KR20170055565A - Ｎ-[5-(아미노설포닐)-4-메틸-1,3-티아졸-2-일]-ｎ-메틸-2-[4-(2-피리디닐)페닐]아세트아미드 메실레이트 일수화물 - Google Patents

Ｎ-[5-(아미노설포닐)-4-메틸-1,3-티아졸-2-일]-ｎ-메틸-2-[4-(2-피리디닐)페닐]아세트아미드 메실레이트 일수화물 Download PDF

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Publication number
KR20170055565A
KR20170055565A KR1020177012548A KR20177012548A KR20170055565A KR 20170055565 A KR20170055565 A KR 20170055565A KR 1020177012548 A KR1020177012548 A KR 1020177012548A KR 20177012548 A KR20177012548 A KR 20177012548A KR 20170055565 A KR20170055565 A KR 20170055565A
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South Korea
Prior art keywords
methyl
phenyl
aminosulfonyl
acetamide
thiazol
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Ceased
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KR1020177012548A
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English (en)
Korean (ko)
Inventor
빌프리드 슈와브
알렉산더 벌크만
쿠르트 뵈그틀리
디터 하그
안드레아스 렌드너
알폰스 그룬넨버그
버짓 카일
요아킴 레제
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아이쿠리스 게엠베하 운트 코. 카게
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Publication of KR20170055565A publication Critical patent/KR20170055565A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
KR1020177012548A 2011-09-26 2012-09-26 Ｎ-[5-(아미노설포닐)-4-메틸-1,3-티아졸-2-일]-ｎ-메틸-2-[4-(2-피리디닐)페닐]아세트아미드 메실레이트 일수화물 Ceased KR20170055565A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11007823.5 2011-09-26
EP11007823A EP2573086A1 (en) 2011-09-26 2011-09-26 N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate
PCT/EP2012/068938 WO2013045479A1 (en) 2011-09-26 2012-09-26 N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate

Related Parent Applications (1)

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KR1020147004026A Division KR101768295B1 (ko) 2011-09-26 2012-09-26 Ｎ-[5-(아미노설포닐)-4-메틸-1,3-티아졸-2-일]-ｎ-메틸-2-[4-(2-피리디닐)페닐]아세트아미드 메실레이트 일수화물

Related Child Applications (1)

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KR1020187021891A Division KR20180088530A (ko) 2011-09-26 2012-09-26 Ｎ-[5-(아미노설포닐)-4-메틸-1,3-티아졸-2-일]-ｎ-메틸-2-[4-(2-피리디닐)페닐]아세트아미드 메실레이트 일수화물

Publications (1)

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KR20170055565A true KR20170055565A (ko) 2017-05-19

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Family Applications (4)

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KR1020197025387A Ceased KR20190104249A (ko) 2011-09-26 2012-09-26 Ｎ-[5-(아미노설포닐)-4-메틸-1,3-티아졸-2-일]-ｎ-메틸-2-[4-(2-피리디닐)페닐]아세트아미드 메실레이트 일수화물
KR1020177012548A Ceased KR20170055565A (ko) 2011-09-26 2012-09-26 Ｎ-[5-(아미노설포닐)-4-메틸-1,3-티아졸-2-일]-ｎ-메틸-2-[4-(2-피리디닐)페닐]아세트아미드 메실레이트 일수화물
KR1020187021891A Ceased KR20180088530A (ko) 2011-09-26 2012-09-26 Ｎ-[5-(아미노설포닐)-4-메틸-1,3-티아졸-2-일]-ｎ-메틸-2-[4-(2-피리디닐)페닐]아세트아미드 메실레이트 일수화물
KR1020147004026A Active KR101768295B1 (ko) 2011-09-26 2012-09-26 Ｎ-[5-(아미노설포닐)-4-메틸-1,3-티아졸-2-일]-ｎ-메틸-2-[4-(2-피리디닐)페닐]아세트아미드 메실레이트 일수화물

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KR1020197025387A Ceased KR20190104249A (ko) 2011-09-26 2012-09-26 Ｎ-[5-(아미노설포닐)-4-메틸-1,3-티아졸-2-일]-ｎ-메틸-2-[4-(2-피리디닐)페닐]아세트아미드 메실레이트 일수화물

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020187021891A Ceased KR20180088530A (ko) 2011-09-26 2012-09-26 Ｎ-[5-(아미노설포닐)-4-메틸-1,3-티아졸-2-일]-ｎ-메틸-2-[4-(2-피리디닐)페닐]아세트아미드 메실레이트 일수화물
KR1020147004026A Active KR101768295B1 (ko) 2011-09-26 2012-09-26 Ｎ-[5-(아미노설포닐)-4-메틸-1,3-티아졸-2-일]-ｎ-메틸-2-[4-(2-피리디닐)페닐]아세트아미드 메실레이트 일수화물

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US (1) US9340535B2 (enExample)
EP (3) EP2573086A1 (enExample)
JP (2) JP6161614B2 (enExample)
KR (4) KR20190104249A (enExample)
CN (2) CN105541829A (enExample)
AR (3) AR088043A1 (enExample)
AU (2) AU2012314536B2 (enExample)
BR (1) BR112014003245B1 (enExample)
CA (1) CA2791142C (enExample)
CL (1) CL2014000149A1 (enExample)
DK (2) DK2598501T3 (enExample)
ES (2) ES2466221T3 (enExample)
HK (1) HK1220978A1 (enExample)
HR (1) HRP20140351T1 (enExample)
IL (2) IL230152A (enExample)
IN (1) IN2014DN01993A (enExample)
JO (2) JO3037B1 (enExample)
MX (2) MX371088B (enExample)
MY (2) MY190878A (enExample)
PE (1) PE20141148A1 (enExample)
PH (2) PH12014500567A1 (enExample)
PL (2) PL2598501T3 (enExample)
PT (1) PT2598501E (enExample)
RU (2) RU2669388C1 (enExample)
SG (1) SG10201407430TA (enExample)
TW (2) TWI567070B (enExample)
UA (2) UA115317C2 (enExample)
WO (1) WO2013045479A1 (enExample)
ZA (2) ZA201401773B (enExample)

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* Cited by examiner, † Cited by third party
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DE102017127669A1 (de) 2017-04-28 2018-10-31 Hyundai Motor Company Wassergekühlter AGR-Kühler

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PT3848369T (pt) * 2016-11-28 2023-04-10 Aicuris Gmbh & Co Kg Hemi-hidrato da base livre de n-[5-(aminossulfonil)-4-metil-1,3-tiazol-2-il]-n-metil-2-[4-(2-piridinil)-fenil]-acetamida, métodos de fabricação e suas utilizações
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KR102535452B1 (ko) 2018-07-06 2023-05-26 파에노 테라퓨틱스 씨오., 엘티디. 티아졸 화합물의 결정형 및 이의 응용
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JP2025530762A (ja) 2022-08-29 2025-09-17 アセンブリー・バイオサイエンシーズ・インコーポレイテッド ヘルペスウイルス用医薬組成物

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DE102017127669A1 (de) 2017-04-28 2018-10-31 Hyundai Motor Company Wassergekühlter AGR-Kühler

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EP2602258B1 (en) 2014-03-19
ES2466221T8 (es) 2016-09-13
TWI567070B (zh) 2017-01-21
TW201625603A (zh) 2016-07-16
EP2602258A1 (en) 2013-06-12
TW201317234A (zh) 2013-05-01
EP2602258B8 (en) 2016-09-28
UA119574C2 (uk) 2019-07-10
JP6353022B2 (ja) 2018-07-04
RU2669388C1 (ru) 2018-10-11
NZ718867A (en) 2016-05-27
BR112014003245B1 (pt) 2021-11-09
PL2602258T3 (pl) 2014-08-29
US20140221433A1 (en) 2014-08-07
AR088043A1 (es) 2014-05-07
JO3037B1 (ar) 2016-09-05
BR112014003245A2 (pt) 2017-03-01
MX338736B (es) 2016-04-29
CL2014000149A1 (es) 2014-09-05
EP2573086A1 (en) 2013-03-27
MX2014003389A (es) 2014-07-09
PH12015502801A1 (en) 2016-10-03
IL234405A (en) 2015-04-30
DK2602258T3 (da) 2014-04-22
AR120291A2 (es) 2022-02-09
AU2012314536A1 (en) 2014-02-06
ES2466221T3 (es) 2014-06-09
AU2015260762B2 (en) 2016-06-09
NZ621615A (en) 2016-04-29
JP2017114859A (ja) 2017-06-29
TWI532739B (zh) 2016-05-11
UA115317C2 (uk) 2017-10-25
KR20180088530A (ko) 2018-08-03
JO3734B1 (ar) 2021-01-31
EP2598501B1 (en) 2014-03-12
RU2014107430A (ru) 2015-11-10
EP2598501A1 (en) 2013-06-05
KR101768295B1 (ko) 2017-08-14
ES2462492T3 (es) 2014-05-23
DK2598501T3 (da) 2014-04-22
KR20190104249A (ko) 2019-09-06
PH12014500567A1 (en) 2014-04-14
US9340535B2 (en) 2016-05-17
MY185063A (en) 2021-04-30
HRP20140351T1 (hr) 2014-07-04
HK1220978A1 (zh) 2017-05-19
RU2620604C2 (ru) 2017-05-29
AU2015260762A1 (en) 2016-02-04
JP2014528948A (ja) 2014-10-30
PE20141148A1 (es) 2014-09-15
AU2012314536B2 (en) 2016-01-14
CN103842359B (zh) 2016-05-25
CA2791142A1 (en) 2013-03-26
IL230152A (en) 2015-04-30
PT2598501E (pt) 2014-06-25
WO2013045479A1 (en) 2013-04-04
KR20140066704A (ko) 2014-06-02
AR116394A2 (es) 2021-05-05
PH12015502801B1 (en) 2016-10-03
CA2791142C (en) 2017-08-01
CN103842359A (zh) 2014-06-04
MY190878A (en) 2022-05-13
ZA201401773B (en) 2015-12-23
MX371088B (es) 2020-01-16
JP6161614B2 (ja) 2017-07-12
SG10201407430TA (en) 2014-12-30
PL2598501T3 (pl) 2014-08-29
IN2014DN01993A (enExample) 2015-05-15
ZA201408734B (en) 2016-08-31
CN105541829A (zh) 2016-05-04

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