KR20180104091A - α겔 형성용 조성물 및 α겔 조성물 - Google Patents
α겔 형성용 조성물 및 α겔 조성물 Download PDFInfo
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- KR20180104091A KR20180104091A KR1020187024167A KR20187024167A KR20180104091A KR 20180104091 A KR20180104091 A KR 20180104091A KR 1020187024167 A KR1020187024167 A KR 1020187024167A KR 20187024167 A KR20187024167 A KR 20187024167A KR 20180104091 A KR20180104091 A KR 20180104091A
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- Prior art keywords
- polyoxyethylene
- acid
- mass
- composition
- gel
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- 239000000203 mixture Substances 0.000 title claims abstract description 35
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Abstract
본 발명의 해결해야 할 과제는 시간 경과에 따라 착색, 결정 석출 등이 없는 안정성이 높은 α겔 형성 조성물 및 이를 사용한 α겔 조성물을 제공하는 데 있는 것으로,
(A) 1종 또는 2종 이상의 탄소수 16 이상의 고급 지방족 알코올 및/또는 고급 지방산 25 내지 50질량%
(B) 특정의 폴리옥시에틸렌스테롤에테르 40 내지 70질량%
(C) 특정의 폴리옥시에틸렌디알킬에스테르 및/또는 에테르를 5 내지 20질량%를 포함하고, 상기 물을 첨가함으로써 생성되는 α겔 조성물이다.
(A) 1종 또는 2종 이상의 탄소수 16 이상의 고급 지방족 알코올 및/또는 고급 지방산 25 내지 50질량%
(B) 특정의 폴리옥시에틸렌스테롤에테르 40 내지 70질량%
(C) 특정의 폴리옥시에틸렌디알킬에스테르 및/또는 에테르를 5 내지 20질량%를 포함하고, 상기 물을 첨가함으로써 생성되는 α겔 조성물이다.
Description
본 발명은 α겔 형성용 조성물 및 α겔 조성물, 특히 겔 형성 물질의 개량에 관한 것이다.
종래부터 화장품, 의약부외품, 의약품 등의 피부 외용제의 유화 안정성을 유지하는 목적에서, 고급 지방족 알코올이나 고급 지방산과 친수성 계면활성제가 형성하는 α겔을 사용한 α겔 함유 피부 외용제가 사용되어 왔다. 이러한 α겔은 높은 점도로 피부 외용제를 안정되게 하지만, 도포 중 미끈미끈한 감촉이 있고, 안정성적으로도 시간 경과에 따라 고급 알코올이나 고급 지방산이 결정으로서 석출되기 쉬운 등의 문제점이 있었다(예를 들면, 비특허문헌 1 참조).
또한, 시간 경과에 따라 점도가 상승하는 경우도 많이 보여서 2쇄형의 양이온 계면활성제 등을 점도 상승 방지제로서 사용하도록 하는 것도 검토되어 왔지만, 충분히 양호한 안정성은 얻지 못했다(예를 들면 비특허문헌 2 참조). 또한, 피부 내부로부터의 수분 증산을 방지하는(오클루전) 효과도 충분한 것은 아니었다.
또한, 피부 내부로부터의 수분 증산을 방지하는 목적에서, 세라마이드류, 디알킬 4급 암모늄염 또는 인지질 등의 2쇄형 화합물과 스테롤류를 포함하는 동일한 제제(예를 들면 특허문헌 1)나 인지질, 폴리옥시에틸렌스테롤에테르류, 고급 알코올을 포함한 제제(예를 들면 특허문헌 2, 비특허문헌 3)가 이용되어 왔지만, 인지질류는 착색이나 냄새 등의 문제점이 있고, 세라마이드에는 결정이 석출되기 쉽다는 문제점이 있었다.
Kei Watanabe et al., J. Oleo Sci., 61, 29-34(2012)
Makoto Uyama et al., J. Oleo Sci., 62, 9-16(2013)
콘노 요시카즈, 일본 화장품 기술자 회지, 45, 83-91(2011)
본 발명은 상기 종래 기술을 감안하여 이루어진 것으로, 그 해결해야 할 과제는 시간 경과에 따라 착색, 결정 석출 등이 없는 안정성이 높은 α겔 형성 조성물 및 이를 사용한 α겔 조성물을 제공하는 데 있다.
상기 과제를 해결하기 위해 본 발명자들이 예의 연구를 거듭한 결과, 고급 지방족 알코올 및/또는 고급 지방산, 폴리옥시에틸렌스테롤에테르와 탄소수 16 이상의 소수기를 2개 갖는 폴리옥시에틸렌디알킬에스테르 및/또는 에테르를 특정 비율로 포함함으로써, 신규한 α겔 조성물을 형성하는 것을 알아내어 본 발명을 완성하기에 이르렀다.
즉, 본 발명에 따른 α겔 형성용 조성물은
(A) 1종 또는 2종 이상의 탄소수 16 이상의 고급 지방족 알코올 및/또는 고급 지방산 25 내지 50질량%
(B) 하기 일반식 (Ⅰ)로 표시되는 폴리옥시에틸렌스테롤에테르 40 내지 70질량%
(Ⅰ)
(단, 일반식 Ⅰ에서 R은 콜레스테롤 및/또는 피토스테롤 잔기, n은 5 내지 20의 정수를 나타냄)
(C) 하기 일반식 (Ⅱ)로 표시되는 폴리옥시에틸렌디알킬에스테르 및/또는 에테르를 5 내지 20질량%
(Ⅱ)
(단, 일반식 Ⅱ에서 R1 및 R2는 탄소수 16 내지 24의 직쇄 지방족산 잔기 또는 직쇄 지방족 알코올 잔기, n은 4 내지 15의 정수)
로 이루어지고, 수상에 첨가되어 겔을 형성하는 것을 특징으로 한다.
또한, 본 발명에 따른 α겔 조성물은 상기 (A) 내지 (C)가 수상 중에서 형성한 것임을 특징으로 한다.
또한, 상기 α겔 조성물에, 질소 원자를 갖는 2쇄형 양친매성 물질을 α겔 조성물 중의 유효분에 대하여 0.1 내지 10질량% 함유하는 것이 바람직하다.
또한, 상기 겔 조성물은 상기 질소 원자를 갖는 2쇄형 양친매성 물질이 인지질, 레시틴, 리조레시틴, 세라마이드, 디알킬 4급 암모늄염으로부터 선택되는 1종 또는 2종 이상으로 이루어지는 것이 바람직하다.
α겔 형성용 조성물에 있어서, 탄소수 16 이상의 고급 지방족 알코올 및/또는 고급 지방산의 배합량은 전체 유효분 중 25 내지 50질량%가 바람직하다. 탄소수 16 이상의 고급 지방족 알코올의 예로는 세틸알코올, 세토스테아릴알코올, 스테아릴알코올, 베헤닐알코올, 바틸알코올 등을 들 수 있다. 고급 지방산의 예로는 팔미트산, 스테아르산, 베헨산 등을 들 수 있다.
또한, 상기 α겔 형성용 조성물에 있어서, (Ⅰ)의 폴리옥시에틸렌스테롤에테르는 소수기로서 피토스테롤, 콜레스테롤, 에르고스테롤을 갖는 것이 바람직하고, 폴리옥시에틸렌 사슬은 5 내지 30몰이 바람직하다. 예로는 폴리옥시에틸렌(5몰)피토스테롤(예를 들면, 닛코케미컬즈사 제조, Nikkol BPS-5), 폴리옥시에틸렌(10몰)피토스테롤(예를 들면, 닛코케미컬즈사 제조, Nikkol BPS-10), 폴리옥시에틸렌(20몰)피토스테롤(예를 들면, 닛코케미컬즈사 제조, Nikkol BPS-20), 폴리옥시에틸렌(30몰)피토스테롤(예를 들면, 닛코케미컬즈사 제조, Nikkol BPS-30), 폴리옥시에틸렌(10몰)콜레스테롤(예를 들면 닛폰에멀션사 제조, Emalex CS-10) 등을 들 수 있다. 배합량으로는 전체 유효분 중 40 내지 70질량%가 바람직하다.
상기 α겔 형성용 조성물에 있어서, (Ⅱ)의 폴리옥시에틸렌디알킬에스테르 및/또는 에테르는 탄소수 16 내지 24의 직쇄 지방족산 잔기 또는 직쇄 지방족 알코올 잔기를 갖는 것이 바람직하고, 폴리옥시에틸렌 사슬은 4 내지 15몰이 바람직하다. 예로는 폴리옥시에틸렌(4몰)디스테아르산(예를 들면, 닛폰에멀션사 제조, Emalex 200DIS), 폴리옥시에틸렌(6몰)디스테아르산(예를 들면, 닛폰에멀션사 제조, Emalex 300DIS), 폴리옥시에틸렌(8몰)디스테아르산(예를 들면, 닛폰에멀션사 제조, Emalex 400DIS), 폴리옥시에틸렌(12몰)디스테아르산(예를 들면, 닛폰에멀션사 제조, Emalex 600DIS), 스테아르산스테아레스-4(예를 들면, 닛폰에멀션사 제조, Emalex SWS-4), 스테아르산 스테아레스-6(예를 들면, 닛폰에멀션사 제조, Emalex SWS-6), 스테아르산 스테아레스-9(예를 들면, 닛폰에멀션사 제조, Emalex SWS-9), 폴리옥시에틸렌(8몰)디베헤닐에테르 등을 들 수 있다. 또한, 폴리옥시에틸렌 사슬과 알킬기의 결합 양식은 에스테르여도 되고, 에테르여도 되고, 또한 그 양쪽이 포함되어도 된다. 배합량으로는 전체 유효분 중 5 내지 20질량%가 바람직하다.
인지질, 레시틴, 리조레시틴, 세라마이드, 디알킬 4급 암모늄염 등의 질소 원자를 갖는 2쇄형 양친매성 물질의 배합량은 α겔 조성물 중의 유효분에 대하여 0.1 내지 10질량%가 바람직하다. 0.1질량% 이하이면 효과가 부족하고, 10질량% 이상의 배합에서는 착색이나 결정 석출 등의 안정성상의 문제가 일어나기 쉽다.
또한, 피부 외용제 조성물 중에 상기 α겔 조성물은 임의의 양을 배합할 수 있지만, 일반적으로는 피부 외용제 중에서 α겔 조성물 중의 유효분으로서 0.1 내지 20질량%가 바람직하다.
본 발명에 따른 α겔 조성물 및 이를 배합하는 것을 특징으로 하는 피부 외용제 조성물은 도포 중에는 산뜻하고, 도포 후에는 피부 내부로부터의 수분 증산을 방지하는(오클루전) 효과가 높으며, 인지질, 레시틴, 리조레시틴, 세라마이드, 디알킬 4급 암모늄염 등의 질소 원자를 갖는 2쇄형 양친매성 물질을 함께 배합해도 시간 경과에 따라 착색, 결정 석출 등의 안정성의 문제가 일어나지 않는다.
도 1은 본 발명에 따른 25℃에서 작성한 폴리옥시에틸렌(6몰)디스테아르산-스테아릴알코올-폴리옥시에틸렌(10몰)피토스테롤의 유효분 50질량% 용매수의 3성분계의 상평형도이다.
도 2는 본 발명에 따른 도 1의 ★표의 X선 산란 스펙트럼이다.
도 3은 본 발명에 따른 폴리옥시에틸렌(6몰)디스테아르산-스테아르산-폴리옥시에틸렌(10몰)피토스테롤=2:2:6의 50질량% 용매수의 X선 산란 스펙트럼이다.
도 2는 본 발명에 따른 도 1의 ★표의 X선 산란 스펙트럼이다.
도 3은 본 발명에 따른 폴리옥시에틸렌(6몰)디스테아르산-스테아르산-폴리옥시에틸렌(10몰)피토스테롤=2:2:6의 50질량% 용매수의 X선 산란 스펙트럼이다.
이하, 본 발명의 구성에 대하여 상세하게 기술한다.
본 발명에 따른 α겔 조성물은 1종 또는 2종 이상의 탄소수 16 이상의 고급 지방족 알코올 및/또는 고급 지방산 25 내지 50질량%와 폴리옥시에틸렌스테롤에테르 40 내지 70질량%와 폴리옥시에틸렌디알킬에스테르 및/또는 에테르를 5 내지 20질량%를 70 내지 80℃에서 용융시키고, 이것에 70 내지 80℃의 이온 교환수를 40 내지 90질량%의 비율로 첨가하여 교반 후, 냉각함으로써 얻어진다. 또한, 1종 또는 2종 이상의 탄소수 16 이상의 고급 지방족 알코올 및/또는 고급 지방산 25 내지 50질량%와 폴리옥시에틸렌스테롤에테르 40 내지 70질량%와 폴리옥시에틸렌디알킬에스테르 및/또는 에테르를 5 내지 20질량%를 70 내지 80℃에서 용융시킨 후, 인지질, 레시틴, 리조레시틴, 세라마이드, 디알킬 4급 암모늄염 등의 질소 원자를 갖는 2쇄형 양친매성 물질을 첨가하여 용융시키고, 이것에 70 내지 80℃의 이온 교환수를 40 내지 90질량%의 비율로 첨가하여 교반 후, 냉각함으로써 얻어진다. 또한, α겔이란 일반적으로는 고급 지방족 알코올과 친수성 계면활성제가 수중에서 형성하는 회합체로서, α구조(후쿠시마 쇼지 저 「세틸알코올의 물리 화학」 프레그런스저널사)를 취하는 겔을 의미한다.
α겔 조성물의 구체예로서 1종 또는 2종 이상의 탄소수 16 이상의 고급 지방족 알코올 및/또는 고급 지방산 스테아릴알코올을, 폴리옥시에틸렌스테롤에테르로서 폴리옥시에틸렌(10몰)피토스테롤(예를 들면, 닛코케미컬즈사 제조, Nikkol BPS-10)을, 폴리옥시에틸렌디알킬에스테르 및/또는 에테르로서 폴리옥시에틸렌(6몰)디스테아르산(예를 들면, 닛폰에멀션사 제조, Emalex 300DIS)을 각각 선정하고, 이들의 혼합물을 70 내지 80℃에서 1상으로 한 후에 전체 유효분량이 전체의 60질량%의 비율이 되도록 동온(同溫)으로 가열한 이온 교환수를 첨가하여 실온까지 냉각해서 얻은 3성분계의 상평형도를 도 1에 나타냈다. 도 1에서 사선 부분은 시차 열량 분석계에서의 융점 피크가 1개이며 X선 분석의 결과, α겔을 시사하는 산란 피크(도 2)가 얻어진 영역이다. 또한, 도 2는 도 1의 ★표로 나타내는 조성물의 X선 산란 스펙트럼이다.
또한, 스테아릴알코올을 스테아르산으로 바꾸어도 동일하게 α겔을 시사하는 X선 산란 스펙트럼이 얻어졌다(도 3). 도 1로부터 분명한 바와 같이 스테아릴알코올 25 내지 50질량%, 폴리옥시에틸렌(10몰)피토스테롤 40 내지 70질량%, 폴리옥시에틸렌(6몰)디스테아르산 5 내지 20질량%의 영역에서 α겔이 되는 것이 확인되었다.
본 발명에서는 상기 3성분만으로 α겔을 구축할 수 있지만, 거친 피부의 개선 등의 목적에서 필요에 따라 인지질, 레시틴, 리조레시틴, 세라마이드, 디알킬 4급 암모늄염 등의 질소 원자를 갖는 2쇄형 양친매성 물질을 함께 배합할 수도 있다.
본 발명의 피부 외용제에 사용되는 유분은 특별히 한정되는 것이 아니며, 예를 들면, 액체 유지, 고체 유지, 왁스류, 탄화수소유, 고급 지방산, 합성 에스테르유, 실리콘유 등을 적절히 배합할 수 있고, 또한 일부의 고급 알코올을 상기 유분에 용해하여 유화할 수도 있다. 목적의 α겔 함유 피부 외용제에 대한 배합량으로는 특별히 한정하지 않지만, 0.05 내지 50질량%가 바람직하다. 0.05질량% 이하인 경우에는 피부 외용제로서의 효과가 부족하고, 50질량%를 초과하면 사용 감촉이 나빠진다.
액체 유지로는 예를 들면, 아보카도유, 동백유, 터틀유, 마카다미아너트유, 옥수수유, 밍크유, 올리브유, 유채씨유, 난황유, 참기름, 살구씨유, 소맥배아유, 산다화유, 피마자유, 아마인유, 사플라워유, 면실유, 들기름, 대두유, 낙화생유, 티오일, 비유, 쌀겨유, 중국동유, 일본동유, 호호바유, 배아유, 트리글리세린 등을 들 수 있다.
고체 유지로는 예를 들면, 카카오지, 야자유, 마지, 경화 야자유, 팜유, 우지, 양지, 경화 우지, 팜핵유, 돈지, 우골지, 목랍핵유, 경화유, 우각지, 목랍, 경화 피마자유 등을 들 수 있다.
왁스류로는 예를 들면, 밀랍, 칸데릴라 왁스, 면 왁스, 카르나우바 왁스, 베이베리 왁스, 백랍, 경랍, 몬탄 왁스, 쌀겨 왁스, 라놀린, 케이폭 왁스, 아세트산 라놀린, 액상 라놀린, 사탕수수 왁스, 라놀린 지방산 이소프로필, 라우르산 헥실, 환원 라놀린, 호호바 왁스, 경질 라놀린, 셸락 왁스, 폴리옥시에틸렌라놀린알코올에테르, 폴리옥시에틸렌라놀린알코올아세테이트, 폴리옥시에틸렌콜레스테롤에테르, 라놀린 지방산 폴리에틸렌글리콜, 폴리옥시에틸렌 수소첨가 라놀린알코올에테르, 팔미트산 세틸 등을 들 수 있다.
탄화수소유로는 예를 들면, 유동 파라핀, 오조케라이트, 스쿠알란, 프리스테인, 파라핀, 세레신, 스쿠알렌, 바셀린, 마이크로크리스탈린왁스 등을 들 수 있다.
고급 지방산으로는 예를 들면, 라우르산, 미리스트산, 팔미트산, 스테아르산, 베헨산, 올레산, 운데실렌산, 톨산, 이소스테아르산, 리놀산, 리놀렌산, 에이코사펜타엔산(EPA), 도코사헥사엔산(DHA) 등을 들 수 있다.
합성 에스테르유로는 예를 들면, 옥탄산 세틸, 미리스트산 미리스틸, 트리 2-에틸헥산산 글리세릴, 테트라 2-에틸헥산산 펜타에리트리트, 숙신산 디옥틸, 디네오펜탄산 트리프로필렌글리콜 등을 들 수 있다.
실리콘유로는 예를 들면, 사슬형 폴리실록산(예를 들면, 디메틸폴리실록산, 메틸페닐폴리실록산, 디페닐폴리실록산 등); 고리형 폴리실록산(예를 들면, 옥타메틸시클로테트라실록산, 데카메틸시클로펜타실록산, 도데카메틸시클로헥사실록산 등), 3차원 그물 구조를 형성하고 있는 실리콘 수지, 실리콘 고무, 각종 변성 폴리실록산(아미노 변성 폴리실록산, 폴리에테르 변성 폴리실록산, 알킬 변성 폴리실록산, 불소 변성 폴리실록산 등), 아크릴실리콘류 등을 들 수 있다.
본 발명에 따른 α겔 함유 피부 외용제는 예를 들면, 피부, 두발 등 신체에 적용할 수 있는 피부 화장료, 두발 세정료, 피부 세정료, 정발료 등에 사용할 수 있다.
또한, 본 발명에 따른 α겔 함유 피부 외용제에는 상기 필수 성분 외에 통상 화장품, 의약품 등에 사용되는 성분을 안정성에 영향을 미치지 않는 범위의 배합량으로 배합할 수 있다. 이러한 성분으로는 예를 들면, 분말 성분, 양쪽성 계면활성제, 이온성 계면활성제, 비이온 계면활성제, 보습제, 증점제, 피막제, 자외선흡수제, 금속 이온 봉쇄제, pH 조정제, 피부 영양제, 비타민, 산화방지제, 산화방지조제, 향료 등을 들 수 있다.
분말 성분으로는 예를 들면, 무기 분말(예를 들면, 탤크, 카올린, 운모, 견운모(세리사이트), 백운모, 금운모, 합성 운모, 홍운모, 흑운모, 버미큘라이트, 벤토나이트, 헥토라이트, 라포나이트, 탄산 마그네슘, 탄산 칼슘, 규산 알루미늄, 규산 바륨, 규산 칼슘, 규산 마그네슘, 규산 스트론튬, 텅스텐산 금속염, 마그네슘, 실리카, 제올라이트, 황산 바륨, 소성 황산 칼슘(소석고), 인산 칼슘, 불소애퍼타이트, 히드록시애퍼타이트, 세라믹 파우더, 금속 비누(예를 들면, 미리스트산 아연, 팔미트산 칼슘, 스테아르산 알루미늄), 질화붕소 등); 유기 분말(예를 들면, 폴리아미드 수지 분말(나일론 분말), 폴리에틸렌 분말, 폴리메타크릴산 메틸 분말, 폴리스티렌 분말, 스티렌과 아크릴산의 공중합체 수지 분말, 벤조구아나민 수지 분말, 폴리사불화에틸렌 분말, 셀룰로오스 분말 등); 무기 백색 안료(예를 들면, 이산화티탄, 산화아연 등); 무기 적색계 안료(예를 들면, 산화철(벵갈라), 티탄산철 등); 무기 갈색계 안료(예를 들면, γ-산화철 등); 무기 황색계 안료(예를 들면, 황산화철, 황토 등); 무기 흑색계 안료(예를 들면, 흑산화철, 저차 산화티탄 등); 무기 자색계 안료(예를 들면, 망고바이올렛, 코발트바이올렛 등); 무기 녹색계 안료(예를 들면, 산화크롬, 수산화크롬, 티탄산 코발트 등); 무기 청색계 안료(예를 들면, 군청, 감청 등); 펄 안료(예를 들면, 산화티탄 피복 마이카, 산화티탄 피복 옥시염화비스무트, 산화티탄 피복 탤크, 착색 산화티탄 피복 마이카, 옥시염화비스무트, 어린박 등); 금속 분말 안료(예를 들면, 알루미늄파우더, 코퍼 파우더 등); 지르코늄, 바륨 또는 알루미늄레이크 등의 유기 안료(예를 들면, 적색 201호, 적색 202호, 적색 204호, 적색 205호, 적색 220호, 적색 226호, 적색 228호, 적색 405호, 등색 203호, 등색 204호, 황색 205호, 황색 401호, 및 청색 404호 등의 유기 안료, 적색 3호, 적색 104호, 적색 106호, 적색 227호, 적색 230호, 적색 401호, 적색 505호, 등색 205호, 황색 4호, 황색 5호, 황색 202호, 황색 203호, 녹색 3호 및 청색 1호 등); 천연 색소(예를 들면, 클로로필, β-카로틴 등) 등을 들 수 있다.
양쪽성 계면활성제로는 예를 들면, 이미다졸린계 양쪽성 계면활성제(예를 들면, 2-운데실-N,N,N-(히드록시에틸카르복시메틸)-2-이미다졸린나트륨, 2-코코일-2-이미다졸리늄히드록사이드-1-카르복시에틸옥시2나트륨염 등); 베타인계 계면활성제(예를 들면, 2-헵타데실-N-카르복시메틸-N-히드록시에틸이미다졸리늄베타인, 라우릴디메틸아미노아세트산 베타인, 알킬베타인, 아미드베타인, 술포베타인 등) 등을 들 수 있다.
이온성 계면활성제로는 N-아실메틸타우린염, N-아실글루탐산염, 알킬황산염, 폴리옥시에틸렌알킬황산염, 지방산 비누, 알킬 4급 암모늄염 등을 들 수 있다.
친유성 비이온 계면활성제로는 예를 들면, 소르비탄지방산 에스테르류(예를 들면, 소르비탄모노올리에이트, 소르비탄모노이소스테아레이트, 소르비탄모노라우레이트, 소르비탄모노팔미테이트, 소르비탄모노스테아레이트, 소르비탄세스퀴올리에이트, 소르비탄트리올리에이트, 펜타-2-에틸헥실산 디글리세롤소르비탄, 테트라-2-에틸헥실산 디글리세롤소르비탄 등); 글리세린폴리글리세린지방산류(예를 들면, 모노면실유지방산 글리세린, 모노에루크산 글리세린, 세스퀴올레산 글리세린, 모노스테아르산 글리세린, α,α'-올레산피로글루탐산 글리세린, 모노스테아르산 글리세린말산 등); 프로필렌글리콜지방산 에스테르류(예를 들면, 모노스테아르산 프로필렌글리콜 등); 경화 피마자유 유도체; 글리세린알킬에테르 등을 들 수 있다.
친수성 비이온 계면활성제로는 예를 들면, 폴리옥시에틸렌소르비탄지방산 에스테르류(예를 들면, 폴리옥시에틸렌소르비탄모노올리에이트, 폴리옥시에틸렌소르비탄모노스테아레이트, 폴리옥시에틸렌소르비탄모노올리에이트, 폴리옥시에틸렌소르비탄테트라올리에이트 등); 폴리옥시에틸렌소르비트지방산 에스테르류(예를 들면, 폴리옥시에틸렌소르비트모노라우레이트, 폴리옥시에틸렌소르비트모노올리에이트, 폴리옥시에틸렌소르비트펜타올리에이트, 폴리옥시에틸렌소르비트모노스테아레이트 등); 폴리옥시에틸렌글리세린지방산 에스테르류(예를 들면, 폴리옥시에틸렌글리세린모노스테아레이트, 폴리옥시에틸렌글리세린모노이소스테아레이트, 폴리옥시에틸렌글리세린트리이소스테아레이트 등의 폴리옥시에틸렌모노올리에이트 등); 폴리옥시에틸렌지방산 에스테르류(예를 들면, 폴리옥시에틸렌디스테아레이트, 폴리옥시에틸렌모노디올리에이트, 디스테아르산에틸렌글리콜 등); 폴리옥시에틸렌알킬에테르류(예를 들면, 폴리옥시에틸렌라우릴에테르, 폴리옥시에틸렌올레일에테르, 폴리옥시에틸렌스테아릴에테르, 폴리옥시에틸렌베헤닐에테르, 폴리옥시에틸렌2-옥틸도데실에테르, 폴리옥시에틸렌콜레스탄올에테르 등); 플루로닉형류(예를 들면, 플루로닉 등); 폴리옥시에틸렌·폴리옥시프로필렌알킬에테르류(예를 들면, 폴리옥시에틸렌·폴리옥시프로필렌세틸에테르, 폴리옥시에틸렌·폴리옥시프로필렌2-데실테트라데실에테르, 폴리옥시에틸렌·폴리옥시프로필렌모노부틸에테르, 폴리옥시에틸렌·폴리옥시프로필렌 수첨 라놀린, 폴리옥시에틸렌·폴리옥시프로필렌글리세린에테르 등); 테트라폴리옥시에틸렌·테트라폴리옥시프로필렌에틸렌디아민 축합물류(예를 들면, 테트로닉 등); 폴리옥시에틸렌 피마자유 경화피마자유 유도체(예를 들면, 폴리옥시에틸렌 피마자유, 폴리옥시에틸렌 경화피마자유, 폴리옥시에틸렌 경화피마자유 모노이소스테아레이트, 폴리옥시에틸렌 경화피마자유 트리이소스테아레이트, 폴리옥시에틸렌 경화피마자유 모노피로글루탐산 모노이소스테아르산 디에스테르, 폴리옥시에틸렌 경화피마자유 말레산 등); 폴리옥시에틸렌 밀랍·라놀린 유도체(예를 들면, 폴리옥시에틸렌소르비트밀랍 등); 알칸올아미드(예를 들면, 야자유 지방산 디에탄올아미드, 라우르산 모노에탄올아미드, 지방산 이소프로판올아미드 등); 폴리옥시에틸렌프로필렌글리콜지방산 에스테르; 폴리옥시에틸렌알킬아민; 폴리옥시에틸렌지방산 아미드; 자당지방산 에스테르; 알킬에톡시디메틸아민옥시드; 트리올레일인산 등을 들 수 있다.
천연의 수용성 고분자로는 예를 들면, 식물계 고분자(예를 들면, 아라비아검, 트라가칸트검, 갈락탄, 구아검, 캐롭검, 카라야검, 로커스트빈검, 타마린드검, 카라기난, 펙틴, 한천, 퀸스시드(마르멜로), 조류 콜로이드(갈조진액), 전분(쌀, 옥수수, 감자, 밀), 글리시리진산); 미생물계 고분자(예를 들면, 잔탄검, 덱스트란, 석시노글루칸, 풀루란 등); 동물계 고분자(예를 들면, 콜라겐, 카세인, 알부민, 젤라틴 등) 등을 들 수 있다.
반합성의 수용성 고분자로는 예를 들면, 전분계 고분자(예를 들면, 카르복시메틸전분, 메틸히드록시프로필전분 등); 셀룰로오스계 고분자(메틸셀룰로오스, 에틸셀룰로오스, 메틸히드록시프로필셀룰로오스, 히드록시에틸셀룰로오스, 셀룰로오스황산 나트륨, 디알킬디메틸암모늄황산 셀룰로오스, 히드록시프로필셀룰로오스, 카르복시메틸셀룰로오스, 카르복시메틸셀룰로오스나트륨, 결정 셀룰로오스, 셀룰로오스 분말 및 이들 고분자의 소수 변성 화합물<예: 일부를 스테아록시 변성> 및 이들 고분자의 양이온 변성 화합물 등); 알긴산계 고분자(예를 들면, 알긴산나트륨, 알긴산프로필렌글리콜에스테르 등); 펙틴산 나트륨 등을 들 수 있다.
합성의 수용성 고분자로는 예를 들면, 비닐계 고분자(예를 들면, 폴리비닐알코올, 폴리비닐메틸에테르, 폴리비닐피롤리돈, 카르복시비닐 폴리머 등); 폴리옥시에틸렌계 고분자(예를 들면, 폴리에틸렌글리콜 20,000, 40,000, 60,000의 폴리옥시에틸렌폴리옥시프로필렌 공중합체 등); 폴리(디메틸디알릴암모늄할라이드)형 양이온성 고분자(예를 들면, 메르쿼트 100(Merquat 100) 미국 메르크사 제조); 디메틸디알릴암모늄할라이드와 아크릴아미드의 공중합체형 양이온성 폴리머(예를 들면, 메르쿼트 550(Merquat 550) 미국 메르크사 제조); 아크릴계 고분자(예를 들면 폴리아크릴산 나트륨, 폴리에틸아크릴레이트, 폴리아크릴아미드 등); 폴리에틸렌이민; 양이온 폴리머; 규산 AlMg(비검) 등을 들 수 있다.
자외선 흡수제로는 예를 들면, 벤조산계 자외선 흡수제(예를 들면, 파라아미노벤조산(이하, PABA라고 약칭함), PABA 모노글리세린에스테르, N,N-디프로폭시 PABA 에틸에스테르, N,N-디에톡시 PABA 에틸에스테르, N,N-디메틸 PABA 에틸에스테르, N,N-디메틸 PABA 부틸에스테르, N,N-디메틸 PABA 에틸에스테르 등); 안트라닐산계 자외선 흡수제(예를 들면, 호모멘틸-N-아세틸안트라닐레이트 등); 살리실산계 자외선 흡수제(예를 들면, 아밀살리실레이트, 멘틸살리실레이트, 호모멘틸살리실레이트, 옥틸살리실레이트, 페닐살리실레이트, 벤질살리실레이트, p-이소프로판올페닐살리실레이트 등); 신남산계 자외선 흡수제(예를 들면, 옥틸신나메이트, 에틸-4-이소프로필신나메이트, 메틸-2,5-디이소프로필신나메이트, 에틸-2,4-디이소프로필신나메이트, 메틸-2,4-디이소프로필신나메이트, 프로필-p-메톡시신나메이트, 이소프로필-p-메톡시신나메이트, 이소아밀-p-메톡시신나메이트, 옥틸-p-메톡시신나메이트(2-에틸헥실-p-메톡시신나메이트), 2-에톡시에틸-p-메톡시신나메이트, 시클로헥실-p-메톡시신나메이트, 에틸-α-시아노-β-페닐신나메이트, 2-에틸헥실-α-시아노-β-페닐신나메이트, 글리세릴모노-2-에틸헥사노일-디파라메톡시신나메이트 등); 벤조페논계 자외선 흡수제(예를 들면, 2,4-디히드록시벤조페논, 2,2'-디히드록시-4-메톡시벤조페논, 2,2'-디히드록시-4,4'-디메톡시벤조페논, 2,2',4,4'-테트라히드록시벤조페논, 2-히드록시-4-메톡시벤조페논, 2-히드록시-4-메톡시-4'-메틸벤조페논, 2-히드록시-4-메톡시벤조페논-5-설폰산염, 4-페닐벤조페논, 2-에틸헥실-4'-페닐-벤조페논-2-카르복실레이트, 2-히드록시-4-n-옥톡시벤조페논, 4-히드록시-3-카르복시벤조페논 등); 3-(4'-메틸벤질리덴)-d,l-캄퍼, 3-벤질리덴-d,l-캄퍼; 2-페닐-5-메틸벤족사졸; 2,2'-히드록시-5-메틸페닐벤조트리아졸; 2-(2'-히드록시-5'-t-옥틸페닐)벤조트리아졸; 2-(2'-히드록시-5'-메틸페닐벤조트리아졸; 디아니소일메탄; 4-메톡시-4'-t-부틸디벤조일메탄; 5-(3,3-디메틸-2-노르보르닐리덴)-3-펜탄-2-온 등); 트리아진계 자외선 흡수제(예를 들면, 2-4[(2-히드록시-3-도데실옥시프로필)옥시]-2-히드록시페닐)-4,6-비스(2,4-디메틸페닐)-1,3,5-트리아진, 2-4[(2-히드록시-3-트리데실옥시프로필)옥시]-2-히드록시페닐)-4,6-비스(2,4-디메틸페닐)-1,3,5-트리아진 등)를 들 수 있다.
금속 이온 봉쇄제로는 예를 들면, 1-히드록시에탄-1,1-디포스폰산, 1-히드록시에탄-1,1-디포스폰산 사나트륨염, 에데트산 이나트륨, 에데트산 삼나트륨, 에데트산 사나트륨, 시트르산 나트륨, 폴리인산 나트륨, 메타인산 나트륨, 글루콘산, 인산, 시트르산, 아스코르브산, 숙신산, 에데트산, 에틸렌디아민히드록시에틸삼아세트산 삼나트륨 등을 들 수 있다.
pH 조정제로는 예를 들면, 락트산-락트산 나트륨, 시트르산-시트르산 나트륨, 숙신산-숙신산 나트륨 등의 완충제 등을 들 수 있다.
비타민류로는 예를 들면, 비타민 A, B1, B2, B6, C, E 및 그 유도체, 판토텐산 및 그 유도체, 비오틴 등을 들 수 있다.
산화방지제로는 예를 들면, 토코페롤류, 디부틸히드록시톨루엔, 부틸히드록시아니솔, 갈산 에스테르류 등을 들 수 있다.
산화방지조제로는 예를 들면, 인산, 시트르산, 아스코르브산, 말레산, 말론산, 숙신산, 푸마르산, 케파린, 헥사메타포스페이트, 피트산, 에틸렌디아민사아세트산 등을 들 수 있다.
그 외의 배합 가능 성분으로는 예를 들면, 방부제(에틸파라벤, 부틸파라벤, 1,2-알칸디올, 페녹시에탄올, 메틸클로로이소티오졸린온 등); 소염제(예를 들면, 글리시리진산 유도체, 글리시레트산 유도체, 살리실산 유도체, 히노키티올, 산화아연, 알란토인 등); 미백제(예를 들면, 바위취 추출물, 알부틴 등); 각종 추출물(예를 들면, 황벽나무, 황련, 자근, 작약, 쓴풀, 자작나무, 세이지, 비파, 당근, 알로에, 당아욱, 아이리스, 포도, 의이인, 수세미, 백합, 사프란, 천궁, 생강, 고추나물, 오노니스, 마늘, 고추, 진피, 당귀, 해조 등), 부활제(예를 들면, 로열젤리, 감광소, 콜레스테롤 유도체 등); 혈행 촉진제(예를 들면, 노닐산 바닐아미드, 니코틴산 벤질에스테르, 니코틴산 β-부톡시에틸에스테르, 캡사이신, 진저론, 칸타리스팅크, 이크타몰, 타닌산, α-보르네올, 니코틴산 토코페롤, 이노시톨헥사니코티네이트, 시크란델레이트, 신나리진, 트라졸린, 아세틸콜린, 베라파밀, 세파란틴, γ-오리자놀 등); 항지루제(예를 들면, 황, 티안톨 등); 항염증제(예를 들면, 트라넥삼산, 티오타우린, 히포타우린 등); 방향족알코올(벤질알코올, 벤질옥시에탄올 등) 등을 들 수 있다.
또한, 그 외에 향료, 스크럽제 등도 안정성을 해치지 않는 범위에서 적절히 배합할 수 있다.
실시예
이하, 본 발명을 실시예에 의해 더욱 상세하게 설명하지만, 본 발명은 이들에 의해 한정되는 것은 아니다. 또한, 특별히 기재가 없는 한 배합량에 대해서는 모두 질량%로 나타낸다.
[α겔의 오클루전 효과의 비교]
이하의 실시예, 비교예에 따른 조성물을 70℃, 초음파 호모지나이저로 조제하고, 냉각 후, 종이에 각각 5mg/cm2의 비율로 균일 도포하여 1일 방치했다. 항온 항습실(23℃, 상대 습도=45%) 안에서 25mL 용량 바이알병에 5mL의 물을 넣은 후, 바로 바이알의 뚜껑부에 해당 여과지를 끼워 고정하고, 시간적 순서에 따라 수분 증발량을 측정했다. 시간당 수분 증발량(감쇠질량%)을 수분 증발 속도 정수(%/시간)로 정의했다. 따라서, 수분 증발 속도 정수(%/시간)가 작을수록 수분을 유지하는 능력이 높아진다.
실시예
1
배합량
(1) 스테아릴알코올
12.5%
(2) 폴리옥시에틸렌(10몰)피토스테롤
30.0%
(3) 폴리옥시에틸렌(6몰)디스테아르산
7.5%
(4) 이온 교환수
50.0%
실시예
2
배합량
(1) 스테아르산
12.5%
(2) 폴리옥시에틸렌(10몰)피토스테롤
30.0%
(3) 폴리옥시에틸렌(6몰)디스테아르산
7.5%
(4) 이온 교환수
50.0%
실시예
3
배합량
(1) 베헤닐알코올
15.0%
(2) 폴리옥시에틸렌(20몰)피토스테롤
30.0%
(3) 폴리옥시에틸렌(4몰)디스테아르산
5.0%
(4) 이온 교환수
50.0%
비교예
1
배합량
(1) 베헤닐알코올
34.1%
(2) N-스테아로일메틸타우린나트륨
15.9%
(3) 이온 교환수
50.0%
비교예
2
배합량
(1) 베헤닐알코올
30.0%
(2) 폴리옥시에틸렌(20몰)베헤닐에테르
20.0%
(3) 이온 교환수
50.0%
비교예
3
배합량
(1) 스테아릴알코올
12.5%
(2) 폴리옥시에틸렌(10몰)피토스테롤
30.0%
(3) 대두 수소첨가 레시놀
7.5%
(4) 이온 교환수
50.0%
결과
결과를 표 1에 나타냈다. 표 1로부터 분명한 바와 같이 본 발명의 α겔(실시예 1 내지 3)은 베헤닐알코올과 N-스테아로일메틸타우린나트륨, 베헤닐알코올과 폴리옥시에틸렌(20몰)베헤닐에테르, 스테아릴알코올과 폴리옥시에틸렌(10몰)피토스테롤과 대두 수소첨가 레시놀을 사용한 비교예 1 내지 3의 α겔 기제에 비하여 오클루전 효과가 높은 것을 알 수 있었다.
시험 기제 | 수분 증발 속도 정수(%/시간) |
이온 교환수(블랭크) | 0.143 |
실시예 1 | 0.032 |
실시예 2 | 0.041 |
실시예 3 | 0.040 |
비교예 1 | 0.075 |
비교예 2 | 0.086 |
비교예 3 | 0.055 |
[점도 안정성 시험]
또한, 실시예 1 내지 3, 비교예 1 내지 3의 기제를 각각 75℃에서 이온 교환수로 10배로 희석하고, 0 내지 50℃의 각 온도로 보존하고, 시간 경과에 따른 점도를 30℃에서 30분 이상 유지한 후, B형 점도계로 점도(mPa·s)를 측정했다.
결과
결과를 표 2에 나타냈다. 표로부터 분명한 바와 같이 실시예 1 내지 3 및 비교예 3에서는 점도는 안정되어 있었지만, 비교예 1, 2에서는 시간 경과에 따른 증점이 인정되었다. 또한, 점도가 안정되어 있던 비교예 3은 변취가 관찰되었다.
시간 경과, 온도 조건 | 실시예 1 | 실시예 2 | 실시예 3 | 비교예 1 | 비교예 2 | 비교예 3 |
첫날 | 2260 | 2530 | 2760 | 7450 | 5630 | 2600 |
1개월 0℃ | 2450 | 2710 | 2830 | 17600 | 9600 | 2730 |
1개월 25℃ | 2550 | 2680 | 2740 | 20000 | 10100 | 2800 |
1개월 37℃ | 2460 | 2650 | 2690 | 14200 | 18700 | 2750 |
1개월 50℃ | 2400 | 2480 | 2670 | 14000 | 15700 | 2580 |
[냄새 안정성]
실시예 4 내지 6, 비교예 4 내지 6의 기제를 각각 75℃에서 이온 교환수로 10배로 희석하고, 50℃의 각 온도로 보존하고, 1개월 후의 냄새를 전문 패널에 의해 이하의 판정 기준으로 판정했다.
판정 기준
○: 문제 없음, △: 약간 변취, ×: 변취
실시예
4
배합량
(1) 스테아릴알코올
12.5%
(2) 폴리옥시에틸렌(10몰)피토스테롤
30.0%
(3) 폴리옥시에틸렌(6몰)디스테아르산
6.0%
(4) 대두 수소첨가 레시놀
1.5%
(5) 이온 교환수
50.0%
실시예
5
배합량
(1) 스테아르산
12.5%
(2) 폴리옥시에틸렌(10몰)피토스테롤
30.0%
(3) 폴리옥시에틸렌(6몰)디스테아르산
7.0%
(4) 세라마이드 Ⅲ
0.5%
(5) 이온 교환수
50.0%
실시예
6
배합량
(1) 베헤닐알코올
15.0%
(2) 폴리옥시에틸렌(20몰)피토스테롤
30.0%
(3) 폴리옥시에틸렌(4몰)디스테아르산
4.8%
(4) 디스테아릴4급암모늄클로라이드
0.2%
(5) 이온 교환수
50.0%
비교예
4
배합량
(1) 베헤닐알코올
34.1%
(2) N-스테아로일메틸타우린나트륨
14.4%
(3) 대두 수소첨가 레시놀
1.5%
(4) 이온 교환수
50.0%
비교예
5
배합량
(1) 베헤닐알코올
30.0%
(2) 폴리옥시에틸렌(20몰)베헤닐에테르
19.5%
(3) 세라마이드 Ⅲ
0.5%
(4) 이온 교환수
50.0%
비교예
6
배합량
(1) 스테아릴알코올
12.5%
(2) 폴리옥시에틸렌(10몰)피토스테롤
30.0%
(3) 디스테아릴 4급 암모늄클로라이드
7.5%
(4) 이온 교환수
50.0%
결과
결과를 표 3에 나타냈다. 표 3으로부터 분명한 바와 같이 본 발명의 α겔 조성물을 사용함으로써 인지질, 레시틴, 리조레시틴, 세라마이드, 디알킬 4급 암모늄염 등의 질소 원자를 갖는 2쇄형 양친매성 물질의 변취가 없어지는 것을 알 수 있었다.
시험 기제 | 냄새 판정 |
실시예 4 | ○ |
실시예 5 | ○ |
실시예 6 | ○ |
비교예 4 | × |
비교예 5 | △ |
비교예 6 | × |
이하, 보다 구체적인 실시예를 들면 본 발명에 대하여 추가로 설명하지만, 본 발명은 이에 한정되는 것은 아니다.
실시예
7
유액
배합량(질량%)
(1) 스테아릴알코올
1.3
(2) 폴리옥시에틸렌(10몰)피토스테롤
3.0
(3) 폴리옥시에틸렌(6몰)디스테아르산
0.6
(4) 디프로필렌글리콜
5.0
(5) 향료
0.1
(6) 테트라2-에틸헥산산펜타에리트리트
2.0
(7) α올레핀 올리고머
3.0
(8) 디메틸폴리실록산
2.0
(신에츠가가쿠가부시키가이샤 제조, 실리콘 KF96-A6T)
(9) 정제 바셀린
1.0
(10) 1,3-부틸렌글리콜
2.0
(11) 페녹시에탄올
0.5
(12) 글리세린
4.0
(13) 카르복시비닐 폴리머
0.03
(14) 수산화칼륨
0.01
(15) 트라넥삼산
0.1
(16) 시트르산
0.02
(17) 시트르산 나트륨
0.08
(18) 이온 교환수
잔여
(제법)
통상의 방법에 의해 유화하여 상기 유액을 얻었다. 얻어진 유액은 오클루전 효과가 높고, 산뜻하며, 점도안정성 및 냄새 안정성이 양호했다.
실시예
8
미용액
배합량(질량%)
(1) N-스테아로일메틸타우린나트륨
0.01
(2) 스테아릴알코올
0.13
(3) 폴리옥시에틸렌(10몰)피토스테롤
0.3
(4) 폴리옥시에틸렌(6몰)디스테아르산
0.06
(5) 유동 파라핀
0.78
(6) 메틸페닐폴리실록산
0.2
(신에츠가가쿠가부시키가이샤 제조, 실리콘 KF56)
(7) 향료
0.02
(8) 폴리옥시에틸렌(14몰)폴리옥시프로필렌(7몰)디메틸에테르
0.5
(9) 글리세린
3.0
(10) 디프로필렌글리콜
5.0
(11) 1,3-부틸렌글리콜
3.0
(12) 시트르산
0.02
(13) 시트르산 나트륨
0.08
(14) EDTA2Na·2H2O
0.01
(15) 일반 알코올 95%
5.0
(16) 페녹시에탄올
0.5
(17) 이온 교환수
잔여
(제법)
통상의 방법에 의해 유화하여 상기 미용액을 얻었다. 얻어진 미용액은 오클루전 효과가 높고, 산뜻하며, 점도 안정성 및 냄새 안정성이 양호했다.
실시예
9
유액
배합량(질량%)
(1) 스테아릴알코올
1.3
(2) 폴리옥시에틸렌(10몰)피토스테롤
3.0
(3) 폴리옥시에틸렌(6몰)디스테아르산
0.6
(4) 대두 수소첨가 레시놀
0.2
(5) 이소프렌글리콜
4.5
(6) 1,4-부탄디올
1.5
(7) 향료
0.09
(8) 트리스테아르산 글리세릴
2.5
(9) 스쿠알란
4.5
(10) 디메틸폴리실록산
1.0
(신에츠가가쿠가부시키가이샤 제조, 실리콘 KF96-A6T)
(11) 프로필렌글리콜
7.0
(12) 에리트리톨
1.3
(13) 다이나마이트글리세린
6.0
(14) 페녹시에탄올
0.3
(15) 잔탄검
0.5
(16) 헥사메타인산 소다
0.03
(17) 이온 교환수
잔여
(제법)
통상의 방법에 의해 유화하여 상기 유액을 얻었다. 얻어진 유액은 오클루전 효과가 높고, 산뜻하며, 점도 안정성 및 냄새 안정성이 양호했다.
실시예
10
자외선 차단 크림
배합량(질량%)
(1) 베헤닐알코올
1.5
(2) 폴리옥시에틸렌(20몰)피토스테롤
3.0
(3) 폴리옥시에틸렌(4몰)디스테아르산
0.5
(4) 세라마이드 Ⅱ
0.2
(5) 디프로필렌글리콜
6.0
(6) 향료
0.08
(7) 트리2-에틸헥산산 글리세릴
2.0
(8) 숙신산 디2-에틸헥실
3.0
(9) p-메톡시신남산 2-에틸헥실
5.0
(10) 아보벤존
3.0
(11) 비스에틸헥실옥시페놀메톡시페닐트리아진
1.0
(12) 1,3-부틸렌글리콜
5.0
(13) 페녹시에탄올
0.5
(14) 글리세린
9.0
(15) EDTA-3나트륨염
0.1
(16) 에리트리톨
0.1
(17) 시트르산
0.02
(18) 시트르산 나트륨
0.08
(19) 이온 교환수
잔여
(제법)
통상의 방법에 의해 유화하여 상기 자외선 차단 크림을 얻었다. 얻어진 자외선 차단 크림은 오클루전 효과가 높고, 산뜻하며, 점도 안정성 및 냄새 안정성이 양호했다.
실시예
11
크림
배합량(질량%)
(1) 스테아릴알코올
2.5
(2) 폴리옥시에틸렌(10몰)피토스테롤
6.0
(3) 폴리옥시에틸렌(6몰)디스테아르산
1.2
(4) 1,3-부틸렌글리콜
6.5
(5) 향료
0.05
(6) 디메틸폴리실록산
7.4
(신에츠가가쿠가부시키가이샤 제조, 실리콘 KF96-A6T)
(7) 스쿠알란
4.0
(8) 정제 바셀린
1.0
(9) 디프로필렌글리콜
5.0
(10) 페녹시에탄올
0.5
(11) 글리세린
7.0
(12) EDTA-3나트륨염
0.1
(13) 카모마일 엑기스
0.1
(14) 시트르산
0.02
(15) 시트르산 나트륨
0.08
(제법)
통상의 방법에 의해 유화하여 크림을 얻었다. 얻어진 크림은 오클루전 효과가 높고, 산뜻하며, 점도 안정성 및 냄새 안정성이 양호했다.
Claims (5)
- (A) 1종 또는 2종 이상의 탄소수 16 이상의 고급 지방족 알코올 및/또는 고급 지방산 25 내지 50질량%
(B) 하기 일반식 (Ⅰ)로 표시되는 폴리옥시에틸렌스테롤에테르 40 내지 70질량%
(Ⅰ)
(단, 일반식 Ⅰ에서 R은 콜레스테롤 및/또는 피토스테롤 잔기, n은 5 내지 20의 정수를 나타냄)
(C) 하기 일반식 (Ⅱ)로 표시되는 폴리옥시에틸렌디알킬에스테르 및/또는 에테르를 5 내지 20질량%
(Ⅱ)
(단, 일반식 Ⅱ에서 R1 및 R2는 탄소수 16 내지 24의 직쇄 지방족산 잔기 또는 직쇄 지방족 알코올 잔기, n은 4 내지 15의 정수)
를 포함하고, 상기 물을 첨가함으로써 생성되는, α겔 형성용 조성물. - 제 1 항에 있어서,
(A) 내지 (C)를 수중에 배합하여 조제된, α겔 형성용 조성물. - 제 2 항에 있어서,
추가로 질소 원자를 갖는 2쇄형 양친매성 물질을 α겔 조성물 중의 유효분에 대하여 0.1 내지 10질량% 함유하는, α겔 형성용 조성물. - 제 3 항에 있어서,
질소 원자를 갖는 2쇄형 양친매성 물질이 인지질, 레시틴, 리조레시틴, 세라마이드, 디알킬 4급 암모늄염으로부터 선택되는 1종 또는 2종 이상인, α겔 형성용 조성물. - 제 2 항에 기재된 α겔 형성용 조성물을 배합하는, 피부 외용제 조성물.
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TWI414317B (zh) * | 2008-05-29 | 2013-11-11 | Shiseido Co Ltd | 皮膚外用劑 |
JP2010120857A (ja) * | 2008-11-17 | 2010-06-03 | Doctor Program Kk | 皮膚外用剤 |
TWI398264B (zh) * | 2009-02-03 | 2013-06-11 | Shiseido Co Ltd | 毛髮調理劑組成物及其低能量製造方法 |
JP5690516B2 (ja) * | 2009-07-06 | 2015-03-25 | 花王株式会社 | 乳化組成物 |
CN103260594B (zh) * | 2010-11-11 | 2015-11-25 | 荷兰联合利华有限公司 | 包含12-羟基硬脂酸的留存型非固体皮肤调理组合物 |
JP6513667B2 (ja) * | 2013-08-08 | 2019-05-15 | ノヴァン,インコーポレイテッド | 局所用組成物およびそれを使用する方法 |
KR101811167B1 (ko) * | 2014-06-13 | 2018-01-25 | 가부시키가이샤 시세이도 | α겔 중간체 조성물 및 상기 조성물을 사용한 α겔 함유 O/W 유화화장료의 제조방법 |
US10898426B2 (en) * | 2016-01-27 | 2021-01-26 | Shiseido Company, Ltd. | Alpha-gel formation composition, external skin care composition using alpha-gel formation composition, and alpha-gel composition using alpha-gel formation composition |
KR102685043B1 (ko) * | 2016-01-27 | 2024-07-12 | 가부시키가이샤 시세이도 | α겔 형성용 조성물, 및 이를 이용한 피부 외용 조성물 및 α겔 조성물 |
CN107693844A (zh) * | 2016-08-07 | 2018-02-16 | 李媚 | 一种组合物凝胶与应用 |
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2016
- 2016-01-27 JP JP2016013181A patent/JP6426635B2/ja active Active
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RU2018128456A (ru) | 2020-02-27 |
TWI740882B (zh) | 2021-10-01 |
JP2017132709A (ja) | 2017-08-03 |
BR112018015257A2 (pt) | 2018-12-18 |
US11033479B2 (en) | 2021-06-15 |
EP3417845B1 (en) | 2021-03-31 |
RU2732289C2 (ru) | 2020-09-15 |
TW201801710A (zh) | 2018-01-16 |
EP3417845A1 (en) | 2018-12-26 |
EP3417845A4 (en) | 2019-07-03 |
US20210100732A1 (en) | 2021-04-08 |
AU2017212886A1 (en) | 2018-08-16 |
CN108472224B (zh) | 2021-05-07 |
RU2018128456A3 (ko) | 2020-02-27 |
BR112018015257B1 (pt) | 2021-11-16 |
CN108472224A (zh) | 2018-08-31 |
WO2017130655A1 (ja) | 2017-08-03 |
JP6426635B2 (ja) | 2018-11-21 |
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