CN103842359B - N-[5-(氨基磺酰基)-4-甲基-1,3-噻唑-2-基]-n-甲基-2-[4-(2-吡啶基)苯基]乙酰胺甲磺酸盐一水合物 - Google Patents

N-[5-(氨基磺酰基)-4-甲基-1,3-噻唑-2-基]-n-甲基-2-[4-(2-吡啶基)苯基]乙酰胺甲磺酸盐一水合物 Download PDF

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Publication number
CN103842359B
CN103842359B CN201280046744.6A CN201280046744A CN103842359B CN 103842359 B CN103842359 B CN 103842359B CN 201280046744 A CN201280046744 A CN 201280046744A CN 103842359 B CN103842359 B CN 103842359B
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methyl
phenyl
thiazol
acetamide
aminosulfonyl
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Chinese (zh)
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CN103842359A (zh
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W·施瓦布
A·比克曼
K·弗格特利
D·哈格
A·伦德
A·格瓦嫩博格
B·凯尔
J·雷泽
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Aike 316 Co ltd
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Aicuris GmbH and Co KG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
CN201280046744.6A 2011-09-26 2012-09-26 N-[5-(氨基磺酰基)-4-甲基-1,3-噻唑-2-基]-n-甲基-2-[4-(2-吡啶基)苯基]乙酰胺甲磺酸盐一水合物 Active CN103842359B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201511005819.8A CN105541829A (zh) 2011-09-26 2012-09-26 N-[5-(氨基磺酰基)-4-甲基-1,3-噻唑-2-基]-n-甲基-2-[4-(2-吡啶基)苯基]乙酰胺甲磺酸盐一水合物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11007823.5 2011-09-26
EP11007823A EP2573086A1 (en) 2011-09-26 2011-09-26 N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate
PCT/EP2012/068938 WO2013045479A1 (en) 2011-09-26 2012-09-26 N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate

Related Child Applications (1)

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CN201511005819.8A Division CN105541829A (zh) 2011-09-26 2012-09-26 N-[5-(氨基磺酰基)-4-甲基-1,3-噻唑-2-基]-n-甲基-2-[4-(2-吡啶基)苯基]乙酰胺甲磺酸盐一水合物

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CN103842359A CN103842359A (zh) 2014-06-04
CN103842359B true CN103842359B (zh) 2016-05-25

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CN201511005819.8A Pending CN105541829A (zh) 2011-09-26 2012-09-26 N-[5-(氨基磺酰基)-4-甲基-1,3-噻唑-2-基]-n-甲基-2-[4-(2-吡啶基)苯基]乙酰胺甲磺酸盐一水合物

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US (1) US9340535B2 (enExample)
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WO (1) WO2013045479A1 (enExample)
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EP2573086A1 (en) * 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate
AR108175A1 (es) * 2016-04-06 2018-07-25 Innovative Molecules Gmbh Compuestos antivíricos de tiazol acetamida
WO2018096170A1 (en) * 2016-11-28 2018-05-31 Aicuris Anti-Infective Cures Gmbh N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)-phenyl]-acetamide free base hemihydrate, methods of manufacture and uses thereof
UY37497A (es) * 2016-11-28 2018-06-29 Aicuris Anti Infective Cures Gmbh Formulación tópica que comprende n-[5-(aminosulfonil)-4-metil-1,3-tiazol-2-il]-n-metil-2-[4-(2-piridinil)-fenil]-acetamida
TWI808591B (zh) 2016-11-28 2023-07-11 德商艾庫瑞斯公司 N-[5-(胺基磺醯基)-4-甲基-1,3-噻唑-2-基]-n-甲基-2-[4-(2-吡啶基)-苯基]-乙醯胺之游離鹼之硫酸鹽、其醫藥調配物及其用途
KR102335327B1 (ko) 2017-04-28 2021-12-03 현대자동차 주식회사 수냉식 이지알 쿨러
IL271725B2 (en) * 2017-06-28 2025-09-01 Aicuris Anti Infective Cures Ag Intravaginally applicable devices comprising antiviral compounds
EP4209491A1 (en) 2017-10-05 2023-07-12 Innovative Molecules GmbH Enantiomers of substituted thiazoles as antiviral compounds
KR102535452B1 (ko) * 2018-07-06 2023-05-26 파에노 테라퓨틱스 씨오., 엘티디. 티아졸 화합물의 결정형 및 이의 응용
EP4509118A3 (en) * 2018-09-19 2025-05-14 ModernaTX, Inc. High-purity peg lipids and uses thereof
TW202038947A (zh) 2018-11-28 2020-11-01 德商創新分子有限責任公司 在與溶瘤病毒之組合療法中治療癌症的解旋酶引子酶抑制劑
WO2021191320A1 (en) * 2020-03-26 2021-09-30 Aicuris Gmbh & Co. Kg Ophthalmic formulation comprising n-[5-(aminosulfonyl)-4-methyl-1,3- thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl]acetamide hemihydrate
US20260070900A1 (en) 2022-08-29 2026-03-12 Assembly Biosciences, Inc. A novel crystalline form of pritelivir
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WO2006103011A1 (de) * 2005-03-30 2006-10-05 Aicuris Gmbh & Co. Kg Pharmazeutische zubereitung von n-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl]acetamid

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PT2598501E (pt) 2014-06-25
EP2602258B8 (en) 2016-09-28
TWI532739B (zh) 2016-05-11
JP6161614B2 (ja) 2017-07-12
UA119574C2 (uk) 2019-07-10
ZA201408734B (en) 2016-08-31
UA115317C2 (uk) 2017-10-25
MX2014003389A (es) 2014-07-09
NZ718867A (en) 2016-05-27
MX338736B (es) 2016-04-29
EP2598501B1 (en) 2014-03-12
PE20141148A1 (es) 2014-09-15
ES2466221T8 (es) 2016-09-13
DK2598501T3 (da) 2014-04-22
AU2015260762B2 (en) 2016-06-09
JO3037B1 (ar) 2016-09-05
TW201625603A (zh) 2016-07-16
PL2602258T3 (pl) 2014-08-29
EP2602258A1 (en) 2013-06-12
PH12015502801A1 (en) 2016-10-03
MX371088B (es) 2020-01-16
IL230152A (en) 2015-04-30
CL2014000149A1 (es) 2014-09-05
JP2014528948A (ja) 2014-10-30
PL2598501T3 (pl) 2014-08-29
PH12014500567A1 (en) 2014-04-14
KR20180088530A (ko) 2018-08-03
US9340535B2 (en) 2016-05-17
IN2014DN01993A (enExample) 2015-05-15
TWI567070B (zh) 2017-01-21
AR088043A1 (es) 2014-05-07
KR20170055565A (ko) 2017-05-19
PH12015502801B1 (en) 2016-10-03
KR101768295B1 (ko) 2017-08-14
BR112014003245A2 (pt) 2017-03-01
HRP20140351T1 (hr) 2014-07-04
AU2012314536B2 (en) 2016-01-14
CN103842359A (zh) 2014-06-04
JP2017114859A (ja) 2017-06-29
JP6353022B2 (ja) 2018-07-04
HK1220978A1 (zh) 2017-05-19
RU2669388C1 (ru) 2018-10-11
TW201317234A (zh) 2013-05-01
ES2462492T3 (es) 2014-05-23
EP2598501A1 (en) 2013-06-05
US20140221433A1 (en) 2014-08-07
RU2620604C2 (ru) 2017-05-29
DK2602258T3 (da) 2014-04-22
KR20190104249A (ko) 2019-09-06
ES2466221T3 (es) 2014-06-09
SG10201407430TA (en) 2014-12-30
JO3734B1 (ar) 2021-01-31
ZA201401773B (en) 2015-12-23
AR116394A2 (es) 2021-05-05
AR120291A2 (es) 2022-02-09
AU2012314536A1 (en) 2014-02-06
CA2791142C (en) 2017-08-01
CA2791142A1 (en) 2013-03-26
MY185063A (en) 2021-04-30
RU2014107430A (ru) 2015-11-10
EP2602258B1 (en) 2014-03-19
KR20140066704A (ko) 2014-06-02
NZ621615A (en) 2016-04-29
BR112014003245B1 (pt) 2021-11-09
CN105541829A (zh) 2016-05-04
EP2573086A1 (en) 2013-03-27
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AU2015260762A1 (en) 2016-02-04
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