Phe Val Thr Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 123 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> D-Asp <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 123 Phe Gln Ser Lys Asp Ala Val Phe Val Thr Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 124 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Carboxyfluorescein <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 124 Xaa Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg 1 5 10 15 Leu Arg Ala Lys Leu 20 <210> 125 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> N-methyl-Gly <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 125 Phe Gln Ser Lys Gly Asn Val Phe Val Thr Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 126 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> D-Ala <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is Norleucine <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 126 Phe Gln Ser Lys Ala Asn Val Phe Val Asp Gly Tyr Phe Ala Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 127 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> D-Ala <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 127 Phe Gln Ser Lys Ala Asn Val Phe Val Ala Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 128 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> D-Pro <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal N-ethyl <400> 128 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 129 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 129 Phe Gln Ser Lys Pro Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 130 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 130 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu Cys 20 <210> 131 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 131 Phe Gln Ser Lys Gly Asn Val Phe Val Ser Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 132 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 132 Phe Gln Ser Lys Gly Asn Val Phe Val Val Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 133 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 133 Phe Gln Ser Lys His His Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 134 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 134 Phe Gln Ser Arg Arg Gly Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 135 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 135 Phe Gln Cys Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 136 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 136 Phe Gln Ser Lys Gly Cys Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 137 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 137 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Cys Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 138 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 138 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Cys Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 139 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 139 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 140 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 140 Phe Gln Ser Lys Ala Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 141 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 141 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Met Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 142 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 142 Phe Gln Ser Lys Asp Asn Val Phe Val His Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 143 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 143 Tyr Gln Ser Lys Asn Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 144 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 144 Phe Gln Ser Lys Gly His Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 145 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 145 Phe Gln Ser Lys Gln Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 146 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 146 Phe Gln Ser Lys Glu Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 147 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 147 Phe Gln Ser Lys Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 148 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 148 Phe Gln Ser Lys Asp Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 149 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 149 Phe Gln Ser Lys Asn Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 150 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 150 Phe Gln Ser Lys Asp His Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 151 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 151 Phe Gln Ser Lys His Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 152 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 152 Phe Gln Ser Lys His His Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 153 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 153 Phe Gln Ser Lys His Asn Val Tyr Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 154 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 154 Phe Gln Ser Arg Arg Gly Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 155 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 155 Tyr Gln Ser Lys Gln Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 156 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 156 Phe Gln Ser Glu His Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 157 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 157 Phe Gln Ser Lys Asn Asp Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 158 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 158 Phe Gln Ser Lys Arg Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 159 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 159 Phe Gln Ser Pro Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 160 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 160 Phe Gln Ser Gly Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 161 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> N-methyl-Gly <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 161 Phe Gln Ser Lys Gly Asn Val Phe Val Ala Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 162 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (4)..(4) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 162 Phe Gln Ser Xaa Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 163 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 163 Phe Gln Ser Lys Xaa Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 164 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> N-methyl-Gly <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 164 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 165 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> N-methyl-Gly <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 165 Phe Gln Ser Lys Gly Asn Val Phe Val Thr Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 166 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Aminooxy acetate <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 166 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 167 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (14)..(21) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 167 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu Cys 20 <210> 168 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (14)..(21) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is 2-Amino-isobutryic acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 168 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Cys Arg Leu 1 5 10 15 Xaa Ala Lys Leu Cys 20 <210> 169 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 169 Phe Gln Ser Lys Gly Asn Ile Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 His Ala Lys Leu 20 <210> 170 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 170 Phe Gln Ser Lys Asn Asn Val Phe Val Asp Gly Tyr Phe Lys Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 171 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 171 Tyr Gln Thr Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 172 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 172 Phe Gln Thr Lys Asp Asn Val His Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 173 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 173 Leu Gln Gln Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 174 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal pegylation <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 174 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 175 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal pegylation <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 175 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 176 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (21)..(21) <223> PEGYLATION <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 176 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu Cys 20 <210> 177 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> D-Pro <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 177 Phe Gln Ser Lys Pro Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 178 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> D-Pro <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 178 Phe Gln Ser Lys Pro Asn Val His Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 179 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 179 Pro Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg 1 5 10 15 Leu Arg Ala Lys Leu 20 <210> 180 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 180 Pro Glu Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu 1 5 10 15 Arg Leu Arg Ala Lys Leu 20 <210> 181 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (6)..(6) <223> (S)-N-methyl-Glu <220> <221> MOD_RES <222> (18)..(18) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 181 Pro Phe Gln Ser Lys Glu Asn Val Phe Val Asp Gly Tyr Phe Glu Arg 1 5 10 15 Leu Xaa Ala Lys Leu 20 <210> 182 <211> 26 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (26)..(26) <223> C-terminal amidation <400> 182 Lys Lys Ala Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe 1 5 10 15 Glu Arg Leu Arg Ala Lys Leu Thr Lys Lys 20 25 <210> 183 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 183 Phe Gln Ser Lys Asn Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 184 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 184 Phe Gln Ser Lys Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 185 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 185 Phe Gln Ser Lys Lys Asn Val Phe Val Ser Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 186 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 186 Phe Gln Ser Lys Asn Asn Val Phe Val Tyr Gly Tyr Phe Asp Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 187 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 187 Phe Gln Ser Lys Asn Asn Val Phe Val Phe Gly Tyr Phe Asp Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 188 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 188 Phe Gln Ser Lys Lys Asn Val Phe Val Asp Gly Tyr Phe Asp Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 189 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Carboxyfluorescein <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 189 Ala Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg 1 5 10 15 Leu Arg Ala Lys 20 <210> 190 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 190 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 191 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 191 Phe Gln Ser Lys Lys Asn Val Phe Val Val Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 192 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 192 Phe Gln Ser Lys Lys Asn Val His Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 193 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 193 Phe Gln Ser Lys Lys Asn Val Phe Val Lys Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 194 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 194 Phe Gln Ser Lys Lys Asn Val Phe Val Pro Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 195 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 195 Phe Gln Ser Lys Lys Asn Val Phe Val Arg Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 196 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 196 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Glu Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 197 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 197 Phe Gln Ser Lys Gln Asn Val Phe Val Asn Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 198 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 198 Phe Gln Ser Lys Gln Asn Val Phe Val His Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 199 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 199 Phe Gln Ser Lys Gln Asn Val Phe Val Lys Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 200 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 200 Phe Gln Ser Lys Gln Asn Val Phe Val Glu Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 201 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (1)..(1) <223> (S)-N-methyl-phenylalanine <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 201 Ala Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 202 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (4)..(4) <223> (S)-N-methyl-lysine <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 202 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 203 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (17)..(17) <223> beta-Homoarginine <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 203 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 204 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> beta-Homoleucine <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 204 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 205 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 205 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Lys Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 206 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> N-methyl-Gly <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 206 Phe Gln Ser Lys Gly Ala Val Phe Val Phe Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 207 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> D-Lys <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 207 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 208 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 208 Phe Gln Ser Lys Gly Asn Val Phe Val Asn Gly Tyr Phe Asp Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 209 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 209 Phe Gln Ser Lys Gly Asn Val Phe Val Lys Gly Tyr Phe Asp Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 210 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 210 Phe Gln Ser Lys Gly Asn Val Phe Val Glu Gly Tyr Phe Asp Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 211 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 211 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Lys Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 212 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 212 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 213 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> N-methyl-Gly <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is Norleucine <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 213 Phe Gln Ser Lys Gly Asn Val Phe Val Thr Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 214 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> D-Ala <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 214 Phe Gln Ser Lys Ala Ala Val Phe Val Thr Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 215 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> D-Ala <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 215 Phe Gln Ser Lys Ala Asn Val Phe Val Asp Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 216 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 216 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ile Ala Lys Leu 20 <210> 217 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> D-Ala <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 217 Phe Gln Ser Lys Ala Asn Val Phe Val Phe Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 218 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> N-methyl-Gly <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is Norleucine <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 218 Phe Gln Ser Lys Gly Ala Val Phe Val Ala Gly Tyr Phe Ala Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 219 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 219 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Val Ala Lys Leu 20 <210> 220 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 220 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Trp Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 221 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 221 Phe Gln Ser Lys Asp Ala Val Phe Val Asp Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 222 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 222 Phe Gln Ser Lys Gly Ala Val Phe Val Ala Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 223 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 223 Phe Gln Ser Lys Asp Ala Val Phe Val Ala Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 224 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 224 Phe Gln Ser Lys Gly Ala Val Phe Val Lys Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 225 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 225 Phe Gln Ser Lys Asp Ala Val Phe Val Lys Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 226 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 226 Phe Gln Ser Lys Gly Ala Val Phe Val Thr Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 227 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 227 Phe Gln Ser Lys Asp Ala Val Phe Val Thr Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 228 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal N-methyl <400> 228 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 229 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 229 Phe Gln Ser Lys Phe Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 230 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 230 Phe Gln Ser Lys Gly Asn Val Phe Val Ala Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 231 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 231 Phe Gln Ser Lys Gly Asn Val Phe Val Met Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 232 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 232 Phe Gln Ser Lys Gly Asn Val Phe Val Pro Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 233 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 233 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Met Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 234 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 234 Tyr Gln Ser Lys Asn Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 235 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 235 Phe Gln Ser Lys Gly His Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 236 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 236 Phe Gln Ser Lys Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 237 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 237 Phe Gln Thr Lys His Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 238 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 238 Phe Gln Ser Lys Tyr Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 239 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 239 Phe Gln Ser Lys Asn Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 240 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 240 Phe Gln Ser Lys Asp His Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 241 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 241 Phe Gln Ser Lys His Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Arg Lys Leu 20 <210> 242 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 242 Phe Gln Ser Lys His Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 243 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 243 Phe Gln Ser Lys Leu Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 244 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 244 Phe Gln Ser Val Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ser Ala Lys Leu 20 <210> 245 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 245 Phe Gln Ser Tyr Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 246 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 246 Phe Gln Ser Gly Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 247 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (13)..(13) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 247 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Xaa Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 248 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (14)..(14) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 248 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Xaa Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 249 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 249 Phe Gln Ser Tyr Lys His Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 250 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 250 Phe Gln Ser Lys Gly Ile Val Phe Val Asp Gly Tyr Phe Lys Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 251 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 251 Phe Gln Ser Tyr Lys Arg Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 252 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (21)..(21) <223> PEGYLATION <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 252 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu Cys 20 <210> 253 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 253 Ser Gly Val Gly Arg Leu Gln Val Ala Phe Gln Ser Lys Lys Asn Val 1 5 10 15 Phe Val Phe Gly Tyr Phe Glu Arg Leu Arg Ala Lys Leu Thr Ser 20 25 30 <210> 254 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 254 Lys Lys Ala Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe 1 5 10 15 Glu Arg Leu Arg Ala Lys Lys Lys 20 <210> 255 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 255 Lys Lys Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg 1 5 10 15 Leu Arg Ala Lys Leu Thr Lys Lys 20 <210> 256 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 256 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 257 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 257 Tyr Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 258 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 258 Phe Gln Ser Lys Lys Asn Val Phe Val Ala Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 259 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 259 Phe Gln Ser Lys Lys Asn Val Phe Val Leu Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 260 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 260 Phe Gln Ser Lys Lys Asn Val Phe Val Gln Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 261 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 261 Phe Gln Ser Lys Lys Asn Val Phe Val Tyr Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 262 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 262 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Asp Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 263 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <400> 263 Phe Gln Ser Lys Asn Asn Val Phe Val Ala Gly Tyr Phe Asp Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 264 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 264 Phe Gln Ser Lys Lys Asn Gln Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 265 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 265 Phe Gln Ser Pro Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 266 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 266 Phe Gln Ser Lys Lys Asn Val Phe Val Gly Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 267 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 267 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Leu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 268 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is 13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 268 Xaa Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg 1 5 10 15 Leu Arg Ala Lys Leu 20 <210> 269 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (11)..(11) <223> N-methyl-Gly <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 269 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 270 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> beta-Ala <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 270 Phe Gln Ser Lys Ala Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 271 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (6)..(6) <223> beta-Homoasparagin <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 271 Phe Gln Ser Lys Gly Asp Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 272 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (14)..(14) <223> beta-Homoaspartic acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 272 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Asp Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 273 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is (S)-Citrullin <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 273 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 274 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 274 Phe Gln Ser Gly Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 275 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 275 Phe Gln Ser Lys Lys Gly Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 276 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 276 Phe Gln Lys Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 277 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 277 Phe Gln Ser Lys Lys Lys Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 278 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 278 Phe Gln Ser Lys Lys Asn Lys Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 279 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 279 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Lys Ala Lys Leu 20 <210> 280 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 280 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Lys Lys Leu 20 <210> 281 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 281 Phe Gln Asp Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 282 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 282 Phe Gln Ser Lys Lys Asp Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 283 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <400> 283 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 284 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 284 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 285 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <400> 285 Gly Ser Phe Gln Ser Lys Lys Asn Val Phe Val Asp Gly Tyr Phe Glu 1 5 10 15 Arg Leu Arg Ala Lys Leu 20 <210> 286 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 286 Phe Gln Ser Lys Gly Asn Leu Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 287 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 287 Phe Gln Ser Lys Gly Asn Val Phe Ile Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 288 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 288 Phe Gln Ser Lys Lys Ala Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 289 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 289 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 290 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (4)..(4) <223> D-Lys <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 290 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 291 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (9)..(9) <223> D-Phe <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 291 Phe Gln Ser Lys Lys Asn Val Phe Phe Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 292 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 292 Phe Gln Ser Lys Gly Asn Val Phe Val His Gly Tyr Phe Asp Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 293 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (17)..(17) <223> omega-methyl-Arg <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 293 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 294 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 294 Phe Gln Ala Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 295 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 295 Phe Gln Ser Ala Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 296 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 296 Phe Gln Ser Asp Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 297 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 297 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Asp Lys Leu 20 <210> 298 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 298 Phe Gln Glu Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 299 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 299 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Glu Lys Leu 20 <210> 300 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> D-Ala <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 300 Phe Gln Ser Lys Ala Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 301 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 301 Phe Gln Ser Phe Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 302 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> D-Ala <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 302 Phe Gln Ser Lys Ala Ala Val Phe Val Ala Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 303 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 303 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Phe Ala Lys Leu 20 <210> 304 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 304 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Phe Lys Leu 20 <210> 305 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 305 Phe Gln Ser Lys Ala Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 306 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 306 Phe Gln His Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 307 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 307 Phe Gln Ser His Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 308 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 308 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe His Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 309 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 309 Ile Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 310 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 310 Phe Gln Ile Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 311 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 311 Phe Gln Ser Lys Gly Ile Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 312 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 312 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Ile Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 313 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 313 Phe Gln Ser Lys Gly Leu Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 314 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 314 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Leu Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 315 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 315 Phe Gln Asn Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 316 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 316 Phe Gln Ser Asn Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 317 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 317 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Asn Ala Lys Leu 20 <210> 318 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 318 Phe Gln Ser Gln Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 319 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 319 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Gln Lys Leu 20 <210> 320 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 320 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Arg Leu 20 <210> 321 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 321 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Arg 20 <210> 322 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <400> 322 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Ser Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 323 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <400> 323 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Thr Ala Lys Leu 20 <210> 324 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <400> 324 Val Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 325 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 325 Phe Gln Val Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 326 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 326 Phe Gln Ser Val Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 327 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 327 Phe Gln Ser Lys Gly Val Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 328 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 328 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Val Lys Leu 20 <210> 329 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 329 Trp Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 330 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 330 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Trp Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 331 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 331 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Trp Lys Leu 20 <210> 332 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 332 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Trp 20 <210> 333 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 333 Phe Gln Ser Lys Gly Tyr Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 334 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 334 Phe Gln Ser Lys Gly Asn Tyr Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 335 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 335 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Tyr Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 336 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 336 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Tyr Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 337 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 337 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Tyr Ala Lys Leu 20 <210> 338 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 338 Phe Gln Ser Lys Xaa Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 339 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 339 Phe Gln Ser Lys Ala Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 340 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 340 Phe Gln Ser Lys His Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 341 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 341 Phe Gln Ser Lys Leu Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 342 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 342 Phe Gln Ser Lys Arg Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 343 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 343 Phe Gln Ser Lys Tyr Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 344 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 344 Phe Gln Ser Lys Gly Asn Val Phe Val Gly Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 345 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 345 Phe Gln Ser Lys Gly Asn Val Phe Val Trp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 346 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 346 Phe Gln Ser Lys Gly Asn Val Phe Val Tyr Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 347 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 347 Phe Gln Ser Lys Ala Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 348 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 348 Phe Gln Ser Arg Glu Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 349 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 349 Phe Gln Ser Lys Asp Asn Val Phe Val His Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 350 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 350 Phe Gln Ser Lys Glu Arg Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 351 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 351 Phe Gln Ser Lys Gln Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ile Lys Leu 20 <210> 352 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 352 Phe Gln Ser Lys Tyr Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Val Lys Leu 20 <210> 353 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 353 Phe Gln Ser Arg Asn Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 354 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 354 Phe Gln Ser Arg Gln Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 355 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 355 Phe Gln Ser Lys Gln Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 356 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 356 Phe Gln Ser Ser Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 357 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 357 Phe Gln Ser Lys Glu Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 358 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 358 Phe Gln Ser Lys Asp Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 359 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 359 Phe Gln Ser Lys Asp Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Arg Leu 20 <210> 360 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 360 Phe Gln Ser Lys His Asn Val Tyr Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 361 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 361 Phe Gln Ser Lys Tyr Asn Ile Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 362 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 362 Phe Gln Ser Lys Asn Asp Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 363 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 363 Phe Gln Ser Gly Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 364 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 364 Phe Gln Ser Pro Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 365 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 365 Phe Gln Ser Pro Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 366 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 366 Phe Gln Ser Arg Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 367 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 367 Phe Gln Ser Lys Lys Arg Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 368 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 368 Phe Gln Ser Ile Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 369 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 369 Cys Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 370 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 370 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Cys Lys Leu 20 <210> 371 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 371 Phe Gln Ser Lys Phe Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 372 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 372 Phe Gln Ser Lys Tyr Asn Val Phe Val Asp Gly Tyr His Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 373 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 373 Phe Gln Ser Ser His Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 374 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 374 Phe Gln Ser Arg Glu Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 375 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 375 Phe Gln Ser Cys Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 376 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 376 Phe Gln Asp Pro Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 377 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 377 Phe Gln Ser Lys Thr Asn Ile Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 378 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 378 Phe Gln Ser His Tyr Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 379 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 379 Phe Gln Ser Arg Gln Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 380 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 380 Phe Gln Ser Ser Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 381 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 381 Phe Gln Ser His His Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 382 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 382 Phe Gln Thr Lys His Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 383 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 383 Phe Gln Ser Lys Ala Asn Val His Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 384 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 384 Phe Gln Ser Lys His Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Arg Lys Leu 20 <210> 385 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 385 Phe Gln Ser Lys Ser Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 386 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 386 Phe Gln Ser His Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 387 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 387 Phe Gln Ser Lys Asp Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Phe 20 <210> 388 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 388 Phe Gln Ser Lys Met Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 389 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 389 Phe Gln Ser Ala Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 390 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 390 Phe Gln Ser Lys His Val Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 391 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 391 Phe Gln Ser Lys Asp Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Arg Leu 20 <210> 392 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 392 Phe Gln Ser Lys Lys His Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 393 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 393 Phe Gln Ser Asn Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 394 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 394 Phe Gln Ser Glu Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 395 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 395 Phe Gln Ser Lys Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Phe Lys Leu 20 <210> 396 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 396 Phe Gln Ser Lys Gln Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ser Ala Lys Leu 20 <210> 397 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 397 Phe Gln Ser Lys Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ser Ala Lys Leu 20 <210> 398 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 398 Phe Gln Ser Lys Asp Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ser Ala Lys Leu 20 <210> 399 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 399 Phe Gln Ser Lys His Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ser Ala Lys Leu 20 <210> 400 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (20)..(20) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 400 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Xaa 20 <210> 401 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (10)..(21) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 401 Phe Gln Ser Lys Gly Asn Val Phe Val Cys Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu Cys 20 <210> 402 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (1)..(17) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 402 Cys Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg 1 5 10 15 Leu Cys Ala Lys Leu 20 <210> 403 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (1)..(11) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (18)..(18) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 403 Cys Phe Gln Ser Lys Gly Asn Val Phe Val Cys Gly Tyr Phe Glu Arg 1 5 10 15 Leu Xaa Ala Lys Leu 20 <210> 404 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> DISULFID <222> (1)..(7) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (18)..(18) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 404 Cys Phe Gln Ser Lys Gly Cys Val Phe Val Glu Gly Tyr Phe Glu Arg 1 5 10 15 Leu Xaa Ala Lys Leu 20 <210> 405 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 405 Phe Gln Ser Lys Tyr Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Phe Ala Lys Leu 20 <210> 406 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (22)..(22) <223> C-terminal amidation <400> 406 Lys Lys Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg 1 5 10 15 Leu Arg Ala Lys Lys Lys 20 <210> 407 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 407 Phe Gln Asn Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 408 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 408 Phe Gln Ser Lys Lys Asn Val Phe Ala Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 409 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 409 Phe Gln Ser Lys Lys Asn Val Phe Ser Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 410 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 410 Phe Gln Ser Lys Lys Asn Val Phe Thr Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 411 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 411 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Lys Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 412 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 412 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Tyr Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 413 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Carboxyfluorescein <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 413 Xaa Ala Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu 1 5 10 15 Arg Leu Arg Ala Lys 20 <210> 414 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 414 Phe Gln Ser Lys Lys Asn Ala Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 415 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 415 Phe Gln Ser Lys Lys Asn Pro Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 416 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 416 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Val Leu 20 <210> 417 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (7)..(7) <223> (S)-N-methyl-Val <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 417 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 418 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (10)..(10) <223> (S)-N-methyl-Phe <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 418 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 419 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> (S)-N-methyl-Leu <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 419 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 420 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> beta-Homophenylalanine <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 420 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 421 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (3)..(3) <223> beta-Homoserine <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 421 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 422 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (4)..(4) <223> beta-Homolysine <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 422 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 423 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (19)..(19) <223> beta-Ala <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 423 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Ala Lys Leu 20 <210> 424 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (19)..(19) <223> beta-Homolysine <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 424 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 425 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is Norleucine <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 425 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 426 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 426 Gly Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 427 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 427 Phe Gly Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 428 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 428 Phe Gln Gly Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 429 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 429 Phe Gln Ser Lys Lys Asn Gly Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 430 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 430 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Gly Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 431 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 431 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Gly Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 432 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 432 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Gly Lys Leu 20 <210> 433 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 433 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Gly 20 <210> 434 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 434 Lys Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 435 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 435 Phe Lys Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 436 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 436 Phe Gln Ser Lys Lys Asn Val Lys Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 437 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 437 Phe Gln Ser Lys Lys Asn Val Phe Lys Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 438 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 438 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Lys Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 439 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 439 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Lys Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 440 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 440 Phe Gln Ser Lys Lys Asn Phe Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 441 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 441 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Phe Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 442 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 442 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Phe 20 <210> 443 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 443 Asp Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 444 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 444 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Asp Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 445 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 445 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Asp Lys Leu 20 <210> 446 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 446 Phe Gln Ser Lys Lys Asn Leu Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 447 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 447 Phe Gln Ala Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 448 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 448 Phe Gln Ser Ala Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 449 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 449 Phe Gln Ser Lys Ala Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 450 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 450 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 451 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 451 Phe Gln Pro Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 452 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 452 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Pro Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 453 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 453 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Pro 1 5 10 15 Arg Ala Lys Leu 20 <210> 454 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 454 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Pro 20 <210> 455 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 455 Phe Gln Ser Ser Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 456 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 456 Phe Gln Ser Lys Lys Ser Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 457 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 457 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Ser Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 458 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 458 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ser Lys Leu 20 <210> 459 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 459 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Ser Leu 20 <210> 460 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 460 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Leu Leu 20 <210> 461 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (10)..(10) <223> D-Phe <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 461 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 462 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (12)..(12) <223> D-Tyr <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 462 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 463 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (14)..(14) <223> D-Glu <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 463 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 464 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (15)..(15) <223> D-Arg <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 464 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 465 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (17)..(17) <223> D-Arg <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 465 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 466 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (1)..(1) <223> D-Phe <220> <221> MOD_RES <222> (2)..(2) <223> D-Gln <220> <221> MOD_RES <222> (3)..(3) <223> D-Ser <220> <221> MOD_RES <222> (4)..(4) <223> D-Lys <220> <221> MOD_RES <222> (5)..(5) <223> D-Lys <220> <221> MOD_RES <222> (6)..(6) <223> D-Asn <220> <221> MOD_RES <222> (7)..(7) <223> D-Val <220> <221> MOD_RES <222> (8)..(8) <223> D-Phe <220> <221> MOD_RES <222> (9)..(9) <223> D-Val <220> <221> MOD_RES <222> (10)..(10) <223> D-Phe <220> <221> MOD_RES <222> (11)..(11) <223> D-Gly <220> <221> MOD_RES <222> (12)..(12) <223> D-Tyr <220> <221> MOD_RES <222> (13)..(13) <223> D-Phe <220> <221> MOD_RES <222> (14)..(14) <223> D-Glu <220> <221> MOD_RES <222> (15)..(15) <223> D-Arg <220> <221> MOD_RES <222> (16)..(16) <223> D-Leu <220> <221> MOD_RES <222> (17)..(17) <223> D-Arg <220> <221> MOD_RES <222> (18)..(18) <223> D-Ala <220> <221> MOD_RES <222> (19)..(19) <223> D-Lys <220> <221> MOD_RES <222> (20)..(20) <223> D-Leu <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 466 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 467 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (1)..(1) <223> D-Leu <220> <221> MOD_RES <222> (2)..(2) <223> D-Lys <220> <221> MOD_RES <222> (3)..(3) <223> D-Ala <220> <221> MOD_RES <222> (4)..(4) <223> D-Arg <220> <221> MOD_RES <222> (5)..(5) <223> D-Leu <220> <221> MOD_RES <222> (6)..(6) <223> D-Arg <220> <221> MOD_RES <222> (7)..(7) <223> D-Glu <220> <221> MOD_RES <222> (8)..(8) <223> D-Phe <220> <221> MOD_RES <222> (9)..(9) <223> D-Tyr <220> <221> MOD_RES <222> (10)..(10) <223> D-Gly <220> <221> MOD_RES <222> (11)..(11) <223> D-Phe <220> <221> MOD_RES <222> (12)..(12) <223> D-Val <220> <221> MOD_RES <222> (13)..(13) <223> D-Phe <220> <221> MOD_RES <222> (14)..(14) <223> D-Val <220> <221> MOD_RES <222> (15)..(15) <223> D-Asn <220> <221> MOD_RES <222> (16)..(16) <223> D-Lys <220> <221> MOD_RES <222> (17)..(17) <223> D-Lys <220> <221> MOD_RES <222> (18)..(18) <223> D-Ser <220> <221> MOD_RES <222> (19)..(19) <223> D-Gln <220> <221> MOD_RES <222> (20)..(20) <223> D-Phe <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 467 Leu Lys Ala Arg Leu Arg Glu Phe Tyr Gly Phe Val Phe Val Asn Lys 1 5 10 15 Lys Ser Gln Phe 20 <210> 468 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (15)..(15) <223> omega-methyl-Arg <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 468 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 469 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 469 Ala Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 470 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 470 Phe Ala Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 471 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 471 Phe Gln Ser Lys Gly Asn Ala Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 472 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 472 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Ala Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 473 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 473 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Ala Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 474 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 474 Phe Gln Asp Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 475 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 475 Phe Gln Ser Lys Gly Asp Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 476 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 476 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Asp Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 477 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 477 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Asp Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 478 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 478 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Asp Ala Lys Leu 20 <210> 479 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 479 Glu Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 480 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 480 Phe Gln Ser Lys Gly Glu Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 481 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 481 Phe Gln Ser Lys Gly Asn Glu Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 482 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 482 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Glu Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 483 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 483 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Glu Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 484 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 484 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Glu Ala Lys Leu 20 <210> 485 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 485 Phe Phe Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 486 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 486 Phe Gln Phe Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 487 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 487 Phe Gln Ser Lys Gly Phe Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 488 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 488 Phe Gln Ser Lys Gly Asn Phe Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 489 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 489 Phe Gln Ser Lys Gly Asn Val Phe Phe Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 490 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> D-Ala <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is (S)-Norleucine <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 490 Phe Gln Ser Lys Ala Ala Val Phe Val Ala Gly Tyr Phe Ala Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 491 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 491 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Phe Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 492 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 492 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Phe Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 493 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 493 Phe Gly Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 494 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 494 Phe Gln Gly Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 495 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 495 Phe Gln Ser Gly Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 496 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 496 Phe Gln Ser Lys Gly Gly Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 497 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 497 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Gly Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 498 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 498 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Gly Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 499 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 499 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Gly Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 500 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 500 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Gly Ala Lys Leu 20 <210> 501 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 501 His Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 502 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 502 Phe Gln Ser Lys Gly His Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 503 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 503 Phe Gln Ser Lys Gly Asn His Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 504 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 504 Phe Gln Ser Lys Gly Asn Val Phe Val Asp His Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 505 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 505 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr His Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 506 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 506 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg His Lys Leu 20 <210> 507 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 507 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys His 20 <210> 508 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 508 Phe Ile Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 509 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 509 Phe Gln Ser Lys Gly Asn Val Phe Ile Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 510 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 510 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Ile Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 511 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 511 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ile Lys Leu 20 <210> 512 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 512 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Ile 20 <210> 513 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 513 Lys Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 514 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 514 Phe Gln Lys Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 515 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 515 Phe Gln Ser Lys Gly Asn Val Phe Lys Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 516 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 516 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Lys Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 517 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 517 Leu Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 518 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 518 Phe Gln Leu Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 519 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 519 Phe Gln Ser Lys Gly Asn Leu Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 520 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 520 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Leu Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 521 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 521 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Leu Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 522 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 522 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Leu Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 523 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 523 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Met Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 524 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 524 Asn Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 525 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 525 Phe Asn Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 526 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 526 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Asn Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 527 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 527 Phe Gln Ser Lys Gly Asn Pro Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 528 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 528 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Pro Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 529 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 529 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Pro Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 530 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 530 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Pro Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 531 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 531 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Pro Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 532 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 532 Gln Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 533 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 533 Phe Gln Ser Lys Gly Asn Gln Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 534 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 534 Phe Gln Ser Lys Gly Asn Val Phe Gln Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 535 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 535 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gln Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 536 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 536 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Gln Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 537 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 537 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Gln Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 538 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 538 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Gln Ala Lys Leu 20 <210> 539 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 539 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Gln 20 <210> 540 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 540 Arg Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 541 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 541 Phe Arg Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 542 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 542 Phe Gln Ser Lys Gly Asn Arg Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 543 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 543 Phe Gln Ser Lys Gly Asn Val Arg Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 544 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 544 Phe Gln Ser Lys Gly Asn Val Phe Arg Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 545 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 545 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Arg Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 546 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 546 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Arg 1 5 10 15 Arg Ala Lys Leu 20 <210> 547 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 547 Phe Ser Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 548 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 548 Phe Gln Ser Ser Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 549 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 549 Phe Gln Ser Lys Gly Asn Ser Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 550 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 550 Phe Gln Ser Lys Gly Asn Val Phe Ser Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 551 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 551 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Ser Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 552 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 552 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Ser Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 553 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 553 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ser Ala Lys Leu 20 <210> 554 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 554 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ser Lys Leu 20 <210> 555 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 555 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Ser 20 <210> 556 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 556 Thr Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 557 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 557 Phe Gln Thr Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 558 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 558 Phe Gln Ser Thr Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 559 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 559 Phe Gln Ser Lys Gly Thr Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 560 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 560 Phe Gln Ser Lys Gly Asn Thr Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 561 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 561 Phe Gln Ser Lys Gly Asn Val Phe Thr Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 562 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 562 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Thr Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 563 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 563 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Thr Lys Leu 20 <210> 564 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 564 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Thr 20 <210> 565 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> D-Ala <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 565 Phe Gln Ser Lys Ala Ala Val Phe Val Phe Gly Tyr Phe Ala Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 566 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 566 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Val Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 567 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 567 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Val 1 5 10 15 Arg Ala Lys Leu 20 <210> 568 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 568 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Val 20 <210> 569 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 569 Phe Gln Trp Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 570 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 570 Phe Gln Ser Lys Gly Trp Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 571 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 571 Phe Gln Ser Lys Gly Asn Trp Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 572 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 572 Phe Gln Ser Lys Gly Asn Val Trp Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 573 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 573 Phe Gln Ser Lys Gly Asn Val Phe Trp Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 574 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 574 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Trp Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 575 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 575 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Trp 1 5 10 15 Arg Ala Lys Leu 20 <210> 576 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 576 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Trp Ala Lys Leu 20 <210> 577 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 577 Phe Gln Tyr Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 578 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 578 Phe Gln Ser Lys Gly Asn Val Phe Tyr Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 579 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 579 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Tyr Lys Leu 20 <210> 580 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 580 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Tyr 20 <210> 581 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 581 Phe Gln Ser Lys Glu Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 582 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 582 Phe Gln Ser Lys Ile Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 583 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 583 Phe Gln Ser Lys Pro Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 584 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 584 Phe Gln Ser Lys Ser Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 585 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 585 Phe Gln Ser Lys Thr Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 586 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 586 Phe Gln Ser Lys Val Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 587 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 587 Phe Gln Ser Lys Trp Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 588 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 588 Phe Gln Ser Lys Gly Asn Val Phe Val Ile Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 589 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 589 Phe Gln Ser Lys Gly Asn Val Phe Val Leu Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 590 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 590 Phe Gln Ser Lys Gly Asn Val Phe Val Gln Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 591 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 591 Phe Gln Ser Lys Phe Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 592 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 592 Phe Gln Ser Lys Tyr Asn Val Phe Val Asp Gly Tyr His Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 593 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 593 Phe Gln Ser Ser His Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 594 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 594 Phe Gln Ser Ala Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 595 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 595 Phe Gln Ser Phe Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 596 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 596 Phe Gln Asp Pro Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 597 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 597 Phe Gln Ser Lys Val Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 598 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 598 Phe Gln Ser Ile Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 599 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 599 Phe Gln Ser Lys Thr Asn Ile Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 600 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 600 Phe Gln Ser His Tyr Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 601 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 601 Phe Gln Ser Lys Glu Asn Val Phe Val Asp Gly Tyr Phe Asp Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 602 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 602 Phe Gln Ser His His Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 603 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 603 Phe Gln Ser Tyr Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 604 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 604 Phe Gln Ser Lys His Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Phe Lys Leu 20 <210> 605 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 605 Phe Gln Ser Phe Lys His Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 606 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 606 Phe Gln Ser Lys Ala Asn Val His Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 607 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 607 Phe Gln Ser Lys Ser Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 608 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 608 Phe Gln Ser His Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 609 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 609 Phe Gln Ser Lys Asp Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Phe 20 <210> 610 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 610 Phe Gln Ser Lys Met Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 611 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 611 Phe Gln Ser Ala Tyr Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 612 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 612 Phe Gln Ser Lys Gly Asn Trp Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 613 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 613 Phe Gln Ser Ala Lys Asn Val Phe Val Asp Gly Tyr Phe Val Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 614 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 614 Phe Gln Ser Lys Thr Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 615 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 615 Phe Gln Ser Lys His Val Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 616 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 616 Phe Gln Ser Lys Lys His Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 617 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 617 Phe Gln Ser Asp Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 618 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 618 Phe Gln Ser Asn Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 619 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 619 Phe Gln Ser His Lys Asn Val Phe Val Glu Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 620 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 620 Phe Gln Ser Tyr Lys Asp Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Thr Lys Leu 20 <210> 621 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 621 Phe Gln Ser Lys Asn Asn Phe Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Arg Leu 20 <210> 622 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 622 Phe Gln Ser Glu Gln Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 623 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 623 Phe Gln Ser Glu His Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 624 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 624 Phe Gln Ser Glu Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 625 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 625 Phe Gln Ser Lys Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Phe Lys Leu 20 <210> 626 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 626 Phe Gln Ser Lys Arg Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 627 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 627 Phe Gln Ser Gly Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 628 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 628 Phe Gln Ser Tyr Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Phe Ala Lys Leu 20 <210> 629 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 629 Phe Cys Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 630 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 630 Phe Gln Ser Cys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 631 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 631 Phe Gln Ser Lys Gly Asn Cys Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 632 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 632 Phe Gln Ser Lys Gly Asn Val Phe Val Cys Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 633 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 633 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Cys Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 634 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 634 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Cys 1 5 10 15 Arg Ala Lys Leu 20 <210> 635 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 635 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Cys 20 <210> 636 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 636 Phe Gln Ser Phe Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 637 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 637 Phe Gln Ser Lys Val Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 638 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 638 Phe Gln Ser Ile Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 639 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 639 Phe Gln Ser Lys Glu Arg Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 640 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 640 Phe Gln Ser Lys Glu Asn Val Phe Val Asp Gly Tyr Phe Asp Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 641 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 641 Phe Gln Ser Lys Gln Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ile Lys Leu 20 <210> 642 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 642 Phe Gln Ser Lys Tyr Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Val Lys Leu 20 <210> 643 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 643 Phe Gln Ser Tyr Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 644 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 644 Phe Gln Ser Lys His Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Phe Lys Leu 20 <210> 645 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 645 Phe Gln Ser Lys Tyr Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 646 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 646 Phe Gln Ser Phe Lys His Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 647 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 647 Leu Gln Ser Lys Thr Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 648 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 648 Phe Gln Ser Lys Cys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 649 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 649 Phe Gln Ser Lys Phe Asn Val Phe Val Asp Gly Tyr Thr Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 650 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 650 Phe Gln Ser Val Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 651 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 651 Phe Gln Ser Lys Gly Asn Trp Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 652 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 652 Phe Gln Ser Lys Val Ala Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 653 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 653 Phe Gln Ser Cys Lys Asn Val Phe Val Asp Gly Tyr Phe Val Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 654 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 654 Phe Gln Ser Lys Thr Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 655 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 655 Phe Gln Ser Lys Lys Asp Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 656 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 656 Phe Gln Ser Lys Ser Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Arg Leu 20 <210> 657 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 657 Phe Gln Ser Asp Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 658 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 658 Phe Gln Ser His Lys Asn Val Phe Val Glu Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 659 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 659 Phe Gln Ser Lys Pro Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 660 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 660 Phe Gln Ser Tyr Lys Asp Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Thr Lys Leu 20 <210> 661 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 661 Phe Gln Ser Lys Leu Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 662 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 662 Phe Gln Ser Lys Asn Asn Phe Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Arg Leu 20 <210> 663 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 663 Phe Gln Ser Lys Tyr Asn Ile Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 664 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 664 His Gln Gln Phe Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 665 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (3)..(3) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 665 Phe Gln Xaa Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 666 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (6)..(6) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 666 Phe Gln Ser Lys Gly Xaa Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 667 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (9)..(9) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 667 Phe Gln Ser Lys Gly Asn Val Phe Xaa Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 668 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> misc_feature <222> (10)..(10) <223> Xaa can be any naturally occurring amino acid <220> <221> MOD_RES <222> (11)..(11) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 668 Phe Gln Ser Lys Gly Asn Val Phe Val Xaa Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 669 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (11)..(11) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 669 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Xaa Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 670 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (5)..(17) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 670 Phe Gln Ser Lys Cys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 671 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (10)..(17) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 671 Phe Gln Ser Lys Gly Asn Val Phe Val Cys Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 672 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 672 Phe Gln Ser Lys Lys Asn Asn Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 673 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 673 Phe Gln Ser Lys Lys Asn Val Val Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 674 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 674 Phe Gln Ser Lys Lys Asn Val Phe Gln Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 675 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (3)..(3) <223> (S)-N-methyl-Ser <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 675 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 676 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (9)..(9) <223> (S)-N-methyl-Val <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 676 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 677 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (13)..(13) <223> (S)-N-methyl-Phe <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 677 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 678 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (14)..(14) <223> (S)-N-methyl-Glu <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 678 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 679 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (18)..(18) <223> (S)-N-methyl-Ala <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 679 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 680 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (2)..(2) <223> beta-Homoglutamine <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 680 Phe Glu Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 681 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (8)..(8) <223> beta-Homophenylalanine <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 681 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 682 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (10)..(10) <223> beta-Homophenylalanine <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 682 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 683 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (13)..(13) <223> beta-Homophenylalanine <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 683 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 684 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (16)..(16) <223> beta-Homoleucine <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 684 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 685 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (15)..(15) <223> Xaa is (S)-Citrullin <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 685 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Xaa Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 686 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 686 Phe Gln Ser Lys Lys Asn Val Gly Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 687 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 687 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Gly 1 5 10 15 Arg Ala Lys Leu 20 <210> 688 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 688 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Gly Leu 20 <210> 689 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 689 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Lys Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 690 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 690 Phe Gln Ser Lys Phe Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 691 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 691 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Phe Lys Leu 20 <210> 692 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 692 Leu Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 693 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 693 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Leu Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 694 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 694 Phe Gln Ser Lys Gly Asn Val Phe Leu Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 695 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 695 Phe Ala Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 696 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 696 Phe Gln Ser Lys Lys Pro Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 697 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 697 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Ser Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 698 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 698 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Leu Lys Leu 20 <210> 699 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (3)..(3) <223> D-Ser <220> <221> MOD_RES <222> (20)..(20) <223> N-terminal acetylation <400> 699 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 700 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (13)..(13) <223> D-Phe <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 700 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 701 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 701 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Gly Lys Leu 20 <210> 702 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 702 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Lys Lys Leu 20 <210> 703 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 703 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Lys 20 <210> 704 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is Norleucine <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 704 Phe Gln Ser Lys Ala Asn Val Phe Val Thr Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 705 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 705 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Gly Ala Lys Leu 20 <210> 706 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 706 Phe Gln Ser Val Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 707 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 707 Phe Gln Ser Lys Val Ala Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 708 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 708 Phe Gln Ser Lys Glu Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Tyr Lys Leu 20 <210> 709 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 709 Phe Gln Ser Thr Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 710 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (2)..(2) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 710 Phe Xaa Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 711 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (7)..(7) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 711 Phe Gln Ser Lys Gly Asn Xaa Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 712 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 712 Lys Lys Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu Arg 1 5 10 15 Ala Lys Leu Thr Ser Lys Lys 20 <210> 713 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 713 Phe Ser Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 714 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (12)..(12) <223> (S)-N-methyl-Tyr <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 714 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 715 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 715 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Lys 1 5 10 15 Arg Ala Lys Leu 20 <210> 716 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 716 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Asp Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 717 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 717 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Asp Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 718 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 718 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Asp Leu 20 <210> 719 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 719 Phe Gln Ser Lys Lys Asn Val Leu Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 720 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <400> 720 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 721 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 721 Ala Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 722 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 722 Phe Gln Ser Lys Pro Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 723 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 723 Phe Gln Ser Lys Lys Asn Val Phe Pro Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 724 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 724 Phe Gln Ser Lys Lys Asn Ser Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 725 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 725 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Leu Ala Lys Leu 20 <210> 726 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (1)..(1) <223> D-Phe <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 726 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 727 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (2)..(2) <223> D-Gln <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 727 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 728 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (6)..(6) <223> D-Asn <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 728 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 729 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (7)..(7) <223> D-Val <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 729 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 730 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (8)..(8) <223> D-Phe <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 730 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 731 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 731 Phe Gln Ser Lys Gly Asn Val Phe Ala Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 732 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 732 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Ala 20 <210> 733 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 733 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Asn 20 <210> 734 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 734 Ser Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 735 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 735 Phe Gln Ser Lys Lys Asn Val Phe Phe Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 736 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 736 Phe Gln Ser Lys Lys Asp Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 737 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 737 Phe Gln Ser Lys Ser Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Arg Leu 20 <210> 738 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 738 Phe Gln Ser Thr Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 739 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 739 Tyr Gln Ser Lys Gln Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 740 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 740 Phe Gln Ser Phe Glu Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 His Ala Lys Leu 20 <210> 741 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 741 Xaa Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 742 <211> 30 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (30)..(30) <223> C-terminal amidation <400> 742 Val Val Glu Lys Leu Thr Phe Val Gln Leu Ser Phe Leu Asn Arg Arg 1 5 10 15 Arg Phe Ser Gln Tyr Ala Gly Phe Lys Gly Ala Gly Lys Val 20 25 30 <210> 743 <211> 30 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (30)..(30) <223> C-terminal amidation <400> 743 Arg Val Phe Leu Tyr Phe Ser Gly Lys Ala Gly Gly Leu Val Lys Leu 1 5 10 15 Val Glu Arg Gln Ala Phe Gln Thr Asn Val Ser Lys Phe Arg 20 25 30 <210> 744 <211> 29 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (29)..(29) <223> C-terminal amidation <400> 744 Lys Lys Ser Gly Val Gly Arg Leu Gln Val Ala Phe Gln Ser Lys Lys 1 5 10 15 Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu Lys Lys 20 25 <210> 745 <211> 26 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (26)..(26) <223> C-terminal amidation <400> 745 Lys Lys Ser Gly Val Gly Arg Leu Gln Val Ala Phe Gln Ser Lys Lys 1 5 10 15 Asn Val Phe Val Phe Gly Tyr Phe Lys Lys 20 25 <210> 746 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 746 Lys Lys Ser Gly Val Gly Arg Leu Gln Val Ala Phe Gln Ser Lys Lys 1 5 10 15 Asn Val Phe Val Phe Lys Lys 20 <210> 747 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 747 Phe Gln Ser Lys Gln Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 748 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 748 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Asn 20 <210> 749 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (19)..(19) <223> C-terminal amidation <400> 749 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys <210> 750 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 750 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Leu Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 751 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (8)..(8) <223> (S)-methyl-Phe <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 751 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 752 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (15)..(15) <223> (S)-methyl-Arg <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 752 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 753 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (16)..(16) <223> (S)-N-methyl-Leu <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 753 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 754 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (17)..(17) <223> (S)-N-methyl-Arg <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 754 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 755 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (19)..(19) <223> (S)-N-methyl-Lys <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 755 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 756 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (7)..(7) <223> beta-Leu <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 756 Phe Gln Ser Lys Gly Asn Leu Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 757 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (9)..(9) <223> beta-Leu <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 757 Phe Gln Ser Lys Gly Asn Val Phe Leu Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 758 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (11)..(11) <223> beta-Ala <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 758 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Ala Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 759 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (12)..(12) <223> beta-Tyr <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 759 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 760 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (15)..(15) <223> beta-Homoarginine <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 760 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 761 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (15)..(15) <223> Xaa is Norleucine <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 761 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Xaa Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 762 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 762 Phe Gln Ser Lys Lys Asn Val Phe Gly Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 763 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 763 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Gly Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 764 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 764 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Gly Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 765 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 765 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Lys 20 <210> 766 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 766 Phe Phe Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 767 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 767 Phe Gln Phe Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 768 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 768 Phe Gln Ser Phe Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 769 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 769 Phe Gln Ser Lys Lys Phe Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 770 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 770 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Phe Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 771 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 771 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Phe Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 772 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 772 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Phe Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 773 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 773 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Phe 1 5 10 15 Arg Ala Lys Leu 20 <210> 774 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 774 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Phe Ala Lys Leu 20 <210> 775 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 775 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Phe Leu 20 <210> 776 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 776 Phe Asp Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 777 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 777 Phe Gln Ser Asp Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 778 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 778 Phe Gln Ser Lys Lys Asn Asp Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 779 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 779 Phe Gln Ser Lys Lys Asn Val Asp Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 780 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 780 Phe Gln Ser Lys Lys Asn Val Phe Asp Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 781 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 781 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Asp Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 782 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 782 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Asp 1 5 10 15 Arg Ala Lys Leu 20 <210> 783 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 783 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Asp Ala Lys Leu 20 <210> 784 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 784 Phe Leu Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 785 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 785 Phe Gln Leu Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 786 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 786 Phe Gln Ser Leu Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 787 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 787 Phe Gln Ser Lys Leu Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 788 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 788 Phe Gln Ser Lys Lys Leu Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 789 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 789 Phe Gln Ser Lys Lys Asn Val Phe Leu Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 790 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 790 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Leu Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 791 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 791 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Leu Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 792 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 792 Phe Gln Ser Lys Lys Asn Val Ala Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 793 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 793 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Ala Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 794 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 794 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Ala Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 795 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 795 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Ala Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 796 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 796 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Ala Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 797 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 797 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Ala 1 5 10 15 Arg Ala Lys Leu 20 <210> 798 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 798 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Ala Leu 20 <210> 799 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 799 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Ala 20 <210> 800 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 800 Pro Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 801 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 801 Phe Pro Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 802 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 802 Phe Gln Ser Lys Lys Asn Val Pro Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 803 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 803 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Pro Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 804 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 804 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Pro Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 805 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 805 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Pro Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 806 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 806 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Pro Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 807 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 807 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Pro Ala Lys Leu 20 <210> 808 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 808 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Pro Lys Leu 20 <210> 809 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 809 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Pro Leu 20 <210> 810 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 810 Ser Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 811 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 811 Phe Gln Ser Lys Ser Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 812 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 812 Phe Gln Ser Lys Lys Asn Val Ser Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 813 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 813 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Ser Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 814 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 814 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Ser Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 815 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 815 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Ser Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 816 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 816 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Ser 1 5 10 15 Arg Ala Lys Leu 20 <210> 817 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 817 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ser Ala Lys Leu 20 <210> 818 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 818 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Ser 20 <210> 819 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (16)..(16) <223> D-Leu <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 819 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 820 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (18)..(18) <223> D-Ala <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 820 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 821 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (19)..(19) <223> D-Lys <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 821 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 822 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> D-Leu <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 822 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 823 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (15)..(15) <223> omega-methyl-Arg <220> <221> MOD_RES <222> (17)..(17) <223> omega-methyl-Arg <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 823 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 824 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 824 Phe Gln Ser Lys Gly Asn Val Ala Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 825 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 825 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Ala Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 826 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 826 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Ala Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 827 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 827 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Ala 1 5 10 15 Arg Ala Lys Leu 20 <210> 828 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 828 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Ala Leu 20 <210> 829 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 829 Asp Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 830 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 830 Phe Asp Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 831 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 831 Phe Gln Ser Lys Gly Asn Asp Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 832 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 832 Phe Gln Ser Lys Gly Asn Val Asp Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 833 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 833 Phe Gln Ser Lys Gly Asn Val Phe Asp Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 834 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 834 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Asp Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 835 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 835 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Asp Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 836 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 836 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Asp 1 5 10 15 Arg Ala Lys Leu 20 <210> 837 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 837 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Asp Leu 20 <210> 838 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 838 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Asp 20 <210> 839 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 839 Phe Glu Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 840 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 840 Phe Gln Ser Lys Gly Asn Val Glu Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 841 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 841 Phe Gln Ser Lys Gly Asn Val Phe Glu Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 842 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 842 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Glu Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 843 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 843 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Glu Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 844 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 844 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Glu 1 5 10 15 Arg Ala Lys Leu 20 <210> 845 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 845 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Glu Leu 20 <210> 846 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 846 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Glu 20 <210> 847 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 847 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Phe Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 848 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 848 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Phe Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 849 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 849 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Phe 1 5 10 15 Arg Ala Lys Leu 20 <210> 850 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 850 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Phe Leu 20 <210> 851 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 851 Gly Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 852 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 852 Phe Gln Ser Lys Gly Asn Gly Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 853 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 853 Phe Gln Ser Lys Gly Asn Val Gly Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 854 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 854 Phe Gln Ser Lys Gly Asn Val Phe Gly Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 855 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 855 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Gly Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 856 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 856 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Gly 1 5 10 15 Arg Ala Lys Leu 20 <210> 857 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 857 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Gly Leu 20 <210> 858 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 858 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Gly 20 <210> 859 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 859 Phe His Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 860 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 860 Phe Gln Ser Lys Gly Asn Val Phe His Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 861 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 861 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly His Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 862 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 862 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu His Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 863 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 863 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg His 1 5 10 15 Arg Ala Lys Leu 20 <210> 864 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 864 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala His Leu 20 <210> 865 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 865 Phe Gln Ser Lys Gly Asn Val Ile Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 866 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 866 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Ile Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 867 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 867 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Ile Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 868 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 868 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Ile Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 869 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 869 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Ile 1 5 10 15 Arg Ala Lys Leu 20 <210> 870 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 870 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Ile Leu 20 <210> 871 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 871 Phe Lys Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 872 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 872 Phe Gln Ser Lys Gly Asn Lys Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 873 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 873 Phe Gln Ser Lys Gly Asn Val Lys Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 874 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 874 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Lys Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 875 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 875 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Lys Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 876 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 876 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Lys Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 877 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 877 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Lys 1 5 10 15 Arg Ala Lys Leu 20 <210> 878 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 878 Phe Leu Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 879 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 879 Phe Gln Ser Lys Gly Asn Val Leu Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 880 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 880 Phe Gln Ser Lys Gly Asn Val Phe Leu Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 881 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 881 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Leu Leu 20 <210> 882 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 882 Phe Gln Ser Lys Gly Asn Met Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 883 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 883 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Met 1 5 10 15 Arg Ala Lys Leu 20 <210> 884 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 884 Phe Gln Ser Lys Gly Asn Asn Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 885 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 885 Phe Gln Ser Lys Gly Asn Val Asn Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 886 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 886 Phe Gln Ser Lys Gly Asn Val Phe Asn Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 887 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 887 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Asn Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 888 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 888 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Asn Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 889 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 889 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Asn 1 5 10 15 Arg Ala Lys Leu 20 <210> 890 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 890 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Asn Leu 20 <210> 891 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 891 Pro Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 892 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 892 Phe Pro Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 893 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 893 Phe Gln Pro Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 894 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 894 Phe Gln Ser Lys Gly Pro Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 895 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 895 Phe Gln Ser Lys Gly Asn Val Pro Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 896 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 896 Phe Gln Ser Lys Gly Asn Val Phe Pro Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 897 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 897 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Pro Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 898 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 898 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Pro 1 5 10 15 Arg Ala Lys Leu 20 <210> 899 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 899 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Pro Ala Lys Leu 20 <210> 900 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 900 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Pro Lys Leu 20 <210> 901 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 901 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Pro Leu 20 <210> 902 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 902 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Pro 20 <210> 903 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 903 Phe Gln Ser Lys Gly Asn Val Gln Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 904 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 904 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Gln Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 905 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 905 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Gln 1 5 10 15 Arg Ala Lys Leu 20 <210> 906 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 906 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Gln Leu 20 <210> 907 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 907 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Arg Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 908 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 908 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Arg Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 909 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 909 Phe Gln Ser Lys Gly Asn Val Ser Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 910 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 910 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Ser Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 911 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 911 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Ser Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 912 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 912 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Ser 1 5 10 15 Arg Ala Lys Leu 20 <210> 913 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 913 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Ser Leu 20 <210> 914 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 914 Phe Thr Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 915 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 915 Phe Gln Ser Lys Gly Asn Val Thr Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 916 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 916 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Thr Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 917 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 917 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Thr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 918 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 918 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Thr Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 919 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 919 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Thr 1 5 10 15 Arg Ala Lys Leu 20 <210> 920 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 920 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Thr Leu 20 <210> 921 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 921 Phe Val Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 922 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 922 Phe Gln Ser Lys Gly Asn Val Val Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 923 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 923 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Val Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 924 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 924 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Val Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 925 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 925 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Val Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 926 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 926 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Val Leu 20 <210> 927 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 927 Phe Trp Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 928 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 928 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Trp Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 929 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 929 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Trp Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 930 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 930 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Trp Leu 20 <210> 931 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 931 Phe Tyr Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 932 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 932 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Tyr Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 933 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 933 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Tyr Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 934 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 934 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Tyr 1 5 10 15 Arg Ala Lys Leu 20 <210> 935 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 935 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Tyr Leu 20 <210> 936 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (9)..(9) <223> D-Val <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 936 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 937 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 937 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Asp 20 <210> 938 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 938 Leu Gln Ser Lys Thr Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 939 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 939 Phe Gln Ser Lys Phe Asn Val Phe Val Asp Gly Tyr Thr Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 940 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 940 Phe Gln Ser Lys His Asn Val Phe Val Asp Gly His Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 941 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 941 Phe Gln Ser Val His Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Pro 1 5 10 15 Ala Ala Lys Leu 20 <210> 942 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 942 Phe Gln Ser Lys Tyr Asn Val Phe Val Asp Glu Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 943 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 943 Phe Gln Ser Lys Pro Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 944 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 944 His Gln Gln Phe Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Ala Ala Lys Leu 20 <210> 945 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 945 Phe Gln Ser Lys His Asn Val Phe Val Asp Ala Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 946 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 946 Phe Gln Ser Lys Lys Asn Val Phe Val Asp Gly Tyr Ser Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 947 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 947 Phe Gln Ser Lys Gly Asn Val Cys Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 948 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 948 Phe Gln Ser Lys Gly Asn Val Phe Cys Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 949 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 949 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Cys Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 950 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 950 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Cys Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 951 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 951 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Cys Leu 20 <210> 952 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 952 Phe Gln Ser Cys Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 953 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 953 Phe Gln Ser Ala Tyr Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 954 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 954 Phe Gln Ser Val His Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Pro 1 5 10 15 Cys Ala Lys Leu 20 <210> 955 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 955 Phe Gln Ser Lys Tyr Asn Val Phe Val Asp Glu Tyr Phe Glu Arg Leu 1 5 10 15 Cys Ala Lys Leu 20 <210> 956 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (8)..(8) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 956 Phe Gln Ser Lys Gly Asn Val Xaa Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 957 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (12)..(12) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 957 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Xaa Phe Glu Arg Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 958 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (15)..(15) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 958 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Xaa Leu 1 5 10 15 Xaa Ala Lys Leu 20 <210> 959 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (19)..(19) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 959 Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Xaa Ala Xaa Leu 20 <210> 960 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (11)..(11) <223> C-terminal amidation <400> 960 Asp Gly Tyr Phe Glu Arg Leu Arg Ala Lys Leu 1 5 10 <210> 961 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (7)..(7) <223> C-terminal amidation <400> 961 Phe Gln Ser Lys Lys Asn Val 1 5 <210> 962 <211> 32 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (32)..(32) <223> C-terminal amidation <400> 962 Xaa Ser Gly Val Gly Arg Leu Gln Val Ala Phe Gln Ser Lys Lys Asn 1 5 10 15 Val Phe Val Phe Gly Tyr Phe Glu Arg Leu Arg Ala Lys Leu Thr Ser 20 25 30 <210> 963 <211> 33 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (32)..(32) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (33)..(33) <223> Xaa is Lysin(biotin) <220> <221> MOD_RES <222> (33)..(33) <223> C-terminal amidation <400> 963 Ser Gly Val Gly Arg Leu Gln Val Ala Phe Gln Ser Lys Lys Asn Val 1 5 10 15 Phe Val Phe Gly Tyr Phe Glu Arg Leu Arg Ala Lys Leu Thr Ser Xaa 20 25 30 Xaa <210> 964 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 964 Xaa Ala Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu 1 5 10 15 Arg Leu Arg Ala Lys 20 <210> 965 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 965 Xaa Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg 1 5 10 15 Leu Arg Ala Lys Leu 20 <210> 966 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (2)..(2) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (22)..(22) <223> C-terminal amidation <400> 966 Xaa Xaa Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg 1 5 10 15 Leu Arg Ala Lys Leu Thr 20 <210> 967 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (19)..(19) <223> C-terminal amidation <400> 967 Xaa Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys <210> 968 <211> 25 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (25)..(25) <223> C-terminal amidation <400> 968 Xaa Lys Lys Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe 1 5 10 15 Glu Arg Leu Arg Ala Lys Leu Lys Lys 20 25 <210> 969 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 969 Xaa Gly Lys Asn Ala Lys Phe Tyr Leu Phe Glu Ser Leu Arg Gln Val 1 5 10 15 Lys Phe Val Phe Arg 20 <210> 970 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 970 Xaa Tyr Lys Phe Ser Phe Asn Lys Glu Leu Phe Lys Gln Ala Arg Leu 1 5 10 15 Arg Phe Val Gly Val 20 <210> 971 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 971 Xaa Ser Gly Val Gly Arg Leu Gln Val Ala Phe Gln Ser Lys Lys Asn 1 5 10 15 Val Phe Val Phe Gly 20 <210> 972 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 972 Xaa Phe Gln Ser Lys Lys Asn Val Phe Val Asp Gly Tyr Phe Glu Arg 1 5 10 15 Leu Arg Ala Lys Leu 20 <210> 973 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 973 Xaa Phe Gln Ser Lys Asn Asn Val Phe Val Phe Gly Tyr Phe Glu Arg 1 5 10 15 Leu Arg Ala Lys Leu 20 <210> 974 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> C-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 974 Xaa Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Asp Arg 1 5 10 15 Leu Arg Ala Lys Leu 20 <210> 975 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 975 Phe Gln Ser Lys Lys Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 976 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 976 Phe Gln Ser Lys Asp Asn Val Phe Val Asp Gly Tyr Phe Asp Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 977 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 977 Xaa Phe Gln Ser Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg 1 5 10 15 Leu Arg Ala Lys Leu 20 <210> 978 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal N-propyl <400> 978 Phe Gln Ser Lys Gly Asn Val Phe Val Phe Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 979 <400> 979 000 <210> 980 <400> 980 000 <210> 981 <400> 981 000 <210> 982 <400> 982 000 <210> 983 <400> 983 000 <210> 984 <400> 984 000 <210> 985 <400> 985 000 <210> 986 <400> 986 000 <210> 987 <400> 987 000 <210> 988 <400> 988 000 <210> 989 <400> 989 000 <210> 990 <400> 990 000 <210> 991 <400> 991 000 <210> 992 <400> 992 000 <210> 993 <400> 993 000 <210> 994 <400> 994 000 <210> 995 <400> 995 000 <210> 996 <400> 996 000 <210> 997 <400> 997 000 <210> 998 <400> 998 000 <210> 999 <400> 999 000 <210> 1000 <400> 1000 000 <210> 1001 <211> 35 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (12)..(23) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (35)..(35) <223> C-terminal amidation <400> 1001 Lys Lys Ser Gly Ala Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp 1 5 10 15 Met Lys Gly Thr Met Ser Cys Val Trp Val Lys Phe Arg Tyr Asp Thr 20 25 30 Ser Lys Lys 35 <210> 1002 <211> 28 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (10)..(21) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (28)..(28) <223> C-terminal amidation <400> 1002 Ser Gly Ala Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys 1 5 10 15 Gly Thr Met Ser Cys Val Trp Val Lys Phe Arg Tyr 20 25 <210> 1003 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1003 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1004 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1004 Ser Arg Tyr Lys Trp Phe Cys Ala Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1005 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal amidation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1005 Ser Arg Tyr Lys Trp Phe Cys Ala Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1006 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1006 Ser Arg Tyr Lys Trp Phe Cys Gly Met Pro Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1007 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1007 Asp Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1008 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1008 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Asp Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1009 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1009 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Asp 20 <210> 1010 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1010 Ser Phe Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1011 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1011 Ser Arg Phe Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1012 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1012 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Phe Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1013 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1013 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Phe 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1014 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1014 Gly Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1015 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1015 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Gly Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1016 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1016 Lys Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1017 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1017 Ser Arg Tyr Lys Trp Phe Cys Gly Met Lys Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1018 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1018 Leu Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1019 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1019 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Leu Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1020 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1020 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Leu 20 <210> 1021 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1021 Ser Arg Tyr Lys Trp Phe Cys Ser Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1022 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1022 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Ser Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1023 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1023 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Pro Phe 20 <210> 1024 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1024 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1025 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (12)..(12) <223> D-Leu <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1025 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Leu Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1026 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1026 Ser Met Tyr Lys Trp His Cys Gly Met Arg Asp Met Lys Gly Thr Tyr 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1027 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1027 Phe His Tyr Lys Trp His Cys Gly Met Arg Asp Met Lys Gly Thr Tyr 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1028 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1028 Ser Tyr Tyr Lys Trp His Cys Gly Met Arg Asp Met Lys Gly Ile Met 1 5 10 15 Ser Cys Ala Trp Val Lys Phe 20 <210> 1029 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1029 Ser Tyr Tyr Lys Trp His Cys Gly Met Arg Asp Met Lys Gly Ile Met 1 5 10 15 Ser Cys Val Trp Val Lys Tyr 20 <210> 1030 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1030 Ser Tyr Tyr Lys Trp His Cys Gly Met Arg Asp Met Lys Gly Ile Asp 1 5 10 15 Ser Cys Val Trp Val Arg Phe 20 <210> 1031 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1031 Ser Tyr Tyr Lys Trp His Cys Gly Met Arg Asp Met Lys Gly Ile Met 1 5 10 15 Ser Cys Val Trp Val Lys Ala 20 <210> 1032 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1032 Ser Tyr Tyr Lys Trp His Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Thr Cys Val Trp Val Lys Phe 20 <210> 1033 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1033 Ser Tyr Tyr Lys Trp His Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Ser 20 <210> 1034 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1034 Ser His Tyr Lys Trp His Cys Ala Met Arg Asp Met Lys Gly Thr Tyr 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1035 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1035 Ser Tyr Tyr Lys Trp His Cys Gly Val Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Ser 20 <210> 1036 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (22)..(22) <223> C-terminal amidation <400> 1036 Gly His Tyr Lys Trp His Cys Gly Met Arg Asp Met Lys Gly Thr Phe 1 5 10 15 Ser Cys Val Trp Val Phe 20 <210> 1037 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1037 Ala Tyr Tyr Lys Trp His Cys Gly Met Arg Asp Leu Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Ser 20 <210> 1038 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1038 Ser Tyr Tyr Lys Trp His Cys Gly Met Arg Asp Met Lys Gly Thr Tyr 1 5 10 15 Ser Cys Val Trp Val Lys Met 20 <210> 1039 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (22)..(22) <223> C-terminal amidation <400> 1039 Ser His Tyr Lys Trp His Cys Gly Met Arg Asp Met Lys Gly Ile Met 1 5 10 15 Ser Cys Val Trp Val Phe 20 <210> 1040 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1040 Phe Tyr Tyr Lys Trp His Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Ala Trp Val Lys Phe 20 <210> 1041 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1041 Ser Tyr Tyr Lys Trp His Cys Gly Met Arg Asp Met Lys Gly Thr Asp 1 5 10 15 Ser Cys Val Trp Val Trp Tyr 20 <210> 1042 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1042 Ser His Tyr Lys Trp His Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Ala Trp Val Lys Phe 20 <210> 1043 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1043 His Tyr Tyr Lys Trp His Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Ser 20 <210> 1044 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1044 Ser Tyr Tyr Lys Trp His Cys Ala Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Thr Cys Val Trp Val Lys Phe 20 <210> 1045 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1045 Ser Tyr Tyr Lys Trp His Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Leu Phe 20 <210> 1046 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1046 Ser His Tyr Lys Trp His Cys Ala Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Ala Trp Val Lys Phe 20 <210> 1047 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (10)..(22) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 1047 Ser Gly Ala Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys 1 5 10 15 Gly Thr Met Ser Cys Val Trp Val Lys Phe Arg Tyr Asp Thr Ser 20 25 30 <210> 1048 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1048 Ala Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1049 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1049 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Ala Trp Val Lys Phe 20 <210> 1050 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (6)..(17) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (22)..(22) <223> C-terminal amidation <400> 1050 Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met Ser 1 5 10 15 Cys Val Trp Val Lys Phe 20 <210> 1051 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (12)..(12) <223> D-Met <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1051 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1052 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1052 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Asp Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1053 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1053 Phe Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1054 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1054 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Phe Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1055 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1055 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Gly Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1056 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1056 Ser Lys Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1057 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1057 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Lys Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1058 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1058 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Lys Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1059 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1059 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Lys 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1060 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1060 Ser Leu Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1061 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1061 Ser Arg Tyr Lys Trp Leu Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1062 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1062 Ser Arg Tyr Lys Trp Phe Cys Gly Met Leu Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1063 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1063 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Leu Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1064 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1064 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Leu 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1065 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1065 Ser Ser Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1066 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1066 Ser Arg Ser Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1067 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1067 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Ser Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1068 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1068 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Ser Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1069 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1069 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Ser 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1070 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1070 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Ser Phe 20 <210> 1071 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1071 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Ser 20 <210> 1072 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1072 Pro Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1073 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> DISULFID <222> (6)..(17) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (22)..(22) <223> C-terminal amidation <400> 1073 Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met Ser 1 5 10 15 Cys Val Trp Val Lys Phe 20 <210> 1074 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (12)..(12) <223> D-Phe <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1074 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Phe Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1075 <211> 28 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (10)..(21) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (28)..(28) <223> C-terminal amidation <400> 1075 Ser Gly Ala Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys 1 5 10 15 Gly Thr Met Ser Cys Val Trp Val Lys Phe Arg Tyr 20 25 <210> 1076 <211> 28 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (28)..(28) <223> C-terminal amidation <400> 1076 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe Arg Tyr Asp Thr Ser 20 25 <210> 1077 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (9)..(9) <223> Xaa is (S)-Norleucine <220> <221> MOD_RES <222> (12)..(12) <223> Xaa is (S)-Norleucine <220> <221> MOD_RES <222> (16)..(16) <223> Xaa is (S)-Norleucine <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1077 Ser Arg Tyr Lys Trp Phe Cys Gly Xaa Arg Asp Xaa Lys Gly Thr Xaa 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1078 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1078 Ser Ala Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1079 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1079 Ser Arg Tyr Lys Trp Phe Cys Gly Met Ala Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1080 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1080 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Ala Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1081 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1081 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Ala Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1082 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1082 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Ala Phe 20 <210> 1083 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1083 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Ala 20 <210> 1084 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1084 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Pro Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1085 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1085 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Asp Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1086 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1086 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Asp 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1087 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1087 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Phe Trp Val Lys Phe 20 <210> 1088 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1088 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Gly Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1089 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1089 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Gly Phe 20 <210> 1090 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1090 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Gly 20 <210> 1091 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1091 Ser Arg Tyr Lys Trp Lys Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1092 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1092 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Leu Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1093 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1093 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Leu Trp Val Lys Phe 20 <210> 1094 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1094 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Leu Lys Phe 20 <210> 1095 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1095 Ser Arg Tyr Lys Trp Phe Cys Gly Met Ser Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1096 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1096 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Ser Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1097 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1097 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Ser Trp Val Lys Phe 20 <210> 1098 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <400> 1098 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1099 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <400> 1099 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1100 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (9)..(9) <223> D-Pro <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1100 Ser Arg Tyr Lys Trp Phe Cys Gly Pro Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1101 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (12)..(12) <223> D-Asp <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1101 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Asp Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1102 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (12)..(12) <223> D-Lys <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1102 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Lys Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1103 <211> 25 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (10)..(21) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (25)..(25) <223> C-terminal amidation <400> 1103 Ser Gly Ala Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys 1 5 10 15 Gly Thr Met Ser Cys Val Trp Val Lys 20 25 <210> 1104 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (10)..(21) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (12)..(12) <223> Xaa is (S)-Noreleucine <220> <221> MOD_RES <222> (15)..(15) <223> Xaa is (S)-Noreleucine <220> <221> MOD_RES <222> (19)..(19) <223> Xaa is (S)-Noreleucine <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 1104 Ser Gly Ala Ser Arg Tyr Lys Trp Phe Cys Gly Xaa Arg Asp Xaa Lys 1 5 10 15 Gly Thr Xaa Ser Cys Val Trp Val Lys Phe Arg Tyr Asp Thr Ser 20 25 30 <210> 1105 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1105 Ser Arg Ala Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1106 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> D-Ala <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is Norleucine <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1106 Ser Arg Tyr Ala Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1107 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1107 Ser Arg Tyr Lys Trp Phe Cys Gly Ala Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1108 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1108 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Ala Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1109 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (5)..(5) <223> N-methyl-Gly <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1109 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Ala 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1110 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1110 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ala Cys Val Trp Val Lys Phe 20 <210> 1111 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (5)..(16) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 1111 Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met Ser Cys 1 5 10 15 Val Trp Val Lys Phe 20 <210> 1112 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (7)..(7) <223> Homo-Cys <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1112 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1113 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (9)..(9) <223> D-Met <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1113 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1114 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (13)..(13) <223> D-Lys <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1114 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1115 <211> 25 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (9)..(20) <223> Cys residues linked via disulfide bond <400> 1115 Gly Ser Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly 1 5 10 15 Thr Met Ser Cys Val Trp Val Lys Phe 20 25 <210> 1116 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1116 Ser Asp Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1117 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1117 Ser Arg Tyr Asp Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1118 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1118 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Asp Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1119 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1119 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Asp Cys Val Trp Val Lys Phe 20 <210> 1120 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1120 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Asp Phe 20 <210> 1121 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1121 Ser Arg Tyr Phe Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1122 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1122 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Phe Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1123 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1123 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Phe Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1124 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1124 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Phe Cys Val Trp Val Lys Phe 20 <210> 1125 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1125 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Phe Val Lys Phe 20 <210> 1126 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1126 Ser Gly Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1127 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1127 Ser Arg Tyr Gly Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1128 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1128 Ser Arg Tyr Lys Trp Phe Cys Gly Met Gly Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1129 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1129 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Gly Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1130 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1130 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Gly 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1131 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1131 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Gly Cys Val Trp Val Lys Phe 20 <210> 1132 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1132 Ser Arg Lys Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1133 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1133 Ser Arg Tyr Lys Trp Phe Cys Gly Lys Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1134 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1134 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Lys Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1135 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1135 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Lys Cys Val Trp Val Lys Phe 20 <210> 1136 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1136 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Lys 20 <210> 1137 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1137 Ser Arg Leu Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1138 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1138 Ser Arg Tyr Leu Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1139 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1139 Ser Arg Tyr Lys Trp Phe Cys Gly Leu Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1140 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1140 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Leu Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1141 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1141 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Leu Cys Val Trp Val Lys Phe 20 <210> 1142 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1142 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Leu Phe 20 <210> 1143 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1143 Ser Arg Tyr Ser Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1144 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1144 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Ser Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1145 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1145 Ser Pro Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1146 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1146 Ser Arg Tyr Lys Trp Phe Cys Gln Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1147 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1147 Ser Arg Tyr Lys Trp Phe Cys Arg Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1148 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (5)..(16) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1148 Ser Arg Tyr Lys Trp Phe Cys Thr Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1149 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 1149 Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met Ser Cys 1 5 10 15 Val Trp Val Lys Phe 20 <210> 1150 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (9)..(9) <223> D-Ala <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1150 Ser Arg Tyr Lys Trp Phe Cys Gly Ala Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1151 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (12)..(12) <223> D-Ala <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1151 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Ala Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1152 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (12)..(12) <223> D-Ser <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1152 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Ser Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1153 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (13)..(13) <223> D-Asp <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1153 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Asp Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1154 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (13)..(13) <223> D-Ser <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1154 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Ser Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1155 <211> 25 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (4)..(15) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (25)..(25) <223> C-terminal amidation <400> 1155 Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met Ser Cys Val 1 5 10 15 Trp Val Lys Phe Arg Tyr Asp Thr Ser 20 25 <210> 1156 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (4)..(15) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 1156 Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met Ser Cys Val 1 5 10 15 Trp Val Lys Phe 20 <210> 1157 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1157 Ser Arg Tyr Lys Trp Phe Ala Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1158 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1158 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Ala Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1159 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1159 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Ala Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1160 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1160 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Ala Val Trp Val Lys Phe 20 <210> 1161 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1161 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Ala Lys Phe 20 <210> 1162 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (10)..(15) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1162 Ser Arg Tyr Lys Trp Phe Gly Met Arg Cys Asp Met Lys Gly Cys Thr 1 5 10 15 Met Ser Val Trp Val Lys Phe 20 <210> 1163 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (18)..(18) <223> Homo-Cys <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1163 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1164 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (22)..(22) <223> C-terminal amidation <400> 1164 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Lys Gly Thr Met Ser 1 5 10 15 Cys Val Trp Val Lys Phe 20 <210> 1165 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (22)..(22) <223> C-terminal amidation <400> 1165 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Gly Thr Met Ser 1 5 10 15 Cys Val Trp Val Lys Phe 20 <210> 1166 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (22)..(22) <223> C-terminal amidation <400> 1166 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Met Ser 1 5 10 15 Cys Val Trp Val Lys Phe 20 <210> 1167 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (7)..(7) <223> d-Cys <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 1167 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1168 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (11)..(11) <223> D-Asp <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1168 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1169 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (15)..(15) <223> D-Thr <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1169 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1170 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (17)..(17) <223> D-Ser <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1170 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1171 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (18)..(18) <223> D-Cys <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1171 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1172 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1172 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Pro Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1173 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1173 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Pro Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1174 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1174 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Pro Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1175 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1175 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Pro 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1176 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1176 Ser Arg Asp Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1177 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1177 Ser Arg Tyr Lys Trp Phe Cys Gly Asp Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1178 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1178 Ser Arg Tyr Lys Trp Phe Cys Gly Phe Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1179 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1179 Ser Arg Tyr Lys Trp Phe Cys Gly Met Phe Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1180 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1180 Ser Arg Gly Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1181 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1181 Ser Arg Tyr Lys Trp Phe Cys Gly Gly Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1182 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1182 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Gly Trp Val Lys Phe 20 <210> 1183 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1183 Ser Arg Tyr Lys Trp Phe Cys Lys Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1184 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1184 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Lys Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1185 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1185 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Leu Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1186 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1186 Ser Arg Tyr Lys Trp Phe Cys Gly Ser Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1187 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1187 Ser Arg Pro Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1188 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1188 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Pro 20 <210> 1189 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1189 Ser Arg Tyr Lys Trp Phe Cys Met Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1190 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1190 Ser Arg Tyr Lys Trp Phe Cys Asn Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1191 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1191 Ser Arg Tyr Lys Trp Phe Cys Trp Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1192 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (9)..(9) <223> D-Phe <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1192 Ser Arg Tyr Lys Trp Phe Cys Gly Phe Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1193 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (9)..(9) <223> D-Lys <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1193 Ser Arg Tyr Lys Trp Phe Cys Gly Lys Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1194 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (9)..(9) <223> D-Leu <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1194 Ser Arg Tyr Lys Trp Phe Cys Gly Leu Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1195 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (9)..(9) <223> D-Ser <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1195 Ser Arg Tyr Lys Trp Phe Cys Gly Ser Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1196 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (12)..(12) <223> D-Pro <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1196 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Pro Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1197 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (13)..(13) <223> D-Ala <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1197 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Ala Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1198 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (13)..(13) <223> D-Phe <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1198 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Phe Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1199 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (13)..(13) <223> D-Leu <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1199 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Leu Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1200 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (13)..(13) <223> D-Pro <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1200 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Pro Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1201 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 1201 Lys Lys Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly 1 5 10 15 Thr Met Ser Cys Val Trp Lys Lys 20 <210> 1202 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 1202 Lys Lys Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met Ser 1 5 10 15 Cys Val Trp Val Lys Phe Lys Lys 20 <210> 1203 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (4)..(15) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 1203 Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met Ser Cys Val 1 5 10 15 Trp Val Lys Phe 20 <210> 1204 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 1204 Ser Gly Ala Ser Arg Tyr Lys Trp Phe Ser Gly Met Arg Asp Met Lys 1 5 10 15 Gly Thr Met Ser Ser Val Trp Val Lys Phe Arg Tyr Asp Thr Ser 20 25 30 <210> 1205 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (6)..(6) <223> Xaa is (S)-Norleucine <220> <221> MOD_RES <222> (9)..(9) <223> Xaa is (S)-Norleucine <220> <221> MOD_RES <222> (13)..(13) <223> Xaa is (S)-Norleucine <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 1205 Lys Trp Phe Ser Gly Xaa Arg Asp Xaa Lys Gly Thr Xaa Ser Ser Val 1 5 10 15 Trp Val Lys Phe 20 <210> 1206 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 1206 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp 20 <210> 1207 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 1207 Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met Ser Cys Val 1 5 10 15 Trp Val Lys Phe 20 <210> 1208 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (12)..(12) <223> Xaa is (S)-Norleucine <220> <221> MOD_RES <222> (15)..(15) <223> Xaa is (S)-Norleucine <220> <221> MOD_RES <222> (19)..(19) <223> Xaa is (S)-Norleucine <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 1208 Ser Gly Ala Ser Arg Tyr Lys Trp Phe Ser Gly Xaa Arg Asp Xaa Lys 1 5 10 15 Gly Thr Xaa Ser Ser Val Trp Val Lys Phe Arg Tyr Asp Thr Ser 20 25 30 <210> 1209 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (4)..(15) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (6)..(6) <223> Xaa is (S)-Norleucine <220> <221> MOD_RES <222> (9)..(9) <223> Xaa is (S)-Norleucine <220> <221> MOD_RES <222> (13)..(13) <223> Xaa is (S)-Norleucine <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 1209 Lys Trp Phe Cys Gly Xaa Arg Asp Xaa Lys Gly Thr Xaa Ser Cys Val 1 5 10 15 Trp Val Lys Phe 20 <210> 1210 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (9)..(9) <223> Xaa is (S)-Norleucine <220> <221> MOD_RES <222> (12)..(12) <223> Xaa is (S)-Norleucine <220> <221> MOD_RES <222> (16)..(16) <223> Xaa is (S)-Norleucine <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1210 Ser Arg Tyr Lys Trp Phe Ser Gly Xaa Arg Asp Xaa Lys Gly Thr Xaa 1 5 10 15 Ser Ser Val Trp Val Lys Phe 20 <210> 1211 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (10)..(21) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 1211 Arg Lys Arg Asp Val Ser Gly Lys Met Cys Trp Ser Gly Phe Gly Ser 1 5 10 15 Lys Trp Phe Arg Cys Ala Asp Met Met Thr Tyr Tyr Ser Val Thr 20 25 30 <210> 1212 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (10)..(21) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 1212 Arg Trp Ser Gly Lys Ser Thr Tyr Ser Cys Asp Ala Met Val Arg Arg 1 5 10 15 Met Gly Met Lys Cys Phe Ser Phe Gly Trp Thr Asp Val Tyr Lys 20 25 30 <210> 1213 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 1213 Ser Gly Ala Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys 1 5 10 15 Gly Thr Met Ser Cys Val Trp Val Lys Phe Arg Tyr Asp Thr Ser 20 25 30 <210> 1214 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 1214 Lys Lys Ser Gly Ala Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp 1 5 10 15 Met Lys Gly Thr Met Ser Lys Lys 20 <210> 1215 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 1215 Lys Lys Cys Gly Met Arg Asp Met Lys Gly Thr Met Ser Cys Val Trp 1 5 10 15 Val Lys Phe Arg Tyr Asp Lys Lys 20 <210> 1216 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 1216 Lys Lys Met Arg Asp Met Lys Gly Thr Met Ser Cys Val Trp Val Lys 1 5 10 15 Phe Arg Tyr Asp Thr Ser Lys Lys 20 <210> 1217 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (10)..(21) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (22)..(22) <223> C-terminal amidation <400> 1217 Ser Gly Ala Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys 1 5 10 15 Gly Thr Met Ser Cys Val 20 <210> 1218 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (19)..(19) <223> C-terminal amidation <400> 1218 Ser Gly Ala Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys 1 5 10 15 Gly Thr Met <210> 1219 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (1)..(12) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (22)..(22) <223> C-terminal amidation <400> 1219 Cys Gly Met Arg Asp Met Lys Gly Thr Met Ser Cys Val Trp Val Lys 1 5 10 15 Phe Arg Tyr Asp Thr Ser 20 <210> 1220 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (19)..(19) <223> C-terminal amidation <400> 1220 Arg Asp Met Lys Gly Thr Met Ser Cys Val Trp Val Lys Phe Arg Tyr 1 5 10 15 Asp Thr Ser <210> 1221 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (19)..(19) <223> C-terminal amidation <400> 1221 Arg Asp Met Lys Gly Thr Met Ser Cys Val Trp Val Lys Phe Arg Tyr 1 5 10 15 Asp Thr Ser <210> 1222 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 1222 Ser Gly Ala Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys 1 5 10 15 Gly Thr Met Ser 20 <210> 1223 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 1223 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp 20 <210> 1224 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (1)..(12) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 1224 Cys Gly Met Arg Asp Met Lys Gly Thr Met Ser Cys Val Trp Val Lys 1 5 10 15 Phe Arg Tyr Asp 20 <210> 1225 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 1225 Met Arg Asp Met Lys Gly Thr Met Ser Cys Val Trp Val Lys Phe Arg 1 5 10 15 Tyr Asp Thr Ser 20 <210> 1226 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 1226 Met Arg Asp Met Lys Gly Thr Met Ser Cys Val Trp Val Lys Phe Arg 1 5 10 15 Tyr Asp Thr Ser 20 <210> 1227 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 1227 Cys Gly Met Arg Asp Met Lys Gly Thr Met Ser Cys Val Trp Val Lys 1 5 10 15 Phe Arg Tyr Asp 20 <210> 1228 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 1228 Lys Trp Phe Ser Gly Met Arg Asp Met Lys Gly Thr Met Ser Ser Val 1 5 10 15 Trp Val Lys Phe 20 <210> 1229 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1229 Ser Arg Tyr Lys Trp Phe Ser Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Ser Val Trp Val Lys Phe 20 <210> 1230 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 1230 Ser Arg Tyr Lys Ala Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1231 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1231 Ser Arg Tyr Lys Trp Ala Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1232 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1232 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Ala Val Lys Phe 20 <210> 1233 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (9)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1233 Ser Arg Tyr Lys Trp Phe Gly Met Cys Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1234 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (11)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1234 Ser Arg Tyr Lys Trp Phe Gly Met Arg Asp Cys Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1235 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (13)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1235 Ser Arg Tyr Lys Trp Phe Gly Met Arg Asp Met Lys Cys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1236 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(16) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1236 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Cys 1 5 10 15 Met Ser Val Trp Val Lys Phe 20 <210> 1237 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(14) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1237 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Cys Gly Thr 1 5 10 15 Met Ser Val Trp Val Lys Phe 20 <210> 1238 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(12) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1238 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Cys Met Lys Gly Thr 1 5 10 15 Met Ser Val Trp Val Lys Phe 20 <210> 1239 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (8)..(17) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1239 Ser Arg Tyr Lys Trp Phe Gly Cys Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Cys Ser Val Trp Val Lys Phe 20 <210> 1240 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (9)..(16) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1240 Ser Arg Tyr Lys Trp Phe Gly Met Cys Arg Asp Met Lys Gly Thr Cys 1 5 10 15 Met Ser Val Trp Val Lys Phe 20 <210> 1241 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (7)..(7) <223> Homo-Cys <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (18)..(18) <223> Homo-Cys <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1241 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1242 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (7)..(7) <223> Xaa is (S)-Diaminopropionic acid <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1242 Ser Arg Tyr Lys Trp Phe Xaa Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Asp Val Trp Val Lys Phe 20 <210> 1243 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1243 Ser Arg Tyr Lys Trp Phe Lys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Asp Val Trp Val Lys Phe 20 <210> 1244 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(17) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (22)..(22) <223> C-terminal amidation <400> 1244 Ser Arg Tyr Lys Trp Phe Cys Met Arg Asp Met Lys Gly Thr Met Ser 1 5 10 15 Cys Val Trp Val Lys Phe 20 <210> 1245 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (10)..(10) <223> D-Arg <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1245 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1246 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (16)..(16) <223> D-Met <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1246 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1247 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1247 Ser Arg Tyr Lys Trp Phe Cys Pro Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1248 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1248 Ser Arg Tyr Lys Trp Phe Cys Gly Pro Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1249 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1249 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Pro Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1250 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1250 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Pro Cys Val Trp Val Lys Phe 20 <210> 1251 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1251 Ser Arg Tyr Lys Asp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1252 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1252 Ser Arg Tyr Lys Trp Asp Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1253 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1253 Ser Arg Tyr Lys Trp Phe Cys Asp Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1254 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1254 Ser Arg Tyr Lys Trp Phe Cys Gly Met Asp Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1255 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1255 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Asp Trp Val Lys Phe 20 <210> 1256 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1256 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Asp Val Lys Phe 20 <210> 1257 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1257 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Asp Lys Phe 20 <210> 1258 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1258 Ser Arg Tyr Lys Phe Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1259 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1259 Ser Arg Tyr Lys Trp Phe Cys Phe Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1260 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1260 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Phe Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1261 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1261 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Phe Lys Phe 20 <210> 1262 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1262 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Phe Phe 20 <210> 1263 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1263 Ser Arg Tyr Lys Gly Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1264 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1264 Ser Arg Tyr Lys Trp Gly Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1265 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1265 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Gly Val Lys Phe 20 <210> 1266 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1266 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Gly Lys Phe 20 <210> 1267 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1267 Ser Arg Tyr Lys Lys Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1268 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1268 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Lys Trp Val Lys Phe 20 <210> 1269 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1269 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Lys Val Lys Phe 20 <210> 1270 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1270 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Lys Lys Phe 20 <210> 1271 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1271 Ser Arg Tyr Lys Leu Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1272 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1272 Ser Arg Tyr Lys Trp Phe Cys Leu Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1273 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1273 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Leu Val Lys Phe 20 <210> 1274 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1274 Ser Arg Tyr Lys Ser Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1275 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1275 Ser Arg Tyr Lys Trp Ser Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1276 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1276 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Ser Val Lys Phe 20 <210> 1277 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1277 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Ser Lys Phe 20 <210> 1278 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1278 Ser Arg Tyr Pro Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1279 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1279 Ser Arg Tyr Lys Pro Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1280 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1280 Ser Arg Tyr Lys Trp Pro Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1281 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1281 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Pro Trp Val Lys Phe 20 <210> 1282 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1282 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Pro Val Lys Phe 20 <210> 1283 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1283 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Pro Lys Phe 20 <210> 1284 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 1284 Ser Arg Tyr Lys Trp Phe Cys Glu Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1285 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1285 Ser Arg Tyr Lys Trp Phe Cys His Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1286 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1286 Ser Arg Tyr Lys Trp Phe Cys Ile Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1287 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1287 Ser Arg Tyr Lys Trp Phe Cys Val Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1288 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1288 Ser Arg Tyr Lys Trp Phe Cys Tyr Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1289 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (9)..(9) <223> D-Asp <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1289 Ser Arg Tyr Lys Trp Phe Cys Gly Asp Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1290 <211> 32 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> DISULFID <222> (11)..(22) <223> Cys residues linked via disufide bond <220> <221> MOD_RES <222> (32)..(32) <223> C-terminal amidation <400> 1290 Xaa Ser Gly Ala Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met 1 5 10 15 Lys Gly Thr Met Ser Cys Val Trp Val Lys Phe Arg Tyr Asp Thr Ser 20 25 30 <210> 1291 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> DISULFID <222> (8)..(19) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 1291 Xaa Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr 1 5 10 15 Met Ser Cys Val Trp Val Lys Phe 20 <210> 1292 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 1292 Ser Arg Tyr Lys Trp Phe Cys Gly Met Arg Asp Met Lys Gly Thr Met 1 5 10 15 Ser Cys Val Trp Val Lys Phe 20 <210> 1293 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 1293 Ser Gly Gly Arg Lys His Lys His Phe Leu Arg Ser Asn Gly Lys Pro 1 5 10 15 Ser Arg Ala Leu Ser Ser Met His Phe Trp Arg Trp Ser Thr Ser 20 25 30 <210> 1294 <400> 1294 000 <210> 1295 <400> 1295 000 <210> 1296 <400> 1296 000 <210> 1297 <400> 1297 000 <210> 1298 <400> 1298 000 <210> 1299 <400> 1299 000 <210> 1300 <400> 1300 000 <210> 1301 <400> 1301 000 <210> 1302 <400> 1302 000 <210> 1303 <400> 1303 000 <210> 1304 <400> 1304 000 <210> 1305 <400> 1305 000 <210> 1306 <400> 1306 000 <210> 1307 <400> 1307 000 <210> 1308 <400> 1308 000 <210> 1309 <400> 1309 000 <210> 1310 <400> 1310 000 <210> 1311 <400> 1311 000 <210> 1312 <400> 1312 000 <210> 1313 <400> 1313 000 <210> 1314 <400> 1314 000 <210> 1315 <400> 1315 000 <210> 1316 <400> 1316 000 <210> 1317 <400> 1317 000 <210> 1318 <400> 1318 000 <210> 1319 <400> 1319 000 <210> 1320 <400> 1320 000 <210> 1321 <400> 1321 000 <210> 1322 <400> 1322 000 <210> 1323 <400> 1323 000 <210> 1324 <400> 1324 000 <210> 1325 <400> 1325 000 <210> 1326 <400> 1326 000 <210> 1327 <400> 1327 000 <210> 1328 <400> 1328 000 <210> 1329 <400> 1329 000 <210> 1330 <400> 1330 000 <210> 1331 <400> 1331 000 <210> 1332 <400> 1332 000 <210> 1333 <400> 1333 000 <210> 1334 <400> 1334 000 <210> 1335 <400> 1335 000 <210> 1336 <400> 1336 000 <210> 1337 <400> 1337 000 <210> 1338 <400> 1338 000 <210> 1339 <400> 1339 000 <210> 1340 <400> 1340 000 <210> 1341 <400> 1341 000 <210> 1342 <400> 1342 000 <210> 1343 <400> 1343 000 <210> 1344 <400> 1344 000 <210> 1345 <400> 1345 000 <210> 1346 <400> 1346 000 <210> 1347 <400> 1347 000 <210> 1348 <400> 1348 000 <210> 1349 <400> 1349 000 <210> 1350 <400> 1350 000 <210> 1351 <400> 1351 000 <210> 1352 <400> 1352 000 <210> 1353 <400> 1353 000 <210> 1354 <400> 1354 000 <210> 1355 <400> 1355 000 <210> 1356 <400> 1356 000 <210> 1357 <400> 1357 000 <210> 1358 <400> 1358 000 <210> 1359 <400> 1359 000 <210> 1360 <400> 1360 000 <210> 1361 <400> 1361 000 <210> 1362 <400> 1362 000 <210> 1363 <400> 1363 000 <210> 1364 <400> 1364 000 <210> 1365 <400> 1365 000 <210> 1366 <400> 1366 000 <210> 1367 <400> 1367 000 <210> 1368 <400> 1368 000 <210> 1369 <400> 1369 000 <210> 1370 <400> 1370 000 <210> 1371 <400> 1371 000 <210> 1372 <400> 1372 000 <210> 1373 <400> 1373 000 <210> 1374 <400> 1374 000 <210> 1375 <400> 1375 000 <210> 1376 <400> 1376 000 <210> 1377 <400> 1377 000 <210> 1378 <400> 1378 000 <210> 1379 <400> 1379 000 <210> 1380 <400> 1380 000 <210> 1381 <400> 1381 000 <210> 1382 <400> 1382 000 <210> 1383 <400> 1383 000 <210> 1384 <400> 1384 000 <210> 1385 <400> 1385 000 <210> 1386 <400> 1386 000 <210> 1387 <400> 1387 000 <210> 1388 <400> 1388 000 <210> 1389 <400> 1389 000 <210> 1390 <400> 1390 000 <210> 1391 <400> 1391 000 <210> 1392 <400> 1392 000 <210> 1393 <400> 1393 000 <210> 1394 <400> 1394 000 <210> 1395 <400> 1395 000 <210> 1396 <400> 1396 000 <210> 1397 <400> 1397 000 <210> 1398 <400> 1398 000 <210> 1399 <400> 1399 000 <210> 1400 <400> 1400 000 <210> 1401 <400> 1401 000 <210> 1402 <400> 1402 000 <210> 1403 <400> 1403 000 <210> 1404 <400> 1404 000 <210> 1405 <400> 1405 000 <210> 1406 <400> 1406 000 <210> 1407 <400> 1407 000 <210> 1408 <400> 1408 000 <210> 1409 <400> 1409 000 <210> 1410 <400> 1410 000 <210> 1411 <400> 1411 000 <210> 1412 <400> 1412 000 <210> 1413 <400> 1413 000 <210> 1414 <400> 1414 000 <210> 1415 <400> 1415 000 <210> 1416 <400> 1416 000 <210> 1417 <400> 1417 000 <210> 1418 <400> 1418 000 <210> 1419 <400> 1419 000 <210> 1420 <400> 1420 000 <210> 1421 <400> 1421 000 <210> 1422 <400> 1422 000 <210> 1423 <400> 1423 000 <210> 1424 <400> 1424 000 <210> 1425 <400> 1425 000 <210> 1426 <400> 1426 000 <210> 1427 <400> 1427 000 <210> 1428 <400> 1428 000 <210> 1429 <400> 1429 000 <210> 1430 <400> 1430 000 <210> 1431 <400> 1431 000 <210> 1432 <400> 1432 000 <210> 1433 <400> 1433 000 <210> 1434 <400> 1434 000 <210> 1435 <400> 1435 000 <210> 1436 <400> 1436 000 <210> 1437 <400> 1437 000 <210> 1438 <400> 1438 000 <210> 1439 <400> 1439 000 <210> 1440 <400> 1440 000 <210> 1441 <400> 1441 000 <210> 1442 <400> 1442 000 <210> 1443 <400> 1443 000 <210> 1444 <400> 1444 000 <210> 1445 <400> 1445 000 <210> 1446 <400> 1446 000 <210> 1447 <400> 1447 000 <210> 1448 <400> 1448 000 <210> 1449 <400> 1449 000 <210> 1450 <400> 1450 000 <210> 1451 <400> 1451 000 <210> 1452 <400> 1452 000 <210> 1453 <400> 1453 000 <210> 1454 <400> 1454 000 <210> 1455 <400> 1455 000 <210> 1456 <400> 1456 000 <210> 1457 <400> 1457 000 <210> 1458 <400> 1458 000 <210> 1459 <400> 1459 000 <210> 1460 <400> 1460 000 <210> 1461 <400> 1461 000 <210> 1462 <400> 1462 000 <210> 1463 <400> 1463 000 <210> 1464 <400> 1464 000 <210> 1465 <400> 1465 000 <210> 1466 <400> 1466 000 <210> 1467 <400> 1467 000 <210> 1468 <400> 1468 000 <210> 1469 <400> 1469 000 <210> 1470 <400> 1470 000 <210> 1471 <400> 1471 000 <210> 1472 <400> 1472 000 <210> 1473 <400> 1473 000 <210> 1474 <400> 1474 000 <210> 1475 <400> 1475 000 <210> 1476 <400> 1476 000 <210> 1477 <400> 1477 000 <210> 1478 <400> 1478 000 <210> 1479 <400> 1479 000 <210> 1480 <400> 1480 000 <210> 1481 <400> 1481 000 <210> 1482 <400> 1482 000 <210> 1483 <400> 1483 000 <210> 1484 <400> 1484 000 <210> 1485 <400> 1485 000 <210> 1486 <400> 1486 000 <210> 1487 <400> 1487 000 <210> 1488 <400> 1488 000 <210> 1489 <400> 1489 000 <210> 1490 <400> 1490 000 <210> 1491 <400> 1491 000 <210> 1492 <400> 1492 000 <210> 1493 <400> 1493 000 <210> 1494 <400> 1494 000 <210> 1495 <400> 1495 000 <210> 1496 <400> 1496 000 <210> 1497 <400> 1497 000 <210> 1498 <400> 1498 000 <210> 1499 <400> 1499 000 <210> 1500 <400> 1500 000 <210> 1501 <400> 1501 000 <210> 1502 <400> 1502 000 <210> 1503 <400> 1503 000 <210> 1504 <400> 1504 000 <210> 1505 <400> 1505 000 <210> 1506 <400> 1506 000 <210> 1507 <400> 1507 000 <210> 1508 <400> 1508 000 <210> 1509 <400> 1509 000 <210> 1510 <400> 1510 000 <210> 1511 <400> 1511 000 <210> 1512 <400> 1512 000 <210> 1513 <400> 1513 000 <210> 1514 <400> 1514 000 <210> 1515 <400> 1515 000 <210> 1516 <400> 1516 000 <210> 1517 <400> 1517 000 <210> 1518 <400> 1518 000 <210> 1519 <400> 1519 000 <210> 1520 <400> 1520 000 <210> 1521 <400> 1521 000 <210> 1522 <400> 1522 000 <210> 1523 <400> 1523 000 <210> 1524 <400> 1524 000 <210> 1525 <400> 1525 000 <210> 1526 <400> 1526 000 <210> 1527 <400> 1527 000 <210> 1528 <400> 1528 000 <210> 1529 <400> 1529 000 <210> 1530 <400> 1530 000 <210> 1531 <400> 1531 000 <210> 1532 <400> 1532 000 <210> 1533 <400> 1533 000 <210> 1534 <400> 1534 000 <210> 1535 <400> 1535 000 <210> 1536 <400> 1536 000 <210> 1537 <400> 1537 000 <210> 1538 <400> 1538 000 <210> 1539 <400> 1539 000 <210> 1540 <400> 1540 000 <210> 1541 <400> 1541 000 <210> 1542 <400> 1542 000 <210> 1543 <400> 1543 000 <210> 1544 <400> 1544 000 <210> 1545 <400> 1545 000 <210> 1546 <400> 1546 000 <210> 1547 <400> 1547 000 <210> 1548 <400> 1548 000 <210> 1549 <400> 1549 000 <210> 1550 <400> 1550 000 <210> 1551 <400> 1551 000 <210> 1552 <400> 1552 000 <210> 1553 <400> 1553 000 <210> 1554 <400> 1554 000 <210> 1555 <400> 1555 000 <210> 1556 <400> 1556 000 <210> 1557 <400> 1557 000 <210> 1558 <400> 1558 000 <210> 1559 <400> 1559 000 <210> 1560 <400> 1560 000 <210> 1561 <400> 1561 000 <210> 1562 <400> 1562 000 <210> 1563 <400> 1563 000 <210> 1564 <400> 1564 000 <210> 1565 <400> 1565 000 <210> 1566 <400> 1566 000 <210> 1567 <400> 1567 000 <210> 1568 <400> 1568 000 <210> 1569 <400> 1569 000 <210> 1570 <400> 1570 000 <210> 1571 <400> 1571 000 <210> 1572 <400> 1572 000 <210> 1573 <400> 1573 000 <210> 1574 <400> 1574 000 <210> 1575 <400> 1575 000 <210> 1576 <400> 1576 000 <210> 1577 <400> 1577 000 <210> 1578 <400> 1578 000 <210> 1579 <400> 1579 000 <210> 1580 <400> 1580 000 <210> 1581 <400> 1581 000 <210> 1582 <400> 1582 000 <210> 1583 <400> 1583 000 <210> 1584 <400> 1584 000 <210> 1585 <400> 1585 000 <210> 1586 <400> 1586 000 <210> 1587 <400> 1587 000 <210> 1588 <400> 1588 000 <210> 1589 <400> 1589 000 <210> 1590 <400> 1590 000 <210> 1591 <400> 1591 000 <210> 1592 <400> 1592 000 <210> 1593 <400> 1593 000 <210> 1594 <400> 1594 000 <210> 1595 <400> 1595 000 <210> 1596 <400> 1596 000 <210> 1597 <400> 1597 000 <210> 1598 <400> 1598 000 <210> 1599 <400> 1599 000 <210> 1600 <400> 1600 000 <210> 1601 <400> 1601 000 <210> 1602 <400> 1602 000 <210> 1603 <400> 1603 000 <210> 1604 <400> 1604 000 <210> 1605 <400> 1605 000 <210> 1606 <400> 1606 000 <210> 1607 <400> 1607 000 <210> 1608 <400> 1608 000 <210> 1609 <400> 1609 000 <210> 1610 <400> 1610 000 <210> 1611 <400> 1611 000 <210> 1612 <400> 1612 000 <210> 1613 <400> 1613 000 <210> 1614 <400> 1614 000 <210> 1615 <400> 1615 000 <210> 1616 <400> 1616 000 <210> 1617 <400> 1617 000 <210> 1618 <400> 1618 000 <210> 1619 <400> 1619 000 <210> 1620 <400> 1620 000 <210> 1621 <400> 1621 000 <210> 1622 <400> 1622 000 <210> 1623 <400> 1623 000 <210> 1624 <400> 1624 000 <210> 1625 <400> 1625 000 <210> 1626 <400> 1626 000 <210> 1627 <400> 1627 000 <210> 1628 <400> 1628 000 <210> 1629 <400> 1629 000 <210> 1630 <400> 1630 000 <210> 1631 <400> 1631 000 <210> 1632 <400> 1632 000 <210> 1633 <400> 1633 000 <210> 1634 <400> 1634 000 <210> 1635 <400> 1635 000 <210> 1636 <400> 1636 000 <210> 1637 <400> 1637 000 <210> 1638 <400> 1638 000 <210> 1639 <400> 1639 000 <210> 1640 <400> 1640 000 <210> 1641 <400> 1641 000 <210> 1642 <400> 1642 000 <210> 1643 <400> 1643 000 <210> 1644 <400> 1644 000 <210> 1645 <400> 1645 000 <210> 1646 <400> 1646 000 <210> 1647 <400> 1647 000 <210> 1648 <400> 1648 000 <210> 1649 <400> 1649 000 <210> 1650 <400> 1650 000 <210> 1651 <400> 1651 000 <210> 1652 <400> 1652 000 <210> 1653 <400> 1653 000 <210> 1654 <400> 1654 000 <210> 1655 <400> 1655 000 <210> 1656 <400> 1656 000 <210> 1657 <400> 1657 000 <210> 1658 <400> 1658 000 <210> 1659 <400> 1659 000 <210> 1660 <400> 1660 000 <210> 1661 <400> 1661 000 <210> 1662 <400> 1662 000 <210> 1663 <400> 1663 000 <210> 1664 <400> 1664 000 <210> 1665 <400> 1665 000 <210> 1666 <400> 1666 000 <210> 1667 <400> 1667 000 <210> 1668 <400> 1668 000 <210> 1669 <400> 1669 000 <210> 1670 <400> 1670 000 <210> 1671 <400> 1671 000 <210> 1672 <400> 1672 000 <210> 1673 <400> 1673 000 <210> 1674 <400> 1674 000 <210> 1675 <400> 1675 000 <210> 1676 <400> 1676 000 <210> 1677 <400> 1677 000 <210> 1678 <400> 1678 000 <210> 1679 <400> 1679 000 <210> 1680 <400> 1680 000 <210> 1681 <400> 1681 000 <210> 1682 <400> 1682 000 <210> 1683 <400> 1683 000 <210> 1684 <400> 1684 000 <210> 1685 <400> 1685 000 <210> 1686 <400> 1686 000 <210> 1687 <400> 1687 000 <210> 1688 <400> 1688 000 <210> 1689 <400> 1689 000 <210> 1690 <400> 1690 000 <210> 1691 <400> 1691 000 <210> 1692 <400> 1692 000 <210> 1693 <400> 1693 000 <210> 1694 <400> 1694 000 <210> 1695 <400> 1695 000 <210> 1696 <400> 1696 000 <210> 1697 <400> 1697 000 <210> 1698 <400> 1698 000 <210> 1699 <400> 1699 000 <210> 1700 <400> 1700 000 <210> 1701 <400> 1701 000 <210> 1702 <400> 1702 000 <210> 1703 <400> 1703 000 <210> 1704 <400> 1704 000 <210> 1705 <400> 1705 000 <210> 1706 <400> 1706 000 <210> 1707 <400> 1707 000 <210> 1708 <400> 1708 000 <210> 1709 <400> 1709 000 <210> 1710 <400> 1710 000 <210> 1711 <400> 1711 000 <210> 1712 <400> 1712 000 <210> 1713 <400> 1713 000 <210> 1714 <400> 1714 000 <210> 1715 <400> 1715 000 <210> 1716 <400> 1716 000 <210> 1717 <400> 1717 000 <210> 1718 <400> 1718 000 <210> 1719 <400> 1719 000 <210> 1720 <400> 1720 000 <210> 1721 <400> 1721 000 <210> 1722 <400> 1722 000 <210> 1723 <400> 1723 000 <210> 1724 <400> 1724 000 <210> 1725 <400> 1725 000 <210> 1726 <400> 1726 000 <210> 1727 <400> 1727 000 <210> 1728 <400> 1728 000 <210> 1729 <400> 1729 000 <210> 1730 <400> 1730 000 <210> 1731 <400> 1731 000 <210> 1732 <400> 1732 000 <210> 1733 <400> 1733 000 <210> 1734 <400> 1734 000 <210> 1735 <400> 1735 000 <210> 1736 <400> 1736 000 <210> 1737 <400> 1737 000 <210> 1738 <400> 1738 000 <210> 1739 <400> 1739 000 <210> 1740 <400> 1740 000 <210> 1741 <400> 1741 000 <210> 1742 <400> 1742 000 <210> 1743 <400> 1743 000 <210> 1744 <400> 1744 000 <210> 1745 <400> 1745 000 <210> 1746 <400> 1746 000 <210> 1747 <400> 1747 000 <210> 1748 <400> 1748 000 <210> 1749 <400> 1749 000 <210> 1750 <400> 1750 000 <210> 1751 <400> 1751 000 <210> 1752 <400> 1752 000 <210> 1753 <400> 1753 000 <210> 1754 <400> 1754 000 <210> 1755 <400> 1755 000 <210> 1756 <400> 1756 000 <210> 1757 <400> 1757 000 <210> 1758 <400> 1758 000 <210> 1759 <400> 1759 000 <210> 1760 <400> 1760 000 <210> 1761 <400> 1761 000 <210> 1762 <400> 1762 000 <210> 1763 <400> 1763 000 <210> 1764 <400> 1764 000 <210> 1765 <400> 1765 000 <210> 1766 <400> 1766 000 <210> 1767 <400> 1767 000 <210> 1768 <400> 1768 000 <210> 1769 <400> 1769 000 <210> 1770 <400> 1770 000 <210> 1771 <400> 1771 000 <210> 1772 <400> 1772 000 <210> 1773 <400> 1773 000 <210> 1774 <400> 1774 000 <210> 1775 <400> 1775 000 <210> 1776 <400> 1776 000 <210> 1777 <400> 1777 000 <210> 1778 <400> 1778 000 <210> 1779 <400> 1779 000 <210> 1780 <400> 1780 000 <210> 1781 <400> 1781 000 <210> 1782 <400> 1782 000 <210> 1783 <400> 1783 000 <210> 1784 <400> 1784 000 <210> 1785 <400> 1785 000 <210> 1786 <400> 1786 000 <210> 1787 <400> 1787 000 <210> 1788 <400> 1788 000 <210> 1789 <400> 1789 000 <210> 1790 <400> 1790 000 <210> 1791 <400> 1791 000 <210> 1792 <400> 1792 000 <210> 1793 <400> 1793 000 <210> 1794 <400> 1794 000 <210> 1795 <400> 1795 000 <210> 1796 <400> 1796 000 <210> 1797 <400> 1797 000 <210> 1798 <400> 1798 000 <210> 1799 <400> 1799 000 <210> 1800 <400> 1800 000 <210> 1801 <400> 1801 000 <210> 1802 <400> 1802 000 <210> 1803 <400> 1803 000 <210> 1804 <400> 1804 000 <210> 1805 <400> 1805 000 <210> 1806 <400> 1806 000 <210> 1807 <400> 1807 000 <210> 1808 <400> 1808 000 <210> 1809 <400> 1809 000 <210> 1810 <400> 1810 000 <210> 1811 <400> 1811 000 <210> 1812 <400> 1812 000 <210> 1813 <400> 1813 000 <210> 1814 <400> 1814 000 <210> 1815 <400> 1815 000 <210> 1816 <400> 1816 000 <210> 1817 <400> 1817 000 <210> 1818 <400> 1818 000 <210> 1819 <400> 1819 000 <210> 1820 <400> 1820 000 <210> 1821 <400> 1821 000 <210> 1822 <400> 1822 000 <210> 1823 <400> 1823 000 <210> 1824 <400> 1824 000 <210> 1825 <400> 1825 000 <210> 1826 <400> 1826 000 <210> 1827 <400> 1827 000 <210> 1828 <400> 1828 000 <210> 1829 <400> 1829 000 <210> 1830 <400> 1830 000 <210> 1831 <400> 1831 000 <210> 1832 <400> 1832 000 <210> 1833 <400> 1833 000 <210> 1834 <400> 1834 000 <210> 1835 <400> 1835 000 <210> 1836 <400> 1836 000 <210> 1837 <400> 1837 000 <210> 1838 <400> 1838 000 <210> 1839 <400> 1839 000 <210> 1840 <400> 1840 000 <210> 1841 <400> 1841 000 <210> 1842 <400> 1842 000 <210> 1843 <400> 1843 000 <210> 1844 <400> 1844 000 <210> 1845 <400> 1845 000 <210> 1846 <400> 1846 000 <210> 1847 <400> 1847 000 <210> 1848 <400> 1848 000 <210> 1849 <400> 1849 000 <210> 1850 <400> 1850 000 <210> 1851 <400> 1851 000 <210> 1852 <400> 1852 000 <210> 1853 <400> 1853 000 <210> 1854 <400> 1854 000 <210> 1855 <400> 1855 000 <210> 1856 <400> 1856 000 <210> 1857 <400> 1857 000 <210> 1858 <400> 1858 000 <210> 1859 <400> 1859 000 <210> 1860 <400> 1860 000 <210> 1861 <400> 1861 000 <210> 1862 <400> 1862 000 <210> 1863 <400> 1863 000 <210> 1864 <400> 1864 000 <210> 1865 <400> 1865 000 <210> 1866 <400> 1866 000 <210> 1867 <400> 1867 000 <210> 1868 <400> 1868 000 <210> 1869 <400> 1869 000 <210> 1870 <400> 1870 000 <210> 1871 <400> 1871 000 <210> 1872 <400> 1872 000 <210> 1873 <400> 1873 000 <210> 1874 <400> 1874 000 <210> 1875 <400> 1875 000 <210> 1876 <400> 1876 000 <210> 1877 <400> 1877 000 <210> 1878 <400> 1878 000 <210> 1879 <400> 1879 000 <210> 1880 <400> 1880 000 <210> 1881 <400> 1881 000 <210> 1882 <400> 1882 000 <210> 1883 <400> 1883 000 <210> 1884 <400> 1884 000 <210> 1885 <400> 1885 000 <210> 1886 <400> 1886 000 <210> 1887 <400> 1887 000 <210> 1888 <400> 1888 000 <210> 1889 <400> 1889 000 <210> 1890 <400> 1890 000 <210> 1891 <400> 1891 000 <210> 1892 <400> 1892 000 <210> 1893 <400> 1893 000 <210> 1894 <400> 1894 000 <210> 1895 <400> 1895 000 <210> 1896 <400> 1896 000 <210> 1897 <400> 1897 000 <210> 1898 <400> 1898 000 <210> 1899 <400> 1899 000 <210> 1900 <400> 1900 000 <210> 1901 <400> 1901 000 <210> 1902 <400> 1902 000 <210> 1903 <400> 1903 000 <210> 1904 <400> 1904 000 <210> 1905 <400> 1905 000 <210> 1906 <400> 1906 000 <210> 1907 <400> 1907 000 <210> 1908 <400> 1908 000 <210> 1909 <400> 1909 000 <210> 1910 <400> 1910 000 <210> 1911 <400> 1911 000 <210> 1912 <400> 1912 000 <210> 1913 <400> 1913 000 <210> 1914 <400> 1914 000 <210> 1915 <400> 1915 000 <210> 1916 <400> 1916 000 <210> 1917 <400> 1917 000 <210> 1918 <400> 1918 000 <210> 1919 <400> 1919 000 <210> 1920 <400> 1920 000 <210> 1921 <400> 1921 000 <210> 1922 <400> 1922 000 <210> 1923 <400> 1923 000 <210> 1924 <400> 1924 000 <210> 1925 <400> 1925 000 <210> 1926 <400> 1926 000 <210> 1927 <400> 1927 000 <210> 1928 <400> 1928 000 <210> 1929 <400> 1929 000 <210> 1930 <400> 1930 000 <210> 1931 <400> 1931 000 <210> 1932 <400> 1932 000 <210> 1933 <400> 1933 000 <210> 1934 <400> 1934 000 <210> 1935 <400> 1935 000 <210> 1936 <400> 1936 000 <210> 1937 <400> 1937 000 <210> 1938 <400> 1938 000 <210> 1939 <400> 1939 000 <210> 1940 <400> 1940 000 <210> 1941 <400> 1941 000 <210> 1942 <400> 1942 000 <210> 1943 <400> 1943 000 <210> 1944 <400> 1944 000 <210> 1945 <400> 1945 000 <210> 1946 <400> 1946 000 <210> 1947 <400> 1947 000 <210> 1948 <400> 1948 000 <210> 1949 <400> 1949 000 <210> 1950 <400> 1950 000 <210> 1951 <400> 1951 000 <210> 1952 <400> 1952 000 <210> 1953 <400> 1953 000 <210> 1954 <400> 1954 000 <210> 1955 <400> 1955 000 <210> 1956 <400> 1956 000 <210> 1957 <400> 1957 000 <210> 1958 <400> 1958 000 <210> 1959 <400> 1959 000 <210> 1960 <400> 1960 000 <210> 1961 <400> 1961 000 <210> 1962 <400> 1962 000 <210> 1963 <400> 1963 000 <210> 1964 <400> 1964 000 <210> 1965 <400> 1965 000 <210> 1966 <400> 1966 000 <210> 1967 <400> 1967 000 <210> 1968 <400> 1968 000 <210> 1969 <400> 1969 000 <210> 1970 <400> 1970 000 <210> 1971 <400> 1971 000 <210> 1972 <400> 1972 000 <210> 1973 <400> 1973 000 <210> 1974 <400> 1974 000 <210> 1975 <400> 1975 000 <210> 1976 <400> 1976 000 <210> 1977 <400> 1977 000 <210> 1978 <400> 1978 000 <210> 1979 <400> 1979 000 <210> 1980 <400> 1980 000 <210> 1981 <400> 1981 000 <210> 1982 <400> 1982 000 <210> 1983 <400> 1983 000 <210> 1984 <400> 1984 000 <210> 1985 <400> 1985 000 <210> 1986 <400> 1986 000 <210> 1987 <400> 1987 000 <210> 1988 <400> 1988 000 <210> 1989 <400> 1989 000 <210> 1990 <400> 1990 000 <210> 1991 <400> 1991 000 <210> 1992 <400> 1992 000 <210> 1993 <400> 1993 000 <210> 1994 <400> 1994 000 <210> 1995 <400> 1995 000 <210> 1996 <400> 1996 000 <210> 1997 <400> 1997 000 <210> 1998 <400> 1998 000 <210> 1999 <400> 1999 000 <210> 2000 <400> 2000 000 <210> 2001 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 2001 Ser Gly Tyr Ala Ser Phe Ala Leu Ala Val Gln Leu His Val Ser Lys 1 5 10 15 Arg Ser Lys Glu Met Ala Leu Ala Arg Leu Tyr Tyr Lys Thr Ser 20 25 30 <210> 2002 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 2002 Ser Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys 1 5 10 15 Arg Ser Lys Glu Met Ala Leu Ala Arg Leu Tyr Tyr Lys Thr Ser 20 25 30 <210> 2003 <211> 35 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (35)..(35) <223> C-terminal amidation <400> 2003 Lys Lys Ser Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val 1 5 10 15 Ser Lys Arg Ser Lys Glu Met Ala Leu Ala Arg Leu Tyr Tyr Lys Thr 20 25 30 Ser Lys Lys 35 <210> 2004 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 2004 Ala Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys 1 5 10 15 Arg Ser Lys Glu Met Ala Leu Ala Arg Leu Tyr Tyr Lys Thr Ser 20 25 30 <210> 2005 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 2005 Ser Ala Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys 1 5 10 15 Arg Ser Lys Glu Met Ala Leu Ala Arg Leu Tyr Tyr Lys Thr Ser 20 25 30 <210> 2006 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 2006 Ser Gly Tyr Ala Ala Phe Pro Leu Ala Val Gln Leu His Val Ser Lys 1 5 10 15 Arg Ser Lys Glu Met Ala Leu Ala Arg Leu Tyr Tyr Lys Thr Ser 20 25 30 <210> 2007 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 2007 Ser Gly Tyr Ala Ser Phe Pro Leu Ala Val Ala Leu His Val Ser Lys 1 5 10 15 Arg Ser Lys Glu Met Ala Leu Ala Arg Leu Tyr Tyr Lys Thr Ser 20 25 30 <210> 2008 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 2008 Ser Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ala Lys 1 5 10 15 Arg Ser Lys Glu Met Ala Leu Ala Arg Leu Tyr Tyr Lys Thr Ser 20 25 30 <210> 2009 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 2009 Ser Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys 1 5 10 15 Arg Ala Lys Glu Met Ala Leu Ala Arg Leu Tyr Tyr Lys Thr Ser 20 25 30 <210> 2010 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 2010 Ser Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys 1 5 10 15 Arg Ser Ala Glu Met Ala Leu Ala Arg Leu Tyr Tyr Lys Thr Ser 20 25 30 <210> 2011 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 2011 Ser Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys 1 5 10 15 Arg Ser Lys Glu Met Ala Leu Ala Ala Leu Tyr Tyr Lys Thr Ser 20 25 30 <210> 2012 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 2012 Ser Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys 1 5 10 15 Arg Ser Lys Glu Met Ala Leu Ala Arg Leu Tyr Tyr Ala Thr Ser 20 25 30 <210> 2013 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 2013 Ser Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys 1 5 10 15 Arg Ser Lys Glu Met Ala Leu Ala Arg Leu Tyr Tyr Lys Ala Ser 20 25 30 <210> 2014 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 2014 Ser Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys 1 5 10 15 Arg Ser Lys Glu Met Ala Leu Ala Arg Leu Tyr Tyr Lys Thr Ala 20 25 30 <210> 2015 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2015 Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ala Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2016 <211> 32 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (32)..(32) <223> C-terminal amidation <400> 2016 Lys Lys Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala Leu Ala Arg Leu Tyr Tyr Lys Thr Ser Lys Lys 20 25 30 <210> 2017 <211> 25 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (25)..(25) <223> C-terminal amidation <400> 2017 Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys Arg Ser Lys 1 5 10 15 Glu Met Ala Leu Ala Arg Leu Tyr Tyr 20 25 <210> 2018 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 2018 Ser Gly Tyr Ala Ser Phe Pro Ala Ala Val Gln Leu His Val Ser Lys 1 5 10 15 Arg Ser Lys Glu Met Ala Leu Ala Arg Leu Tyr Tyr Lys Thr Ser 20 25 30 <210> 2019 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 2019 Ser Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Ala His Val Ser Lys 1 5 10 15 Arg Ser Lys Glu Met Ala Leu Ala Arg Leu Tyr Tyr Lys Thr Ser 20 25 30 <210> 2020 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 2020 Ser Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys 1 5 10 15 Arg Ser Lys Ala Met Ala Leu Ala Arg Leu Tyr Tyr Lys Thr Ser 20 25 30 <210> 2021 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 2021 Ser Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys 1 5 10 15 Arg Ser Lys Glu Met Ala Leu Ala Arg Ala Tyr Tyr Lys Thr Ser 20 25 30 <210> 2022 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2022 Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Met Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2023 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2023 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2024 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2024 Ala Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2025 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2025 Gly Tyr Ala Ala Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2026 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2026 Gly Tyr Ala Ser Phe Pro Trp Ala Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2027 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2027 Gly Tyr Ala Ser Phe Pro Trp Phe Val Ala Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2028 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2028 Cys Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2029 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2029 Gly Cys Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2030 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2030 Gly Tyr Cys Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2031 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2031 Gly Tyr Ala Cys Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2032 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2032 Gly Tyr Ala Ser Cys Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2033 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2033 Gly Tyr Ala Ser Phe Pro Cys Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2034 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2034 Gly Tyr Ala Ser Phe Pro Trp Cys Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2035 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2035 Gly Tyr Ala Ser Phe Pro Trp Phe Cys Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2036 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2036 Gly Tyr Ala Ser Phe Pro Trp Phe Val Cys Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2037 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2037 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Cys His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2038 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2038 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val Cys Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2039 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2039 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Cys Trp Glu Met Ala 20 <210> 2040 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2040 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Cys Glu Met Ala 20 <210> 2041 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2041 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Cys Met Ala 20 <210> 2042 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2042 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Cys Ala 20 <210> 2043 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2043 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Cys 20 <210> 2044 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2044 Asp Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2045 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2045 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val Phe Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2046 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2046 Gly Tyr Gly Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2047 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2047 Gly Tyr Ala Gly Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2048 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2048 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Gly Trp Glu Met Ala 20 <210> 2049 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2049 Gly Tyr His Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2050 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2050 Gly Tyr Ala His Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2051 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2051 Gly Tyr Ala Ser His Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2052 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2052 Gly Tyr Ala Ser Phe Pro Trp His Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2053 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2053 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp His Met Ala 20 <210> 2054 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2054 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met His 20 <210> 2055 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2055 Gly Tyr Ile Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2056 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2056 Gly Tyr Ala Ile Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2057 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2057 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Ile His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2058 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2058 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val Ile Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2059 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2059 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ile Trp Glu Met Ala 20 <210> 2060 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2060 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Ile Glu Met Ala 20 <210> 2061 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2061 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ile 20 <210> 2062 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2062 Lys Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2063 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2063 Gly Lys Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2064 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2064 Gly Tyr Lys Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2065 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2065 Gly Tyr Ala Lys Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2066 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2066 Gly Tyr Ala Ser Lys Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2067 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2067 Gly Tyr Ala Ser Phe Pro Trp Lys Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2068 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2068 Gly Tyr Ala Ser Phe Pro Trp Phe Val Lys Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2069 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2069 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Lys His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2070 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2070 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Lys His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2071 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2071 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Lys Trp Glu Met Ala 20 <210> 2072 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2072 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Lys Met Ala 20 <210> 2073 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2073 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Lys 20 <210> 2074 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2074 Leu Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2075 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2075 Gly Tyr Leu Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2076 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2076 Gly Tyr Ala Leu Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2077 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2077 Gly Tyr Ala Ser Phe Pro Trp Phe Val Leu Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2078 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2078 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Leu Trp Glu Met Ala 20 <210> 2079 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2079 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Leu 20 <210> 2080 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2080 Met Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2081 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2081 Gly Tyr Met Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2082 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2082 Gly Tyr Ala Met Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2083 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2083 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Met His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2084 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2084 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Met 20 <210> 2085 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2085 Asn Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2086 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2086 Gly Tyr Ala Asn Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2087 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2087 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Asn Trp Glu Met Ala 20 <210> 2088 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2088 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Asn 20 <210> 2089 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2089 Pro Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2090 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2090 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Gln Trp Glu Met Ala 20 <210> 2091 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2091 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Gln 20 <210> 2092 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2092 Arg Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2093 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2093 Gly Arg Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2094 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2094 Gly Tyr Arg Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2095 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2095 Gly Tyr Ala Arg Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2096 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2096 Gly Tyr Ala Ser Arg Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2097 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2097 Gly Tyr Ala Ser Phe Pro Arg Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2098 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2098 Gly Tyr Ala Ser Phe Pro Trp Arg Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2099 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2099 Gly Tyr Ala Ser Phe Pro Trp Phe Arg Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2100 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2100 Gly Tyr Ala Ser Phe Pro Trp Phe Val Arg Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2101 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2101 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Arg His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2102 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2102 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Arg His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2103 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2103 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val Arg Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2104 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2104 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Arg Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2105 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2105 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Arg Trp Glu Met Ala 20 <210> 2106 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2106 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Arg Glu Met Ala 20 <210> 2107 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2107 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Arg Met Ala 20 <210> 2108 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2108 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Arg 20 <210> 2109 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2109 Ser Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2110 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2110 Gly Tyr Ser Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2111 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2111 Gly Tyr Ala Ser Phe Pro Trp Phe Val Ser Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2112 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2112 Thr Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2113 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2113 Gly Tyr Thr Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2114 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2114 Gly Tyr Ala Thr Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2115 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2115 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Thr Trp Glu Met Ala 20 <210> 2116 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2116 Gly Tyr Ala Ser Phe Pro Trp Val Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2117 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2117 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Val His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2118 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2118 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Val Trp Glu Met Ala 20 <210> 2119 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2119 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Val 20 <210> 2120 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2120 Gly Trp Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2121 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2121 Gly Tyr Trp Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2122 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2122 Gly Tyr Ala Ser Trp Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2123 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2123 Gly Tyr Ala Ser Phe Pro Trp Trp Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2124 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2124 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Trp His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2125 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 2125 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Trp 20 <210> 2126 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2126 Gly Tyr Ala Ser Phe Pro Trp Tyr Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2127 <211> 30 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (30)..(30) <223> C-terminal amidation <400> 2127 Met Lys Ser Arg Ser Leu Gly Leu Ala Tyr Phe Ala Lys His Ser Ser 1 5 10 15 Leu Glu Val Leu Gln Thr Arg Lys Val Ala Ala Pro Tyr Tyr 20 25 30 <210> 2128 <211> 29 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (29)..(29) <223> C-terminal amidation <400> 2128 Lys Lys Ser Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val 1 5 10 15 Ser Lys Arg Ser Lys Glu Met Ala Leu Ala Arg Lys Lys 20 25 <210> 2129 <211> 29 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (29)..(29) <223> C-terminal amidation <400> 2129 Lys Lys Pro Leu Ala Val Gln Leu His Val Ser Lys Arg Ser Lys Glu 1 5 10 15 Met Ala Leu Ala Arg Leu Tyr Tyr Lys Thr Ser Lys Lys 20 25 <210> 2130 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 2130 Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys Arg Ser Lys 1 5 10 15 Glu Met Ala Leu Ala Arg Leu Tyr 20 <210> 2131 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 2131 Ser Gly Ala Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys 1 5 10 15 Arg Ser Lys Glu Met Ala Leu Ala Arg Leu Tyr Tyr Lys Thr Ser 20 25 30 <210> 2132 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 2132 Ser Gly Tyr Ala Ser Ala Pro Leu Ala Val Gln Leu His Val Ser Lys 1 5 10 15 Arg Ser Lys Glu Met Ala Leu Ala Arg Leu Tyr Tyr Lys Thr Ser 20 25 30 <210> 2133 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 2133 Ser Gly Tyr Ala Ser Phe Pro Leu Ala Ala Gln Leu His Val Ser Lys 1 5 10 15 Arg Ser Lys Glu Met Ala Leu Ala Arg Leu Tyr Tyr Lys Thr Ser 20 25 30 <210> 2134 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 2134 Ser Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu Ala Val Ser Lys 1 5 10 15 Arg Ser Lys Glu Met Ala Leu Ala Arg Leu Tyr Tyr Lys Thr Ser 20 25 30 <210> 2135 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 2135 Ser Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Ala Ser Lys 1 5 10 15 Arg Ser Lys Glu Met Ala Leu Ala Arg Leu Tyr Tyr Lys Thr Ser 20 25 30 <210> 2136 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 2136 Ser Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Ala 1 5 10 15 Arg Ser Lys Glu Met Ala Leu Ala Arg Leu Tyr Tyr Lys Thr Ser 20 25 30 <210> 2137 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 2137 Ser Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys 1 5 10 15 Ala Ser Lys Glu Met Ala Leu Ala Arg Leu Tyr Tyr Lys Thr Ser 20 25 30 <210> 2138 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 2138 Ser Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys 1 5 10 15 Arg Ser Lys Glu Ala Ala Leu Ala Arg Leu Tyr Tyr Lys Thr Ser 20 25 30 <210> 2139 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 2139 Ser Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys 1 5 10 15 Arg Ser Lys Glu Met Ala Ala Ala Arg Leu Tyr Tyr Lys Thr Ser 20 25 30 <210> 2140 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 2140 Ser Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys 1 5 10 15 Arg Ser Lys Glu Met Ala Leu Ala Arg Leu Ala Tyr Lys Thr Ser 20 25 30 <210> 2141 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 2141 Ser Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys 1 5 10 15 Arg Ser Lys Glu Met Ala Leu Ala Arg Leu Tyr Ala Lys Thr Ser 20 25 30 <210> 2142 <211> 33 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <400> 2142 Gly Ser Ser Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val 1 5 10 15 Ser Lys Arg Ser Lys Glu Met Ala Leu Ala Arg Leu Tyr Tyr Lys Thr 20 25 30 Ser <210> 2143 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2143 Gly Tyr Trp Ser Phe Pro His Ala Val Trp His His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2144 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2144 Gly Tyr Ala Ser Phe Trp Gln Ala Val Gln Leu His Val Trp Lys Arg 1 5 10 15 Ser Lys Glu Ile Ala 20 <210> 2145 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2145 Gly Tyr Ala Ser Phe Pro Leu Ile Val Trp Leu His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2146 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2146 Gly Tyr Ala Ser Phe Trp Gln Ala Val Gln Leu His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Ile Ala 20 <210> 2147 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2147 Gly Tyr Ala Ser Phe Pro Ala Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2148 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2148 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Ala His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2149 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2149 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Ala His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2150 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2150 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val Ala Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2151 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2151 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Ala Met Ala 20 <210> 2152 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2152 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Ala Ala 20 <210> 2153 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2153 Gly Tyr Ala Ser Phe Cys Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2154 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2154 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu Cys Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2155 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2155 Gly Asp Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2156 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2156 Gly Tyr Asp Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2157 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2157 Gly Tyr Ala Asp Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2158 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2158 Gly Tyr Ala Ser Asp Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2159 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2159 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Asp Met Ala 20 <210> 2160 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2160 Gly Tyr Glu Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2161 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2161 Gly Tyr Ala Glu Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2162 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2162 Phe Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2163 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2163 Gly Phe Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2164 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2164 Gly Tyr Phe Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2165 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2165 Gly Tyr Ala Phe Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2166 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2166 Gly Tyr Ala Ser Phe Pro Phe Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2167 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2167 Gly Tyr Ala Ser Phe Pro Trp Phe Phe Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2168 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2168 Gly Tyr Ala Ser Phe Pro Trp Phe Val Phe Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2169 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2169 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Phe His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2170 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2170 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Phe 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2171 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2171 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Phe Trp Glu Met Ala 20 <210> 2172 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2172 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Phe Glu Met Ala 20 <210> 2173 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2173 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Phe Met Ala 20 <210> 2174 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2174 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Phe Ala 20 <210> 2175 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2175 Gly Tyr Ala Ser Gly Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2176 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2176 Gly Tyr Ala Ser Phe Pro Gly Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2177 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2177 Gly Tyr Ala Ser Phe Pro Trp Gly Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2178 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2178 Gly Tyr Ala Ser Phe Pro Trp Phe Gly Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2179 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2179 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gly Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2180 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2180 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Gly His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2181 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2181 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Gly His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2182 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2182 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val Gly Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2183 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2183 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Gly Met Ala 20 <210> 2184 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2184 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Gly Ala 20 <210> 2185 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2185 Gly His Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2186 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2186 Gly Tyr Ala Ser Phe Pro His Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2187 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2187 Gly Tyr Ala Ser Phe Pro Trp Phe His Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2188 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2188 Gly Tyr Ala Ser Phe Pro Trp Phe Val His Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2189 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2189 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His His His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2190 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2190 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu His Ala 20 <210> 2191 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2191 Ile Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2192 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2192 Gly Tyr Ala Ser Ile Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2193 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2193 Gly Tyr Ala Ser Phe Pro Ile Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2194 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2194 Gly Tyr Ala Ser Phe Pro Trp Phe Ile Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2195 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2195 Gly Tyr Ala Ser Phe Pro Trp Phe Val Ile Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2196 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2196 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu Ile Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2197 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2197 Gly Tyr Ala Ser Phe Lys Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2198 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2198 Gly Tyr Ala Ser Phe Pro Lys Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2199 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2199 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu Lys Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2200 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2200 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2201 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2201 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Lys Ala 20 <210> 2202 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2202 Gly Tyr Ala Ser Leu Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2203 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2203 Gly Tyr Ala Ser Phe Pro Leu Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2204 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2204 Gly Tyr Ala Ser Phe Pro Trp Leu Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2205 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2205 Gly Tyr Ala Ser Phe Pro Trp Phe Leu Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2206 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2206 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu Leu Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2207 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2207 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Leu His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2208 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2208 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val Leu Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2209 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2209 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Leu Glu Met Ala 20 <210> 2210 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2210 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Leu Met Ala 20 <210> 2211 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2211 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Leu Ala 20 <210> 2212 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2212 Gly Met Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2213 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2213 Gly Tyr Ala Ser Met Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2214 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2214 Gly Tyr Ala Ser Phe Pro Trp Met Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2215 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2215 Gly Tyr Ala Ser Phe Pro Trp Phe Met Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2216 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2216 Gly Tyr Ala Ser Phe Pro Trp Phe Val Met Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2217 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2217 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Met His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2218 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2218 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val Met Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2219 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2219 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Met Glu Met Ala 20 <210> 2220 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2220 Gly Asn Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2221 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2221 Gly Tyr Asn Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2222 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2222 Gly Tyr Ala Ser Asn Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2223 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2223 Gly Tyr Ala Ser Phe Pro Asn Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2224 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2224 Gly Tyr Ala Ser Phe Pro Trp Asn Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2225 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2225 Gly Tyr Ala Ser Phe Pro Trp Phe Val Asn Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2226 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2226 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Asn His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2227 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2227 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val Asn Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2228 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal N-methyl <400> 2228 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Asn Met Ala 20 <210> 2229 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2229 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Asn Ala 20 <210> 2230 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2230 Gly Pro Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2231 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2231 Gly Tyr Pro Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2232 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2232 Gly Tyr Ala Ser Pro Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2233 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2233 Gly Tyr Ala Ser Phe Pro Trp Pro Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2234 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2234 Gly Tyr Ala Ser Phe Pro Trp Phe Val Pro Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2235 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2235 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Pro Met Ala 20 <210> 2236 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2236 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Pro 20 <210> 2237 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2237 Gln Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2238 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2238 Gly Tyr Gln Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2239 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2239 Gly Tyr Ala Gln Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2240 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2240 Gly Tyr Ala Ser Gln Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2241 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2241 Gly Tyr Ala Ser Phe Pro Trp Gln Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2242 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2242 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Gln His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2243 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2243 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val Gln Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2244 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2244 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Gln Glu Met Ala 20 <210> 2245 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2245 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Gln Met Ala 20 <210> 2246 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2246 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Gln Ala 20 <210> 2247 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2247 Gly Tyr Ala Ser Phe Arg Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2248 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2248 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu Arg Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2249 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2249 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Arg Ala 20 <210> 2250 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2250 Gly Ser Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2251 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2251 Gly Tyr Ala Ser Ser Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2252 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2252 Gly Tyr Ala Ser Phe Pro Ser Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2253 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2253 Gly Tyr Ala Ser Phe Pro Trp Ser Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2254 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2254 Gly Tyr Ala Ser Phe Pro Trp Phe Ser Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2255 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2255 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Ser His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2256 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2256 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Ser His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2257 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2257 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val Ser Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2258 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2258 Gly Thr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2259 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2259 Gly Tyr Ala Ser Thr Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2260 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2260 Gly Tyr Ala Ser Phe Pro Thr Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2261 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2261 Gly Tyr Ala Ser Phe Pro Trp Thr Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2262 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2262 Gly Tyr Ala Ser Phe Pro Trp Phe Thr Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2263 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2263 Gly Tyr Ala Ser Phe Pro Trp Phe Val Thr Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2264 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2264 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Thr His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2265 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2265 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val Thr Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2266 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2266 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Thr 20 <210> 2267 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2267 Gly Tyr Ala Val Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2268 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2268 Gly Tyr Ala Ser Val Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2269 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2269 Gly Tyr Ala Ser Phe Pro Trp Phe Val Val Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2270 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2270 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val Val Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2271 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2271 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Val Glu Met Ala 20 <210> 2272 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2272 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Val Met Ala 20 <210> 2273 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2273 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Val Ala 20 <210> 2274 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2274 Trp Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2275 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2275 Gly Tyr Ala Trp Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2276 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2276 Gly Tyr Ala Ser Phe Pro Trp Phe Trp Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2277 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2277 Gly Tyr Ala Ser Phe Pro Trp Phe Val Trp Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2278 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2278 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Trp His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2279 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2279 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val Trp Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2280 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2280 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Trp Trp Glu Met Ala 20 <210> 2281 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2281 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Trp Met Ala 20 <210> 2282 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2282 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Trp Ala 20 <210> 2283 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2283 Gly Tyr Tyr Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2284 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 2284 Gly Tyr Ala Tyr Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2285 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acytlation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2285 Gly Tyr Ala Ser Tyr Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2286 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2286 Gly Tyr Ala Ser Phe Pro Tyr Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2287 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2287 Gly Tyr Ala Ser Phe Pro Trp Phe Tyr Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2288 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2288 Gly Tyr Ala Ser Phe Pro Trp Phe Val Tyr Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2289 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2289 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Tyr His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2290 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2290 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Tyr His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2291 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2291 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val Tyr Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2292 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2292 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Tyr Trp Glu Met Ala 20 <210> 2293 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2293 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Tyr Glu Met Ala 20 <210> 2294 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2294 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Tyr Met Ala 20 <210> 2295 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2295 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Tyr Ala 20 <210> 2296 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2296 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Tyr 20 <210> 2297 <211> 30 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2297 Lys Met Gln Leu Arg Val Tyr Ala Ser Thr Ala His Ser Arg Tyr Leu 1 5 10 15 Leu Gly Ser Ser Leu Phe Pro Lys Tyr Ala Glu Val Lys Ala 20 25 30 <210> 2298 <211> 32 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2298 Lys Lys Ser Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val 1 5 10 15 Ser Lys Arg Ser Lys Glu Met Ala Leu Ala Arg Leu Tyr Tyr Lys Lys 20 25 30 <210> 2299 <211> 26 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2299 Lys Lys Ser Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val 1 5 10 15 Ser Lys Arg Ser Lys Glu Met Ala Lys Lys 20 25 <210> 2300 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2300 Lys Lys Ser Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val 1 5 10 15 Ser Lys Arg Ser Lys Lys Lys 20 <210> 2301 <211> 26 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (26)..(26) <223> C-terminal amidation <400> 2301 Lys Lys Val Gln Leu His Val Ser Lys Arg Ser Lys Glu Met Ala Leu 1 5 10 15 Ala Arg Leu Tyr Tyr Lys Thr Ser Lys Lys 20 25 <210> 2302 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 2302 Lys Lys His Val Ser Lys Arg Ser Lys Glu Met Ala Leu Ala Arg Leu 1 5 10 15 Tyr Tyr Lys Thr Ser Lys Lys 20 <210> 2303 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 2303 Lys Lys Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser 1 5 10 15 Lys Arg Ser Lys Glu Met Lys Lys 20 <210> 2304 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 2304 Lys Lys Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys 1 5 10 15 Arg Ser Lys Glu Met Ala Lys Lys 20 <210> 2305 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 2305 Lys Lys Val Gln Leu His Val Ser Lys Arg Ser Lys Glu Met Ala Leu 1 5 10 15 Ala Arg Leu Tyr Tyr Lys Lys Lys 20 <210> 2306 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 2306 Lys Lys Gln Leu His Val Ser Lys Arg Ser Lys Glu Met Ala Leu Ala 1 5 10 15 Arg Leu Tyr Tyr Lys Thr Lys Lys 20 <210> 2307 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 2307 Lys Lys Leu His Val Ser Lys Arg Ser Lys Glu Met Ala Leu Ala Arg 1 5 10 15 Leu Tyr Tyr Lys Thr Ser Lys Lys 20 <210> 2308 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 2308 Lys Lys Ser Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val 1 5 10 15 Ser Lys Arg Ser Lys Glu Lys Lys 20 <210> 2309 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (19)..(19) <223> C-terminal amidation <400> 2309 Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys Arg Ser Lys 1 5 10 15 Glu Met Ala <210> 2310 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (18)..(18) <223> C-terminal amidation <400> 2310 Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys Arg Ser Lys Glu 1 5 10 15 Met Ala <210> 2311 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (17)..(17) <223> C-terminal amidation <400> 2311 Phe Pro Leu Ala Val Gln Leu His Val Ser Lys Arg Ser Lys Glu Met 1 5 10 15 Ala <210> 2312 <211> 18 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (18)..(18) <223> C-terminal amidation <400> 2312 Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys Arg Ser Lys 1 5 10 15 Glu Met <210> 2313 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (17)..(17) <223> C-terminal amidation <400> 2313 Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys Arg Ser Lys 1 5 10 15 Glu <210> 2314 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 2314 Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys Arg Ser Lys 1 5 10 15 Glu Met Ala Leu 20 <210> 2315 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2315 Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys Arg Ser Lys 1 5 10 15 Glu Met Ala Leu Ala 20 <210> 2316 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (22)..(22) <223> C-terminal amidation <400> 2316 Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys Arg Ser Lys 1 5 10 15 Glu Met Ala Leu Ala Arg 20 <210> 2317 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 2317 Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys Arg Ser Lys 1 5 10 15 Glu Met Ala Leu Ala Arg Leu 20 <210> 2318 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 2318 Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys Arg Ser 1 5 10 15 Lys Glu Met Ala 20 <210> 2319 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2319 Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2320 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2320 Gly Tyr Ala Ser Phe Ala Leu Ser Val Gln Leu His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2321 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2321 Gly Tyr Ala Ser Phe Ala Leu Ala Val Gln Leu His Val Ala Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2322 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2322 Gly Tyr Ala Ser Phe Ala Leu Ala Val Gln Leu His Val Met Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2323 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (19)..(19) <223> C-terminal amidation <400> 2323 Phe Pro Leu Ala Val Gln Leu His Val Ser Lys Arg Ser Lys Glu Met 1 5 10 15 Ala Leu Ala <210> 2324 <211> 14 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (14)..(14) <223> C-terminal amidation <400> 2324 Gln Leu His Val Ser Lys Arg Ser Lys Glu Met Ala Leu Ala 1 5 10 <210> 2325 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (7)..(7) <223> C-terminal amidation <400> 2325 Ser Gly Tyr Ala Ser Phe Pro 1 5 <210> 2326 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (19)..(19) <223> C-terminal amidation <400> 2326 Leu Ala Val Gln Leu His Val Ser Lys Arg Ser Lys Glu Met Ala Leu 1 5 10 15 Ala Arg Leu <210> 2327 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2327 Val Tyr Ala Ser Phe Phe Leu Thr Val Gln Leu His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2328 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2328 Gly Tyr Trp Ser Phe Pro Gln Ala Val Gln Leu His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2329 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2329 Gly Tyr Ala Ser Phe Ile Leu Ala Val Gln Leu His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2330 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2330 Gly Tyr Trp Ser Phe Tyr Leu Ala Val Gln Leu His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2331 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2331 Ser Tyr Ala Ser Phe Phe Leu Ala Val Gln Leu His Val Ser Lys Arg 1 5 10 15 Ser Glu Glu Met Ala 20 <210> 2332 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2332 Gly Tyr Ala Ser Phe Ile Leu Ala Val Gln Leu His Ile Ile Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2333 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2333 Gly Met Ala Ser Phe Phe Leu Ala Arg Asp Leu His Trp Ser Lys Val 1 5 10 15 Phe Lys Glu Met Ala 20 <210> 2334 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2334 Glu Tyr Ala Gln Phe Trp Leu Ala Val Gln Leu His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2335 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2335 Gly Tyr Ala Ser Phe Pro Leu Ile Val Gln Leu His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2336 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2336 Gly Tyr Ala Ser Phe Pro Ile His Val Gln His His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2337 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2337 Gly Tyr Ala Ser Phe Ala Leu Met Val Gln Leu His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2338 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2338 Gly Tyr Ala Ser Phe His Gln Ala Val Gln Arg His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2339 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2339 Gly Tyr Ala Ser Phe Ala Leu Met Val Gln His His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2340 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2340 Gly Tyr Ala Ser Phe Ser Leu Ala Val Gln Leu His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2341 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2341 Gly Tyr His Ser Phe Lys Leu Ala Val Gln Leu His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Ile Ala 20 <210> 2342 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2342 Gly Tyr Ala Ser Tyr Val Leu Ala Val Gln His His Val Ser Trp Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2343 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2343 His Tyr His Ser Leu Pro Lys Gln Val Gln Leu His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2344 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2344 Gly Tyr Ala Ser Phe Ser Leu Ala Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Tyr Glu Met Ala 20 <210> 2345 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2345 Gly Tyr Ala Ser Phe Glu Leu Leu Val Gln Leu His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2346 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2346 Ser Tyr Ser Ser Phe Lys Leu Ala Val Gln Leu His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2347 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2347 Gly Tyr Ala Trp Phe Pro Leu Asn Val Trp Leu His Val His Lys Arg 1 5 10 15 Ser His Glu Met Ala 20 <210> 2348 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2348 Gly Tyr Ala Ser Phe Trp Leu Ser Val Gln Thr His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2349 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2349 Gly Tyr Ala Ser Phe Pro Leu Met Val Gln Leu His Val Ile Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2350 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2350 Gly Tyr Trp Ser Phe Asn Leu Val Val Gln Leu His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2351 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2351 Gly Tyr Ala Ser Phe His Leu Ala Val Gln Leu His Val Trp Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2352 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2352 Gly Tyr Ala Ser Phe Trp Leu Val Val Gln Leu His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2353 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2353 Gly Tyr Trp Ser Phe Pro Leu Ala Val Gln Leu His Val Trp Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2354 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2354 Gly Tyr Ala Ser Phe Pro Trp Tyr Val Gln Leu His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2355 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2355 Gly Tyr Thr Ser Phe Gln Leu Ala Val Gln Leu His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2356 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2356 Arg Tyr Ala Ser Phe Pro Leu Ala Val Tyr Leu His Val Thr Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2357 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2357 Gly Tyr Trp Ser Phe Pro Leu Ala Val Gln Leu His Val Ser Lys Arg 1 5 10 15 Leu Lys Glu Met Ala 20 <210> 2358 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2358 Gly His Ala Ser Phe Gln Thr Ala Val Gln Gln His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2359 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (11)..(11) <223> C-terminal amidation <400> 2359 Phe His Val Ser Lys Arg Ser Lys Glu Met Ala 1 5 10 <210> 2360 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2360 Gly Tyr Ala Ser Phe Trp His Ala Val Gln Leu His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2361 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2361 Gly Ile Ala Ser Phe Ile Leu Ala Val Gln Leu His Val Tyr Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2362 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2362 Gly Tyr Thr Ser Phe Met Gln Ala Val Gln His His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Ile Ala 20 <210> 2363 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2363 His Tyr His Ser Phe Tyr Leu Ala Val Gln Leu His Val Trp Glu Arg 1 5 10 15 Ser Tyr Glu Met Ala 20 <210> 2364 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2364 Gly Tyr Ala Ser Phe Trp His Ala Val Gln His His Val Thr Lys Arg 1 5 10 15 Ser Arg Glu Met Ala 20 <210> 2365 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2365 Gly Tyr Ala Ser Phe Thr Leu Thr Val Gln Leu His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2366 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2366 Gly Tyr Ala Ser Phe Ile Leu Thr Val Gln Leu His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2367 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2367 Gly Tyr Ala Ser Phe Trp Leu Ala Val Gln Ile His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2368 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2368 Gly Tyr Ala Ser Phe Ile Leu Ala Val Gln His His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2369 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2369 Ser Tyr Ala Ser Phe Pro Pro Ala Val Met Leu His Val Trp Lys Arg 1 5 10 15 Ser Tyr Glu Met Ala 20 <210> 2370 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2370 Gly Tyr Ala Ser Phe Asn Leu Ala Val Gln Leu His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2371 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2371 Gly Tyr Trp Ser Phe Asn Leu Ala Val Gln Leu His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2372 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2372 Gly Tyr Ala Ser Phe Phe Leu Ala Val Gln Leu His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2373 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2373 Gly Tyr Ala Ser Phe Trp Leu Ala Val Gln Met His Val Trp Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2374 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2374 Gly Tyr Ala Ser Phe Ser Leu Ala Ile Gln Leu His Val Ser Lys Arg 1 5 10 15 Ser Lys Glu Met Ala 20 <210> 2375 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2375 Gly Ala Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2376 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2376 Gly Tyr Ala Ser Ala Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2377 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2377 Gly Tyr Ala Ser Phe Ala Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2378 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2378 Gly Tyr Ala Ser Phe Pro Trp Phe Ala Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2379 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2379 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu Ala Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2380 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2380 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Ala Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2381 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2381 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Ala 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2382 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2382 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Ala Glu Met Ala 20 <210> 2383 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2383 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Cys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2384 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2384 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Cys 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2385 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2385 Gly Tyr Ala Ser Phe Asp Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2386 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2386 Gly Tyr Ala Ser Phe Pro Asp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2387 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2387 Gly Tyr Ala Ser Phe Pro Trp Asp Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2388 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2388 Gly Tyr Ala Ser Phe Pro Trp Phe Asp Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2389 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2389 Gly Tyr Ala Ser Phe Pro Trp Phe Val Asp Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2390 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2390 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Asp His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2391 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2391 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu Asp Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2392 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2392 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Asp His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2393 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2393 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val Asp Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2394 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2394 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Asp Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2395 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2395 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Asp 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2396 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2396 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Asp Trp Glu Met Ala 20 <210> 2397 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2397 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Asp Glu Met Ala 20 <210> 2398 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2398 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Asp Ala 20 <210> 2399 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2399 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Asp 20 <210> 2400 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2400 Gly Glu Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2401 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is 2-Amino-isobutyric acid <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2401 Gly Tyr Ala Ser Glu Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2402 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2402 Gly Tyr Ala Ser Phe Glu Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2403 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2403 Gly Tyr Ala Ser Phe Pro Glu Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2404 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2404 Gly Tyr Ala Ser Phe Pro Trp Glu Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2405 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2405 Gly Tyr Ala Ser Phe Pro Trp Phe Glu Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2406 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2406 Gly Tyr Ala Ser Phe Pro Trp Phe Val Glu Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2407 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2407 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Glu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2408 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2408 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu Glu Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2409 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2409 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Glu His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2410 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2410 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val Glu Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2411 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2411 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Glu Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2412 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2412 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Glu 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2413 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2413 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Glu Trp Glu Met Ala 20 <210> 2414 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2414 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Glu Glu Met Ala 20 <210> 2415 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2415 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Glu Ala 20 <210> 2416 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2416 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Glu 20 <210> 2417 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2417 Gly Tyr Ala Ser Phe Phe Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2418 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2418 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu Phe Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2419 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2419 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Phe Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2420 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2420 Gly Tyr Ala Ser Phe Gly Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2421 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2421 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu Gly Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2422 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2422 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Gly Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2423 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2423 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Gly 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2424 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2424 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Gly Glu Met Ala 20 <210> 2425 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2425 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His His Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2426 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2426 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys His 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2427 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2427 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser His Glu Met Ala 20 <210> 2428 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2428 Gly Tyr Ala Ser Phe Ile Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2429 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2429 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Ile Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2430 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2430 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Ile 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2431 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2431 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Lys 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2432 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2432 Gly Tyr Ala Ser Phe Leu Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2433 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2433 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Leu Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2434 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2434 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Leu 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2435 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2435 Gly Tyr Ala Ser Phe Met Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2436 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2436 Gly Tyr Ala Ser Phe Pro Met Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2437 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2437 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu Met Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2438 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2438 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Met Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2439 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2439 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Met 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2440 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2440 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Met Met Ala 20 <210> 2441 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2441 Gly Tyr Ala Ser Phe Asn Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2442 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2442 Gly Tyr Ala Ser Phe Pro Trp Phe Asn Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2443 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2443 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu Asn Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2444 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2444 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Asn His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2445 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2445 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Asn Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2446 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2446 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Asn 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2447 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2447 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Asn Glu Met Ala 20 <210> 2448 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2448 Gly Tyr Ala Ser Phe Pro Pro Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2449 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2449 Gly Tyr Ala Ser Phe Pro Trp Phe Pro Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2450 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2450 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Pro His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2451 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2451 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu Pro Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2452 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2452 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Pro His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2453 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2453 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val Pro Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2454 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2454 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Pro Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2455 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2455 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Pro 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2456 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2456 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Pro Trp Glu Met Ala 20 <210> 2457 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2457 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Pro Glu Met Ala 20 <210> 2458 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2458 Gly Gln Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2459 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2459 Gly Tyr Ala Ser Phe Gln Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2460 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2460 Gly Tyr Ala Ser Phe Pro Gln Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2461 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2461 Gly Tyr Ala Ser Phe Pro Trp Phe Gln Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2462 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 2462 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu Gln Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2463 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2463 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Gln His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2464 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2464 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Gln Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2465 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2465 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Gln 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2466 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2466 Gly Tyr Ala Ser Phe Ser Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2467 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2467 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu Ser Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2468 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2468 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Ser Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2469 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2469 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Ser 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2470 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2470 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Ser Glu Met Ala 20 <210> 2471 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2471 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Ser Met Ala 20 <210> 2472 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2472 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Ser Ala 20 <210> 2473 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2473 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ser 20 <210> 2474 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2474 Gly Tyr Ala Ser Phe Thr Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2475 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2475 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu Thr Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2476 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2476 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Thr His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2477 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2477 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Thr Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2478 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2478 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Thr 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2479 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2479 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Thr Glu Met Ala 20 <210> 2480 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2480 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Thr Met Ala 20 <210> 2481 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2481 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Thr Ala 20 <210> 2482 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2482 Val Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2483 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2483 Gly Val Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2484 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2484 Gly Tyr Val Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2485 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2485 Gly Tyr Ala Ser Phe Val Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2486 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <220> <221> MOD_RES <222> (21)..(21) <223> N-terminal acetylation <400> 2486 Gly Tyr Ala Ser Phe Pro Val Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2487 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2487 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu Val Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2488 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2488 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Val Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2489 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2489 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Val 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2490 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2490 Gly Tyr Ala Ser Phe Trp Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2491 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2491 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu Trp Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2492 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2492 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Trp Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2493 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2493 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Trp 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2494 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2494 Gly Tyr Ala Ser Phe Tyr Trp Phe Val Gln Leu His Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2495 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2495 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu Tyr Val His Lys Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2496 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2496 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Tyr Arg 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2497 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 2497 Gly Tyr Ala Ser Phe Pro Trp Phe Val Gln Leu His Val His Lys Tyr 1 5 10 15 Ser Trp Glu Met Ala 20 <210> 2498 <211> 32 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (32)..(32) <223> C-terminal amidation <400> 2498 Xaa Ser Gly Tyr Ala Ser Phe Pro Leu Ala Val Gln Leu His Val Ser 1 5 10 15 Lys Arg Ser Lys Glu Met Ala Leu Ala Arg Leu Tyr Tyr Lys Thr Ser 20 25 30 <210> 2499 <400> 2499 000 <210> 2500 <400> 2500 000 <210> 2501 <400> 2501 000 <210> 2502 <400> 2502 000 <210> 2503 <400> 2503 000 <210> 2504 <400> 2504 000 <210> 2505 <400> 2505 000 <210> 2506 <400> 2506 000 <210> 2507 <400> 2507 000 <210> 2508 <400> 2508 000 <210> 2509 <400> 2509 000 <210> 2510 <400> 2510 000 <210> 2511 <400> 2511 000 <210> 2512 <400> 2512 000 <210> 2513 <400> 2513 000 <210> 2514 <400> 2514 000 <210> 2515 <400> 2515 000 <210> 2516 <400> 2516 000 <210> 2517 <400> 2517 000 <210> 2518 <400> 2518 000 <210> 2519 <400> 2519 000 <210> 2520 <400> 2520 000 <210> 2521 <400> 2521 000 <210> 2522 <400> 2522 000 <210> 2523 <400> 2523 000 <210> 2524 <400> 2524 000 <210> 2525 <400> 2525 000 <210> 2526 <400> 2526 000 <210> 2527 <400> 2527 000 <210> 2528 <400> 2528 000 <210> 2529 <400> 2529 000 <210> 2530 <400> 2530 000 <210> 2531 <400> 2531 000 <210> 2532 <400> 2532 000 <210> 2533 <400> 2533 000 <210> 2534 <400> 2534 000 <210> 2535 <400> 2535 000 <210> 2536 <400> 2536 000 <210> 2537 <400> 2537 000 <210> 2538 <400> 2538 000 <210> 2539 <400> 2539 000 <210> 2540 <400> 2540 000 <210> 2541 <400> 2541 000 <210> 2542 <400> 2542 000 <210> 2543 <400> 2543 000 <210> 2544 <400> 2544 000 <210> 2545 <400> 2545 000 <210> 2546 <400> 2546 000 <210> 2547 <400> 2547 000 <210> 2548 <400> 2548 000 <210> 2549 <400> 2549 000 <210> 2550 <400> 2550 000 <210> 2551 <400> 2551 000 <210> 2552 <400> 2552 000 <210> 2553 <400> 2553 000 <210> 2554 <400> 2554 000 <210> 2555 <400> 2555 000 <210> 2556 <400> 2556 000 <210> 2557 <400> 2557 000 <210> 2558 <400> 2558 000 <210> 2559 <400> 2559 000 <210> 2560 <400> 2560 000 <210> 2561 <400> 2561 000 <210> 2562 <400> 2562 000 <210> 2563 <400> 2563 000 <210> 2564 <400> 2564 000 <210> 2565 <400> 2565 000 <210> 2566 <400> 2566 000 <210> 2567 <400> 2567 000 <210> 2568 <400> 2568 000 <210> 2569 <400> 2569 000 <210> 2570 <400> 2570 000 <210> 2571 <400> 2571 000 <210> 2572 <400> 2572 000 <210> 2573 <400> 2573 000 <210> 2574 <400> 2574 000 <210> 2575 <400> 2575 000 <210> 2576 <400> 2576 000 <210> 2577 <400> 2577 000 <210> 2578 <400> 2578 000 <210> 2579 <400> 2579 000 <210> 2580 <400> 2580 000 <210> 2581 <400> 2581 000 <210> 2582 <400> 2582 000 <210> 2583 <400> 2583 000 <210> 2584 <400> 2584 000 <210> 2585 <400> 2585 000 <210> 2586 <400> 2586 000 <210> 2587 <400> 2587 000 <210> 2588 <400> 2588 000 <210> 2589 <400> 2589 000 <210> 2590 <400> 2590 000 <210> 2591 <400> 2591 000 <210> 2592 <400> 2592 000 <210> 2593 <400> 2593 000 <210> 2594 <400> 2594 000 <210> 2595 <400> 2595 000 <210> 2596 <400> 2596 000 <210> 2597 <400> 2597 000 <210> 2598 <400> 2598 000 <210> 2599 <400> 2599 000 <210> 2600 <400> 2600 000 <210> 2601 <400> 2601 000 <210> 2602 <400> 2602 000 <210> 2603 <400> 2603 000 <210> 2604 <400> 2604 000 <210> 2605 <400> 2605 000 <210> 2606 <400> 2606 000 <210> 2607 <400> 2607 000 <210> 2608 <400> 2608 000 <210> 2609 <400> 2609 000 <210> 2610 <400> 2610 000 <210> 2611 <400> 2611 000 <210> 2612 <400> 2612 000 <210> 2613 <400> 2613 000 <210> 2614 <400> 2614 000 <210> 2615 <400> 2615 000 <210> 2616 <400> 2616 000 <210> 2617 <400> 2617 000 <210> 2618 <400> 2618 000 <210> 2619 <400> 2619 000 <210> 2620 <400> 2620 000 <210> 2621 <400> 2621 000 <210> 2622 <400> 2622 000 <210> 2623 <400> 2623 000 <210> 2624 <400> 2624 000 <210> 2625 <400> 2625 000 <210> 2626 <400> 2626 000 <210> 2627 <400> 2627 000 <210> 2628 <400> 2628 000 <210> 2629 <400> 2629 000 <210> 2630 <400> 2630 000 <210> 2631 <400> 2631 000 <210> 2632 <400> 2632 000 <210> 2633 <400> 2633 000 <210> 2634 <400> 2634 000 <210> 2635 <400> 2635 000 <210> 2636 <400> 2636 000 <210> 2637 <400> 2637 000 <210> 2638 <400> 2638 000 <210> 2639 <400> 2639 000 <210> 2640 <400> 2640 000 <210> 2641 <400> 2641 000 <210> 2642 <400> 2642 000 <210> 2643 <400> 2643 000 <210> 2644 <400> 2644 000 <210> 2645 <400> 2645 000 <210> 2646 <400> 2646 000 <210> 2647 <400> 2647 000 <210> 2648 <400> 2648 000 <210> 2649 <400> 2649 000 <210> 2650 <400> 2650 000 <210> 2651 <400> 2651 000 <210> 2652 <400> 2652 000 <210> 2653 <400> 2653 000 <210> 2654 <400> 2654 000 <210> 2655 <400> 2655 000 <210> 2656 <400> 2656 000 <210> 2657 <400> 2657 000 <210> 2658 <400> 2658 000 <210> 2659 <400> 2659 000 <210> 2660 <400> 2660 000 <210> 2661 <400> 2661 000 <210> 2662 <400> 2662 000 <210> 2663 <400> 2663 000 <210> 2664 <400> 2664 000 <210> 2665 <400> 2665 000 <210> 2666 <400> 2666 000 <210> 2667 <400> 2667 000 <210> 2668 <400> 2668 000 <210> 2669 <400> 2669 000 <210> 2670 <400> 2670 000 <210> 2671 <400> 2671 000 <210> 2672 <400> 2672 000 <210> 2673 <400> 2673 000 <210> 2674 <400> 2674 000 <210> 2675 <400> 2675 000 <210> 2676 <400> 2676 000 <210> 2677 <400> 2677 000 <210> 2678 <400> 2678 000 <210> 2679 <400> 2679 000 <210> 2680 <400> 2680 000 <210> 2681 <400> 2681 000 <210> 2682 <400> 2682 000 <210> 2683 <400> 2683 000 <210> 2684 <400> 2684 000 <210> 2685 <400> 2685 000 <210> 2686 <400> 2686 000 <210> 2687 <400> 2687 000 <210> 2688 <400> 2688 000 <210> 2689 <400> 2689 000 <210> 2690 <400> 2690 000 <210> 2691 <400> 2691 000 <210> 2692 <400> 2692 000 <210> 2693 <400> 2693 000 <210> 2694 <400> 2694 000 <210> 2695 <400> 2695 000 <210> 2696 <400> 2696 000 <210> 2697 <400> 2697 000 <210> 2698 <400> 2698 000 <210> 2699 <400> 2699 000 <210> 2700 <400> 2700 000 <210> 2701 <400> 2701 000 <210> 2702 <400> 2702 000 <210> 2703 <400> 2703 000 <210> 2704 <400> 2704 000 <210> 2705 <400> 2705 000 <210> 2706 <400> 2706 000 <210> 2707 <400> 2707 000 <210> 2708 <400> 2708 000 <210> 2709 <400> 2709 000 <210> 2710 <400> 2710 000 <210> 2711 <400> 2711 000 <210> 2712 <400> 2712 000 <210> 2713 <400> 2713 000 <210> 2714 <400> 2714 000 <210> 2715 <400> 2715 000 <210> 2716 <400> 2716 000 <210> 2717 <400> 2717 000 <210> 2718 <400> 2718 000 <210> 2719 <400> 2719 000 <210> 2720 <400> 2720 000 <210> 2721 <400> 2721 000 <210> 2722 <400> 2722 000 <210> 2723 <400> 2723 000 <210> 2724 <400> 2724 000 <210> 2725 <400> 2725 000 <210> 2726 <400> 2726 000 <210> 2727 <400> 2727 000 <210> 2728 <400> 2728 000 <210> 2729 <400> 2729 000 <210> 2730 <400> 2730 000 <210> 2731 <400> 2731 000 <210> 2732 <400> 2732 000 <210> 2733 <400> 2733 000 <210> 2734 <400> 2734 000 <210> 2735 <400> 2735 000 <210> 2736 <400> 2736 000 <210> 2737 <400> 2737 000 <210> 2738 <400> 2738 000 <210> 2739 <400> 2739 000 <210> 2740 <400> 2740 000 <210> 2741 <400> 2741 000 <210> 2742 <400> 2742 000 <210> 2743 <400> 2743 000 <210> 2744 <400> 2744 000 <210> 2745 <400> 2745 000 <210> 2746 <400> 2746 000 <210> 2747 <400> 2747 000 <210> 2748 <400> 2748 000 <210> 2749 <400> 2749 000 <210> 2750 <400> 2750 000 <210> 2751 <400> 2751 000 <210> 2752 <400> 2752 000 <210> 2753 <400> 2753 000 <210> 2754 <400> 2754 000 <210> 2755 <400> 2755 000 <210> 2756 <400> 2756 000 <210> 2757 <400> 2757 000 <210> 2758 <400> 2758 000 <210> 2759 <400> 2759 000 <210> 2760 <400> 2760 000 <210> 2761 <400> 2761 000 <210> 2762 <400> 2762 000 <210> 2763 <400> 2763 000 <210> 2764 <400> 2764 000 <210> 2765 <400> 2765 000 <210> 2766 <400> 2766 000 <210> 2767 <400> 2767 000 <210> 2768 <400> 2768 000 <210> 2769 <400> 2769 000 <210> 2770 <400> 2770 000 <210> 2771 <400> 2771 000 <210> 2772 <400> 2772 000 <210> 2773 <400> 2773 000 <210> 2774 <400> 2774 000 <210> 2775 <400> 2775 000 <210> 2776 <400> 2776 000 <210> 2777 <400> 2777 000 <210> 2778 <400> 2778 000 <210> 2779 <400> 2779 000 <210> 2780 <400> 2780 000 <210> 2781 <400> 2781 000 <210> 2782 <400> 2782 000 <210> 2783 <400> 2783 000 <210> 2784 <400> 2784 000 <210> 2785 <400> 2785 000 <210> 2786 <400> 2786 000 <210> 2787 <400> 2787 000 <210> 2788 <400> 2788 000 <210> 2789 <400> 2789 000 <210> 2790 <400> 2790 000 <210> 2791 <400> 2791 000 <210> 2792 <400> 2792 000 <210> 2793 <400> 2793 000 <210> 2794 <400> 2794 000 <210> 2795 <400> 2795 000 <210> 2796 <400> 2796 000 <210> 2797 <400> 2797 000 <210> 2798 <400> 2798 000 <210> 2799 <400> 2799 000 <210> 2800 <400> 2800 000 <210> 2801 <400> 2801 000 <210> 2802 <400> 2802 000 <210> 2803 <400> 2803 000 <210> 2804 <400> 2804 000 <210> 2805 <400> 2805 000 <210> 2806 <400> 2806 000 <210> 2807 <400> 2807 000 <210> 2808 <400> 2808 000 <210> 2809 <400> 2809 000 <210> 2810 <400> 2810 000 <210> 2811 <400> 2811 000 <210> 2812 <400> 2812 000 <210> 2813 <400> 2813 000 <210> 2814 <400> 2814 000 <210> 2815 <400> 2815 000 <210> 2816 <400> 2816 000 <210> 2817 <400> 2817 000 <210> 2818 <400> 2818 000 <210> 2819 <400> 2819 000 <210> 2820 <400> 2820 000 <210> 2821 <400> 2821 000 <210> 2822 <400> 2822 000 <210> 2823 <400> 2823 000 <210> 2824 <400> 2824 000 <210> 2825 <400> 2825 000 <210> 2826 <400> 2826 000 <210> 2827 <400> 2827 000 <210> 2828 <400> 2828 000 <210> 2829 <400> 2829 000 <210> 2830 <400> 2830 000 <210> 2831 <400> 2831 000 <210> 2832 <400> 2832 000 <210> 2833 <400> 2833 000 <210> 2834 <400> 2834 000 <210> 2835 <400> 2835 000 <210> 2836 <400> 2836 000 <210> 2837 <400> 2837 000 <210> 2838 <400> 2838 000 <210> 2839 <400> 2839 000 <210> 2840 <400> 2840 000 <210> 2841 <400> 2841 000 <210> 2842 <400> 2842 000 <210> 2843 <400> 2843 000 <210> 2844 <400> 2844 000 <210> 2845 <400> 2845 000 <210> 2846 <400> 2846 000 <210> 2847 <400> 2847 000 <210> 2848 <400> 2848 000 <210> 2849 <400> 2849 000 <210> 2850 <400> 2850 000 <210> 2851 <400> 2851 000 <210> 2852 <400> 2852 000 <210> 2853 <400> 2853 000 <210> 2854 <400> 2854 000 <210> 2855 <400> 2855 000 <210> 2856 <400> 2856 000 <210> 2857 <400> 2857 000 <210> 2858 <400> 2858 000 <210> 2859 <400> 2859 000 <210> 2860 <400> 2860 000 <210> 2861 <400> 2861 000 <210> 2862 <400> 2862 000 <210> 2863 <400> 2863 000 <210> 2864 <400> 2864 000 <210> 2865 <400> 2865 000 <210> 2866 <400> 2866 000 <210> 2867 <400> 2867 000 <210> 2868 <400> 2868 000 <210> 2869 <400> 2869 000 <210> 2870 <400> 2870 000 <210> 2871 <400> 2871 000 <210> 2872 <400> 2872 000 <210> 2873 <400> 2873 000 <210> 2874 <400> 2874 000 <210> 2875 <400> 2875 000 <210> 2876 <400> 2876 000 <210> 2877 <400> 2877 000 <210> 2878 <400> 2878 000 <210> 2879 <400> 2879 000 <210> 2880 <400> 2880 000 <210> 2881 <400> 2881 000 <210> 2882 <400> 2882 000 <210> 2883 <400> 2883 000 <210> 2884 <400> 2884 000 <210> 2885 <400> 2885 000 <210> 2886 <400> 2886 000 <210> 2887 <400> 2887 000 <210> 2888 <400> 2888 000 <210> 2889 <400> 2889 000 <210> 2890 <400> 2890 000 <210> 2891 <400> 2891 000 <210> 2892 <400> 2892 000 <210> 2893 <400> 2893 000 <210> 2894 <400> 2894 000 <210> 2895 <400> 2895 000 <210> 2896 <400> 2896 000 <210> 2897 <400> 2897 000 <210> 2898 <400> 2898 000 <210> 2899 <400> 2899 000 <210> 2900 <400> 2900 000 <210> 2901 <400> 2901 000 <210> 2902 <400> 2902 000 <210> 2903 <400> 2903 000 <210> 2904 <400> 2904 000 <210> 2905 <400> 2905 000 <210> 2906 <400> 2906 000 <210> 2907 <400> 2907 000 <210> 2908 <400> 2908 000 <210> 2909 <400> 2909 000 <210> 2910 <400> 2910 000 <210> 2911 <400> 2911 000 <210> 2912 <400> 2912 000 <210> 2913 <400> 2913 000 <210> 2914 <400> 2914 000 <210> 2915 <400> 2915 000 <210> 2916 <400> 2916 000 <210> 2917 <400> 2917 000 <210> 2918 <400> 2918 000 <210> 2919 <400> 2919 000 <210> 2920 <400> 2920 000 <210> 2921 <400> 2921 000 <210> 2922 <400> 2922 000 <210> 2923 <400> 2923 000 <210> 2924 <400> 2924 000 <210> 2925 <400> 2925 000 <210> 2926 <400> 2926 000 <210> 2927 <400> 2927 000 <210> 2928 <400> 2928 000 <210> 2929 <400> 2929 000 <210> 2930 <400> 2930 000 <210> 2931 <400> 2931 000 <210> 2932 <400> 2932 000 <210> 2933 <400> 2933 000 <210> 2934 <400> 2934 000 <210> 2935 <400> 2935 000 <210> 2936 <400> 2936 000 <210> 2937 <400> 2937 000 <210> 2938 <400> 2938 000 <210> 2939 <400> 2939 000 <210> 2940 <400> 2940 000 <210> 2941 <400> 2941 000 <210> 2942 <400> 2942 000 <210> 2943 <400> 2943 000 <210> 2944 <400> 2944 000 <210> 2945 <400> 2945 000 <210> 2946 <400> 2946 000 <210> 2947 <400> 2947 000 <210> 2948 <400> 2948 000 <210> 2949 <400> 2949 000 <210> 2950 <400> 2950 000 <210> 2951 <400> 2951 000 <210> 2952 <400> 2952 000 <210> 2953 <400> 2953 000 <210> 2954 <400> 2954 000 <210> 2955 <400> 2955 000 <210> 2956 <400> 2956 000 <210> 2957 <400> 2957 000 <210> 2958 <400> 2958 000 <210> 2959 <400> 2959 000 <210> 2960 <400> 2960 000 <210> 2961 <400> 2961 000 <210> 2962 <400> 2962 000 <210> 2963 <400> 2963 000 <210> 2964 <400> 2964 000 <210> 2965 <400> 2965 000 <210> 2966 <400> 2966 000 <210> 2967 <400> 2967 000 <210> 2968 <400> 2968 000 <210> 2969 <400> 2969 000 <210> 2970 <400> 2970 000 <210> 2971 <400> 2971 000 <210> 2972 <400> 2972 000 <210> 2973 <400> 2973 000 <210> 2974 <400> 2974 000 <210> 2975 <400> 2975 000 <210> 2976 <400> 2976 000 <210> 2977 <400> 2977 000 <210> 2978 <400> 2978 000 <210> 2979 <400> 2979 000 <210> 2980 <400> 2980 000 <210> 2981 <400> 2981 000 <210> 2982 <400> 2982 000 <210> 2983 <400> 2983 000 <210> 2984 <400> 2984 000 <210> 2985 <400> 2985 000 <210> 2986 <400> 2986 000 <210> 2987 <400> 2987 000 <210> 2988 <400> 2988 000 <210> 2989 <400> 2989 000 <210> 2990 <400> 2990 000 <210> 2991 <400> 2991 000 <210> 2992 <400> 2992 000 <210> 2993 <400> 2993 000 <210> 2994 <400> 2994 000 <210> 2995 <400> 2995 000 <210> 2996 <400> 2996 000 <210> 2997 <400> 2997 000 <210> 2998 <400> 2998 000 <210> 2999 <400> 2999 000 <210> 3000 <400> 3000 000 <210> 3001 <211> 30 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> DISULFID <222> (6)..(28) <223> Cys residues linked via disfide bond <220> <221> MOD_RES <222> (30)..(30) <223> C-terminal amidation <400> 3001 Xaa Ser Gly Arg Gly Cys Thr Lys Val Ile Val Phe Thr Phe Arg His 1 5 10 15 Asn Lys Leu Ile Gly Tyr Glu Arg Arg Tyr Asn Cys Thr Ser 20 25 30 <210> 3002 <211> 30 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (30)..(30) <223> C-terminal amidation <400> 3002 Xaa Ser Gly Arg Gly Cys Thr Lys Val Ile Val Phe Thr Phe Arg His 1 5 10 15 Asn Lys Leu Ile Gly Tyr Glu Arg Arg Tyr Asn Cys Thr Ser 20 25 30 <210> 3003 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <220> <221> MOD_RES <222> (30)..(30) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (31)..(31) <223> Linked to Biotin <400> 3003 Ser Gly Arg Gly Cys Thr Lys Val Ile Val Phe Thr Phe Arg His Asn 1 5 10 15 Lys Leu Ile Gly Tyr Glu Arg Arg Tyr Asn Cys Thr Ser Xaa Lys 20 25 30 <210> 3004 <211> 34 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (34)..(34) <223> C-terminal amidation <400> 3004 Xaa Lys Lys Ser Gly Val Trp Gln Thr His Pro Arg Tyr Phe Trp Thr 1 5 10 15 Met Trp Pro Asp Ile Lys Gly Glu Val Ile Val Leu Phe Gly Thr Ser 20 25 30 Lys Lys <210> 3005 <211> 35 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (32)..(32) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (35)..(35) <223> Linked to Biotin <220> <221> MOD_RES <222> (35)..(35) <223> C-terminal amidation <400> 3005 Lys Lys Ser Gly Val Trp Gln Thr His Pro Arg Tyr Phe Trp Thr Met 1 5 10 15 Trp Pro Asp Ile Lys Gly Glu Val Ile Val Leu Phe Gly Thr Ser Xaa 20 25 30 Lys Lys Lys 35 <210> 3006 <211> 32 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (32)..(32) <223> C-terminal amidation <400> 3006 Xaa Ser Gly Asn Thr Phe Val Asp Glu Arg Leu Leu Tyr Phe Leu Thr 1 5 10 15 Ile Gly Asn Met Gly Met Tyr Ala Ala Gln Leu Lys Phe Arg Thr Ser 20 25 30 <210> 3007 <211> 13 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (13)..(13) <223> C-terminal amidation <400> 3007 Xaa Leu Ser Leu Val Gly Ser Phe Ala Val Leu Cys Ala 1 5 10 <210> 3008 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 3008 Xaa Gly Arg Gly Cys Thr Lys Val Ile Val Phe Thr Phe Arg His Asn 1 5 10 15 Lys Leu Ile Gly Tyr 20 <210> 3009 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotin <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 3009 Xaa Cys Thr Lys Val Ile Val Phe Thr Phe Arg His Asn Lys Leu Ile 1 5 10 15 Gly Tyr Glu Arg Arg 20 <210> 3010 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotin <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 3010 Xaa Gly Cys Thr Lys Val Ile Val Phe Thr Phe Arg His Asn Lys Leu 1 5 10 15 Ile Gly Tyr Glu Arg 20 <210> 3011 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotin <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 3011 Xaa Val Ile Val Phe Thr Phe Arg His Asn Lys Leu Ile Gly Tyr Glu 1 5 10 15 Arg Arg Tyr Asn Cys 20 <210> 3012 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (19)..(19) <223> C-terminal amidation <400> 3012 Xaa Tyr Phe Leu Thr Ile Gly Asn Met Gly Met Tyr Ala Ala Gln Leu 1 5 10 15 Lys Phe Arg <210> 3013 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 3013 Xaa Tyr Phe Leu Thr Ile Gly Asn Met Gly Met Tyr Ala Ala Gln Leu 1 5 10 15 Lys Phe Arg Thr Ser 20 <210> 3014 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 3014 Xaa Leu Tyr Phe Leu Thr Ile Gly Asn Met Gly Met Tyr Ala Ala Gln 1 5 10 15 Leu Lys Phe Arg Thr 20 <210> 3015 <211> 32 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (32)..(32) <223> C-terminal amidation <400> 3015 Xaa Ser Gly Gln Phe Trp His Gly Leu Leu Leu Pro Lys Gly Ile Val 1 5 10 15 Leu Asn Trp Thr Leu Lys Pro Trp Trp Met Ile Gly Ala Phe Thr Ser 20 25 30 <210> 3016 <211> 33 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (32)..(32) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (33)..(33) <223> Linked to Biotin <220> <221> MOD_RES <222> (33)..(33) <223> C-terminal amidation <400> 3016 Ser Gly Gln Phe Trp His Gly Leu Leu Leu Pro Lys Gly Ile Val Leu 1 5 10 15 Asn Trp Thr Leu Lys Pro Trp Trp Met Ile Gly Ala Phe Thr Ser Xaa 20 25 30 Lys <210> 3017 <211> 32 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (32)..(32) <223> C-terminal amidation <400> 3017 Xaa Ser Gly Arg Val Ser Tyr Tyr Trp Gly Val Lys Trp Ser Gln Gln 1 5 10 15 Met Pro Met Ser Trp Trp Pro Asp Thr Trp Tyr Thr Phe Asp Thr Ser 20 25 30 <210> 3018 <211> 33 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (32)..(32) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (33)..(33) <223> Linked to Biotin <220> <221> MOD_RES <222> (33)..(33) <223> C-terminal amidation <400> 3018 Ser Gly Asn Thr Phe Val Asp Glu Arg Leu Leu Tyr Phe Leu Thr Ile 1 5 10 15 Gly Asn Met Gly Met Tyr Ala Ala Gln Leu Lys Phe Arg Thr Ser Xaa 20 25 30 Lys <210> 3019 <211> 32 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (32)..(32) <223> C-terminal amidation <400> 3019 Xaa Ser Gly Arg Phe Thr Thr Arg Leu Trp Tyr Phe Ser Trp Asp Arg 1 5 10 15 Leu Pro Trp Tyr Met Pro Phe Lys Gln Tyr Val Leu Ser Ser Thr Ser 20 25 30 <210> 3020 <211> 32 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (32)..(32) <223> C-terminal amidation <400> 3020 Xaa Ser Gly Ser Tyr Gln Trp Trp Ala Arg Pro Tyr Arg Met Trp Phe 1 5 10 15 Gly Leu Pro Tyr Trp Asn Gln Arg Val Ile Phe Pro Trp Asn Thr Ser 20 25 30 <210> 3021 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 3021 Xaa Leu Leu Tyr Phe Leu Thr Ile Gly Asn Met Gly Met Tyr Ala Ala 1 5 10 15 Gln Leu Lys Phe Arg 20 <210> 3022 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (21)..(21) <223> C-terminal amidation <400> 3022 Xaa Thr Lys Val Ile Val Phe Thr Phe Arg His Asn Lys Leu Ile Gly 1 5 10 15 Tyr Glu Arg Arg Tyr 20 <210> 3023 <211> 17 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (17)..(17) <223> C-terminal amidation <400> 3023 Xaa Val Ile Val Phe Thr Phe Arg His Asn Lys Leu Ile Gly Tyr Glu 1 5 10 15 Arg <210> 3024 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 3024 Phe Gln Arg Lys Gly Asn Val Phe Val Asp Gly Tyr Phe Glu Arg Leu 1 5 10 15 Arg Ala Lys Leu 20 <210> 3025 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 3025 Ser Gly Asn Thr Phe Val Asp Glu Arg Leu Leu Tyr Phe Leu Thr Ile 1 5 10 15 Gly Asn Met Gly Met Tyr Ala Ala Gln Leu Lys Phe Arg Thr Ser 20 25 30 <210> 3026 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 3026 Cys Thr Lys Val Ile Val Phe Thr Phe Arg His Asn Lys Leu Ile Gly 1 5 10 15 Tyr Glu Arg Arg Tyr Asn Cys 20 <210> 3027 <211> 30 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (30)..(30) <223> C-terminal amidation <400> 3027 Lys Lys Ser Gly Arg Gly Cys Thr Lys Val Ile Val Phe Thr Phe Arg 1 5 10 15 His Asn Lys Leu Ile Gly Tyr Glu Arg Arg Tyr Asn Lys Lys 20 25 30 <210> 3028 <211> 32 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (32)..(32) <223> C-terminal amidation <400> 3028 Lys Lys Ser Gly Val Trp Gln Thr His Pro Arg Tyr Phe Trp Thr Met 1 5 10 15 Trp Pro Asp Ile Lys Gly Glu Val Ile Val Leu Phe Gly Thr Lys Lys 20 25 30 <210> 3029 <211> 33 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (33)..(33) <223> C-terminal amidation <400> 3029 Lys Lys Ser Gly Arg Gly Cys Thr Lys Val Ile Val Phe Thr Phe Arg 1 5 10 15 His Asn Lys Leu Ile Gly Tyr Glu Arg Arg Tyr Asn Cys Thr Ser Lys 20 25 30 Lys <210> 3030 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 3030 Lys Lys Val Ile Val Phe Thr Phe Arg His Asn Lys Leu Ile Gly Tyr 1 5 10 15 Glu Arg Arg Tyr Asn Cys Lys Lys 20 <210> 3031 <211> 35 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (35)..(35) <223> C-terminal amidation <400> 3031 Lys Lys Ser Gly Asn Thr Phe Val Asp Glu Arg Leu Leu Tyr Phe Leu 1 5 10 15 Thr Ile Gly Asn Met Gly Met Tyr Ala Ala Gln Leu Lys Phe Arg Thr 20 25 30 Ser Lys Lys 35 <210> 3032 <211> 30 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (30)..(30) <223> C-terminal amidation <400> 3032 Lys Lys Gly Cys Thr Lys Val Ile Val Phe Thr Phe Arg His Asn Lys 1 5 10 15 Leu Ile Gly Tyr Glu Arg Arg Tyr Asn Cys Thr Ser Lys Lys 20 25 30 <210> 3033 <211> 27 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (27)..(27) <223> C-terminal amidation <400> 3033 Lys Lys Lys Val Ile Val Phe Thr Phe Arg His Asn Lys Leu Ile Gly 1 5 10 15 Tyr Glu Arg Arg Tyr Asn Cys Thr Ser Lys Lys 20 25 <210> 3034 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 3034 Val Asp Glu Arg Leu Leu Tyr Phe Leu Thr Ile Gly Asn Met Gly Met 1 5 10 15 Tyr Ala Ala Gln Leu Lys Phe 20 <210> 3035 <211> 30 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (30)..(30) <223> C-terminal amidation <400> 3035 Lys Lys Gly Val Trp Gln Thr His Pro Arg Tyr Phe Trp Thr Met Trp 1 5 10 15 Pro Asp Ile Lys Gly Glu Val Ile Val Leu Phe Gly Lys Lys 20 25 30 <210> 3036 <211> 33 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (33)..(33) <223> C-terminal amidation <400> 3036 Lys Lys Ser Gly Val Trp Gln Thr His Pro Arg Tyr Phe Trp Thr Met 1 5 10 15 Trp Pro Asp Ile Lys Gly Glu Val Ile Val Leu Phe Gly Thr Ser Lys 20 25 30 Lys <210> 3037 <211> 32 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (32)..(32) <223> C-terminal amidation <400> 3037 Lys Lys Gly Val Trp Gln Thr His Pro Arg Tyr Phe Trp Thr Met Trp 1 5 10 15 Pro Asp Ile Lys Gly Glu Val Ile Val Leu Phe Gly Thr Ser Lys Lys 20 25 30 <210> 3038 <211> 25 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Carboxyfluorescein <220> <221> MOD_RES <222> (25)..(25) <223> C-terminal amidation <400> 3038 Thr Phe Val Asp Glu Arg Leu Leu Tyr Phe Leu Thr Ile Gly Asn Met 1 5 10 15 Gly Met Tyr Ala Ala Gln Leu Lys Phe 20 25 <210> 3039 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 3039 Phe Val Asp Glu Arg Leu Leu Tyr Phe Leu Thr Ile Gly Asn Met Gly 1 5 10 15 Met Tyr Ala Ala Gln Leu Lys Phe 20 <210> 3040 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 3040 Thr Phe Val Asp Glu Arg Leu Leu Tyr Phe Leu Thr Ile Gly Asn Met 1 5 10 15 Gly Met Tyr Ala Ala Gln Leu Lys 20 <210> 3041 <211> 26 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (26)..(26) <223> C-terminal amidation <400> 3041 Gly Cys Thr Lys Val Ile Val Phe Thr Phe Arg His Asn Lys Leu Ile 1 5 10 15 Gly Tyr Glu Arg Arg Tyr Asn Cys Thr Ser 20 25 <210> 3042 <211> 25 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (25)..(25) <223> C-terminal amidation <400> 3042 Cys Thr Lys Val Ile Val Phe Thr Phe Arg His Asn Lys Leu Ile Gly 1 5 10 15 Tyr Glu Arg Arg Tyr Asn Cys Thr Ser 20 25 <210> 3043 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 3043 Thr Lys Val Ile Val Phe Thr Phe Arg His Asn Lys Leu Ile Gly Tyr 1 5 10 15 Glu Arg Arg Tyr Asn Cys Thr Ser 20 <210> 3044 <211> 25 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (25)..(25) <223> C-terminal amidation <400> 3044 Gly Cys Thr Lys Val Ile Val Phe Thr Phe Arg His Asn Lys Leu Ile 1 5 10 15 Gly Tyr Glu Arg Arg Tyr Asn Cys Thr 20 25 <210> 3045 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 3045 Gly Cys Thr Lys Val Ile Val Phe Thr Phe Arg His Asn Lys Leu Ile 1 5 10 15 Gly Tyr Glu Arg Arg Tyr Asn Cys 20 <210> 3046 <211> 29 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (29)..(29) <223> C-terminal amidation <400> 3046 Lys Lys Gly Val Trp Gln Thr His Pro Arg Tyr Phe Trp Thr Met Trp 1 5 10 15 Pro Asp Ile Lys Gly Glu Val Ile Val Leu Phe Lys Lys 20 25 <210> 3047 <211> 29 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (29)..(29) <223> C-terminal amidation <400> 3047 Ser Gly Arg Gly Cys Thr Lys Val Ile Val Phe Thr Phe Arg His Asn 1 5 10 15 Lys Leu Ile Gly Tyr Glu Arg Arg Tyr Asn Cys Thr Ser 20 25 <210> 3048 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal aceylation <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 3048 Lys Lys Ser Gly Asn Thr Phe Val Asp Glu Arg Leu Leu Tyr Phe Leu 1 5 10 15 Thr Ile Gly Asn Met Lys Lys 20 <210> 3049 <211> 29 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (29)..(29) <223> C-terminal amidation <400> 3049 Thr Asn Tyr Thr Gly Ser Glu Lys Cys Ile Arg Phe Val Thr Arg Arg 1 5 10 15 Tyr Leu Gly Val Arg Ile Asn Cys Phe His Lys Gly Ser 20 25 <210> 3050 <211> 29 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (29)..(29) <223> C-terminal amidation <400> 3050 Thr Arg Asn Val Val Arg Arg Tyr Glu Cys Phe Gly Ser Thr Gly Cys 1 5 10 15 Ile Lys Tyr Phe Ile His Ser Arg Thr Gly Leu Asn Lys 20 25 <210> 3051 <211> 27 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (27)..(27) <223> C-terminal amidation <400> 3051 Lys Lys Ser Gly Arg Gly Cys Thr Lys Val Ile Val Phe Thr Phe Arg 1 5 10 15 His Asn Lys Leu Ile Gly Tyr Glu Arg Lys Lys 20 25 <210> 3052 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal N-ethyl <400> 3052 Lys Lys Gly Arg Gly Cys Thr Lys Val Ile Val Phe Thr Phe Arg His 1 5 10 15 Asn Lys Leu Ile Gly Tyr Lys Lys 20 <210> 3053 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 3053 Lys Lys Cys Thr Lys Val Ile Val Phe Thr Phe Arg His Asn Lys Leu 1 5 10 15 Ile Gly Tyr Glu Arg Arg Lys Lys 20 <210> 3054 <211> 30 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (30)..(30) <223> C-terminal amidation <400> 3054 Met Leu Gly Val Leu Met Arg Gly Ile Ser Ala Leu Thr Gly Asp Tyr 1 5 10 15 Thr Ala Arg Phe Glu Phe Tyr Leu Asn Lys Gln Thr Phe Asn 20 25 30 <210> 3055 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 3055 Lys Lys Gly Cys Thr Lys Val Ile Val Phe Thr Phe Arg His Asn Lys 1 5 10 15 Leu Ile Gly Tyr Glu Arg Lys Lys 20 <210> 3056 <211> 33 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (33)..(33) <223> C-terminal amidation <400> 3056 Lys Lys Val Gly Ser Val Thr Arg Trp Ser Met Tyr Gly Pro Ile Phe 1 5 10 15 Ile Lys Phe Thr Trp Thr Leu Glu Gln Pro Val Gly Trp Asp His Lys 20 25 30 Lys <210> 3057 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 3057 Lys Lys Phe Trp Thr Met Trp Pro Asp Ile Lys Gly Glu Val Ile Val 1 5 10 15 Leu Phe Gly Thr Ser Lys Lys 20 <210> 3058 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 3058 Lys Lys His Pro Arg Tyr Phe Trp Thr Met Trp Pro Asp Ile Lys Gly 1 5 10 15 Glu Val Ile Val Leu Phe Lys Lys 20 <210> 3059 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 3059 Lys Lys Tyr Phe Trp Thr Met Trp Pro Asp Ile Lys Gly Glu Val Ile 1 5 10 15 Val Leu Phe Gly Thr Ser Lys Lys 20 <210> 3060 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 3060 Lys Lys Ser Gly Asn Thr Phe Val Asp Glu Arg Leu Leu Tyr Phe Leu 1 5 10 15 Thr Ile Gly Asn Met Gly Lys Lys 20 <210> 3061 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 3061 Lys Lys Ser Gly Arg Gly Cys Thr Lys Val Ile Val Phe Thr Phe Arg 1 5 10 15 His Asn Lys Leu Ile Gly Lys Lys 20 <210> 3062 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 3062 Lys Lys Thr Lys Val Ile Val Phe Thr Phe Arg His Asn Lys Leu Ile 1 5 10 15 Gly Tyr Glu Arg Arg Tyr Lys Lys 20 <210> 3063 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 3063 Lys Lys Lys Val Ile Val Phe Thr Phe Arg His Asn Lys Leu Ile Gly 1 5 10 15 Tyr Glu Arg Arg Tyr Asn Lys Lys 20 <210> 3064 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 3064 Lys Lys Ile Val Phe Thr Phe Arg His Asn Lys Leu Ile Gly Tyr Glu 1 5 10 15 Arg Arg Tyr Asn Cys Thr Lys Lys 20 <210> 3065 <211> 33 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (33)..(33) <223> C-terminal amidation <400> 3065 Lys Lys Leu Thr Gly Asp Trp Thr Tyr Phe Trp Ser Lys Val Ile Trp 1 5 10 15 Gly Pro Gly Val Ile Glu Arg Gln Met Pro Val Ser Thr Phe His Lys 20 25 30 Lys <210> 3066 <211> 29 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (29)..(29) <223> C-terminal amidation <400> 3066 Lys Lys Ser Gly Val Trp Gln Thr His Pro Arg Tyr Phe Trp Thr Met 1 5 10 15 Trp Pro Asp Ile Lys Gly Glu Val Ile Val Leu Lys Lys 20 25 <210> 3067 <211> 26 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (26)..(26) <223> C-terminal amidation <400> 3067 Lys Lys Ser Gly Val Trp Gln Thr His Pro Arg Tyr Phe Trp Thr Met 1 5 10 15 Trp Pro Asp Ile Lys Gly Glu Val Lys Lys 20 25 <210> 3068 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 3068 Lys Lys Ser Gly Val Trp Gln Thr His Pro Arg Tyr Phe Trp Thr Met 1 5 10 15 Trp Pro Asp Ile Lys Lys Lys 20 <210> 3069 <211> 29 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (29)..(29) <223> C-terminal amidation <400> 3069 Lys Lys Gln Thr His Pro Arg Tyr Phe Trp Thr Met Trp Pro Asp Ile 1 5 10 15 Lys Gly Glu Val Ile Val Leu Phe Gly Thr Ser Lys Lys 20 25 <210> 3070 <211> 26 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (26)..(26) <223> C-terminal amidation <400> 3070 Lys Lys Pro Arg Tyr Phe Trp Thr Met Trp Pro Asp Ile Lys Gly Glu 1 5 10 15 Val Ile Val Leu Phe Gly Thr Ser Lys Lys 20 25 <210> 3071 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 3071 Lys Lys Ser Gly Val Trp Gln Thr His Pro Arg Tyr Phe Trp Thr Met 1 5 10 15 Trp Pro Asp Ile Lys Gly Lys Lys 20 <210> 3072 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 3072 Lys Lys Trp Gln Thr His Pro Arg Tyr Phe Trp Thr Met Trp Pro Asp 1 5 10 15 Ile Lys Gly Glu Val Ile Lys Lys 20 <210> 3073 <211> 32 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (32)..(32) <223> C-terminal amidation <400> 3073 Lys Lys Ser Gly Asn Thr Phe Val Asp Glu Arg Leu Leu Tyr Phe Leu 1 5 10 15 Thr Ile Gly Asn Met Gly Met Tyr Ala Ala Gln Leu Lys Phe Lys Lys 20 25 30 <210> 3074 <211> 29 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (29)..(29) <223> C-terminal amidation <400> 3074 Lys Lys Ser Gly Asn Thr Phe Val Asp Glu Arg Leu Leu Tyr Phe Leu 1 5 10 15 Thr Ile Gly Asn Met Gly Met Tyr Ala Ala Gln Lys Lys 20 25 <210> 3075 <211> 26 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (26)..(26) <223> C-terminal amidation <400> 3075 Lys Lys Ser Gly Asn Thr Phe Val Asp Glu Arg Leu Leu Tyr Phe Leu 1 5 10 15 Thr Ile Gly Asn Met Gly Met Tyr Lys Lys 20 25 <210> 3076 <211> 32 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (32)..(32) <223> C-terminal amidation <400> 3076 Lys Lys Thr Phe Val Asp Glu Arg Leu Leu Tyr Phe Leu Thr Ile Gly 1 5 10 15 Asn Met Gly Met Tyr Ala Ala Gln Leu Lys Phe Arg Thr Ser Lys Lys 20 25 30 <210> 3077 <211> 29 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (29)..(29) <223> C-terminal amidation <400> 3077 Lys Lys Asp Glu Arg Leu Leu Tyr Phe Leu Thr Ile Gly Asn Met Gly 1 5 10 15 Met Tyr Ala Ala Gln Leu Lys Phe Arg Thr Ser Lys Lys 20 25 <210> 3078 <211> 26 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (26)..(26) <223> C-terminal amidation <400> 3078 Lys Lys Leu Leu Tyr Phe Leu Thr Ile Gly Asn Met Gly Met Tyr Ala 1 5 10 15 Ala Gln Leu Lys Phe Arg Thr Ser Lys Lys 20 25 <210> 3079 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (23)..(23) <223> C-terminal amidation <400> 3079 Lys Lys Phe Leu Thr Ile Gly Asn Met Gly Met Tyr Ala Ala Gln Leu 1 5 10 15 Lys Phe Arg Thr Ser Lys Lys 20 <210> 3080 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 3080 Lys Lys Leu Leu Tyr Phe Leu Thr Ile Gly Asn Met Gly Met Tyr Ala 1 5 10 15 Ala Gln Leu Lys Phe Arg Lys Lys 20 <210> 3081 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 3081 Lys Lys Leu Tyr Phe Leu Thr Ile Gly Asn Met Gly Met Tyr Ala Ala 1 5 10 15 Gln Leu Lys Phe Arg Thr Lys Lys 20 <210> 3082 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 3082 Lys Lys Tyr Phe Leu Thr Ile Gly Asn Met Gly Met Tyr Ala Ala Gln 1 5 10 15 Leu Lys Phe Arg Thr Ser Lys Lys 20 <210> 3083 <211> 24 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (24)..(24) <223> C-terminal amidation <400> 3083 Lys Lys Val Phe Thr Phe Arg His Asn Lys Leu Ile Gly Tyr Glu Arg 1 5 10 15 Arg Tyr Asn Cys Thr Ser Lys Lys 20 <210> 3084 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (22)..(22) <223> C-terminal amidation <400> 3084 Thr Phe Val Asp Glu Arg Leu Leu Tyr Phe Leu Thr Ile Gly Asn Met 1 5 10 15 Gly Met Tyr Ala Ala Gln 20 <210> 3085 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 3085 Ser Gly Asp Thr Phe Val Asp Glu Arg Leu Leu Tyr Phe Leu Thr Ile 1 5 10 15 Gly Asn Met Arg Met Tyr Ala Val Gln Leu Lys Phe Arg Thr Ser 20 25 30 <210> 3086 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 3086 Ser Gly Asp Thr Phe Val Asp Glu Arg Leu Leu Tyr Phe Leu Thr Thr 1 5 10 15 Gly Asn Met Arg Met Tyr Ala Val Gln Leu Lys Phe Arg Thr Ser 20 25 30 <210> 3087 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 3087 Ser Gly Asp Thr Phe Val Asp Glu Arg Leu Leu Tyr Phe Leu Thr Ile 1 5 10 15 Gly Asp Met Arg Met Tyr Ala Val Gln Leu Lys Phe Arg Thr Ser 20 25 30 <210> 3088 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 3088 Lys Lys Gly Val Trp Gln Thr His Pro Arg Tyr Phe Trp Thr Met Trp 1 5 10 15 Pro Asp Ile Lys Gly Glu Val Ile Val Leu Phe Gly Thr Lys Lys 20 25 30 <210> 3089 <211> 30 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (30)..(30) <223> C-terminal amidation <400> 3089 Lys Lys Val Trp Gln Thr His Pro Arg Tyr Phe Trp Thr Met Trp Pro 1 5 10 15 Asp Ile Lys Gly Glu Val Ile Val Leu Phe Gly Thr Lys Lys 20 25 30 <210> 3090 <211> 29 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (29)..(29) <223> C-terminal amidation <400> 3090 Lys Lys Trp Gln Thr His Pro Arg Tyr Phe Trp Thr Met Trp Pro Asp 1 5 10 15 Ile Lys Gly Glu Val Ile Val Leu Phe Gly Thr Lys Lys 20 25 <210> 3091 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 3091 Ser Gly Gly Arg Lys His Lys His Phe Leu Arg Ser Asn Gly Lys Pro 1 5 10 15 Ser Arg Ala Leu Cys Ser Met His Phe Trp Arg Trp Ser Thr Ser 20 25 30 <210> 3092 <211> 32 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal Biotinyl <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is (13-Amino-4,7,10-trioxa-tridecayl)-succinamic acid <220> <221> MOD_RES <222> (32)..(32) <223> C-terminal amidation <400> 3092 Xaa Ser Gly Gly Arg Lys His Leu His Phe Leu Arg Ser Asn Gly Lys 1 5 10 15 Pro Ser Arg Ala Leu Cys Ser Met His Phe Trp Arg Trp Ser Thr Ser 20 25 30 <210> 3093 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 3093 Ser Gly Gly Arg Lys His Lys His Phe Leu Arg Ser Asn Gly Lys Pro 1 5 10 15 Ser Arg Ala Leu Ser Ser Met His Phe Trp Arg Trp Ser Thr Ser 20 25 30 <210> 3094 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 3094 Lys Gly Ser Ser Arg Ser Gly His Asn Ala Leu Lys Thr His Ser Trp 1 5 10 15 Met Ser Pro Phe Arg Arg Arg Gly Ser Trp Ser Leu His Phe Lys 20 25 30 <210> 3095 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 3095 Lys Ser Arg Ser Gly Phe Trp His Ala Trp Ser His Arg Thr Arg Pro 1 5 10 15 Met Lys Ser Arg Leu His Leu Gly Lys Phe Ser Asn Ser Ser Gly 20 25 30 <210> 3096 <211> 28 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (28)..(28) <223> C-terminal amidation <400> 3096 Ser Gly Gly Arg Lys His Lys His Phe Leu Arg Ser Asn Gly Lys Pro 1 5 10 15 Ser Arg Ala Leu Ser Ser Met His Phe Trp Arg Trp 20 25 <210> 3097 <211> 25 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (25)..(25) <223> N-terminal amidation <400> 3097 Ser Gly Gly Arg Lys His Lys His Phe Leu Arg Ser Asn Gly Lys Pro 1 5 10 15 Ser Arg Ala Leu Ser Ser Met His Phe 20 25 <210> 3098 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (22)..(22) <223> C-terminal amidation <400> 3098 Ser Gly Gly Arg Lys His Lys His Phe Leu Arg Ser Asn Gly Lys Pro 1 5 10 15 Ser Arg Ala Leu Ser Ser 20 <210> 3099 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (19)..(19) <223> C-terminal amidation <400> 3099 Ser Gly Gly Arg Lys His Lys His Phe Leu Arg Ser Asn Gly Lys Pro 1 5 10 15 Ser Arg Ala <210> 3100 <211> 28 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (28)..(28) <223> C-terminal amidation <400> 3100 Arg Lys His Lys His Phe Leu Arg Ser Asn Gly Lys Pro Ser Arg Ala 1 5 10 15 Leu Ser Ser Met His Phe Trp Arg Trp Ser Thr Ser 20 25 <210> 3101 <211> 25 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (25)..(25) <223> C-terminal amidation <400> 3101 Lys His Phe Leu Arg Ser Asn Gly Lys Pro Ser Arg Ala Leu Ser Ser 1 5 10 15 Met His Phe Trp Arg Trp Ser Thr Ser 20 25 <210> 3102 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (22)..(22) <223> C-terminal amidation <400> 3102 Leu Arg Ser Asn Gly Lys Pro Ser Arg Ala Leu Ser Ser Met His Phe 1 5 10 15 Trp Arg Trp Ser Thr Ser 20 <210> 3103 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (19)..(19) <223> C-terminal amidation <400> 3103 Asn Gly Lys Pro Ser Arg Ala Leu Ser Ser Met His Phe Trp Arg Trp 1 5 10 15 Ser Thr Ser <210> 3104 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 3104 Ser Gly Gly Arg Lys His Lys His Phe Leu Arg Ser Asn Gly Lys Pro 1 5 10 15 Ser Arg Ala Leu 20 <210> 3105 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 3105 Arg Lys His Lys His Phe Leu Arg Ser Asn Gly Lys Pro Ser Arg Ala 1 5 10 15 Leu Ser Ser Met 20 <210> 3106 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 3106 Lys His Phe Leu Arg Ser Asn Gly Lys Pro Ser Arg Ala Leu Ser Ser 1 5 10 15 Met His Phe Trp 20 <210> 3107 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 3107 Leu Arg Ser Asn Gly Lys Pro Ser Arg Ala Leu Ser Ser Met His Phe 1 5 10 15 Trp Arg Trp Ser 20 <210> 3108 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <400> 3108 Ser Asn Gly Lys Pro Ser Arg Ala Leu Ser Ser Met His Phe Trp Arg 1 5 10 15 Trp Ser Thr Ser 20 <210> 3109 <211> 15 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is selected from the group consisting of Leu, Pro, Lys, Ser, Trp, Val, Asn, and Gln <220> <221> MOD_RES <222> (2)..(2) <223> Xaa is selected from the group consisting of Leu, Arg, Asn, Phe, and Ile <220> <221> MOD_RES <222> (3)..(3) <223> Xaa is selected from the group consisting of Tyr, Val, Pro, and Cys <220> <221> MOD_RES <222> (4)..(4) <223> Xaa is selected from the group consisting of Phe, Leu, Gly <220> <221> MOD_RES <222> (5)..(5) <223> Xaa is selected from the group consisting of Leu, Trp, Val, Ala, Met, Thr, and Ser <220> <221> MOD_RES <222> (6)..(6) <223> Xaa is selected from the group consisting of Thr, Phe, Val, Arg, Ala, Asp, Leu, Glu, Ser, and Tyr <220> <221> MOD_RES <222> (7)..(7) <223> Xaa is selected from the group consisting of Ile, Met, Gly, Gln, Asp, and Arg <220> <221> MOD_RES <222> (8)..(8) <223> Xaa is selected from the group consisting of Gly, Trp, Tyr, Leu, Met, and His <220> <221> MOD_RES <222> (9)..(9) <223> Xaa is selected from the group consisting of Asn, Pro, Phe, His, Lys, and Tyr <220> <221> MOD_RES <222> (10)..(10) <223> Xaa is selected from the group consisting of Met, Asp, Glu, Val, Gly, and Lys <220> <221> MOD_RES <222> (11)..(11) <223> Xaa is selected from the group consisting of Gly, Ile, Arg, Ser, Thr, and Leu <220> <221> MOD_RES <222> (12)..(12) <223> Xaa is selected from the group consisting of Met, Lys, Leu, and Ile <220> <221> MOD_RES <222> (13)..(13) <223> Xaa is selected from the group consisting of Tyr, Gly, Arg, and Ser <220> <221> MOD_RES <222> (14)..(14) <223> Xaa is selected from the group consisting of Ala, Glu, Ser, Cys, and Tyr <220> <221> MOD_RES <222> (15)..(15) <223> Xaa is selected from the group consisting of Ala, Val, Lys, and Glu <400> 3109 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 <210> 3110 <211> 4 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is selected from a group consisting of Val, Trp, Tyr, and Phe <220> <221> MOD_RES <222> (2)..(2) <223> Xaa is selected from a group consisting of Asp, Gln, and Ser <220> <221> MOD_RES <222> (3)..(3) <223> Xaa is selected from a group consisting of Glu, Thr, Asn, and Ser <220> <221> MOD_RES <222> (4)..(4) <223> Xaa is selected from a group consisting of Arg, His, Lys, and Ala <400> 3110 Xaa Xaa Xaa Xaa 1 <210> 3111 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is selected from a group consisting of Phe and Val <220> <221> MOD_RES <222> (2)..(2) <223> Xaa is selected from a group consisting of Val, Trp, Tyr, and Phe <220> <221> MOD_RES <222> (3)..(3) <223> Xaa is selected from a group consisting of Asp, Gln, and Ser <220> <221> MOD_RES <222> (4)..(4) <223> Xaa is selected from a group consisting of Glu, Thr, Asn, and Ser <220> <221> MOD_RES <222> (5)..(5) <223> Xaa is selected from a group consisting of Arg, His, Lys, and Ala <400> 3111 Xaa Xaa Xaa Xaa Xaa 1 5 <210> 3112 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is selected from a group consisting of Thr and Gly <220> <221> MOD_RES <222> (2)..(2) <223> Xaa is selected from a group consisting of Phe and Val <220> <221> MOD_RES <222> (3)..(3) <223> Xaa is selected from a group consisting of Val, Trp, Tyr, and Phe <220> <221> MOD_RES <222> (4)..(4) <223> Xaa is selected from a group consisting of Asp, Gln, and Ser <220> <221> MOD_RES <222> (5)..(5) <223> Xaa is selected from a group consisting of Glu, Thr, Asn, and Ser <220> <221> MOD_RES <222> (6)..(6) <223> Xaa is selected from a group consisting of Arg, His, Lys, and Ala <400> 3112 Xaa Xaa Xaa Xaa Xaa Xaa 1 5 <210> 3113 <211> 4 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is selected from a group consisting of Gln, Ile, Glu, Trp, Arg, Leu, and Asn <220> <221> MOD_RES <222> (2)..(2) <223> Xaa is selected from a group consisting of Leu, Val, Met, and Arg <220> <221> MOD_RES <222> (3)..(3) <223> Xaa is selected from a group consisting of Lys, Leu, Ala, and Tyr <400> 3113 Xaa Xaa Xaa Phe 1 <210> 3114 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is selected from a group consisting of Gln, Ile, Glu, Trp, Arg, Leu, and Asn <220> <221> MOD_RES <222> (2)..(2) <223> Xaa is selected from a group consisting of Leu, Val, Met, and Arg <220> <221> MOD_RES <222> (3)..(3) <223> Xaa is selected from a group consisting of Lys, Leu, Ala, and Tyr <400> 3114 Xaa Xaa Xaa Pro Gly 1 5 <210> 3115 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is selected from a group consisting of Gln, Ile, Glu, Trp, Arg, Leu, and Asn <220> <221> MOD_RES <222> (2)..(2) <223> Xaa is selected from a group consisting of Leu, Val, Met, and Arg <220> <221> MOD_RES <222> (3)..(3) <223> Xaa is selected from a group consisting of Lys, Leu, Ala, and Tyr <400> 3115 Xaa Xaa Xaa Pro Gly Thr 1 5 <210> 3116 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is an amino acid selected from the group consisting of Bhf, Cys, Asp, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Nmf, Gln, Arg, Thr, Val, Trp and Tyr <220> <221> MOD_RES <222> (2)..(2) <223> Xaa is an amino acid selected from the group consisting Gly, Lys, and Gln <220> <221> MOD_RES <222> (3)..(3) <223> Xaa is an amino acid selected from the group consisting Ala, Aib, Bhs, Cys, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Pro, Gln, Arg, Ser, Thr, Val, Trp and Tyr <220> <221> MOD_RES <222> (4)..(4) <223> Xaa is an amino acid selected from the group consisting Ala, Aib, Bhk, Cys, Asp, Glu, Phe, Gly, His, Ile, Lys, D-Lys, Leu, Met, Asn, Nmk, Pro, Gln, Arg, Ser, Thr, Val, Trp and Tyr <220> <221> MOD_RES <222> (5)..(5) <223> Xaa is an amino acid selected from the group consisting D-Ala, Ala, Aib, Bal, Cys, Asp, D-Asp, Glu, Phe, Gly, His, Lys, D-Lys, Leu, Met, Asn, Nmg, D-Pro, Gln, Arg, Ser, Thr, Val, Trp and Tyr <220> <221> MOD_RES <222> (6)..(6) <223> Xaa is an amino acid selected from the group consisting Ala, Aib, Btq, Cys, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Gln, Arg, Ser, Thr, Val, Trp and Tyr <220> <221> MOD_RES <222> (7)..(7) <223> Xaa is an amino acid selected from the group consisting Ala, Phe, Gly, Ile, Lys, Leu, Nmv, Pro, Gln, Ser, Val, Trp and Tyr <220> <221> MOD_RES <222> (8)..(8) <223> Xaa is an amino acid selected from the group consisting Phe, His, Lys, Trp and Tyr <220> <221> MOD_RES <222> (9)..(9) <223> Xaa is an amino acid selected from the group consisting Ala, Aib, D-Phe, Ile, Lys, Ser, Thr, and Val <220> <221> MOD_RES <222> (10)..(10) <223> Xaa is an amino acid selected from the group consisting Ala, Aib, Cys, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Nmf, Pro, Gln, Arg, Ser, Thr, Val, Trp and Tyr <220> <221> MOD_RES <222> (11)..(11) <223> Xaa is an amino acid selected from the group consisting Aib, Cys, Lys, Gly, and Nmg <220> <221> MOD_RES <222> (13)..(13) <223> Xaa is an amino acid selected from the group consisting Ala, Aib, Cys, Glu, Phe, Gly, His, Lys, Leu, Met, Gln, Arg, Trp, and Tyr <220> <221> MOD_RES <222> (14)..(14) <223> Xaa is an amino acid selected from the group consisting Ala, Aib, Bhe, Cys, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Pro, Gln, Arg, Ser, Thr, Val, Trp, and Tyr <220> <221> MOD_RES <222> (15)..(15) <223> Xaa is an amino acid selected from the group consisting (omega-methyl)-Arg, Asp, Glu, Lys and Arg <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is an amino acid selected from the group consisting (omega-methyl)-Arg, Ala, Aib, Bhr, Cys, Cha, Cit, Asp, Dab, Dap, Glu, Eag, Eew, Phe, Gly, His, Har, Hci, Hle, Ile, Lys, Leu, Met, Asn, Nle, Nva, Opa, Orn, Gln, Arg, Ser, Thr, Val, Trp and Tyr <220> <221> MOD_RES <222> (18)..(18) <223> Xaa is an amino acid selected from the group consisting Ala, Bal, Cys, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Gln, Arg, Ser, Thr, Val, Trp and Tyr <220> <221> MOD_RES <222> (19)..(19) <223> Xaa is an amino acid selected from the group consisting Bhk, Lys, Arg, and Val <220> <221> MOD_RES <222> (20)..(20) <223> Xaa is an amino acid selected from the group consisting of Aib, Bhl, Cys, Phe, Gly, His, Ile, Lys, Leu, Nml, Gln, Arg, Ser, Thr, Val, Trp and Tyr or is absent <400> 3116 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa Xaa Leu 1 5 10 15 Xaa Xaa Xaa Xaa 20 <210> 3117 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is selected from any amino acid <220> <221> MOD_RES <222> (3)..(3) <223> Xaa is selected from any amino acid <220> <221> MOD_RES <222> (4)..(4) <223> Xaa is selected from any amino acid <220> <221> MOD_RES <222> (5)..(5) <223> Xaa is selected from any amino acid <220> <221> MOD_RES <222> (6)..(6) <223> Xaa is selected from any amino acid <220> <221> MOD_RES <222> (7)..(7) <223> Xaa is an amino acid selected from the group consisting of Ile and Val <220> <221> MOD_RES <222> (8)..(8) <223> Xaa is selected from any amino acid <220> <221> MOD_RES <222> (10)..(10) <223> Xaa is selected from any amino acid <220> <221> MOD_RES <222> (13)..(13) <223> Xaa is an amino acid selected from the group consisting of Cys and Phe <220> <221> MOD_RES <222> (14)..(14) <223> Xaa is selected from any amino acid <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is selected from any amino acid <220> <221> MOD_RES <222> (18)..(18) <223> Xaa is selected from any amino acid <220> <221> MOD_RES <222> (20)..(20) <223> Xaa is an amino acid selected from the group consisting of Lys and Leu <400> 3117 Xaa Gln Xaa Xaa Xaa Xaa Xaa Xaa Val Xaa Gly Tyr Xaa Xaa Arg Leu 1 5 10 15 Xaa Xaa Lys Xaa 20 <210> 3118 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is an amino acid selected from a group consisting of Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Pro, Arg, Ser, Thr, Val and Trp or is absent <220> <221> MOD_RES <222> (2)..(2) <223> Xaa is an amino acid selected from a group consisting of Ala, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Pro, Arg, Ser, Thr, Val and Trp or is absent <220> <221> misc_feature <222> (3)..(3) <223> Xaa can be any naturally occurring amino acid <220> <221> MOD_RES <222> (4)..(4) <223> Xaa is an amino acid selected from a group consisting of Ala, Asp, Glu, Phe, Gly, Ile, Lys, Leu, Arg, Ser, Thr, Val and Trp <220> <221> MOD_RES <222> (6)..(6) <223> Xaa is an amino acid selected from a group consisting of Phe, His, Ile, Lys, Leu, Arg, Val and Trp <220> <221> MOD_RES <222> (7)..(7) <223> Xaa is an amino acid selected from a group consisting of Cys, Hcy, Dap and Lys, preferably selected from the group consisting of Cys and Hcy <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (8)..(8) <223> Xaa is an amino acid selected from a group consisting of Ala, Gly, Arg, Ser and Thr <220> <221> MOD_RES <222> (9)..(9) <223> Xaa is an amino acid selected from a group consisting of Ala, Ile, Lys, Leu, Met, D-Met, Nle, D-Pro, Arg, and Val <220> <221> MOD_RES <222> (10)..(10) <223> Xaa is an amino acid selected from a group consisting of Ala, Gly, Ile, Lys, Leu, Pro, Arg, Ser, Thr and Val <220> <221> MOD_RES <222> (11)..(11) <223> Xaa is an amino acid selected from a group consisting of Asp, Glu, Gly, Ser and Thr <220> <221> MOD_RES <222> (12)..(12) <223> Xaa is an amino acid selected from a group consisting of Ala, D-Ala, Asp, D-Asp, Glu, D-Glu, Phe, D-Phe, Gly, Ile, Lys, D-Lys, Leu, D-Leul, Met, D-Met, Nle, D-Nle, Pro, D-Pro, Arg, D-Arg, Ser, D-Ser, Thr, D-Thr, Val, D-Val, Trp and D-Trp <220> <221> MOD_RES <222> (13)..(13) <223> Xaa is an amino acid selected from a group consisting of Ala, Asp, D-Asp, Glu, D-Glu, Phe, Gly, Ile, Lys, Leu, Arg, Ser, D-Ser, Thr, Val and Trp <220> <221> MOD_RES <222> (15)..(15) <223> Xaa is an amino acid selected from a group consisting of Ala, Asp, Glu, Phe, Gly, Ile, Lys, Leu, Met, Nle, Arg, Ser, Thr, Val and Trp <220> <221> MOD_RES <222> (16)..(16) <223> Xaa is an amino acid selected from a group consisting of Ala, Asp, Glu, Phe, Ile, Lys, Leu, Met, Nle, Arg, Ser, Thr, Val, Trp and Tyr <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is an amino acid selected from a group consisting of Ala, Asp, Glu, Phe, Gly, Ile, Lys, Leu, Arg, Ser, Thr, Val, Trp and Tyr <220> <221> MOD_RES <222> (18)..(18) <223> Xaa is an amino acid selected from a group consisting of Cys and Asp <220> <221> MOD_RES <222> (19)..(19) <223> Xaa is an amino acid selected from a group consisting of Ala, Phe, Ile, Leu, Ser, Thr, Val, and Trp <220> <221> MOD_RES <222> (20)..(20) <223> Xaa is an amino acid selected from a group consisting of Phe and Trp <220> <221> MOD_RES <222> (21)..(21) <223> Xaa is an amino acid selected from a group consisting of Ile, Leu, and Val <220> <221> MOD_RES <222> (22)..(22) <223> Xaa is an amino acid selected from a group consisting of Ala, Asp, Glu, Phe, Gly, Ile, Lys, Leu, Pro, Arg, Ser, Thr, Val, and Trp <220> <221> MOD_RES <222> (23)..(23) <223> Xaa is an amino acid selected from a group consisting of Ala, Asp, Glu, Phe, Gly, Ile, Lys, Leu, Arg, Ser, Thr, Val, Trp and Tyr or is absent <400> 3118 Xaa Xaa Xaa Xaa Trp Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa Xaa Xaa 20 <210> 3119 <211> 23 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is selected from any amino acid or is absent <220> <221> MOD_RES <222> (2)..(2) <223> Xaa is selected from any amino acid or is absent <220> <221> MOD_RES <222> (3)..(3) <223> Xaa is selected a group of amino acids consisting of Phe and Tyr <220> <221> MOD_RES <222> (6)..(6) <223> Xaa is selected a group of amino acids consisting of Phe and His <220> <221> DISULFID <222> (7)..(18) <223> Cys residues linked via disulfide bond <220> <221> MOD_RES <222> (8)..(8) <223> Xaa is selected from any amino acid <220> <221> MOD_RES <222> (9)..(9) <223> Xaa is selected a group of amino acids consisting of Met and Val <220> <221> MOD_RES <222> (10)..(10) <223> Xaa is selected from any amino acid <220> <221> MOD_RES <222> (12)..(12) <223> Xaa is selected from any amino acid <220> <221> MOD_RES <222> (13)..(13) <223> Xaa is selected from any amino acid <220> <221> MOD_RES <222> (15)..(15) <223> Xaa is selected a group of amino acids consisting of Ile and Thr <220> <221> MOD_RES <222> (16)..(16) <223> Xaa is selected from any amino acid <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is selected a group of amino acids consisting of Ser and Thr <220> <221> MOD_RES <222> (19)..(19) <223> Xaa is selected a group of amino acids consisting of Ala and Val <220> <221> MOD_RES <222> (22)..(22) <223> Xaa is selected from any amino acid <220> <221> MOD_RES <222> (23)..(23) <223> Xaa is selected from any amino acid or is absent <400> 3119 Xaa Xaa Xaa Lys Trp Xaa Cys Xaa Xaa Xaa Asp Xaa Xaa Gly Xaa Xaa 1 5 10 15 Xaa Cys Xaa Trp Val Xaa Xaa 20 <210> 3120 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is an amino acid selected from the group consisting of Ala, Cys, Asp, Phe, Gly, Ile, Lys, Leu, Met, Asn, Pro, Gln, Arg, Ser, Thr, Trp, Glu, His and Tyr or is absent <220> <221> MOD_RES <222> (2)..(2) <223> Xaa is an amino acid selected from the group consisting of Ala, Cys, Asp, Phe, His, Lys, Met, Asn, Pro, Arg, Ser, Thr, Trp, Tyr, Gly, Ile, and Leu or is absent <220> <221> MOD_RES <222> (3)..(3) <223> Xaa is an amino acid selected from the group consisting of Ala, Cys, Asp, Glu, Phe, Gly, His, Ile, Lys, Met, Asn, Pro, Arg, Ser, Thr, Trp, and Tyr <220> <221> MOD_RES <222> (4)..(4) <223> Xaa is an amino acid selected from the group consisting of Ala, Cys, Asp, Glu, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Gln, Arg, Ser, Thr, Val, Trp, Tyr and Pro <220> <221> MOD_RES <222> (5)..(5) <223> Xaa is an amino acid selected from the group consisting of Cys, Asp, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Pro, Arg, Ser, Thr, Val, Trp, and Tyr <220> <221> MOD_RES <222> (6)..(6) <223> Xaa is an amino acid selected from the group consisting of Ala, Trp, Cys, Lys, Pro, Arg, and His <220> <221> MOD_RES <222> (7)..(7) <223> Xaa is an amino acid selected from the group consisting of Gln, Ala, Cys, Phe, Gly, His, Ile, Lys, Leu, Asn, Arg, Thr, Trp and Tyr <220> <221> MOD_RES <222> (8)..(8) <223> Xaa is an amino acid selected from the group consisting of Ala, Cys, Phe, Gly, His, Lys, Leu, Met, Asn, Pro, Gln, Arg, Ser, Thr, Val, Trp, Tyr and Ile <220> <221> MOD_RES <222> (9)..(9) <223> Xaa is an amino acid selected from the group consisting of Ala, Cys, Phe, Gly, His, Ile, Leu, Met, Arg, Ser, Thr, Val, Trp, Tyr and Lys <220> <221> MOD_RES <222> (10)..(10) <223> Xaa is an amino acid selected from the group consisting of Ala, Cys, Phe, Gly, His, Ile, Lys, Leu, Met, Asn, Pro, Gln, Arg, Ser, Thr, Val, Trp, and Tyr <220> <221> MOD_RES <222> (11)..(11) <223> Xaa is an amino acid selected from the group consisting of Ala, Gly, Ile, Lys, Leu, Met, Asn, Gln, Arg, Ser, Thr, Val, Trp, Tyr, Cys, Phe, and His <220> <221> MOD_RES <222> (12)..(12) <223> Xaa is an amino acid selected from the group consisting of Ala, Cys, His, Ile, Lys, Leu, and Arg <220> <221> MOD_RES <222> (13)..(13) <223> Xaa is an amino acid selected from the group consisting of Ala, Cys, Phe, Gly, His, Lys, Leu, Met, Arg, Ser, Val, Trp, Tyr, and Ile <220> <221> MOD_RES <222> (14)..(14) <223> Xaa is an amino acid selected from the group consisting of Ala, Cys, Phe, Gly, His, Ile, Leu, Met, Asn, Gln, Arg, Ser, Thr, Val, Trp, Tyr, and Lys <220> <221> MOD_RES <222> (15)..(15) <223> Xaa is an amino acid selected from the group consisting of Ala, Lys, and Arg <220> <221> MOD_RES <222> (16)..(16) <223> Xaa is an amino acid selected from the group consisting of Ala, Phe, Lys, and Arg <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is an amino acid selected from the group consisting of Ala, Cys, Phe, Gly, Ile, Lys, Leu, Asn, Gln, Arg, Ser, Thr, Val, Trp, Tyr, His, and Met <220> <221> MOD_RES <222> (18)..(18) <223> Xaa is an amino acid selected from the group consisting of Ala, Cys, Phe, Ile, Lys, Leu, Met, Gln, Arg, Val, Trp, and Tyr <220> <221> MOD_RES <222> (19)..(19) <223> Xaa is an amino acid selected from the group consisting of Ala, Cys, Asp, Glu, Phe, Gly, His, Lys, Leu, Asn, Pro, Gln, Arg, Val, Trp, Tyr, and Ile <220> <221> MOD_RES <222> (20)..(20) <223> Xaa is an amino acid selected from the group consisting of Ala, Cys, Phe, Gly, His, Lys, Leu, Met, Asn, Gln, Arg, Val, Trp, Tyr, Ile, and Pro <220> <221> MOD_RES <222> (21)..(21) <223> Xaa is an amino acid selected from the group consisting of Ala, Cys, His, Ile, Lys, Leu, Met, Pro, Arg, Thr, Val, Trp, Tyr, Phe, and Gly <400> 3120 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 15 Xaa Xaa Xaa Xaa Xaa 20 <210> 3121 <211> 21 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is selected from any amino acid or is absent <220> <221> MOD_RES <222> (2)..(2) <223> Xaa is selected from any amino acid or is absent <220> <221> MOD_RES <222> (3)..(3) <223> Xaa is selected from any amino acid <220> <221> MOD_RES <222> (4)..(4) <223> Xaa is selected from any amino acid <220> <221> MOD_RES <222> (5)..(5) <223> Xaa is selected from any amino acid <220> <221> MOD_RES <222> (6)..(6) <223> Xaa is selected from any amino acid <220> <221> MOD_RES <222> (7)..(7) <223> Xaa is selected from any amino acid <220> <221> MOD_RES <222> (8)..(8) <223> Xaa is selected from any amino acid <220> <221> MOD_RES <222> (9)..(9) <223> Xaa is selected from any amino acid <220> <221> MOD_RES <222> (10)..(10) <223> Xaa is selected from any amino acid <220> <221> MOD_RES <222> (11)..(11) <223> Xaa is selected from any amino acid <220> <221> MOD_RES <222> (13)..(13) <223> Xaa is selected from any amino acid <220> <221> MOD_RES <222> (14)..(14) <223> Xaa is selected from any amino acid <220> <221> MOD_RES <222> (15)..(15) <223> Xaa is an amino acid selected from a group consisting of Lys and Arg <220> <221> MOD_RES <222> (17)..(17) <223> Xaa is selected from any amino acid <220> <221> MOD_RES <222> (18)..(18) <223> Xaa is selected from any amino acid <220> <221> MOD_RES <222> (19)..(19) <223> Xaa is selected from any amino acid <220> <221> MOD_RES <222> (20)..(20) <223> Xaa is selected from any amino acid <220> <221> MOD_RES <222> (21)..(21) <223> Xaa is selected from any amino acid <400> 3121 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa His Xaa Xaa Xaa Arg 1 5 10 15 Xaa Xaa Xaa Xaa Xaa 20 <210> 3122 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is an amino acid selected from the group consisting of Ala, Glu, and Pro or is absent <220> <221> MOD_RES <222> (2)..(2) <223> Xaa is an amino acid selected from the group consisting of Phe, Leu, Tyr, and Met <220> <221> MOD_RES <222> (4)..(4) <223> Xaa is an amino acid selected from the group consisting of Met, Gln, Arg, Ser, Thr, and Cys <220> <221> MOD_RES <222> (5)..(5) <223> Xaa is an amino acid selected from the group consisting of Aib, Lys, Pro, Arg, Glu, Ile, Tyr, Met, and Trp <220> <221> MOD_RES <222> (6)..(6) <223> Xaa is an amino acid selected from the group consisting of D-Ala, Aib, Asp, D-Asp, Gly, His, Lys, D-Lys, Asn, Nmg, D-Pro, Gln, Arg, Ala, Glu, Cys, and Met <220> <221> MOD_RES <222> (7)..(7) <223> Xaa is an amino acid selected from the group consisting of Ala, Cys, Asp, Gly, His, Lys, Asn, Gln, Arg, Ser, and Met <220> <221> MOD_RES <222> (8)..(8) <223> Xaa is an amino acid selected from the group consisting of Ile and Val <220> <221> MOD_RES <222> (9)..(9) <223> Xaa is an amino acid selected from the group consisting of Phe, His, and Tyr <220> <221> MOD_RES <222> (11)..(11) <223> Xaa is an amino acid selected from the group consisting of Ala, Asp, Glu, Lys, Met, Asn, Gln, Arg, Phe, His Pro, Ser, Val Trp <220> <221> MOD_RES <222> (14)..(14) <223> Xaa is an amino acid selected from the group consisting of Cys and Phe <220> <221> MOD_RES <222> (15)..(15) <223> Xaa is an amino acid selected from the group consisting of Ala, Cys, Asp, Glu, Lys, Leu, Met Asn, Gln, Arg, Thr, Val and Aib <220> <221> MOD_RES <222> (18)..(18) <223> Xaa is an amino acid selected from the group consisting of Ala, Aib, Cys, Cha, Dab, Dap, Eag, Eew, His, Har, Hci, Hle, Lys, Nle, Nva, Opa, Orn, Arg, Ile, Leu, Ser, and Met <220> <221> MOD_RES <222> (19)..(19) <223> Xaa is an amino acid selected from the group consisting of Ala, Leu, Asn, Met, and Arg <220> <221> MOD_RES <222> (20)..(20) <223> Xaa is an amino acid selected from the group consisting of Lys and Leu <400> 3122 Xaa Xaa Gln Xaa Xaa Xaa Xaa Xaa Xaa Val Xaa Gly Tyr Xaa Xaa Arg 1 5 10 15 Leu Xaa Lys Xaa 20 <210> 3123 <211> 4 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is Leu or Lys <220> <221> MOD_RES <222> (2)..(2) <223> Xaa is Gln or Lys <220> <221> MOD_RES <222> (3)..(3) <223> Xaa is Val or Lys <220> <221> MOD_RES <222> (4)..(4) <223> Xaa is Ala or Lys <400> 3123 Xaa Xaa Xaa Xaa 1 <210> 3124 <211> 5 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is Arg or Lys <220> <221> MOD_RES <222> (2)..(2) <223> Xaa is Leu or Lys <220> <221> MOD_RES <222> (3)..(3) <223> Xaa is Gln or Lys <220> <221> MOD_RES <222> (4)..(4) <223> Xaa is Val or Lys <220> <221> MOD_RES <222> (5)..(5) <223> Xaa is Ala or Lys <400> 3124 Xaa Xaa Xaa Xaa Xaa 1 5 <210> 3125 <211> 6 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is Gly or Lys <220> <221> MOD_RES <222> (2)..(2) <223> Xaa is Arg or Lys <220> <221> MOD_RES <222> (3)..(3) <223> Xaa is Leu or Lys <220> <221> MOD_RES <222> (4)..(4) <223> Xaa is Gln or Lys <220> <221> MOD_RES <222> (5)..(5) <223> Xaa is Val or Lys <220> <221> MOD_RES <222> (6)..(6) <223> Xaa is Ala or Lys <400> 3125 Xaa Xaa Xaa Xaa Xaa Xaa 1 5 <210> 3126 <211> 7 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is Val or Lys <220> <221> MOD_RES <222> (2)..(2) <223> Xaa is Gly or Lys <220> <221> MOD_RES <222> (3)..(3) <223> Xaa is Arg or Lys <220> <221> MOD_RES <222> (4)..(4) <223> Xaa is Leu or Lys <220> <221> MOD_RES <222> (5)..(5) <223> Xaa is Gln or Lys <220> <221> MOD_RES <222> (6)..(6) <223> Xaa is Val or Lys <220> <221> MOD_RES <222> (7)..(7) <223> Xaa is Ala or Lys <400> 3126 Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 <210> 3127 <211> 8 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is Gly or Lys <220> <221> MOD_RES <222> (2)..(2) <223> Xaa is Val or Lys <220> <221> MOD_RES <222> (3)..(3) <223> Xaa is Gly or Lys <220> <221> MOD_RES <222> (4)..(4) <223> Xaa is Arg or Lys <220> <221> MOD_RES <222> (5)..(5) <223> Xaa is Leu or Lys <220> <221> MOD_RES <222> (6)..(6) <223> Xaa is Gln or Lys <220> <221> MOD_RES <222> (7)..(7) <223> Xaa is Val or Lys <220> <221> MOD_RES <222> (8)..(8) <223> Xaa is Ala or Lys <400> 3127 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 <210> 3128 <211> 9 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is Ser or Lys <220> <221> MOD_RES <222> (2)..(2) <223> Xaa is Gly or Lys <220> <221> MOD_RES <222> (3)..(3) <223> Xaa is Val or Lys <220> <221> MOD_RES <222> (4)..(4) <223> Xaa is Gly or Lys <220> <221> MOD_RES <222> (5)..(5) <223> Xaa is Arg or Lys <220> <221> MOD_RES <222> (6)..(6) <223> Xaa is Leu or Lys <220> <221> MOD_RES <222> (7)..(7) <223> Xaa is Gln or Lys <220> <221> MOD_RES <222> (8)..(8) <223> Xaa is Val or Lys <220> <221> MOD_RES <222> (9)..(9) <223> Xaa is Ala or Lys <400> 3128 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 <210> 3129 <211> 10 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (2)..(2) <223> Xaa is Ser or Lys <220> <221> MOD_RES <222> (3)..(3) <223> Xaa is Gly or Lys <220> <221> MOD_RES <222> (4)..(4) <223> Xaa is Val or Lys <220> <221> MOD_RES <222> (5)..(5) <223> Xaa is Gly or Lys <220> <221> MOD_RES <222> (6)..(6) <223> Xaa is Arg or Lys <220> <221> MOD_RES <222> (7)..(7) <223> Xaa is Leu or Lys <220> <221> MOD_RES <222> (8)..(8) <223> Xaa is Gln or Lys <220> <221> MOD_RES <222> (9)..(9) <223> Xaa is Val or Lys <220> <221> MOD_RES <222> (10)..(10) <223> Xaa is Ala or Lys <400> 3129 Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 <210> 3130 <211> 11 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (3)..(3) <223> Xaa is Ser or Lys <220> <221> MOD_RES <222> (4)..(4) <223> Xaa is Gly or Lys <220> <221> MOD_RES <222> (5)..(5) <223> Xaa is Val or Lys <220> <221> MOD_RES <222> (6)..(6) <223> Xaa is Gly or Lys <220> <221> MOD_RES <222> (7)..(7) <223> Xaa is Arg or Lys <220> <221> MOD_RES <222> (8)..(8) <223> Xaa is Leu or Lys <220> <221> MOD_RES <222> (9)..(9) <223> Xaa is Gln or Lys <220> <221> MOD_RES <222> (10)..(10) <223> Xaa is Val or Lys <220> <221> MOD_RES <222> (11)..(11) <223> Xaa is Ala or Lys <400> 3130 Lys Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 10 <210> 3131 <211> 4 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> Xaa is Tyr or Lys <220> <221> MOD_RES <222> (2)..(2) <223> Xaa is Ser or Lys <400> 3131 Xaa Xaa Lys Lys 1 <210> 3132 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 3132 Lys Gly Ser Ser Arg Ser Gly His Asn Ala Leu Lys Thr His Ser Trp 1 5 10 15 Met Ser Pro Phe Arg Arg Arg Gly Ser Trp Ser Leu His Phe Lys 20 25 30 <210> 3133 <211> 31 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (31)..(31) <223> C-terminal amidation <400> 3133 Lys Ser Arg Ser Gly Phe Trp His Ala Trp Ser His Arg Thr Arg Pro 1 5 10 15 Met Lys Ser Arg Leu His Leu Gly Lys Phe Ser Asn Ser Ser Gly 20 25 30 <210> 3134 <211> 28 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (28)..(28) <223> C-terminal amidation <400> 3134 Ser Gly Gly Arg Lys His Lys His Phe Leu Arg Ser Asn Gly Lys Pro 1 5 10 15 Ser Arg Ala Leu Ser Ser Met His Phe Trp Arg Trp 20 25 <210> 3135 <211> 25 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (25)..(25) <223> C-terminal amidation <400> 3135 Ser Gly Gly Arg Lys His Lys His Phe Leu Arg Ser Asn Gly Lys Pro 1 5 10 15 Ser Arg Ala Leu Ser Ser Met His Phe 20 25 <210> 3136 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (22)..(22) <223> C-terminal amidation <400> 3136 Ser Gly Gly Arg Lys His Lys His Phe Leu Arg Ser Asn Gly Lys Pro 1 5 10 15 Ser Arg Ala Leu Ser Ser 20 <210> 3137 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (19)..(19) <223> C-terminal amidation <400> 3137 Ser Gly Gly Arg Lys His Lys His Phe Leu Arg Ser Asn Gly Lys Pro 1 5 10 15 Ser Arg Ala <210> 3138 <211> 28 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <400> 3138 Arg Lys His Lys His Phe Leu Arg Ser Asn Gly Lys Pro Ser Arg Ala 1 5 10 15 Leu Ser Ser Met His Phe Trp Arg Trp Ser Thr Ser 20 25 <210> 3139 <211> 25 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (25)..(25) <223> C-terminal amidation <400> 3139 Lys His Phe Leu Arg Ser Asn Gly Lys Pro Ser Arg Ala Leu Ser Ser 1 5 10 15 Met His Phe Trp Arg Trp Ser Thr Ser 20 25 <210> 3140 <211> 22 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (22)..(22) <223> C-terminal amidation <400> 3140 Leu Arg Ser Asn Gly Lys Pro Ser Arg Ala Leu Ser Ser Met His Phe 1 5 10 15 Trp Arg Trp Ser Thr Ser 20 <210> 3141 <211> 19 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (19)..(19) <223> C-terminal amidation <400> 3141 Asn Gly Lys Pro Ser Arg Ala Leu Ser Ser Met His Phe Trp Arg Trp 1 5 10 15 Ser Thr Ser <210> 3142 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 3142 Ser Gly Gly Arg Lys His Lys His Phe Leu Arg Ser Asn Gly Lys Pro 1 5 10 15 Ser Arg Ala Leu 20 <210> 3143 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 3143 Arg Lys His Lys His Phe Leu Arg Ser Asn Gly Lys Pro Ser Arg Ala 1 5 10 15 Leu Ser Ser Met 20 <210> 3144 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 3144 Lys His Phe Leu Arg Ser Asn Gly Lys Pro Ser Arg Ala Leu Ser Ser 1 5 10 15 Met His Phe Trp 20 <210> 3145 <211> 20 <212> PRT <213> Artificial Sequence <220> <223> Synthetic peptide <220> <221> MOD_RES <222> (1)..(1) <223> N-terminal acetylation <220> <221> MOD_RES <222> (20)..(20) <223> C-terminal amidation <400> 3145 Ser Asn Gly Lys Pro Ser Arg Ala Leu Ser Ser Met His Phe Trp Arg 1 5 10 15 Trp Ser Thr Ser 20

Claims (44)

  1. 하기 화학식 VIII의 구조를 가지는, TFPI에 결합하는 펩티드.
    X3001-X3002-X3003-X3004-X3005-X3006-X3007-X3008-X3009-X3010-X3011-X3012-X3013-X3014-X3015-X3016-X3017-X3018-X3019-X3020-X3021 (VIII) (서열 3120)
    상기 식에서,
    X3001은 존재하거나 부재하고, 존재할 때 X3001은 A, C, D, F, G, I, K, L, M, N, P, Q, R, S, T, W, E, H 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
    X3002는 존재하거나 부재하고, 존재할 때 X3002는 A, C, D, F, H, K, M, N, P, R, S, T, W, Y, G, I 및 L로 이루어진 군 중에서 선택되는 아미노산이고;
    X3003은 A, C, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
    X3004는 A, C, D, E, F, G, H, I, K, L, M, N, Q, R, S, T, V, W, Y 및 P로 이루어진 군 중에서 선택되는 아미노산이고;
    X3005는 C, D, F, G, H, I, K, L, M, N, P, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
    X3006은 A, W, C, K, P, R 및 H로 이루어진 군 중에서 선택되는 아미노산이고;
    X3007은 Q, A, C, F, G, H, I, K, L, N, R, S, T, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
    X3008은 A, C, F, G, H, K, L, M, N, P, Q, R, S, T, V, W, Y 및 I로 이루어진 군 중에서 선택되는 아미노산이고;
    X3009는 A, C, F, G, H, I, L, M, R, S, T, V, W, Y 및 K로 이루어진 군 중에서 선택되는 아미노산이고;
    X3010은 A, C, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
    X3011은 A, G, I, K, L, M, N, Q, R, S, T, V, W, Y, C, F 및 H로 이루어진 군 중에서 선택되는 아미노산이고;
    X3012는 A, C, H, I, K, L 및 R로 이루어진 군 중에서 선택되는 아미노산이고;
    X3013은 A, C, F, G, H, K, L, M, R, S, V, W, Y 및 I로 이루어진 군 중에서 선택되는 아미노산이고;
    X3014는 A, C, F, G, H, I, L, M, N, Q, R, S, T, V, W, Y 및 K로 이루어진 군 중에서 선택되는 아미노산이고;
    X3015는 A, K 및 R로 이루어진 군 중에서 선택되는 아미노산이고;
    X3016은 A, F, K 및 R로 이루어진 군 중에서 선택되는 아미노산이고;
    X3017은 A, C, F, G, I, K, L, N, Q, R, S, T, V, W, Y, H, A 및 M으로 이루어진 군 중에서 선택되는 아미노산이고;
    X3018은 A, C, F, I, K, L, M, Q, R, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
    X3019는 A, C, D, E, F, G, H, K, L, N, P, Q, R, V, W, Y 및 I로 이루어진 군 중에서 선택되는 아미노산이고;
    X3020은 A, C, F, G, H, K, L, M, N, Q, R, V, W, Y, I 및 P로 이루어진 군 중에서 선택되는 아미노산이고;
    X3021은 A, C, H, I, K, L, M, N, P, Q, R, T, V, W, Y, F 및 G로 이루어진 군 중에서 선택되는 아미노산이다.
  2. 제1항에 있어서,
    X3001은 존재하거나 부재하고, 존재할 때 X3001은 A, C, D, G, I, K, L, M, N, P, Q, R, S, T, W, E, H 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
    X3002는 존재하거나 부재하고, 존재할 때 X3002는 C, F, H, K, R, S, W, Y, G, I 및 L로 이루어진 군 중에서 선택되는 아미노산이고;
    X3003은 A, C, D, F, G, H, I, K, L, M, N, P, Q, R, S, T 및 W로 이루어진 군 중에서 선택되는 아미노산이고;
    X3004는 A, C, D, G, H, I, K, L, M, N, R, S, T, V 및 P로 이루어진 군 중에서 선택되는 아미노산이고;
    X3005는 C, F, H, I, K, M, R, T, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
    X3006은 P, H 및 A로 이루어진 군 중에서 선택되는 아미노산이고;
    X3007은 C, G, R, W, A 및 L로 이루어진 군 중에서 선택되는 아미노산이고;
    X3008은 A, C, F, G, H, K, L, M, N, Q, R, T, V, W, Y 및 I로 이루어진 군 중에서 선택되는 아미노산이고;
    X3009는 C, I, R, V 및 K로 이루어진 군 중에서 선택되는 아미노산이고;
    X3010은 A, C, G, H, I, K, L, M, Q, R, S 및 T로 이루어진 군 중에서 선택되는 아미노산이고;
    X3011은 A, I, K, L, M, R, S, V, W, C, F 및 H로 이루어진 군 중에서 선택되는 아미노산이고;
    X3012는 H 및 R로 이루어진 군 중에서 선택되는 아미노산이고;
    X3013은 C, F, K, L, M, R, V 및 I로 이루어진 군 중에서 선택되는 아미노산이고;
    X3014는 A, M, C, F, H, I, L, N, R, S, V, W 및 K로 이루어진 군 중에서 선택되는 아미노산이고;
    X3015는 K 및 R로 이루어진 군 중에서 선택되는 아미노산이고;
    X3016은 K 또는 R이고;
    X3017은 A, C, F, G, I, K, L, N, Q, R, S, T, V, W, H, A 및 M으로 이루어진 군 중에서 선택되는 아미노산이고;
    X3018은 A, K, C, I, L, R 및 W로 이루어진 군 중에서 선택되는 아미노산이고;
    X3019는 A, C, E, H, K, N, Q, R 및 I로 이루어진 군 중에서 선택되는 아미노산이고;
    X3020은 C, H, L, M, R, V, I 및 P로 이루어진 군 중에서 선택되는 아미노산이고;
    X3021은 A, C, H, I, K, L, M, N, Q, R, V, W, Y, F 및 G로 이루어진 군 중에서 선택되는 아미노산인 펩티드.
  3. 제1항 또는 제2항에 있어서,
    X3001은 A, C, D, G, K, L, M, N, P, R, S, T, E, H 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
    X3002는 C, K, R, W, Y, G, I 및 L로 이루어진 군 중에서 선택되는 아미노산이고;
    X3003은 A, C, G, H, I, K, L, M, R, S, T 및 W로 이루어진 군 중에서 선택되는 아미노산이고;
    X3004는 A, C, G, H, I, K, L, M, N, R, S, T 및 P로 이루어진 군 중에서 선택되는 아미노산이고;
    X3005는 C, F, H, K, R 및 W로 이루어진 군 중에서 선택되는 아미노산이고;
    X3006은 A, P 및 H로 이루어진 군 중에서 선택되는 아미노산이고;
    X3007은 L, C, R 및 W로 이루어진 군 중에서 선택되는 아미노산이고;
    X3008은 A, C, F, H, K, R, V, W, Y 및 I로 이루어진 군 중에서 선택되는 아미노산이고;
    X3009는 C, R, V 및 K로 이루어진 군 중에서 선택되는 아미노산이고;
    X3010은 A, C, K, L, Q, R 및 S로 이루어진 군 중에서 선택되는 아미노산이고;
    X3011은 I, K, L, M, R, V, W, C, F 및 H로 이루어진 군 중에서 선택되는 아미노산이고;
    X3012는 H이고;
    X3013은 C, K, R, V 및 I로 이루어진 군 중에서 선택되는 아미노산이고;
    X3014는 A, S, C, F, H, I, R 및 K로 이루어진 군 중에서 선택되는 아미노산이고;
    X3015는 K 및 R로 이루어진 군 중에서 선택되는 아미노산이고;
    X3016은 R이고;
    X3017은 C, G, I, K, L, N, Q, R, S, T, V, H, A 및 M으로 이루어진 군 중에서 선택되는 아미노산이고;
    X3018은 K, C, I, R 및 W로 이루어진 군 중에서 선택되는 아미노산이고;
    X3019는 C, E, H, K, R 및 I로 이루어진 군 중에서 선택되는 아미노산이고;
    X3020은 C, M, I 및 P로 이루어진 군 중에서 선택되는 아미노산이고;
    X3021은 A, C, H, I, K, L, M, N, Q, R, V, W, F 및 G로 이루어진 군 중에서 선택되는 아미노산인 펩티드.
  4. 하기 화학식 IX의 구조를 가지는, TFPI에 결합하는 펩티드.
    X3001-X3002-X3003-X3004-X3005-X3006-X3007-X3008-X3009-X3010-X3011-H-X3013-X3014-K/R-R-X3017-X3018-X3019-X3020-X3021 (IX) (서열 3121)
    상기 식에서,
    X3001 및 X3002는 독립적으로 존재하거나 부재하고, X3001 및/또는 X3002가 존재하는 경우, X3001 및/또는 X3002는 독립적으로 임의의 아미노산으로부터 선택되고,
    X3003, X3004, X3005, X3006, X3007, X3008, X3009, X3010, X3011, X3013, X3014, X3017, X3018, X3019, X3020 및 X3021는 각각 독립적으로 임의의 아미노산으로부터 선택된다.
  5. 제4항에 있어서,
    X3001은 존재하거나 부재하고, 존재할 때 X3001은 A, C, D, F, G, I, K, L, M, N, P, Q, R, S, T, W, E, H 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
    X3002는 존재하거나 부재하고, 존재할 때 X3002는 A, C, D, F, H, K, M, N, P, R, S, T, W, Y, G, I 및 L로 이루어진 군 중에서 선택되는 아미노산이고;
    X3003은 A, C, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
    X3004는 A, C, D, E, F, G, H, I, K, L, M, N, Q, R, S, T, V, W, Y 및 P로 이루어진 군 중에서 선택되는 아미노산이고;
    X3005는 C, D, F, G, H, I, K, L, M, N, P, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
    X3006은 A, W, C, K, P, R 및 H로 이루어진 군 중에서 선택되는 아미노산이고;
    X3007은 Q, A, C, F, G, H, I, K, L, N, R, S, T, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
    X3008은 A, C, F, G, H, K, L, M, N, P, Q, R, S, T, V, W, Y 및 I로 이루어진 군 중에서 선택되는 아미노산이고;
    X3009는 A, C, F, G, H, I, L, M, R, S, T, V, W, Y 및 K로 이루어진 군 중에서 선택되는 아미노산이고;
    X3010은 A, C, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
    X3011은 A, G, I, K, L, M, N, Q, R, S, T, V, W, Y, C, F 및 H로 이루어진 군 중에서 선택되는 아미노산이고;
    X3013은 A, C, F, G, H, K, L, M, R, S, V, W, Y 및 I로 이루어진 군 중에서 선택되는 아미노산이고;
    X3014는 A, C, F, G, H, I, L, M, N, Q, R, S, T, V, W, Y 및 K로 이루어진 군 중에서 선택되는 아미노산이고;
    X3017은 A, C, F, G, I, K, L, N, Q, R, S, T, V, W, Y, H, A 및 M으로 이루어진 군 중에서 선택되는 아미노산이고;
    X3018은 A, C, F, I, K, L, M, Q, R, V, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
    X3019는 A, C, D, E, F, G, H, K, L, N, P, Q, R, V, W, Y 및 I로 이루어진 군 중에서 선택되는 아미노산이고;
    X3020은 A, C, F, G, H, K, L, M, N, Q, R, V, W, Y, I 및 P로 이루어진 군 중에서 선택되는 아미노산이고;
    X3021은 A, C, H, I, K, L, M, N, P, Q, R, T, V, W, Y, F 및 G로 이루어진 군 중에서 선택되는 아미노산인 펩티드.
  6. 제4항 또는 제5항에 있어서,
    X3001은 존재하거나 부재하고, 존재할 때 X3001은 A, C, D, G, I, K, L, M, N, P, Q, R, S, T, W, E, H 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
    X3002는 존재하거나 부재하고, 존재할 때 X3002는 C, F, H, K, R, S, W, Y, G, I 및 L로 이루어진 군 중에서 선택되는 아미노산이고;
    X3003은 A, C, D, F, G, H, I, K, L, M, N, P, Q, R, S, T 및 W로 이루어진 군 중에서 선택되는 아미노산이고;
    X3004는 A, C, D, G, H, I, K, L, M, N, R, S, T, V 및 P로 이루어진 군 중에서 선택되는 아미노산이고;
    X3005는 C, F, H, I, K, M, R, T, W 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
    X3006은 P, H 및 A로 이루어진 군 중에서 선택되는 아미노산이고;
    X3007은 C, G, R, W, A 및 L로 이루어진 군 중에서 선택되는 아미노산이고;
    X3008은 A, C, F, G, H, K, L, M, N, Q, R, T, V, W, Y 및 I로 이루어진 군 중에서 선택되는 아미노산이고;
    X3009는 C, I, R, V 및 K로 이루어진 군 중에서 선택되는 아미노산이고;
    X3010은 A, C, G, H, I, K, L, M, Q, R, S 및 T로 이루어진 군 중에서 선택되는 아미노산이고;
    X3011은 A, I, K, L, M, R, S, V, W, C, F 및 H로 이루어진 군 중에서 선택되는 아미노산이고;
    X3013은 C, F, K, L, M, R, V 및 I로 이루어진 군 중에서 선택되는 아미노산이고;
    X3014는 A, M, C, F, H, I, L, N, R, S, V, W 및 K로 이루어진 군 중에서 선택되는 아미노산이고;
    X3017은 A, C, F, G, I, K, L, N, Q, R, S, T, V, W, H, A 및 M으로 이루어진 군 중에서 선택되는 아미노산이고;
    X3018은 A, K, C, I, L, R 및 W로 이루어진 군 중에서 선택되는 아미노산이고;
    X3019는 A, C, E, H, K, N, Q, R 및 I로 이루어진 군 중에서 선택되는 아미노산이고;
    X3020은 C, H, L, M, R, V, I 및 P로 이루어진 군 중에서 선택되는 아미노산이고;
    X3021은 A, C, H, I, K, L, M, N, Q, R, V, W, Y, F 및 G로 이루어진 군 중에서 선택되는 아미노산인 펩티드.
  7. 제4항 또는 제5항에 있어서,
    X3001은 A, C, D, G, K, L, M, N, P, R, S, T, E, H 및 Y로 이루어진 군 중에서 선택되는 아미노산이고;
    X3002는 C, K, R, W, Y, G, I 및 L로 이루어진 군 중에서 선택되는 아미노산이고;
    X3003은 A, C, G, H, I, K, L, M, R, S, T 및 W로 이루어진 군 중에서 선택되는 아미노산이고;
    X3004는 A, C, G, H, I, K, L, M, N, R, S, T 및 P로 이루어진 군 중에서 선택되는 아미노산이고;
    X3005는 C, F, H, K, R 및 W로 이루어진 군 중에서 선택되는 아미노산이고;
    X3006은 A, P 및 H로 이루어진 군 중에서 선택되는 아미노산이고;
    X3007은 L, C, R 및 W로 이루어진 군 중에서 선택되는 아미노산이고;
    X3008은 A, C, F, H, K, R, V, W, Y 및 I로 이루어진 군 중에서 선택되는 아미노산이고;
    X3009는 C, R, V 및 K로 이루어진 군 중에서 선택되는 아미노산이고;
    X3010은 A, C, K, L, Q, R 및 S로 이루어진 군 중에서 선택되는 아미노산이고;
    X3011은 I, K, L, M, R, V, W, C, F 및 H로 이루어진 군 중에서 선택되는 아미노산이고;
    X3013은 C, K, R, V 및 I로 이루어진 군 중에서 선택되는 아미노산이고;
    X3014는 A, S, C, F, H, I, R 및 K로 이루어진 군 중에서 선택되는 아미노산이고;
    X3017은 C, G, I, K, L, N, Q, R, S, T, V, H, A 및 M으로 이루어진 군 중에서 선택되는 아미노산이고;
    X3018은 K, C, I, R 및 W로 이루어진 군 중에서 선택되는 아미노산이고;
    X3019는 C, E, H, K, R 및 I로 이루어진 군 중에서 선택되는 아미노산이고;
    X3020은 C, M, I 및 P로 이루어진 군 중에서 선택되는 아미노산이고;
    X3021은 A, C, H, I, K, L, M, N, Q, R, V, W, F 및 G로 이루어진 군 중에서 선택되는 아미노산인 펩티드.
  8. 제1항, 제2항, 제4항, 및 제5항 중 어느 한 항에 있어서, 펩티드의 IC50이 50,000 nM 미만, 10,000 nM 미만, 또는 5,000 nM 미만인 펩티드.
  9. 제8항에 있어서, IC50이 경쟁 ELISA에 의해 결정되는 것인 펩티드.
  10. 하기 화학식 X의 서열에 적어도 60% 동일성의 아미노산 서열을 포함하는, TFPI에 결합하는 펩티드.
    Ac-GYASFPWFVQLHVHKRSWEMA-NH2 (서열 2023)
  11. 제10항에 있어서, 아미노산 서열 동일성이 적어도 60%, 적어도 70%, 적어도 80%, 적어도 90% 또는 적어도 95%인 펩티드.
  12. 제10항에 있어서, 펩티드가 제1항, 제2항, 제4항, 및 제5항 중 어느 한 항에 정의된 아미노산 서열을 포함하는 펩티드.
  13. 서열 2001 내지 2126, 2128 내지 2296, 및 2298 내지 2498로 이루어진 군 중에서 선택되는 아미노산 서열로 이루어진 펩티드.
  14. 서열 3001 내지 3048, 3051 내지 3053, 3055, 3057 내지 3064, 및 3066 내지 3108로 이루어진 군 중에서 선택되는 아미노산 서열로 이루어진 펩티드.
  15. 제13항 또는 제14항에 있어서, 펩티드가 TFPI에 결합하는 펩티드.
  16. 제1항, 제2항, 제4항, 제5항, 제10항, 제11항, 제13항, 및 제14항 중 어느 한 항에 있어서, 상기 펩티드가 TFPI 활성을 억제하고, 바람직하게는 펩티드가 10 μM 미만의 해리 상수로 TFPI 1-알파에 결합하는 펩티드.
  17. 제1항, 제2항, 제4항, 제5항, 제10항, 제11항, 제13항, 및 제14항 중 어느 한 항에 있어서, 펩티드가 폴리에틸렌 글리콜 (PEG) 모이어티에 접합되는 펩티드.
  18. 제1항, 제2항, 제4항, 제5항, 제10항, 제11항, 제13항, 및 제14항 중 어느 한 항에 있어서, 대상체를 치료하는 방법에 사용하기 위한 것인 펩티드.
  19. 제18항에 있어서, 방법이 혈액 응고 장애를 치료하기 위한 것인 펩티드.
  20. 제1항, 제2항, 제4항, 제5항, 제10항, 제11항, 제13항, 및 제14항 중 어느 한 항에 있어서, 의약을 제조하기 위한 것인 펩티드.
  21. 제1항, 제2항, 제4항, 제5항, 제10항, 제11항, 제13항, 및 제14항 중 어느 한 항에 있어서, 혈액 응고 장애를 치료하는 의약을 제조하기 위한 것인 펩티드.
  22. 제1항, 제2항, 제4항, 제5항, 제10항, 제11항, 제13항, 및 제14항 중 어느 한 항에 정의된 펩티드 및 제약상 허용되는 담체를 포함하는 제약 조성물.
  23. 제22항에 있어서, 조성물이 추가의 제약상 유효제를 포함하는 제약 조성물.
  24. 제22항에 있어서, 제약 조성물이 혈액 응고 장애의 치료에 사용하기 위한 것인 제약 조성물.
  25. 세포를 제1항, 제2항, 제4항, 제5항, 제10항, 제11항, 제13항, 및 제14항 중 어느 한 항에 정의된 펩티드와 접촉시키는 것을 포함하되, 인간 세포의 경우는 방법이 생체 외에서 수행되는 것을 전제로 하는,
    TFPI를 디스플레이하는 세포를 표적화하는 방법.
  26. 제25항에 있어서, 세포가 포유동물 내에 존재하고, 세포를 접촉시키는 것이 펩티드를 포유동물에게 투여하는 것을 포함하는 것인 방법.
  27. 제25항에 있어서, 세포 상에 디스플레이된 TFPI에 대한 펩티드 결합을 검출하는 것을 추가로 포함하는 방법.
  28. 제25항에 있어서, 펩티드가 모이어티에 접합되고, 상기 모이어티는 바람직하게는 염료, 형광 염료, 방사성 핵종, 방사성 핵종-함유 복합체, 효소, 독소, 항체, 및 세포독성제로 이루어진 군 중에서 선택되는 것인 방법.
  29. 제28항에 있어서, 펩티드-TFPI 결합이 펩티드 또는 모이어티와 복합체화된 상호작용 파트너를 검출함으로써 검출되는 것인 방법.
  30. 제29항에 있어서, 상호작용 파트너가 항체, 안티칼린, 앱타머(aptamer), 및 스피겔머(spiegelmer)로 이루어진 군 중에서 선택되는 것인 방법.
  31. 제29항에 있어서, 상호작용 파트너가 검출 모이어티를 포함하고, 검출 모이어티는 염료, 형광 염료, 방사성 핵종, 방사성 핵종-함유 복합체, 및 효소로 이루어진 군 중에서 선택되는 것인 방법.
  32. 제1항, 제2항, 제4항, 제5항, 제10항, 제11항, 제13항, 및 제14항 중 어느 한 항의 펩티드를 사용하여, 질병에 걸린 또는 질병에 걸릴 위험이 있는 대상체를 치료하기 위한 의약을 제조하는 방법으로, 상기 펩티드가 치료제에 접합되는 것인, 방법.
  33. 제1항, 제2항, 제4항, 제5항, 제10항, 제11항, 제13항, 및 제14항 중 어느 한 항의 펩티드를 사용하여, 질병에 걸린 또는 질병에 걸릴 위험이 있는 대상체를 치료하기 위한 의약을 제조하는 방법으로, (a) 펩티드와 결합하고, (b) 치료제이거나 치료제에 접합되는 상호작용 파트너를 대상체에 투여하는, 방법.
  34. 제33항에 있어서, 상호작용 파트너가 항체, 안티칼린, 앱타머, 및 스피겔머로 이루어진 군 중에서 선택되는 것인 방법.
  35. 제32항에 있어서, 치료제가 염료, 형광 염료, 방사성 핵종, 방사성 핵종-함유 복합체, 효소, 독소, 항체, 및 세포독성제로 이루어진 군 중에서 선택되는 것인 방법.
  36. (a) 검출가능한 모이어티에 접합된, 제1항, 제2항, 제4항, 제5항, 제10항, 제11항, 제13항, 및 제14항 중 어느 한 항에 정의된 펩티드를 대상체로부터의 생물학적 샘플과 접촉시키고;
    (b) 검출가능한 모이어티를 검출하는 것을 포함하는,
    질병에 걸린 또는 질병에 걸릴 위험이 있는 대상체를 진단하기 위한 방법.
  37. (a) 제1항, 제2항, 제4항, 제5항, 제10항, 제11항, 제13항, 및 제14항 중 어느 한 항에 정의된 펩티드를 대상체로부터의 생물학적 샘플과 접촉시키고;
    (b) 검출가능한 모이어티에 접합된 상호작용 파트너를 대상체로부터의 생물학적 샘플과 접촉시키고;
    (c) 검출가능한 모이어티를 검출하는 것을 포함하는,
    질병에 걸린 또는 질병에 걸릴 위험이 있는 대상체를 진단하기 위한 방법.
  38. 제37항에 있어서, 상호작용 파트너가 항체, 안티칼린, 앱타머, 및 스피겔머로 이루어진 군 중에서 선택되는 것인 방법.
  39. 제36항에 있어서, 검출가능한 모이어티가 염료, 형광 염료, 방사성 핵종, 방사성 핵종-함유 복합체, 효소, 독소, 항체, 및 세포독성제로 이루어진 군 중에서 선택되는 것인 방법.
  40. 제36항에 있어서, 질병이 TFPI와 연관된 질병으로서, TFPI의 억제에 의해 치료될 수 있거나 그의 증상이 개선될 수 있는 것이고, 질병은 혈액 응고 장애인 것인 방법.
  41. a) TFPI를 함유하는 샘플을 TFPI와 제1항, 제2항, 제4항, 제5항, 제10항, 제11항, 제13항, 및 제14항 중 어느 한 항에 정의된 펩티드 사이에 복합체를 형성시키기에 적절한 조건 하에 상기 펩티드와 접촉시키고;
    b) 샘플로부터 복합체를 제거하고;
    임의로, c) 복합체를 해리시켜 TFPI를 방출시키는 것을 포함하는,
    TFPI의 정제 방법.
  42. 제41항에 있어서, 상기 펩티드가 지지체, 바람직하게는 고체 지지대에 고정되는 것인 방법.
  43. 제41항에 있어서, 상기 펩티드가 크로마토그래피 정지상에 고정되고, 단계 (c)가 고정된 펩티드에 결합된 TFPI를 용출시키는 것을 포함하는 것인 방법.
  44. 제43항에 있어서, 상기 펩티드가 친화도 크로마토그래피를 통해 정제되는 것인 방법.
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