KR20170100653A - 천연 킬러 세포를 사용하여 혈액학적 장애, 고형 종양, 또는 감염 질환을 치료하는 방법 - Google Patents

천연 킬러 세포를 사용하여 혈액학적 장애, 고형 종양, 또는 감염 질환을 치료하는 방법 Download PDF

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KR20170100653A
KR20170100653A KR1020177021337A KR20177021337A KR20170100653A KR 20170100653 A KR20170100653 A KR 20170100653A KR 1020177021337 A KR1020177021337 A KR 1020177021337A KR 20177021337 A KR20177021337 A KR 20177021337A KR 20170100653 A KR20170100653 A KR 20170100653A
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cells
cell
medium
population
kit
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린 강
샤오구이 장
제프리 해리스
블라디미르 잔코빅
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안트로제네시스 코포레이션
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KR1020177021337A 2014-12-31 2015-12-30 천연 킬러 세포를 사용하여 혈액학적 장애, 고형 종양, 또는 감염 질환을 치료하는 방법 Ceased KR20170100653A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462098547P 2014-12-31 2014-12-31
US62/098,547 2014-12-31
US201562139952P 2015-03-30 2015-03-30
US62/139,952 2015-03-30
PCT/US2015/068069 WO2016109668A1 (en) 2014-12-31 2015-12-30 Methods of treating hematological disorders, solid tumors, or infectious diseases using natural killer cells

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KR20170100653A true KR20170100653A (ko) 2017-09-04

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KR1020177021337A Ceased KR20170100653A (ko) 2014-12-31 2015-12-30 천연 킬러 세포를 사용하여 혈액학적 장애, 고형 종양, 또는 감염 질환을 치료하는 방법

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US (2) US20180021378A1 (enExample)
EP (1) EP3240551A4 (enExample)
JP (2) JP6797803B2 (enExample)
KR (1) KR20170100653A (enExample)
CN (1) CN107249604A (enExample)
AU (2) AU2015374062B2 (enExample)
CA (1) CA2972806A1 (enExample)
HK (2) HK1245140A1 (enExample)
WO (1) WO2016109668A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190083990A (ko) * 2018-01-05 2019-07-15 지엔티 바이오테크 & 메디컬즈 코포레이션 종양 미세환경 및 면역요법의 조절을 위한 약제학적 조합물 및 방법
KR20210002690A (ko) * 2018-04-30 2021-01-08 엑스엔케이 테라퓨틱스 아베 의학 용도

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* Cited by examiner, † Cited by third party
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EP4282419A1 (en) 2012-12-20 2023-11-29 Purdue Research Foundation Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
AU2013204922B2 (en) 2012-12-20 2015-05-14 Celgene Corporation Chimeric antigen receptors
CA2907397C (en) 2013-03-15 2022-11-22 Anthrogenesis Corporation Modified t lymphocytes
KR102211120B1 (ko) 2014-05-15 2021-02-03 내셔널 유니버시티 오브 싱가포르 변형된 천연 살해 세포 및 그의 용도
US10034872B2 (en) * 2014-08-22 2018-07-31 Celgene Corporation Methods of treating multiple myeloma with immunomodulatory compounds in combination with antibodies
KR102236843B1 (ko) 2014-12-01 2021-04-07 수마 헬스 새로운 재생 치료제로서의 camkk1
US10632151B2 (en) 2015-01-22 2020-04-28 University Of Massachusetts Cancer immunotherapy
CA2986765A1 (en) 2015-05-29 2016-12-08 Agenus Inc. Anti-ctla-4 antibodies and methods of use thereof
US12590321B2 (en) 2016-03-19 2026-03-31 Exuma Biotech Corp. Methods and compositions for genetically modifying and expanding lymphocytes and regulating the activity thereof
US11325948B2 (en) 2016-03-19 2022-05-10 Exuma Biotech Corp. Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL
US11111505B2 (en) 2016-03-19 2021-09-07 Exuma Biotech, Corp. Methods and compositions for transducing lymphocytes and regulating the activity thereof
US12144850B2 (en) 2016-04-08 2024-11-19 Purdue Research Foundation Methods and compositions for car T cell therapy
JP7373991B2 (ja) * 2016-07-15 2023-11-06 ビラクタ セラピューティクス，インク． 免疫療法で使用するためのヒストン脱アセチル化酵素阻害剤
KR102576042B1 (ko) 2016-10-11 2023-09-07 아게누스 인코포레이티드 항-lag-3 항체 및 이의 사용 방법
CA3037046A1 (en) 2016-10-31 2018-05-03 University Of Massachusetts Targeting microrna-101-3p in cancer therapy
CN118634323A (zh) 2016-12-07 2024-09-13 艾吉纳斯公司 抗体和其使用方法
FI3551660T3 (fi) 2016-12-07 2023-12-11 Agenus Inc Anti-ctla-4-vasta-aineita ja niiden käyttömenetelmiä
ES2875005T3 (es) 2016-12-09 2021-11-08 Onk Therapeutics Ltd Células asesinas naturales manipuladas y usos de las mismas
WO2018121679A1 (zh) * 2016-12-30 2018-07-05 四川大学 表达cxcr4的嵌合抗原受体修饰的淋巴细胞及制备方法和用途
ES3010559T3 (en) 2017-02-28 2025-04-03 Endocyte Inc Compositions and methods for car t cell therapy
IL269553B2 (en) 2017-03-27 2025-10-01 Nat Univ Singapore Truncated NKG2D chimeric receptors and their uses in immunotherapy with natural killer cells
WO2018177971A1 (en) * 2017-03-27 2018-10-04 INSERM (Institut National de la Santé et de la Recherche Médicale) New method to obtain lymphoid progenitors
WO2018182511A1 (en) 2017-03-27 2018-10-04 National University Of Singapore Stimulatory cell lines for ex vivo expansion and activation of natural killer cells
BR112019024656A2 (pt) * 2017-05-25 2020-06-09 Univ Central Florida Res Found Inc vírus oncolíticos para a sensibilização de células tumorais para morte por células exterminadoras naturais
TWI676483B (zh) * 2017-08-06 2019-11-11 強普生技股份有限公司 醫藥套組及其用途
CA3077325A1 (en) * 2017-09-28 2019-04-04 Celularity Inc. Tumor suppression using human placenta-derived intermediate natural killer (pink) cells in combination with an antibody
AU2018346818B2 (en) * 2017-10-02 2024-12-19 Gamida-Cell Ltd. Expansion and use of expanded NK cell fractions
CN111542545A (zh) * 2017-11-03 2020-08-14 索伦托治疗有限公司 Cd38定向嵌合抗原受体构建体
JP2021505637A (ja) * 2017-12-12 2021-02-18 マクロジェニクス，インコーポレーテッド 二重特異性ｃｄ１６結合分子、及び疾患の治療におけるその使用
CN108060137B (zh) * 2017-12-26 2021-07-02 博生吉医药科技(苏州)有限公司 Il7和il21修饰的nk92细胞、制备方法及其应用
WO2019127215A1 (en) * 2017-12-28 2019-07-04 Nanjing Legend Biotech Co., Ltd. Multispecific chimeric receptors comprising an nkg2d domain and methods of use thereof
US11311576B2 (en) 2018-01-22 2022-04-26 Seattle Children's Hospital Methods of use for CAR T cells
US11814623B2 (en) 2018-01-30 2023-11-14 University Of Massachusetts Methods of treating a wound using epigenetic regulation
AU2019215034C1 (en) 2018-02-01 2022-01-06 Nkmax Co., Ltd. Method of producing natural killer cells and composition for treating cancer
CN111801348A (zh) 2018-02-09 2020-10-20 新加坡国立大学 活化性嵌合受体及其在自然杀伤细胞免疫疗法中的用途
WO2019165121A1 (en) 2018-02-21 2019-08-29 Board Of Regents, The University Of Texas System Methods for activation and expansion of natural killer cells and uses therof
CA3091674A1 (en) 2018-02-23 2019-08-29 Endocyte, Inc. Sequencing method for car t cell therapy
WO2019183094A1 (en) * 2018-03-19 2019-09-26 The Regents Of The University Of Michigan Compositions and methods for t-cell and cytokine activation
SG11202008976YA (en) 2018-04-02 2020-10-29 Nat Univ Singapore Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells
IL277773B2 (en) 2018-04-18 2026-05-01 Summa Health Compositions and methods for treating ischemia and cardiomyopathy
WO2019200586A1 (en) * 2018-04-19 2019-10-24 The Chinese University Of Hong Kong Modified nk cells and uses thereof
KR102373502B1 (ko) * 2018-05-14 2022-03-11 주식회사 금호에이치티 골수유래억제세포 관련 질환의 예방 및 치료 용도
KR102069704B1 (ko) * 2018-05-16 2020-01-23 고려대학교 산학협력단 Hdac 억제제를 이용한 사람 유래 자연살해세포의 확장 배양법
KR20210016567A (ko) * 2018-05-30 2021-02-16 글리코스템 떼라퓨틱스 비.브이. Car nk 세포
EP3806894A4 (en) 2018-06-12 2022-06-08 Promab Biotechnologies, Inc. PLAP-CAR EFFECTOR CELLS
CN108815186A (zh) * 2018-06-14 2018-11-16 上海鸣大生物科技有限公司 一种治疗hpv持续感染引起疾病的药物及制备方法与应用
EP3844186A4 (en) 2018-08-29 2022-08-17 National University of Singapore METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS
SG11202102272UA (en) 2018-09-05 2021-04-29 Univ Arizona State Oncolytic virus platform to treat hematological cancer
AU2019361096A1 (en) 2018-10-19 2021-06-03 Regents Of The University Of Minnesota NK engager molecules and methods of use thereof
WO2020088631A1 (en) 2018-11-01 2020-05-07 Gracell Biotechnologies (Shanghai) Co., Ltd. Compositions and methods for t cell engineering
CA3120563A1 (en) 2018-11-26 2020-06-04 Nkarta, Inc. Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy
EP3886876A1 (en) * 2018-11-30 2021-10-06 Celularity Inc. Placenta-derived allogeneic car-t cells and uses thereof
WO2020180882A1 (en) 2019-03-05 2020-09-10 Nkarta, Inc. Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy
CA3133419A1 (en) * 2019-03-21 2020-09-24 Gamida Cell Ltd. Expansion and use of expanded nk cell fractions suitable for transplantation in combination therapy
WO2020223445A1 (en) 2019-04-30 2020-11-05 Senti Biosciences, Inc. Chimeric receptors and methods of use thereof
WO2021016621A1 (en) * 2019-07-25 2021-01-28 Celularity Inc. Populations of natural killer cells comprising a cd38 chimeric antigen receptor
BR112022003617A2 (pt) * 2019-09-01 2022-09-13 Exuma Biotech Corp Métodos e composições para a modificação e distribuição de linfócitos
KR20220078665A (ko) * 2019-10-10 2022-06-10 아리조나 보드 오브 리젠츠 온 비하프 오브 아리조나 스테이트 유니버시티 다중특이적 면역 세포 인게이저를 발현하는 종양용해 바이러스
EP4065144A4 (en) * 2019-11-27 2024-04-10 Deverra Therapeutics Inc. COMPOSITIONS AND METHODS FOR CULTIVATION OF HEMATOPOETIC STEM CELLS AND PROGENITOR CELLS
JP2023504075A (ja) * 2019-11-28 2023-02-01 グリコステム セラピューティクス ベスローテン フェンノートシャップ Ｃａｒ－ｎｋ細胞を得る方法
US20230111159A1 (en) * 2020-03-05 2023-04-13 Exuma Biotech Corp Methods and compositions for the delivery of modified lymphocyte aggregates
WO2021188836A1 (en) * 2020-03-18 2021-09-23 Barron Annelise E Upregulation of cathelicidin gene expression as an adjuvant to other treatments for diseases
GB2621653A (en) * 2020-09-22 2024-02-21 World Biotech Regenerative Medical Group Ltd Methods and compositions of car-expressing natural killer cells with bispecific antigen-binding molecules as cancer therapeutic agents
US11459372B2 (en) 2020-11-30 2022-10-04 Crispr Therapeutics Ag Gene-edited natural killer cells
US11473060B2 (en) 2020-12-30 2022-10-18 Crispr Therapeutics Ag Compositions and methods for differentiating stem cells into NK cells
AU2022218710A1 (en) * 2021-02-09 2023-08-10 Takeda Pharmaceutical Company Limited Methods and compositions for freezing and thawing mammalian cells
WO2022173737A1 (en) 2021-02-09 2022-08-18 Millennium Pharmaceuticals, Inc. Methods and compositions for freezing and thawing mammalian cells
CN113398264B (zh) * 2021-08-06 2022-04-29 朱有建 Nk细胞及其组合物在治疗癌症中的用途
US20240335472A1 (en) * 2021-08-10 2024-10-10 Gamida Cell Ltd. Anti-her2 car nk cells, methods of their production and uses thereof
CN113577267B (zh) * 2021-09-06 2022-04-08 江西北正干细胞生物科技有限公司 Nk细胞和抗体的药物组合物及其在治疗癌症中的用途
JPWO2023038037A1 (enExample) * 2021-09-08 2023-03-16
EP4180049A1 (en) * 2021-11-16 2023-05-17 Ostravska univerzita Therapeutic composition for cancer treatment
CN114058584B (zh) * 2022-01-07 2022-07-01 山东省齐鲁干细胞工程有限公司 一种临床用自然杀伤细胞的制备方法
CN115927169B (zh) * 2022-10-11 2023-08-11 再造再生医学科技(杭州)有限公司 用于扩增cd34+造血干细胞的培养液和体外扩增cd34+造血干细胞的方法
CN119082021B (zh) * 2024-09-30 2025-03-28 广东壹加再生医学研究院有限公司 一种增强型nk细胞及其制备方法
CN119280423A (zh) * 2024-10-10 2025-01-10 中南大学 一种联合靶向鼻咽癌治疗的载药体系及其制备方法与应用
CN121426926A (zh) * 2025-10-21 2026-01-30 北京京科信拓生物技术有限公司 基因编辑的免疫细胞及其应用
CN121378506A (zh) * 2025-10-21 2026-01-23 北京京科信拓生物技术有限公司 表达car的免疫细胞及其应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5190556A (en) 1991-03-19 1993-03-02 O.B. Tech, Inc. Cord cutter sampler
US5372581A (en) 1993-07-21 1994-12-13 Minneapolis Children's Services Corporation Method and apparatus for placental blood collection
JP2002542349A (ja) 1999-04-16 2002-12-10 ダブリューエム・マーシュ・ライス・ユニバーシティー ポリ（プロピレンフマラート）−ジアクリレートマクロマーで交差結合された生体分解性のポリ（プロピレンフマラート）ネットワーク
US6355699B1 (en) 1999-06-30 2002-03-12 Ethicon, Inc. Process for manufacturing biomedical foams
JP2002045174A (ja) 2000-07-31 2002-02-12 Inst Of Physical & Chemical Res ナチュラルキラー細胞増殖法
EP2206772A3 (en) 2000-12-06 2010-08-04 Robert J. Hariri Method of collecting placental stem cells
US20030187515A1 (en) 2002-03-26 2003-10-02 Hariri Robert J. Collagen biofabric and methods of preparing and using the collagen biofabric
US7147626B2 (en) 2004-09-23 2006-12-12 Celgene Corporation Cord blood and placenta collection kit
EP3594245A1 (en) * 2012-02-13 2020-01-15 Seattle Children's Hospital d/b/a Seattle Children's Research Institute Bispecific chimeric antigen receptors and therapeutic uses thereof
CN103483452B (zh) * 2012-06-12 2021-08-13 上海细胞治疗集团有限公司 双信号独立的嵌合抗原受体及其用途
CA2881792C (en) * 2012-08-13 2024-02-27 Anthrogenesis Corporation Natural killer cells and uses thereof
BR112015020516A2 (pt) * 2013-02-26 2017-10-10 Memorial Sloan Kettering Cancer Center composições e métodos para imunoterapia
HK1220614A1 (zh) * 2013-03-10 2017-05-12 Baylor College Of Medicine 耐化疗免疫细胞
EP2970426B1 (en) * 2013-03-15 2019-08-28 Michael C. Milone Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
EP2992020B1 (en) * 2013-05-03 2020-01-15 Ohio State Innovation Foundation Cs1-specific chimeric antigen receptor engineered immune effector cells
EP3974520A1 (en) * 2013-05-14 2022-03-30 Board of Regents, The University of Texas System Human application of engineered chimeric antigen receptor (car) t-cells

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190083990A (ko) * 2018-01-05 2019-07-15 지엔티 바이오테크 & 메디컬즈 코포레이션 종양 미세환경 및 면역요법의 조절을 위한 약제학적 조합물 및 방법
US11840570B2 (en) 2018-01-05 2023-12-12 Great Novel Therapeutics Biotech & Medicals Corporation Pharmaceutical combination and method for regulation of tumor microenvironment and immunotherapy
KR20210002690A (ko) * 2018-04-30 2021-01-08 엑스엔케이 테라퓨틱스 아베 의학 용도

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