KR20180073687A - 호흡기 질환의 치료를 위한 jak 키나제 저해제 화합물 - Google Patents

호흡기 질환의 치료를 위한 jak 키나제 저해제 화합물 Download PDF

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Publication number
KR20180073687A
KR20180073687A KR1020187015680A KR20187015680A KR20180073687A KR 20180073687 A KR20180073687 A KR 20180073687A KR 1020187015680 A KR1020187015680 A KR 1020187015680A KR 20187015680 A KR20187015680 A KR 20187015680A KR 20180073687 A KR20180073687 A KR 20180073687A
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South Korea
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alkyl
compound
ethyl
imidazo
tetrahydro
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English (en)
Korean (ko)
Inventor
폴 알. 패더리
존 알. 제이콥슨
앤-마리 뷰솔레일
게리 이.엘. 브랜트
멜리사 플뢰리
란 지앙
카메론 스미스
스티븐 디.이. 설리반
오든 로리 진 반
피어-진 콜슨
진 티모시 파스
미로슬라브 랍타
노아 벤자민
마르타 다브로스
벤캇 알. 탈라디
Original Assignee
세라밴스 바이오파마 알앤디 아이피, 엘엘씨
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Publication of KR20180073687A publication Critical patent/KR20180073687A/ko
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020187015680A 2015-11-03 2016-11-02 호흡기 질환의 치료를 위한 jak 키나제 저해제 화합물 Withdrawn KR20180073687A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562250113P 2015-11-03 2015-11-03
US62/250,113 2015-11-03
PCT/US2016/059999 WO2017079205A1 (en) 2015-11-03 2016-11-02 Jak kinase inhibitor compounds for treatment of respiratory disease

Publications (1)

Publication Number Publication Date
KR20180073687A true KR20180073687A (ko) 2018-07-02

Family

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KR1020187015680A Withdrawn KR20180073687A (ko) 2015-11-03 2016-11-02 호흡기 질환의 치료를 위한 jak 키나제 저해제 화합물

Country Status (22)

Country Link
US (6) US10100049B2 (cg-RX-API-DMAC10.html)
EP (1) EP3371186A1 (cg-RX-API-DMAC10.html)
JP (1) JP6800969B2 (cg-RX-API-DMAC10.html)
KR (1) KR20180073687A (cg-RX-API-DMAC10.html)
CN (1) CN108349972B (cg-RX-API-DMAC10.html)
AU (1) AU2016350816B2 (cg-RX-API-DMAC10.html)
BR (1) BR112018008966B1 (cg-RX-API-DMAC10.html)
CA (1) CA3001542C (cg-RX-API-DMAC10.html)
CL (1) CL2018001145A1 (cg-RX-API-DMAC10.html)
CO (1) CO2018005640A2 (cg-RX-API-DMAC10.html)
EA (1) EA034914B1 (cg-RX-API-DMAC10.html)
HK (1) HK1252685A1 (cg-RX-API-DMAC10.html)
IL (1) IL258772B (cg-RX-API-DMAC10.html)
MX (1) MX374605B (cg-RX-API-DMAC10.html)
MY (1) MY195427A (cg-RX-API-DMAC10.html)
NZ (1) NZ741737A (cg-RX-API-DMAC10.html)
PH (1) PH12018500828B1 (cg-RX-API-DMAC10.html)
SA (1) SA518391470B1 (cg-RX-API-DMAC10.html)
TW (1) TWI710560B (cg-RX-API-DMAC10.html)
UA (1) UA123633C2 (cg-RX-API-DMAC10.html)
WO (1) WO2017079205A1 (cg-RX-API-DMAC10.html)
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Cited By (1)

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KR20190140062A (ko) * 2017-05-01 2019-12-18 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 Jak 저해제 화합물을 사용하는 치료 방법

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TWI754019B (zh) * 2017-03-09 2022-02-01 美商施萬生物製藥研發 Ip有限責任公司 含有4員雜環醯胺之jak抑制劑
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TWI754019B (zh) 2017-03-09 2022-02-01 美商施萬生物製藥研發 Ip有限責任公司 含有4員雜環醯胺之jak抑制劑
EP3619208B1 (en) 2017-05-01 2023-06-07 Theravance Biopharma R&D IP, LLC Crystalline forms of a jak inhibitor compound
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190140062A (ko) * 2017-05-01 2019-12-18 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 Jak 저해제 화합물을 사용하는 치료 방법

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CO2018005640A2 (es) 2018-05-31
JP6800969B2 (ja) 2020-12-16
US20190106420A1 (en) 2019-04-11
SA518391470B1 (ar) 2021-03-31
IL258772B (en) 2021-01-31
US10526330B2 (en) 2020-01-07
BR112018008966B1 (pt) 2023-05-02
US20170121327A1 (en) 2017-05-04
AU2016350816A1 (en) 2018-05-17
US20220306624A1 (en) 2022-09-29
BR112018008966A2 (pt) 2018-11-27
US20210130351A1 (en) 2021-05-06
CN108349972A (zh) 2018-07-31
US10100049B2 (en) 2018-10-16
IL258772A (en) 2018-06-28
US10913740B2 (en) 2021-02-09
TWI710560B (zh) 2020-11-21
NZ741737A (en) 2023-11-24
CA3001542C (en) 2021-02-16
US11718616B2 (en) 2023-08-08
CN108349972B (zh) 2021-06-08
JP2018531982A (ja) 2018-11-01
CL2018001145A1 (es) 2018-07-06
TW201726673A (zh) 2017-08-01
MX374605B (es) 2025-03-06
MY195427A (en) 2023-01-20
US11299492B2 (en) 2022-04-12
WO2017079205A1 (en) 2017-05-11
US20180319796A1 (en) 2018-11-08
MX2018005446A (es) 2018-08-01
HK1252685A1 (zh) 2019-05-31
UA123633C2 (uk) 2021-05-05
US20200087303A1 (en) 2020-03-19
ZA201802496B (en) 2025-01-29
PH12018500828B1 (en) 2023-06-30
EA201891091A1 (ru) 2018-12-28
EA034914B1 (ru) 2020-04-06
CA3001542A1 (en) 2017-05-11
AU2016350816B2 (en) 2020-06-25
US10183942B2 (en) 2019-01-22
PH12018500828A1 (en) 2018-10-29
EP3371186A1 (en) 2018-09-12

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