JP6797803B2 - ナチュラルキラー細胞を用いて血液障害、固形腫瘍、又は感染性疾患を治療する方法 - Google Patents

ナチュラルキラー細胞を用いて血液障害、固形腫瘍、又は感染性疾患を治療する方法 Download PDF

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JP6797803B2
JP6797803B2 JP2017534929A JP2017534929A JP6797803B2 JP 6797803 B2 JP6797803 B2 JP 6797803B2 JP 2017534929 A JP2017534929 A JP 2017534929A JP 2017534929 A JP2017534929 A JP 2017534929A JP 6797803 B2 JP6797803 B2 JP 6797803B2
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JP2018502114A5 (enExample
JP2018502114A (ja
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カング リン
カング リン
ズハング キアオクイ
ズハング キアオクイ
ハリス ジェフリー
ハリス ジェフリー
ジャンコビク ウラジミール
ジャンコビク ウラジミール
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Celgene Corp
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JP2017534929A 2014-12-31 2015-12-30 ナチュラルキラー細胞を用いて血液障害、固形腫瘍、又は感染性疾患を治療する方法 Expired - Fee Related JP6797803B2 (ja)

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US201462098547P 2014-12-31 2014-12-31
US62/098,547 2014-12-31
US201562139952P 2015-03-30 2015-03-30
US62/139,952 2015-03-30
PCT/US2015/068069 WO2016109668A1 (en) 2014-12-31 2015-12-30 Methods of treating hematological disorders, solid tumors, or infectious diseases using natural killer cells

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Families Citing this family (80)

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EP4282419A1 (en) 2012-12-20 2023-11-29 Purdue Research Foundation Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics
AU2013204922B2 (en) 2012-12-20 2015-05-14 Celgene Corporation Chimeric antigen receptors
CA2907397C (en) 2013-03-15 2022-11-22 Anthrogenesis Corporation Modified t lymphocytes
KR102211120B1 (ko) 2014-05-15 2021-02-03 내셔널 유니버시티 오브 싱가포르 변형된 천연 살해 세포 및 그의 용도
US10034872B2 (en) * 2014-08-22 2018-07-31 Celgene Corporation Methods of treating multiple myeloma with immunomodulatory compounds in combination with antibodies
KR102236843B1 (ko) 2014-12-01 2021-04-07 수마 헬스 새로운 재생 치료제로서의 camkk1
US10632151B2 (en) 2015-01-22 2020-04-28 University Of Massachusetts Cancer immunotherapy
CA2986765A1 (en) 2015-05-29 2016-12-08 Agenus Inc. Anti-ctla-4 antibodies and methods of use thereof
US12590321B2 (en) 2016-03-19 2026-03-31 Exuma Biotech Corp. Methods and compositions for genetically modifying and expanding lymphocytes and regulating the activity thereof
US11325948B2 (en) 2016-03-19 2022-05-10 Exuma Biotech Corp. Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL
US11111505B2 (en) 2016-03-19 2021-09-07 Exuma Biotech, Corp. Methods and compositions for transducing lymphocytes and regulating the activity thereof
US12144850B2 (en) 2016-04-08 2024-11-19 Purdue Research Foundation Methods and compositions for car T cell therapy
JP7373991B2 (ja) * 2016-07-15 2023-11-06 ビラクタ セラピューティクス,インク. 免疫療法で使用するためのヒストン脱アセチル化酵素阻害剤
KR102576042B1 (ko) 2016-10-11 2023-09-07 아게누스 인코포레이티드 항-lag-3 항체 및 이의 사용 방법
CA3037046A1 (en) 2016-10-31 2018-05-03 University Of Massachusetts Targeting microrna-101-3p in cancer therapy
CN118634323A (zh) 2016-12-07 2024-09-13 艾吉纳斯公司 抗体和其使用方法
FI3551660T3 (fi) 2016-12-07 2023-12-11 Agenus Inc Anti-ctla-4-vasta-aineita ja niiden käyttömenetelmiä
ES2875005T3 (es) 2016-12-09 2021-11-08 Onk Therapeutics Ltd Células asesinas naturales manipuladas y usos de las mismas
WO2018121679A1 (zh) * 2016-12-30 2018-07-05 四川大学 表达cxcr4的嵌合抗原受体修饰的淋巴细胞及制备方法和用途
ES3010559T3 (en) 2017-02-28 2025-04-03 Endocyte Inc Compositions and methods for car t cell therapy
IL269553B2 (en) 2017-03-27 2025-10-01 Nat Univ Singapore Truncated NKG2D chimeric receptors and their uses in immunotherapy with natural killer cells
WO2018177971A1 (en) * 2017-03-27 2018-10-04 INSERM (Institut National de la Santé et de la Recherche Médicale) New method to obtain lymphoid progenitors
WO2018182511A1 (en) 2017-03-27 2018-10-04 National University Of Singapore Stimulatory cell lines for ex vivo expansion and activation of natural killer cells
BR112019024656A2 (pt) * 2017-05-25 2020-06-09 Univ Central Florida Res Found Inc vírus oncolíticos para a sensibilização de células tumorais para morte por células exterminadoras naturais
TWI676483B (zh) * 2017-08-06 2019-11-11 強普生技股份有限公司 醫藥套組及其用途
CA3077325A1 (en) * 2017-09-28 2019-04-04 Celularity Inc. Tumor suppression using human placenta-derived intermediate natural killer (pink) cells in combination with an antibody
AU2018346818B2 (en) * 2017-10-02 2024-12-19 Gamida-Cell Ltd. Expansion and use of expanded NK cell fractions
CN111542545A (zh) * 2017-11-03 2020-08-14 索伦托治疗有限公司 Cd38定向嵌合抗原受体构建体
JP2021505637A (ja) * 2017-12-12 2021-02-18 マクロジェニクス,インコーポレーテッド 二重特異性cd16結合分子、及び疾患の治療におけるその使用
CN108060137B (zh) * 2017-12-26 2021-07-02 博生吉医药科技(苏州)有限公司 Il7和il21修饰的nk92细胞、制备方法及其应用
WO2019127215A1 (en) * 2017-12-28 2019-07-04 Nanjing Legend Biotech Co., Ltd. Multispecific chimeric receptors comprising an nkg2d domain and methods of use thereof
NZ749727A (en) * 2018-01-05 2020-07-31 Gnt Biotech & Medicals Corp A pharmaceutical combination and method for regulation of tumor microenvironment and immunotherapy
US11311576B2 (en) 2018-01-22 2022-04-26 Seattle Children's Hospital Methods of use for CAR T cells
US11814623B2 (en) 2018-01-30 2023-11-14 University Of Massachusetts Methods of treating a wound using epigenetic regulation
AU2019215034C1 (en) 2018-02-01 2022-01-06 Nkmax Co., Ltd. Method of producing natural killer cells and composition for treating cancer
CN111801348A (zh) 2018-02-09 2020-10-20 新加坡国立大学 活化性嵌合受体及其在自然杀伤细胞免疫疗法中的用途
WO2019165121A1 (en) 2018-02-21 2019-08-29 Board Of Regents, The University Of Texas System Methods for activation and expansion of natural killer cells and uses therof
CA3091674A1 (en) 2018-02-23 2019-08-29 Endocyte, Inc. Sequencing method for car t cell therapy
WO2019183094A1 (en) * 2018-03-19 2019-09-26 The Regents Of The University Of Michigan Compositions and methods for t-cell and cytokine activation
SG11202008976YA (en) 2018-04-02 2020-10-29 Nat Univ Singapore Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells
IL277773B2 (en) 2018-04-18 2026-05-01 Summa Health Compositions and methods for treating ischemia and cardiomyopathy
WO2019200586A1 (en) * 2018-04-19 2019-10-24 The Chinese University Of Hong Kong Modified nk cells and uses thereof
GB201807050D0 (en) * 2018-04-30 2018-06-13 Cellprotect Nordic Pharmaceuticals Ab Medical uses
KR102373502B1 (ko) * 2018-05-14 2022-03-11 주식회사 금호에이치티 골수유래억제세포 관련 질환의 예방 및 치료 용도
KR102069704B1 (ko) * 2018-05-16 2020-01-23 고려대학교 산학협력단 Hdac 억제제를 이용한 사람 유래 자연살해세포의 확장 배양법
KR20210016567A (ko) * 2018-05-30 2021-02-16 글리코스템 떼라퓨틱스 비.브이. Car nk 세포
EP3806894A4 (en) 2018-06-12 2022-06-08 Promab Biotechnologies, Inc. PLAP-CAR EFFECTOR CELLS
CN108815186A (zh) * 2018-06-14 2018-11-16 上海鸣大生物科技有限公司 一种治疗hpv持续感染引起疾病的药物及制备方法与应用
EP3844186A4 (en) 2018-08-29 2022-08-17 National University of Singapore METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS
SG11202102272UA (en) 2018-09-05 2021-04-29 Univ Arizona State Oncolytic virus platform to treat hematological cancer
AU2019361096A1 (en) 2018-10-19 2021-06-03 Regents Of The University Of Minnesota NK engager molecules and methods of use thereof
WO2020088631A1 (en) 2018-11-01 2020-05-07 Gracell Biotechnologies (Shanghai) Co., Ltd. Compositions and methods for t cell engineering
CA3120563A1 (en) 2018-11-26 2020-06-04 Nkarta, Inc. Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy
EP3886876A1 (en) * 2018-11-30 2021-10-06 Celularity Inc. Placenta-derived allogeneic car-t cells and uses thereof
WO2020180882A1 (en) 2019-03-05 2020-09-10 Nkarta, Inc. Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy
CA3133419A1 (en) * 2019-03-21 2020-09-24 Gamida Cell Ltd. Expansion and use of expanded nk cell fractions suitable for transplantation in combination therapy
WO2020223445A1 (en) 2019-04-30 2020-11-05 Senti Biosciences, Inc. Chimeric receptors and methods of use thereof
WO2021016621A1 (en) * 2019-07-25 2021-01-28 Celularity Inc. Populations of natural killer cells comprising a cd38 chimeric antigen receptor
BR112022003617A2 (pt) * 2019-09-01 2022-09-13 Exuma Biotech Corp Métodos e composições para a modificação e distribuição de linfócitos
KR20220078665A (ko) * 2019-10-10 2022-06-10 아리조나 보드 오브 리젠츠 온 비하프 오브 아리조나 스테이트 유니버시티 다중특이적 면역 세포 인게이저를 발현하는 종양용해 바이러스
EP4065144A4 (en) * 2019-11-27 2024-04-10 Deverra Therapeutics Inc. COMPOSITIONS AND METHODS FOR CULTIVATION OF HEMATOPOETIC STEM CELLS AND PROGENITOR CELLS
JP2023504075A (ja) * 2019-11-28 2023-02-01 グリコステム セラピューティクス ベスローテン フェンノートシャップ Car-nk細胞を得る方法
US20230111159A1 (en) * 2020-03-05 2023-04-13 Exuma Biotech Corp Methods and compositions for the delivery of modified lymphocyte aggregates
WO2021188836A1 (en) * 2020-03-18 2021-09-23 Barron Annelise E Upregulation of cathelicidin gene expression as an adjuvant to other treatments for diseases
GB2621653A (en) * 2020-09-22 2024-02-21 World Biotech Regenerative Medical Group Ltd Methods and compositions of car-expressing natural killer cells with bispecific antigen-binding molecules as cancer therapeutic agents
US11459372B2 (en) 2020-11-30 2022-10-04 Crispr Therapeutics Ag Gene-edited natural killer cells
US11473060B2 (en) 2020-12-30 2022-10-18 Crispr Therapeutics Ag Compositions and methods for differentiating stem cells into NK cells
AU2022218710A1 (en) * 2021-02-09 2023-08-10 Takeda Pharmaceutical Company Limited Methods and compositions for freezing and thawing mammalian cells
WO2022173737A1 (en) 2021-02-09 2022-08-18 Millennium Pharmaceuticals, Inc. Methods and compositions for freezing and thawing mammalian cells
CN113398264B (zh) * 2021-08-06 2022-04-29 朱有建 Nk细胞及其组合物在治疗癌症中的用途
US20240335472A1 (en) * 2021-08-10 2024-10-10 Gamida Cell Ltd. Anti-her2 car nk cells, methods of their production and uses thereof
CN113577267B (zh) * 2021-09-06 2022-04-08 江西北正干细胞生物科技有限公司 Nk细胞和抗体的药物组合物及其在治疗癌症中的用途
JPWO2023038037A1 (enExample) * 2021-09-08 2023-03-16
EP4180049A1 (en) * 2021-11-16 2023-05-17 Ostravska univerzita Therapeutic composition for cancer treatment
CN114058584B (zh) * 2022-01-07 2022-07-01 山东省齐鲁干细胞工程有限公司 一种临床用自然杀伤细胞的制备方法
CN115927169B (zh) * 2022-10-11 2023-08-11 再造再生医学科技(杭州)有限公司 用于扩增cd34+造血干细胞的培养液和体外扩增cd34+造血干细胞的方法
CN119082021B (zh) * 2024-09-30 2025-03-28 广东壹加再生医学研究院有限公司 一种增强型nk细胞及其制备方法
CN119280423A (zh) * 2024-10-10 2025-01-10 中南大学 一种联合靶向鼻咽癌治疗的载药体系及其制备方法与应用
CN121426926A (zh) * 2025-10-21 2026-01-30 北京京科信拓生物技术有限公司 基因编辑的免疫细胞及其应用
CN121378506A (zh) * 2025-10-21 2026-01-23 北京京科信拓生物技术有限公司 表达car的免疫细胞及其应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5190556A (en) 1991-03-19 1993-03-02 O.B. Tech, Inc. Cord cutter sampler
US5372581A (en) 1993-07-21 1994-12-13 Minneapolis Children's Services Corporation Method and apparatus for placental blood collection
JP2002542349A (ja) 1999-04-16 2002-12-10 ダブリューエム・マーシュ・ライス・ユニバーシティー ポリ(プロピレンフマラート)−ジアクリレートマクロマーで交差結合された生体分解性のポリ(プロピレンフマラート)ネットワーク
US6355699B1 (en) 1999-06-30 2002-03-12 Ethicon, Inc. Process for manufacturing biomedical foams
JP2002045174A (ja) 2000-07-31 2002-02-12 Inst Of Physical & Chemical Res ナチュラルキラー細胞増殖法
EP2206772A3 (en) 2000-12-06 2010-08-04 Robert J. Hariri Method of collecting placental stem cells
US20030187515A1 (en) 2002-03-26 2003-10-02 Hariri Robert J. Collagen biofabric and methods of preparing and using the collagen biofabric
US7147626B2 (en) 2004-09-23 2006-12-12 Celgene Corporation Cord blood and placenta collection kit
EP3594245A1 (en) * 2012-02-13 2020-01-15 Seattle Children's Hospital d/b/a Seattle Children's Research Institute Bispecific chimeric antigen receptors and therapeutic uses thereof
CN103483452B (zh) * 2012-06-12 2021-08-13 上海细胞治疗集团有限公司 双信号独立的嵌合抗原受体及其用途
CA2881792C (en) * 2012-08-13 2024-02-27 Anthrogenesis Corporation Natural killer cells and uses thereof
BR112015020516A2 (pt) * 2013-02-26 2017-10-10 Memorial Sloan Kettering Cancer Center composições e métodos para imunoterapia
HK1220614A1 (zh) * 2013-03-10 2017-05-12 Baylor College Of Medicine 耐化疗免疫细胞
EP2970426B1 (en) * 2013-03-15 2019-08-28 Michael C. Milone Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
EP2992020B1 (en) * 2013-05-03 2020-01-15 Ohio State Innovation Foundation Cs1-specific chimeric antigen receptor engineered immune effector cells
EP3974520A1 (en) * 2013-05-14 2022-03-30 Board of Regents, The University of Texas System Human application of engineered chimeric antigen receptor (car) t-cells

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