KR20160136323A - 골수형성이상증후군 치료용 jak1 억제제 - Google Patents

골수형성이상증후군 치료용 jak1 억제제 Download PDF

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Publication number
KR20160136323A
KR20160136323A KR1020167026668A KR20167026668A KR20160136323A KR 20160136323 A KR20160136323 A KR 20160136323A KR 1020167026668 A KR1020167026668 A KR 1020167026668A KR 20167026668 A KR20167026668 A KR 20167026668A KR 20160136323 A KR20160136323 A KR 20160136323A
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KR
South Korea
Prior art keywords
pyrimidin
pyrrolo
pyrazol
trifluoromethyl
acetonitrile
Prior art date
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Ceased
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KR1020167026668A
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English (en)
Korean (ko)
Inventor
크리쉬나 바디
Original Assignee
인사이트 코포레이션
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Publication of KR20160136323A publication Critical patent/KR20160136323A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • Y10S514/908—

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020167026668A 2014-02-28 2015-02-27 골수형성이상증후군 치료용 jak1 억제제 Ceased KR20160136323A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461946124P 2014-02-28 2014-02-28
US61/946,124 2014-02-28
PCT/US2015/017963 WO2015131031A1 (en) 2014-02-28 2015-02-27 Jak1 inhibitors for the treatment of myelodysplastic syndromes

Publications (1)

Publication Number Publication Date
KR20160136323A true KR20160136323A (ko) 2016-11-29

Family

ID=52693052

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020167026668A Ceased KR20160136323A (ko) 2014-02-28 2015-02-27 골수형성이상증후군 치료용 jak1 억제제

Country Status (29)

Country Link
US (4) US20150246046A1 (enExample)
EP (1) EP3110409B1 (enExample)
JP (1) JP6576941B2 (enExample)
KR (1) KR20160136323A (enExample)
CN (2) CN106456773A (enExample)
AU (1) AU2015222913B2 (enExample)
CA (1) CA2940659C (enExample)
CL (1) CL2016002144A1 (enExample)
CR (1) CR20160449A (enExample)
CY (1) CY1120857T1 (enExample)
DK (1) DK3110409T3 (enExample)
EA (1) EA201691745A1 (enExample)
ES (1) ES2688553T3 (enExample)
HR (1) HRP20181661T1 (enExample)
HU (1) HUE041456T2 (enExample)
IL (1) IL247475B (enExample)
LT (1) LT3110409T (enExample)
MX (1) MX372939B (enExample)
MY (1) MY185392A (enExample)
PE (1) PE20161388A1 (enExample)
PL (1) PL3110409T3 (enExample)
PT (1) PT3110409T (enExample)
RS (1) RS57723B1 (enExample)
SG (2) SG11201607083VA (enExample)
SI (1) SI3110409T1 (enExample)
SM (1) SMT201800551T1 (enExample)
UA (1) UA121857C2 (enExample)
WO (1) WO2015131031A1 (enExample)
ZA (1) ZA201606610B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180069420A (ko) * 2016-12-15 2018-06-25 가톨릭대학교 산학협력단 골수형성이상 증후군 환자의 저메틸화 제제 치료 반응성 및 생존 예후 예측용 조성물

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BRPI1012108B8 (pt) 2009-05-22 2021-05-25 Incyte Corp composto 3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il]octa no- ou heptano-nitrila, sua composição, seus usos e processo para preparar um sal de ácido fosfórico
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TW201924683A (zh) 2017-12-08 2019-07-01 美商英塞特公司 用於治療骨髓增生性贅瘤的低劑量組合療法
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Publication number Priority date Publication date Assignee Title
KR20180069420A (ko) * 2016-12-15 2018-06-25 가톨릭대학교 산학협력단 골수형성이상 증후군 환자의 저메틸화 제제 치료 반응성 및 생존 예후 예측용 조성물

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PE20161388A1 (es) 2016-12-28
NZ724464A (en) 2021-01-29
LT3110409T (lt) 2019-01-25
IL247475B (en) 2020-05-31
DK3110409T3 (en) 2018-10-22
MY185392A (en) 2021-05-17
SMT201800551T1 (it) 2019-01-11
EA201691745A1 (ru) 2016-12-30
HRP20181661T1 (hr) 2018-12-14
SI3110409T1 (sl) 2018-11-30
PL3110409T3 (pl) 2018-12-31
SG11201607083VA (en) 2016-09-29
US20150246046A1 (en) 2015-09-03
US20210069193A1 (en) 2021-03-11
US20190111058A1 (en) 2019-04-18
PT3110409T (pt) 2018-11-07
CA2940659C (en) 2023-01-03
US20220378791A1 (en) 2022-12-01
CL2016002144A1 (es) 2016-12-16
AU2015222913B2 (en) 2019-12-12
MX372939B (es) 2020-04-03
ES2688553T3 (es) 2018-11-05
AU2015222913A1 (en) 2016-09-29
JP6576941B2 (ja) 2019-09-18
MX2016011103A (es) 2017-02-28
CN112494652A (zh) 2021-03-16
BR112016019511A2 (enExample) 2017-08-15
IL247475A0 (en) 2016-11-30
RS57723B1 (sr) 2018-12-31
UA121857C2 (uk) 2020-08-10
HUE041456T2 (hu) 2019-05-28
CN106456773A (zh) 2017-02-22
WO2015131031A1 (en) 2015-09-03
CA2940659A1 (en) 2015-09-03
SG10201807952PA (en) 2018-10-30
CY1120857T1 (el) 2019-12-11
JP2017506659A (ja) 2017-03-09
BR112016019511A8 (pt) 2023-01-24
ZA201606610B (en) 2020-08-26
EP3110409A1 (en) 2017-01-04
EP3110409B1 (en) 2018-08-15
CR20160449A (es) 2016-12-20

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