CN108349972B - 用于治疗呼吸疾病的jak激酶抑制剂化合物 - Google Patents

用于治疗呼吸疾病的jak激酶抑制剂化合物 Download PDF

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Publication number
CN108349972B
CN108349972B CN201680063886.1A CN201680063886A CN108349972B CN 108349972 B CN108349972 B CN 108349972B CN 201680063886 A CN201680063886 A CN 201680063886A CN 108349972 B CN108349972 B CN 108349972B
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alkyl
compound
ethyl
formula
hydrogen
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CN108349972A (zh
Inventor
保罗·R·法特里
约翰·R·雅各布森
安妮-玛丽·博索莱伊
加里·E·L·勃兰特
梅丽莎·弗勒里
姜岚
卡梅伦·史密斯
史蒂文·D·E·沙利文
洛里·琼·范奥登
皮埃尔-让·科尔松
吉恩·蒂莫西·法斯
米罗斯拉夫·拉普塔
诺亚·本杰明
马尔塔·达布罗斯
文卡特·R·萨兰迪
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Theravance Biopharma R&D IP LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201680063886.1A 2015-11-03 2016-11-02 用于治疗呼吸疾病的jak激酶抑制剂化合物 Expired - Fee Related CN108349972B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562250113P 2015-11-03 2015-11-03
US62/250,113 2015-11-03
PCT/US2016/059999 WO2017079205A1 (en) 2015-11-03 2016-11-02 Jak kinase inhibitor compounds for treatment of respiratory disease

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CN108349972A CN108349972A (zh) 2018-07-31
CN108349972B true CN108349972B (zh) 2021-06-08

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EP (1) EP3371186A1 (cg-RX-API-DMAC10.html)
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JP7580136B2 (ja) * 2019-12-30 2024-11-11 路良 Ｊａｋ阻害剤化合物及びその使用
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TW202207934A (zh) * 2020-03-27 2022-03-01 瑞典商阿斯特捷利康公司 用於肺遞送的乾粉配製物及使用方法
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CN119403552A (zh) 2022-05-05 2025-02-07 施万生物制药研发Ip有限责任公司 用于通过雾化口腔吸入递送的奈珠西替尼

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CO2018005640A2 (es) 2018-05-31
JP6800969B2 (ja) 2020-12-16
US20190106420A1 (en) 2019-04-11
SA518391470B1 (ar) 2021-03-31
IL258772B (en) 2021-01-31
US10526330B2 (en) 2020-01-07
BR112018008966B1 (pt) 2023-05-02
US20170121327A1 (en) 2017-05-04
AU2016350816A1 (en) 2018-05-17
US20220306624A1 (en) 2022-09-29
BR112018008966A2 (pt) 2018-11-27
US20210130351A1 (en) 2021-05-06
CN108349972A (zh) 2018-07-31
US10100049B2 (en) 2018-10-16
IL258772A (en) 2018-06-28
US10913740B2 (en) 2021-02-09
TWI710560B (zh) 2020-11-21
NZ741737A (en) 2023-11-24
CA3001542C (en) 2021-02-16
US11718616B2 (en) 2023-08-08
JP2018531982A (ja) 2018-11-01
CL2018001145A1 (es) 2018-07-06
TW201726673A (zh) 2017-08-01
MX374605B (es) 2025-03-06
MY195427A (en) 2023-01-20
KR20180073687A (ko) 2018-07-02
US11299492B2 (en) 2022-04-12
WO2017079205A1 (en) 2017-05-11
US20180319796A1 (en) 2018-11-08
MX2018005446A (es) 2018-08-01
HK1252685A1 (zh) 2019-05-31
UA123633C2 (uk) 2021-05-05
US20200087303A1 (en) 2020-03-19
ZA201802496B (en) 2025-01-29
PH12018500828B1 (en) 2023-06-30
EA201891091A1 (ru) 2018-12-28
EA034914B1 (ru) 2020-04-06
CA3001542A1 (en) 2017-05-11
AU2016350816B2 (en) 2020-06-25
US10183942B2 (en) 2019-01-22
PH12018500828A1 (en) 2018-10-29
EP3371186A1 (en) 2018-09-12

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